Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)

1399  relevant articles (17 outcomes, 123 trials/studies) found for this Disease

Creutzfeldt-Jakob Disease; CJD; Encephalopathy, Subacute Spongiform; Subacute Spongiform Encephalopathy; Syndrome, Creutzfeldt-Jakob; CJD (Creutzfeldt-Jakob Disease); Creutzfeldt-Jakob Disease, Familial; Creutzfeldt-Jakob Disease, New Variant; Familial Creutzfeldt-Jakob Disease; Jakob-Creutzfeldt Disease; Jakob-Creutzfeldt Syndrome; V-CJD (Variant-Creutzfeldt-Jakob Disease); CJD (Creutzfeldt Jakob Disease); CJD Variant (V CJD); CJD Variants (V-CJD); CJDs (Creutzfeldt-Jakob Disease); Creutzfeldt Jakob Disease; Creutzfeldt Jakob Disease, Familial; Creutzfeldt Jakob Disease, New Variant; Creutzfeldt Jakob Syndrome; Creutzfeldt-Jakob Diseases, Familial; Disease, Creutzfeldt-Jakob; Disease, Familial Creutzfeldt-Jakob; Disease, Jakob-Creutzfeldt; Encephalopathies, Subacute Spongiform; Familial Creutzfeldt Jakob Disease; Familial Creutzfeldt-Jakob Diseases; Jakob Creutzfeldt Disease; Jakob Creutzfeldt Syndrome; New Variant Creutzfeldt Jakob Disease; Spongiform Encephalopathies, Subacute; Subacute Spongiform Encephalopathies; Syndrome, Jakob-Creutzfeldt; Variant, CJD (V-CJD); Variants, CJD (V-CJD); CJD Variant (V-CJD); New Variant Creutzfeldt-Jakob Disease; Spongiform Encephalopathy, Subacute

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)
2.	Scrapie
3.	Kuru
4.	Bovine Spongiform Encephalopathy (Mad Cow Disease)
5.	Infection
141 Diseases and 708 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Zerr, Inga: 8 articles (01/2007 - 08/2003)
2.	Will, R G: 7 articles (10/2006 - 09/2000)
3.	Kitamoto, Tetsuyuki: 7 articles (08/2006 - 06/2002)
4.	Collinge, John: 6 articles (10/2008 - 12/2002)
5.	Hill, Andrew F: 6 articles (03/2008 - 10/2002)
6.	Kretzschmar, Hans A: 6 articles (11/2007 - 05/2003)
7.	Kitamoto, T: 6 articles (07/2007 - 08/2000)
8.	Satoh, Katsuya: 6 articles (01/2007 - 10/2003)
9.	Ironside, J W: 6 articles (03/2006 - 10/2000)
10.	Poser, S: 6 articles (03/2005 - 09/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Creutzfeldt-Jakob Syndrome:

1.	14-3-3 Proteins (14-3-3 Protein)IBA 01/01/2007 - "However, this assay cannot be used for screening because of the high rate of false-positive results, whereas patients with variant CJD are often negative for 14-3-3 proteins" 04/01/2003 - "Because a recent position paper from the American Academy of Neurology characterized CSF protein 14-3-3 as a gold standard for clinically diagnosing CJD, the authors reviewed studies of CJD in which DWI-MRI imaging and CSF protein 14-3-3 studies were both performed" 01/01/2008 - "CONCLUSION: The results suggest that 14-3-3 protein may be the better marker for CJD, tTau/P-Tau ratio and tTau are also efficient markers, but showed slightly inferior diagnostic properties in this study, with tTau/P-Tau marginally better than tTau." 06/01/2003 - "Previous studies have suggested that, in the proper clinical context, the 14-3-3 protein in cerebrospinal fluid is a reliable marker for sporadic CJD" 03/14/2000 - "Detection of the 14-3-3 protein in CSF, considered as an additional diagnostic criterion for clinically probable CJD, resulted in a slight increase in the estimated incidence when the French or European study criteria were applied" Get all the results and reference details, order at left...
2.	PrionsIBA 10/01/2008 - "To understand the pathophysiology specific to variant Creutzfeldt-Jakob Disease (vCJD), in vitro electrophysiological studies were performed in a mouse model in which human-derived vCJD prions were transmitted to transgenic mice expressing human instead of murine prion protein" 07/01/2003 - "Thus, sandwich CDI represents a powerful tool to study prions in bodily fluids of CJD/vCJD patients, with a turnaround time of less than 24 h." 05/01/2002 - "A small number of clinical studies reported transmission of CJD by human blood, urine and lymphoid tissues and the role of B lymphocytes in neuroinvasion and transmission of prions" 10/15/1999 - "Our study suggests that human sporadic CJD-related prions display a significant heterogeneity." 01/01/1996 - "This article reviews available information on CJD, BSE and other diseases caused by prions, transmission studies and the report of the CJD Surveillance Unit and discusses possible links between BSE and the new variant of CJD." Get all the results and reference details, order at left...
