Chronic Idiopathic Jaundice (Dubin Johnson Syndrome)

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125 relevant articles (7 outcomes, 7 trials/studies) found for this Disease

Description: A benign, autosomally recessive inherited hyperbilirubinemia characterized by the presence of a dark pigment in the centrilobular region of the liver cells. There is a functional defect in biliary excretion of bilirubin, cholephilic dyes, and porphyrins. Affected persons may be asymptomatic or have vague constitutional or gastrointestinal symptoms. The liver may be slightly enlarged, and oral and intravenous cholangiography fails to visualize the biliary tract.

Also Known As:

Dubin Johnson Syndrome; Syndrome, Dubin-Johnson; Jaundice, Chronic Idiopathic; Chronic Idiopathic Jaundices; Idiopathic Jaundice, Chronic; Idiopathic Jaundices, Chronic; Jaundices, Chronic Idiopathic; Dubin-Johnson Syndrome

Relationship Network

Disease Context: Research Results

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 420

Inborn Genetic Diseases: 547

Inborn Errors Metabolism: 401

Hereditary Hyperbilirubinemia: 16

Chronic Idiopathic Jaundice: 125

Diseases Newborn Infant

Neonatal Hyperbilirubinemia: 319

Neonatal Jaundice: 622

Chronic Idiopathic Jaundice: 125

Nutritional and Metabolic Diseases

Metabolic Diseases: 1264

Inborn Errors Metabolism: 401

Hereditary Hyperbilirubinemia: 16

Chronic Idiopathic Jaundice: 125

Related Diseases

1.	Jaundice
2.	Syndrome
3.	Hereditary Hyperbilirubinemia (Rotor Syndrome)
4.	Liver Diseases (Liver Disease)
5.	Iron Overload
45 Diseases and 57 more articles analyzed in the Research Interface, order at left...

Experts

1.	Poupon, Raoul: 1 article (10/2006)
2.	Wendum, Dominique: 1 article (10/2006)
3.	Barbu, Véronique: 1 article (10/2006)
4.	Matsuda, Fumihiko: 1 article (10/2006)
5.	Ping, Chen: 1 article (10/2006)
6.	Corpechot, Christophe: 1 article (10/2006)
7.	Mor-Cohen, Ronit: 1 article (02/2005)
8.	Seligsohn, Uri: 1 article (02/2005)
9.	Rosenberg, Nurit: 1 article (02/2005)
10.	Goldberg, Iris: 1 article (02/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Idiopathic Jaundice:

