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Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)

A rare transmissible encephalopathy most prevalent between the ages of 50 and 70 years. Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset. A familial form exhibiting autosomal dominant inheritance and a new variant CJD (potentially associated with ENCEPHALOPATHY, BOVINE SPONGIFORM) have been described. Pathological features include prominent cerebellar and cerebral cortical spongiform degeneration and the presence of PRIONS. (From N Engl J Med, 1998 Dec 31;339(27))
Also Known As:
Creutzfeldt-Jakob Disease; Encephalopathy, Subacute Spongiform; Subacute Spongiform Encephalopathy; Syndrome, Creutzfeldt-Jakob; CJD (Creutzfeldt-Jakob Disease); Creutzfeldt Jacob Disease; Creutzfeldt-Jakob Disease, Familial; Creutzfeldt-Jakob Disease, New Variant; Familial Creutzfeldt-Jakob Disease; Jakob-Creutzfeldt Disease; Jakob-Creutzfeldt Syndrome; V-CJD (Variant-Creutzfeldt-Jakob Disease); Variant Creutzfeldt-Jakob Disease; CJD (Creutzfeldt Jakob Disease); Creutzfeldt Jakob Disease; Creutzfeldt Jakob Disease, Familial; Creutzfeldt Jakob Disease, New Variant; Creutzfeldt Jakob Syndrome; Creutzfeldt-Jakob Disease, Variant; Creutzfeldt-Jakob Diseases, Familial; Disease, Creutzfeldt Jacob; Disease, Creutzfeldt-Jakob; Disease, Familial Creutzfeldt-Jakob; Disease, Jakob-Creutzfeldt; Encephalopathies, Subacute Spongiform; Familial Creutzfeldt Jakob Disease; Familial Creutzfeldt-Jakob Diseases; Jacob Disease, Creutzfeldt; Jakob Creutzfeldt Disease; Jakob Creutzfeldt Syndrome; New Variant Creutzfeldt Jakob Disease; Spongiform Encephalopathies, Subacute; Subacute Spongiform Encephalopathies; Syndrome, Jakob-Creutzfeldt; Variant Creutzfeldt Jakob Disease; New Variant Creutzfeldt-Jakob Disease; Spongiform Encephalopathy, Subacute
Networked: 1449 relevant articles (8 outcomes, 80 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1. Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)
2. Scrapie
3. Bovine Spongiform Encephalopathy (Mad Cow Disease)
4. Kuru
5. Alzheimer Disease (Alzheimer's Disease)

Experts

1. Kitamoto, Tetsuyuki: 32 articles (10/2013 - 06/2002)
2. Zerr, Inga: 32 articles (05/2013 - 06/2002)
3. Ironside, James W: 27 articles (01/2014 - 01/2002)
4. Collinge, John: 26 articles (07/2013 - 12/2002)
5. Kretzschmar, Hans A: 18 articles (01/2012 - 05/2003)
6. Budka, Herbert: 17 articles (05/2012 - 01/2002)
7. Prusiner, Stanley B: 16 articles (12/2013 - 03/2002)
8. Head, Mark W: 14 articles (01/2014 - 01/2002)
9. Ironside, J W: 14 articles (10/2011 - 10/2000)
10. Yamada, Masahito: 13 articles (10/2013 - 10/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Creutzfeldt-Jakob Syndrome:
1. 14-3-3 Proteins (14-3-3 Protein)IBA
2. Acquired CJDIBA
3. PrionsIBA
4. Amyloid (Amyloid Fibrils)IBA
5. PrPSc ProteinsIBA
6. Growth Hormone (Somatotropin)IBA
7. ParaffinIBA
8. Formaldehyde (Formol)FDA Link
9. Recombinant DNA (Recombinant DNA Research)IBA
10. Codon (Codons)IBA

Therapies and Procedures

1. Homologous Transplantation (Allograft)
2. Blood Transfusion (Blood Transfusions)
3. Transplants (Transplant)
4. Lenses
5. Surgical Instruments (Clip)

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