3.	AntibodiesIBA 08/01/1986 - "Earlier studies showed that these antibodies react with both rodent and human CJD PrP" 11/01/2006 - "Significant increased expression levels of AQP1 (as revealed with two different antibodies) and AQP4 were seen in CJD, but not in advanced AD and DLB cases when compared with controls" 08/01/2005 - "After the finding that anti-prion antibodies stain sensory and sympathetic ganglia in variant Creutzfeldt-Jakob disease (vCJD), it was suggested that this localization supported the oral route of entry" 08/01/2004 - "Five cases of variant CJD were examined, using a panel of anti-PrP antibodies" 12/04/2003 - "The antibodies strongly immunostained the cytoplasm, dendrites and torpedoes of Purkinje cells in CJD" Get all the results and reference details, order at left...
4.	Amyloid (Amyloid Fibrils)IBA 12/01/2008 - "Aim of this study was to investigate whether changes related to phospho-tau accumulation are present in the brain of patients with variant Creutzfeldt-Jakob disease (vCJD) that shares with Gerstmann-Sträussler-Scheinker disease abundant prion protein (PrP) deposition in amyloid form" 01/26/2001 - "Hence, this study compared the spatial patterns of prion protein (PrP) deposits in the cerebral cortex and hippocampus in cases of sporadic CJD with those of beta-amyloid (Abeta) deposits in sporadic AD" 01/01/1996 - "This is the first report of a definite case of Creutzfeldt-Jakob disease in an Iranian and it has been confirmed by a neuropathological study and by the immunoelectrophoretic demonstration of PrP, the pathological amyloid protein specific to the spongiform encephalopathies" 01/01/2008 - "Association between deposition of beta-amyloid and pathological prion protein in sporadic Creutzfeldt-Jakob disease." 02/01/2007 - "Moreover, the zeta isoform has been detected in prion protein (PrP) amyloid deposits of CJD patients" Get all the results and reference details, order at left...
5.	Growth Hormone (Somatotropin)IBA 04/27/1996 - "Trial begins into victims of CJD growth hormone." 04/01/1994 - "Iatrogenic Creutzfeldt-Jakob disease in three growth hormone recipients: a neuropathological study." 04/01/2004 - "OBJECTIVE: Patients who received pituitary-derived growth hormone (GH) are at excess risk of mortality from Creutzfeldt-Jakob disease" 01/01/2004 - "We have compared this with the distribution and biochemical forms found in all of the major subtypes of sporadic Creutzfeldt-Jakob disease and in a case of iatrogenic Creutzfeldt-Jakob disease associated with growth hormone therapy" 10/01/2003 - "CONCLUSIONS: These findings suggest that, although not the presenting feature, mild cognitive decline may be evident in the early stages of CJD associated with human cadaveric growth hormone treatment." Get all the results and reference details, order at left...
6.	tau Proteins (tau Protein)IBA 03/01/2003 - "However, false negative results in autopsy-proven, sporadic CJD cases, as well as false positive results in several other disorders including AD and FTD showing high CSF tau protein levels, limit the potential of this marker" 01/01/2007 - "Moreover, the data in this study showed that detection of t-tau protein combined with DWI identified 98% of the early-stage cases, and these tests should be included as diagnostic criteria for CJD." 01/01/2007 - "CONCLUSION: We concluded that t-tau protein was the most sensitive of the diagnostic markers for CJD" 01/01/2007 - "Total tau protein in cerebrospinal fluid and diffusion-weighted MRI as an early diagnostic marker for Creutzfeldt-Jakob disease." 01/01/2007 - "METHODS: We studied tau protein gene (MAPT) haplotypic variations in a population of sporadic and variant CJD patients" Get all the results and reference details, order at left...
7.	Nucleic AcidsIBA 01/01/1993 - "To further define these and other viral-like sequences we cloned nucleic acids from highly infectious CJD fractions, and tested the efficacy of our methods using a selected retroviral probe" 04/01/2002 - "In support of such a notion, in this study we show increased oxidative damage to nucleic acids in affected brains of patients with Creutzfeldt-Jakob disease" 01/01/1993 - "The effective extraction and amplification of highly protected SHIAP nucleic acids of significant length sets the stage for identifying additional protected viral elements that may specify the CJD agent." 01/01/1993 - "In order to identify viral-like nucleic acids we previously developed methods to substantially purify the human CJD agent from experimentally infected hamster brains, and demonstrated selected retroviral-like LTR bands at pg levels that were insufficient for sequencing" 07/01/1990 - "These strategies set the stage for the identification of similar nucleic acids that may be specific for the CJD agent." Get all the results and reference details, order at left...