1.	Phenobarbital (Luminal)FDA Link 04/01/1996 - "Following phenobarbital administration, the ICG secondary rise in the 5 patients with Dubin-Johnson syndrome disappeared, and ICG was rapidly cleared from blood" 04/01/1996 - "However, in patients with Dubin-Johnson syndrome, BSP clearance in serum did not show any change before and after phenobarbital administration" 05/16/1976 - "Phenobarbital in Dubin-Johnson syndrome]" 01/01/1976 - "The effect of phenobarbital on patients with Dubin-Johnson syndrome." 08/01/1974 - "Effect of phenobarbital on liver functions in patients with Dubin-Johnson syndrome." Get all the results and reference details, order at left...
2.	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 04/27/1981 - "Abnormality of oral ursodeoxycholic acid tolerance test in the Dubin-Johnson syndrome." 07/01/1981 - "As the area under the curve reflects the hepatic clearance of intestinally absorbed ursodeoxycholic acid and therefore gives a quantitative estimate of hepatic ursodeoxycholic acid clearance, the hepatic clearance of ursodeoxycholic acid seems to be impaired in patients with Gilbert's syndrome and Dubin-Johnson syndrome" 01/01/2002 - "We suggest ursodeoxycholic acid in treatment for Dubin-Johnson Syndrome with severe direct hyperbilirubinemia presenting in the neonatal age." 01/01/2002 - "Treatment of severe cholestasis in neonatal Dubin-Johnson syndrome with ursodeoxycholic acid." 07/01/1981 - "An oral tolerance test using a 25-mg dose of ursodeoxycholic acid was carried out in 46 patients with constitutional hyperbilirubinemias: 26 with Gilbert's syndrome, 9 with Dubin-Johnson syndrome, 7 with Rotor Syndrome, 3 with constitutional indocyanine green intolerance, and 1 with Crigler-Najjar syndrome type II; they were compared with 14 healthy control subjects" Get all the results and reference details, order at left...
3.	Technetium Tc 99m LidofeninIBA 05/01/1983 - "99mTc-HIDA cholescintigraphy in children with Dubin-Johnson syndrome." 03/01/1982 - "It is concluded that 99mTc-HIDA cholescintigraphy may be helpful in the diagnosis of Dubin-Johnson syndrome and Rotor syndrome and in the differential diagnosis between these two conditions." 03/01/1982 - "99mTc-HIDA cholescintigraphy was performed in 6 patients with Dubin-Johnson syndrome and 1 patient with Rotor syndrome" Get all the results and reference details, order at left...
4.	Iron (Serum Iron Level)IBA 09/01/2004 - "In conclusion, deep jaundice in a patient with Dubin-Johnson syndrome complicated by hepatitis C virus-positive chronic liver disease and iron overload was partially improved by iron-reduction therapy." 01/01/1987 - "Patients with metal and pigment metabolic disorders include iron storage disease, either hemochromatosis or transfusional hemosiderosis, Menkes' kinky hair syndrome, and Dubin-Johnson syndrome" 09/01/2004 - "Iron-reduction therapy by venesection, an alternative to interferon, was performed in a 55-year-old male patient with Dubin-Johnson syndrome complicated by hepatitis C virus-positive chronic liver disease and hepatic iron overload" Get all the results and reference details, order at left...
5.	Rose BengalIBA 03/15/1973 - "Excretion of rose bengal labeled with I 131 and plasma clearance of bromosulphalein in Dubin-Johnson syndrome]" Get all the results and reference details, order at left...
6.	Glycocholic AcidIBA 10/01/1980 - "Serum bile salt measurements and intravenous clearance of glycocholate were performed in a woman with Dubin-Johnson syndrome" Get all the results and reference details, order at left...
7.	BilirubinIBA 02/01/2007 - "Acquired or hereditary deficiency of ABCC2, the latter known as Dubin-Johnson syndrome in humans, causes an increased concentration of bilirubin glucuronosides in blood because of their efflux from hepatocytes via the basolateral ABCC3, which compensates for the deficiency in ABCC2-mediated apical efflux" 01/01/2003 - "Mutations in human MRP2 result in defects in excretion of conjugated bilirubin and other cholephiles known as the Dubin-Johnson syndrome" 03/01/1998 - "These results demonstrate that SnMP can lower plasma bilirubin concentrations for extended periods in a new mutant rat model of Dubin-Johnson syndrome." 01/01/1990 - "Dubin-Johnson syndrome (DJS), a congenital metabolic disorder of bilirubin excretion, was classically diagnosed by the bromsulfalein (BSP) curve and needle hepatic biopsy methods" 12/01/1980 - "While the preoperative serum bilirubin level is one of the criteria in determining the indication for radical hepatic resection, it does not play a decisive role in the case of combined Dubin-Johnson syndrome." Get all the results and reference details, order at left...
8.	Uridine Diphosphate Glucose (UDP Glucose)IBA 06/15/1976 - "Therapeutic afficacy of UDPG in non-hemolytic familial jaundice: metabolic studies in a patient with Dubin-Johnson syndrome" 02/29/1976 - "Study of bilirubin kinetics in a case of Dubin-Johnson syndrome before and after treatment with UDPG]" Get all the results and reference details, order at left...
9.	Sulfobromophthalein (Sulfobromophthalein Sodium)IBA 10/31/1969 - "Metabolism of sulfobromophthalein (BSF) in Dubin-Johnson syndrome (study of 4 cases)]" 02/01/1982 - "Impairment of bromosulfophthalein clearance by bile salt administration in normal volunteers and patients with Dubin-Johnson syndrome." 06/01/1972 - "Metabolism of the bromsulphalein in Dubin-Johnson syndrome" 12/01/1970 - "Sulfobromophthalein tolerance test in patients with Dubin-Johnson syndrome and their relatives." 01/01/1963 - "KINETICS OF BROMSULPHALEIN IN THE DUBIN-JOHNSON SYNDROME.]" Get all the results and reference details, order at left...
10.	Adenosine Triphosphate (ATP)IBA 11/01/2002 - "Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome." 04/01/2002 - "A new mutation of the ATP-binding cassette, sub-family C, member 2 (ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome." 10/01/2000 - "Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome]" 03/01/1999 - "Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome." 06/01/1996 - "Hepatic excretion of non-bile acid organic anions is reported to be ATP-dependent and a defect of this transport has been reported in congenitally jaundiced rats, animal models of human Dubin-Johnson syndrome" Get all the results and reference details, order at left...
71 Drugs and Important Bio-Agents and 122 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Segmental Mastectomy (Lumpectomy) 05/01/2004 - "Hepatocellular carcinoma in a case of Dubin-Johnson syndrome treated successfully with a central bilateral segmentectomy." 05/01/2004 - "A 72-year-old woman with hepatocellular carcinoma and HCV cirrhosis combined with Dubin-Johnson syndrome was successfully treated by a central bilateral segmentectomy" Get all the results and reference details, order at left...
2.	Lasers (Laser) 05/01/1996 - "In the present study we show the selective absence of the canalicular isoform of MRP (cMRP) from the hepatocytes in a patient with Dubin-Johnson syndrome by double-label immunofluorescence and confocal laser scanning microscopy using antibodies directed against MRP and dipeptidyl-peptidase IV (DPPIV)" Get all the results and reference details, order at left...
3.	Aftercare (After-Treatment) 02/29/1976 - "Study of bilirubin kinetics in a case of Dubin-Johnson syndrome before and after treatment with UDPG]" Get all the results and reference details, order at left...
4.	Hepatectomy 01/01/1998 - "Postoperative management following massive hepatectomy in a patient with Dubin-Johnson syndrome: report of a case." 02/01/1983 - "Patient with Dubin-Johnson syndrome tolerated major hepatectomy" Get all the results and reference details, order at left...
5.	Anesthesia 01/01/1991 - "Anesthesia and postoperative management of a patient with Gilbert's syndrome and one with Dubin-Johnson syndrome is reported" Get all the results and reference details, order at left...
5 Therapies and Procedures and 6 more articles analyzed in the Research Interface, order at left...

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