|1.||Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)
|3.||Bovine Spongiform Encephalopathy (Mad Cow Disease)
|5.||Alzheimer Disease (Alzheimer's Disease)
|1.||Zerr, Inga: 40 articles (08/2015 - 06/2002)|
|2.||Kitamoto, Tetsuyuki: 37 articles (08/2015 - 06/2002)|
|3.||Collinge, John: 32 articles (11/2015 - 12/2002)|
|4.||Ironside, James W: 29 articles (12/2014 - 01/2002)|
|5.||Prusiner, Stanley B: 18 articles (10/2015 - 03/2002)|
|6.||Gambetti, Pierluigi: 18 articles (06/2015 - 03/2003)|
|7.||Budka, Herbert: 18 articles (01/2014 - 01/2002)|
|8.||Kretzschmar, Hans A: 18 articles (01/2012 - 05/2003)|
|9.||Yamada, Masahito: 17 articles (08/2015 - 10/2003)|
|10.||Pocchiari, Maurizio: 17 articles (07/2015 - 01/2002)|
|1.||14-3-3 Proteins (14-3-3 Protein)IBA
08/07/2012 - "In this study, tau is superior to 14-3-3 protein as a marker in the diagnosis of Creutzfeldt-Jakob disease, and is as efficient singly compared to a variety of combinations with 14-3-3 protein. "
01/01/1998 - "Diagnosis of Creutzfeldt-Jakob disease (CJD) at lifetime according to the international diagnostic criteria may be greatly improved by the additional assay of 14-3-3 protein in cerebrospinal fluid (CSF). "
01/01/2015 - "Characteristics of Korean patients with suspected Creutzfeldt-Jakob disease with 14-3-3 protein in cerebrospinal fluid: Preliminary study of the Korean Creutzfeldt-Jakob disease active surveillance program."
10/02/2012 - "The question asked is "Does CSF 14-3-3 protein accurately identify Creutzfeldt-Jakob disease (CJD) in patients with sCJD?" The analysis was conducted on the basis of samples of 1,849 patients with suspected sCJD from 9 Class II studies. "
07/28/2001 - "To study whether an algorithm that includes additional diagnostic information could increase the specificity of the 14-3-3 protein testing in patients suspected to suffer from Creutzfeldt-Jakob disease (CJD). "
01/01/2013 - "Here, we review the results of the recent high-resolution nuclear magnetic resonance (NMR) structural studies on HuPrPs with pathological Q212P and V210I mutations linked with Gerstmann-Sträussler-Scheinker (GSS) syndrome and familial Creutzfeldt-Jakob disease (fCJD), respectively, and HuPrP carrying naturally occurring E219K polymorphism considered to protect against sporadic CJD (sCJD). "
07/01/2011 - "Human genome wide association has been done in variant Creutzfeldt-Jakob disease (CJD) and are ongoing in larger collections of sporadic CJD with findings around, but not clearly beyond, the levels of statistical significance required in these studies (THRB-RARB, STMN2). "
01/01/2011 - "The E200K mutation is the most frequent prion protein gene (PRNP) mutation detected worldwide that is associated with Creutzfeldt-Jakob disease (CJD) and thought to have overlapping features with sporadic CJD, yet detailed neuropathological studies have not been reported. "
08/01/2015 - "It has long been recognized that 129M/M homozygotes are overrepresented in sporadic Creutzfeldt-Jakob disease (CJD) patients and variant CJD patients, whereas 219E/K heterozygotes are absent in sporadic CJD patients. "
08/01/2009 - "We report here an autopsy case of sporadic Creutzfeldt-Jakob disease (CJD) without hereditary burden and with a clinical course typical of sporadic CJD. "
04/01/2013 - "In addition, we report on the adaptation of quantitative PMCA to human variant Creutzfeldt-Jakob disease (vCJD) prions on steel wires for prion disinfection studies. "
10/01/2008 - "To understand the pathophysiology specific to variant Creutzfeldt-Jakob Disease (vCJD), in vitro electrophysiological studies were performed in a mouse model in which human-derived vCJD prions were transmitted to transgenic mice expressing human instead of murine prion protein. "
09/01/2007 - "The study of brain histological specimens from patients with Creutzfeldt-Jakob disease (CJD) revealed the active reproduction and accumulation of pathological prions in the epitheliocytes of cerebral vascular brain plexuses in a new variant of CJD. "
10/01/2015 - "Disappointingly, none of the four new 2-AMTs prolonged the lives of mice expressing a chimeric human/mouse PrP transgene inoculated with Creutzfeldt-Jakob disease prions. "
04/01/2015 - "Compared with transgenic mice expressing unaltered human PrP, mice expressing the human-elk chimeric PrP were highly susceptible to elk and deer CWD prions but were concurrently less susceptible to human Creutzfeldt-Jakob disease prions. "
|4.||Amyloid (Amyloid Fibrils)IBA
12/01/2008 - "Aim of this study was to investigate whether changes related to phospho-tau accumulation are present in the brain of patients with variant Creutzfeldt-Jakob disease (vCJD) that shares with Gerstmann-Sträussler-Scheinker disease abundant prion protein (PrP) deposition in amyloid form. "
09/01/2015 - "To explore potential mechanistic links between PrionD and AD, we exposed human brain aggregates (BrnAggs) to a brain homogenate from a patient with sporadic Creutzfeldt-Jakob disease and found that neurons in human BrnAggs produced many β-amyloid (Aβ; Aβ42) inclusions, whereas uninfected control-exposed human BrnAggs did not. "
05/01/2011 - "Different CSF β-amyloid processing in Alzheimer's and Creutzfeldt-Jakob disease."
