|1.||Dietrich, Wulf: 8 articles (02/2009 - 08/2004)|
|2.||Taylor, K M: 7 articles (05/2008 - 08/2000)|
|3.||Levy, Jerrold H: 7 articles (02/2008 - 01/2004)|
|4.||Augoustides, John G T: 6 articles (06/2008 - 07/2005)|
|5.||Landis, R C: 6 articles (05/2008 - 08/2000)|
|6.||Spinale, Francis G: 5 articles (05/2012 - 08/2008)|
|7.||Reeves, Scott T: 5 articles (05/2012 - 08/2008)|
|8.||Hunt, B J: 5 articles (01/2010 - 02/2000)|
|9.||Royston, David: 5 articles (01/2010 - 08/2004)|
|10.||van der Linden, Jan: 5 articles (08/2009 - 08/2005)|
08/01/2002 - "Large-dose aprotinin was safe and effective in dramatically reducing the measured and calculated bleeding and the amount of transfused red blood cell units after major orthopedic surgery. "
02/01/2000 - "High-dose aprotinin was highly effective in reducing bleeding in this high-risk group of patients. "
12/01/1996 - "All three aprotinin doses were highly effective in reducing bleeding and transfusion requirements. "
04/01/1998 - "Aprotinin is widely used and has proven efficacy in the management of excess bleeding. "
01/01/2013 - "In contrast, aprotinin might probably be beneficial in high risk cardiac surgery as it reduces risk of transfusion and bleeding complications."
05/01/2010 - "Aprotinin dosage regimen of 40,000 KIU/kg at induction, in CPB prime and postoperatively for three hours was most effective in reducing postoperative blood loss and PRBC transfusion requirements. "
09/01/1999 - "Although administered intraoperatively, aprotinin treatment dramatically reduced intraoperative and 24-h postoperative blood loss and autologous transfusion requirements but did not change homologous transfusion in posterior lumbar spine fusion. "
06/01/2004 - "Full-dose aprotinin significantly reduces postoperative blood loss and has been demonstrated in multiple prospective blinded studies to be safe and effective. "
05/01/2008 - "Aprotinin was associated with a significant reduction in postoperative blood loss (p < 0.001) and less excessive postoperative hemorrhage (p < 0.001) compared with the control group. "
03/01/2001 - "A significant reduction in postoperative blood loss (approximately 470 ml) occurred in patients receiving aprotinin. "
06/01/1999 - "In conclusion, aprotinin at high concentrations may be beneficial for the survival of skeletal muscle and provides protection from platelet accumulation in the microcirculation of skeletal muscle exposed to ischaemia and reperfusion injury."
06/01/2000 - "When aprotinin was used, LV pressure was inclined to be higher while liver portal vein pressure was lower, thus providing protection against liver and heart reperfusion injury."
05/01/2004 - "Aprotinin ameliorates ischemia/reperfusion injury in a rat hind limb model."
02/01/2003 - "Improved myocardial function has been observed with aprotinin treatment in animal models of ischemia-reperfusion injury. "
11/01/2000 - "The enhanced oxygenation suggests that aprotinin may offer protection against early reperfusion injury."
03/01/1985 - "These species differences of the aprotinin blockade should be considered when seeking reasons why aprotinin has not proven effective in preventing the morbidity and mortality of human pancreatitis."
01/01/1984 - "The efficacy of MTI on these types of pancreatitis were higher than those of aprotinin. "
09/01/1980 - "Steroid administration worsened pancreatitis, Trasylol had no effect, and albumin was markedly effective in ameliorating pancreatitis. "
05/01/1964 - "TRASYLOL: A NEW TREATMENT FOR PANCREATITIS."
12/13/1974 - "[Efficacy of trasylol in the treatment of acute pancreatitis]."
12/01/2004 - "Meta-analysis of clinical trials demonstrates a decreased incidence of stroke after CABG when aprotinin is administrated perioperatively. "
07/01/2010 - "In this experimental model of stroke occurring during CPB, aprotinin decreased the systemic inflammatory response to CPB. "
01/01/2010 - "In the aprotinin group, a higher rate of late events of ischemic stroke (3.4% versus 0.9%; P = 0.02) and neurologic disability (5.8% versus 2.4%; P = 0.02) was found. "
12/01/2006 - "In contrast, however, a recent cohort study has raised concerns about aprotinin, suggesting that its use is associated with a significant increased risk of stroke in uncomplicated CABG surgery. "
12/01/2006 - "We conclude that there is evidence from three meta-analyses and two more recent RCTs that the use of aprotinin is associated with a decreased incidence of stroke and neurological complications in some patients undergoing cardiac surgery. "
|1.||Tranexamic Acid (AMCA)
|3.||Serine Proteases (Serine Protease)
|4.||6-Aminocaproic Acid (6 Aminocaproic Acid)
|6.||Protease Inhibitors (Protease Inhibitor)
|8.||Fibrin Tissue Adhesive (Fibrin Sealant)
|10.||Peptide Hydrolases (Proteases)
|1.||Cardiopulmonary Bypass (Heart-Lung Bypass)
|3.||Blood Transfusion (Blood Transfusions)
|4.||Coronary Artery Bypass (Coronary Artery Bypass Surgery)