|2.||Hereditary Hyperbilirubinemia (Rotor Syndrome)
|3.||Liver Diseases (Liver Disease)
|5.||Hepatocellular Carcinoma (Hepatoma)
|1.||Hayashi, Hisao: 4 articles (10/2007 - 01/2003)|
|2.||Yano, Motoyoshi: 4 articles (10/2007 - 01/2003)|
|3.||Wakusawa, Shinya: 4 articles (10/2007 - 01/2003)|
|4.||Jirsa, Milan: 3 articles (02/2013 - 07/2005)|
|5.||Keppler, Dietrich: 3 articles (02/2007 - 07/2002)|
|6.||Machida, Ikuo: 3 articles (04/2005 - 01/2003)|
|7.||Jansen, P L: 3 articles (12/2000 - 01/2000)|
|8.||Uchiumi, Takeshi: 2 articles (05/2013 - 11/2002)|
|9.||Elleder, Milan: 2 articles (02/2013 - 07/2005)|
|10.||Mor-Cohen, Ronit: 2 articles (03/2007 - 02/2005)|
|1.||Phenobarbital (Luminal)FDA Link
04/01/1996 - "Following phenobarbital administration, the ICG secondary rise in the 5 patients with Dubin-Johnson syndrome disappeared, and ICG was rapidly cleared from blood. "
04/01/1996 - "However, in patients with Dubin-Johnson syndrome, BSP clearance in serum did not show any change before and after phenobarbital administration. "
05/16/1976 - "[Phenobarbital in Dubin-Johnson syndrome]."
01/01/1976 - "The effect of phenobarbital on patients with Dubin-Johnson syndrome."
08/01/1974 - "Effect of phenobarbital on liver functions in patients with Dubin-Johnson syndrome."
|2.||Ursodeoxycholic Acid (Urso)FDA LinkGeneric
04/27/1981 - "Abnormality of oral ursodeoxycholic acid tolerance test in the Dubin-Johnson syndrome."
07/01/1981 - "As the area under the curve reflects the hepatic clearance of intestinally absorbed ursodeoxycholic acid and therefore gives a quantitative estimate of hepatic ursodeoxycholic acid clearance, the hepatic clearance of ursodeoxycholic acid seems to be impaired in patients with Gilbert's syndrome and Dubin-Johnson syndrome. "
01/01/2002 - "We suggest ursodeoxycholic acid in treatment for Dubin-Johnson Syndrome with severe direct hyperbilirubinemia presenting in the neonatal age."
01/01/2002 - "Treatment of severe cholestasis in neonatal Dubin-Johnson syndrome with ursodeoxycholic acid."
07/01/1981 - "An oral tolerance test using a 25-mg dose of ursodeoxycholic acid was carried out in 46 patients with constitutional hyperbilirubinemias: 26 with Gilbert's syndrome, 9 with Dubin-Johnson syndrome, 7 with Rotor Syndrome, 3 with constitutional indocyanine green intolerance, and 1 with Crigler-Najjar syndrome type II; they were compared with 14 healthy control subjects. "
|3.||Technetium Tc 99m LidofeninIBA
05/01/1983 - "99mTc-HIDA cholescintigraphy in children with Dubin-Johnson syndrome."
03/01/1982 - "It is concluded that 99mTc-HIDA cholescintigraphy may be helpful in the diagnosis of Dubin-Johnson syndrome and Rotor syndrome and in the differential diagnosis between these two conditions."
03/01/1982 - "99mTc-HIDA cholescintigraphy was performed in 6 patients with Dubin-Johnson syndrome and 1 patient with Rotor syndrome. "
09/01/2004 - "In conclusion, deep jaundice in a patient with Dubin-Johnson syndrome complicated by hepatitis C virus-positive chronic liver disease and iron overload was partially improved by iron-reduction therapy."