04/01/2010 - "Amyloid formation: age-related mechanism in Creutzfeldt-Jakob disease?"
10/01/2009 - "Codistribution of amyloid beta plaques and spongiform degeneration in familial Creutzfeldt-Jakob disease with the E200K-129M haplotype."
|5.||Growth Hormone (Somatotropin)IBA
01/01/2015 - "The present study compares the clinical, pathological and molecular features of a United States (US) case of growth hormone (GH)-associated Creutzfeldt-Jakob disease (GH-CJD) (index case) to those of two earlier referred US cases of GH-CJD and one case of dura mater (d)-associated CJD (dCJD). "
04/01/1994 - "Iatrogenic Creutzfeldt-Jakob disease in three growth hormone recipients: a neuropathological study."
12/01/2015 - "These were, first, Creutzfeldt-Jakob disease from contaminated growth hormone extracted from cadavers, which led parents to instigate legal procedure - a quite unusual practice in France. "
11/01/2015 - "Patients with iatrogenic Creutzfeldt-Jakob disease due to administration of cadaver-sourced growth hormone during childhood are still being seen in the UK 30 years after cessation of this treatment. "
01/01/2015 - "Distinct pathological phenotypes of Creutzfeldt-Jakob disease in recipients of prion-contaminated growth hormone."
01/01/2009 - "To establish with improved accuracy the prevalence of disease related prion protein (PrP(CJD)) in the population of Britain and thereby guide a proportionate public health response to limit the threat of healthcare associated transmission of variant Creutzfeldt-Jakob disease (vCJD). "
07/26/2007 - "Molecular studies of PrP(res), followed by transmission studies to mice, gave the first evidence for the accidental transmission of the BSE agent to humans where it induced a variant form of the fatal Creutzfeldt-Jakob disease (CJD) and also to different animal species including a goat in France. "
06/01/2000 - "Immunohistochemical studies of the PrP(CJD) deposition in Creutzfeldt-Jakob disease."
08/07/2014 - "A test that detects the specific marker for Creutzfeldt-Jakob disease, the prion protein (PrP(CJD)), by means of real-time quaking-induced conversion (RT-QuIC) testing of cerebrospinal fluid has a sensitivity of 80 to 90% for the diagnosis of sporadic Creutzfeldt-Jakob disease. "
08/01/2009 - "Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion protein."
09/01/2009 - "METHODS MATERIALS AND PATIENTS: Paraffin-embedded tissue blot (PET-blot), immunohistochemistry (IHC) and Western blotting (WB) were combined to study the morphology and localization of disease related PrP in Danish patients with different subtypes of sporadic Creutzfeldt-Jakob disease, familiar Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease. "
08/01/2004 - "Advances in the detection of prion protein in peripheral tissues of variant Creutzfeldt-Jakob disease patients using paraffin-embedded tissue blotting."
01/01/1992 - "We examined paraffin-embedded brain sections from three patients with Creutzfeldt-Jakob disease (CJD) and four patients with Gerstmann-Sträussler syndrome (GSS) who also had beta protein deposits in the brains. "
01/01/2004 - "Using immunohistochemistry, paraffin-embedded tissue blot, and Western blot, we demonstrated abundant PrP(Sc) in the muscle of a patient with sporadic Creutzfeldt-Jakob disease and inclusion body myositis. "
03/01/2003 - "We examined paraffin-embedded brain sections of sporadic MV2 Creutzfeldt-Jakob disease (sCJD) with Kuru plaques, sporadic VV2 CJD with plaque-like PrP(sc) (the abnornal form of prion protein) deposits, variant CJD (vCJD) with florid plaques, Gerstmann-Straüssler-Scheinker (GSS) with multicentric plaques and of Alzheimer's disease (AD) with senile plaques. "
|8.||Formaldehyde (Formol)FDA Link
07/01/2000 - "PrP immunohistochemistry: different protocols, including a procedure for long formalin fixation, and a proposed schematic classification for deposits in sporadic Creutzfeldt-Jakob disease."
06/01/1990 - "Phenolized formalin fixation may obscure early histological changes of Creutzfeldt-Jakob disease."
06/01/1990 - "A simple and effective method for inactivating virus infectivity in formalin-fixed tissue samples from patients with Creutzfeldt-Jakob disease."
09/08/1988 - "Routine use of phenolized formalin in fixation of autopsy brain tissue to reduce risk of inadvertent transmission of Creutzfeldt-Jakob disease."
11/01/1986 - "Decontamination of formaldehyde-fixed tissues of Creutzfeldt-Jakob disease."
|9.||Recombinant DNA (Recombinant DNA Research)IBA
11/05/2010 - "In our present study, we show CSF protein patterns from patients with the two most frequent subtypes of sporadic Creutzfeldt-Jakob disease (sCJD) defined by the codon 129 genotype (MM, MV, and VV) and the protease-resistant form of prion protein (type 1 and type 2). "
06/01/2000 - "This study examined trends in mortality from sporadic Creutzfeldt-Jakob disease in France for 1992-7 by age, genotype at the codon 129 of the prion protein gene, and geographical area. "
11/01/1996 - "Mutation in the prion protein gene at codon 232 in Japanese patients with Creutzfeldt-Jakob disease: a clinicopathological, immunohistochemical and transmission study."
04/01/2015 - "Susceptibility to and phenotypic expression of Creutzfeldt-Jakob disease (CJD) depend on both the prion strain and genotype at polymorphic codon 129 of the PRNP gene. "
04/01/2015 - "For example, while the most common sporadic Creutzfeldt-Jakob disease (CJD) subtype, sporadic CJD-MM1 (M1 strain), induces a single phenotype after experimental transmission regardless of the codon 129 genotype of the recipient animal, the phenotype elicited by sporadic CJD-VV2 (V2 strain), the second most common subtype, varies according to the host codon 129 genotype. "
|1.||Homologous Transplantation (Allograft)
11/01/1988 - "Further research is required to determine the efficacy of otologic homograft sterilization techniques against HIV and Creutzfeldt-Jakob disease."
02/01/2008 - "Despite the fact that cartilage, cortical bone and corneal homograft tissue is still widely used in South Africa and that there has never been a reported case of human immunodeficiency virus or Creutzfeldt-Jakob disease infection transmission via this route, otolaryngologists are still reluctant to use homograft ossicles. "
08/01/2003 - "The allograft inflammatory factor-1 in Creutzfeldt-Jakob disease brains."
01/01/1990 - "The possible accidental transmission of Creutzfeldt-Jacob disease by the use of homograft materials in otologic surgery is discussed."
01/01/1990 - "Progressive fatal dementia (Creutzfeldt-Jakob disease) in a patient who received homograft tissue for tympanic membrane closure."
|2.||Blood Transfusion (Blood Transfusions)
10/01/2014 - "In this study, we compare variant Creutzfeldt-Jakob disease (vCJD) cases definitely linked to blood transfusion, those with a history of blood transfusion in which no donor has developed vCJD and primary cases with no history of blood transfusion. "
11/01/2006 - "A study was set up in the UK in 1997 to examine whether there is any evidence that variant Creutzfeldt-Jakob disease (vCJD) is transmitted by blood transfusion. "
10/01/2006 - "Creutzfeldt-Jakob disease and blood transfusion: results of the UK Transfusion Medicine Epidemiological Review study."
11/01/2001 - "The concern that variant Creutzfeldt-Jakob disease could be transmitted via blood transfusion has prompted studies of blood infectivity in animal models. "
01/01/1999 - "Studies in experimental animals and case-reports of transmission of Creutzfeldt-Jakob Disease (CJD) by blood transfusion or by albumin products have raised the possibility that CJD may be transmitted by transfusion. "
06/01/2003 - "A patient with dura-associated Creutzfeldt-Jakob disease (D-CJD) which occurred about 15 years after a dura mater graft is reported in the present study. "
01/01/2014 - "Creutzfeldt-Jakob disease secondary to dural graft performed in 1988."
01/01/2014 - "Dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) can be divided into two subgroups that exhibit distinct clinical and neuropathological features, with the majority represented by a non-plaque-type of dCJD (np-dCJD) and the minority by a plaque-type of dCJD (p-dCJD). "
01/01/2014 - "Distinct origins of dura mater graft-associated Creutzfeldt-Jakob disease: past and future problems."
10/01/2013 - "More than 60% of patients worldwide with Creutzfeldt-Jakob disease (CJD) associated with dura mater graft (dCJD) have been diagnosed in Japan. "
01/09/1975 - "Nursing care study: Jakob-Creutzfeldt disease."
05/17/2005 - "Creutzfeldt-Jakob disease: diagnosis and nursing care issues."
07/01/1997 - "Nursing care of the resident with Creutzfeldt-Jakob disease."
08/25/1981 - "[Creutzfeldt-Jakob disease: diagnosis, transmissibility and preventive measures in the examination and nursing care of patients]."
07/01/1997 - "Comparison is made between Alzheimer's disease and Creutzfeldt-Jakob disease, the symptoms and causative agent, precautions that need to be followed, nursing care and medications used in maintaining the resident's comfort, and the maximum quality of life possible during the course of this terminal disease."