01/01/1987 - "Patients with metal and pigment metabolic disorders include iron storage disease, either hemochromatosis or transfusional hemosiderosis, Menkes' kinky hair syndrome, and Dubin-Johnson syndrome. "
09/01/2004 - "Iron-reduction therapy by venesection, an alternative to interferon, was performed in a 55-year-old male patient with Dubin-Johnson syndrome complicated by hepatitis C virus-positive chronic liver disease and hepatic iron overload. "
06/01/2014 - "Impairment of bilirubin secretion leads to accumulation of conjugated bilirubin (Dubin-Johnson syndrome). "
01/01/2013 - "Dubin-Johnson syndrome (DJS) is a rare autosomal recessive inheritance disorder of bilirubin metabolism. "
02/01/2007 - "Acquired or hereditary deficiency of ABCC2, the latter known as Dubin-Johnson syndrome in humans, causes an increased concentration of bilirubin glucuronosides in blood because of their efflux from hepatocytes via the basolateral ABCC3, which compensates for the deficiency in ABCC2-mediated apical efflux. "
01/01/2003 - "Mutations in human MRP2 result in defects in excretion of conjugated bilirubin and other cholephiles known as the Dubin-Johnson syndrome. "
03/01/1998 - "These results demonstrate that SnMP can lower plasma bilirubin concentrations for extended periods in a new mutant rat model of Dubin-Johnson syndrome."
|8.||Sulfobromophthalein (Sulfobromophthalein Sodium)IBA
10/31/1969 - "[Metabolism of sulfobromophthalein (BSF) in Dubin-Johnson syndrome (study of 4 cases)]."
02/01/1982 - "Impairment of bromosulfophthalein clearance by bile salt administration in normal volunteers and patients with Dubin-Johnson syndrome."
06/01/1972 - "Metabolism of the bromsulphalein in Dubin-Johnson syndrome. "
12/01/1970 - "Sulfobromophthalein tolerance test in patients with Dubin-Johnson syndrome and their relatives."
01/01/1963 - "[KINETICS OF BROMSULPHALEIN IN THE DUBIN-JOHNSON SYNDROME]."
|9.||Adenosine Triphosphate (ATP)IBA
11/01/2002 - "Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome."
04/01/2002 - "A new mutation of the ATP-binding cassette, sub-family C, member 2 (ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome."
10/01/2000 - "[Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome]."
03/01/1999 - "Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome."
06/01/1996 - "Hepatic excretion of non-bile acid organic anions is reported to be ATP-dependent and a defect of this transport has been reported in congenitally jaundiced rats, animal models of human Dubin-Johnson syndrome. "
04/01/2005 - "Recent studies have indicated that dysfunction or loss of the multidrug resistance protein 2 (MRP2) is the molecular basis of Dubin-Johnson syndrome (DJS). "
05/01/2013 - "Mutation and functional analysis of ABCC2/multidrug resistance protein 2 in a Japanese patient with Dubin-Johnson syndrome."
02/01/2005 - "A novel ancestral splicing mutation in the multidrug resistance protein 2 gene causes Dubin-Johnson syndrome in Ashkenazi Jewish patients."
10/05/2001 - "Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome."
12/01/2000 - "Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome."
|1.||Segmental Mastectomy (Lumpectomy)
05/01/2004 - "Hepatocellular carcinoma in a case of Dubin-Johnson syndrome treated successfully with a central bilateral segmentectomy."
05/01/2004 - "A 72-year-old woman with hepatocellular carcinoma and HCV cirrhosis combined with Dubin-Johnson syndrome was successfully treated by a central bilateral segmentectomy. "
05/01/1996 - "In the present study we show the selective absence of the canalicular isoform of MRP (cMRP) from the hepatocytes in a patient with Dubin-Johnson syndrome by double-label immunofluorescence and confocal laser scanning microscopy using antibodies directed against MRP and dipeptidyl-peptidase IV (DPPIV). "
01/01/1998 - "Postoperative management following massive hepatectomy in a patient with Dubin-Johnson syndrome: report of a case."
02/01/1983 - "Patient with Dubin-Johnson syndrome tolerated major hepatectomy. "
02/01/2013 - "Hepatectomy in a hepatocellular carcinoma case with Dubin-Johnson syndrome and indocyanine green excretory defect."