8.	Proteins (Proteins, Gene)IBA 08/22/2006 - "CONCLUSIONS: The detection of elevated levels of brain-derived proteins in the CSF in patients with suspected Creutzfeldt-Jakob disease is a valuable diagnostic test" 01/01/2006 - "These findings suggest that altered AChE glycosylation in CJD may be a consequence of the general perturbation of the glycosylation machinery that affects prion protein, as well as other proteins" 05/01/2005 - "Our result suggests that urine samples from CJD patients can be identified by the presence of protease resistant proteins such as LC." 09/01/2004 - "Despite this achievement, TTIDs remain a public health concern, and attention is refocusing on new and emerging pathogens, such as West Nile virus, infectious proteins (the presumed cause of variant Creutzfeldt-Jakob disease), and other transmissible organisms such as bacteria and parasites" 03/01/2004 - "Measurement of these proteins are highly specific and sensitive for the diagnosis of CJD, but not available as a rapid routine examination at present" Get all the results and reference details, order at left...
9.	ParaffinIBA 07/01/2008 - "Hospital records from the Department of Neurology of the National Hospital from the years 1960-1980 were scrutinised and paraffin blocks from the collection of the Department of Pathology from cases with the diagnosis CJD and some suspect cases were obtained and analysed" 03/01/2006 - "Therefore, we have used the same high-sensitivity Western blotting technique, in combination with paraffin-embedded tissue blotting, to screen for PrP(Sc) in muscle tissue specimens taken at autopsy from 49 CJD patients in the United Kingdom" 08/01/2004 - "Advances in the detection of prion protein in peripheral tissues of variant Creutzfeldt-Jakob disease patients using paraffin-embedded tissue blotting." 06/01/1988 - "We examined paraffin sections from 45 patients with CJD or GSS and from 51 patients with other neurologic diseases, using an antiserum against GSS amyloid plaque cores" 01/01/2004 - "Using immunohistochemistry, paraffin-embedded tissue blot, and Western blot, we demonstrated abundant PrP(Sc) in the muscle of a patient with sporadic Creutzfeldt-Jakob disease and inclusion body myositis" Get all the results and reference details, order at left...
10.	Quinacrine (Mepacrine)IBA 02/01/2005 - "On compassionate grounds, quinacrine was administered to Creutzfeldt-Jakob disease patients, despite the absence of preclinical in vivo studies to evaluate efficacy" 08/01/2002 - "Here we report the results of clinical trials of quinacrine administration to the patients of Creutzfeldt-Jakob disease" 05/24/2005 - "Compassionate use of quinacrine in Creutzfeldt-Jakob disease fails to show significant effects." 12/28/2004 - "Compassionate use of quinacrine in Creutzfeldt-Jakob disease fails to show significant effects." 04/01/2004 - "1. A clinical trial of quinacrine in patients with Creutzfeldt-Jakob disease is now in progress" Get all the results and reference details, order at left...
396 Drugs and Important Bio-Agents and 1201 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Homologous Transplantation (Allograft) 11/01/1988 - "Further research is required to determine the efficacy of otologic homograft sterilization techniques against HIV and Creutzfeldt-Jakob disease." 08/01/2003 - "The allograft inflammatory factor-1 in Creutzfeldt-Jakob disease brains." 04/01/1996 - "In Australia the use of dural homografts in neurosurgery was abandoned in 1987; as the mean incubation period (determined from a world-wide review) has been about 65 months, it is now hoped that this cause of CJD will not recur in the Australian population, although it is premature to state this with confidence" 04/01/1996 - "Creutzfeldt-Jakob (CJD) disease has been reported after the insertion of dural homografts" 02/01/2008 - "Despite the fact that cartilage, cortical bone and corneal homograft tissue is still widely used in South Africa and that there has never been a reported case of human immunodeficiency virus or Creutzfeldt-Jakob disease infection transmission via this route, otolaryngologists are still reluctant to use homograft ossicles" Get all the results and reference details, order at left...
2.	Donor Selection 08/21/1993 - "Donor selection and preservation methods for the prevention of transmission of AIDS and Creutzfeldt-Jakob disease via allogeneic transplants in ear surgery]" 09/01/1995 - "Over the past several years, improvements in donor screening criteria, such as excluding potential donors with infection and those with behaviors risky for HIV-1 and hepatitis infection, and introduction of new donor blood tests have greatly reduced the risk of HIV-1 and hepatitis and may have nearly eliminated the risk of tuberculosis and CJD" Get all the results and reference details, order at left...
3.	Blood Transfusion (Blood Transfusions) 11/01/2006 - "A study was set up in the UK in 1997 to examine whether there is any evidence that variant Creutzfeldt-Jakob disease (vCJD) is transmitted by blood transfusion" 10/01/2006 - "Creutzfeldt-Jakob disease and blood transfusion: results of the UK Transfusion Medicine Epidemiological Review study." 06/01/2003 - "However, in man, epidemiological case control, lookback and surveillance studies have failed to demonstrate any evidence of sporadic CJD transmission by blood transfusion" 11/01/2001 - "BACKGROUND AND OBJECTIVES: The concern that variant Creutzfeldt-Jakob disease could be transmitted via blood transfusion has prompted studies of blood infectivity in animal models" 12/12/2008 - "The link between a new variant form of Creutzfeldt-Jakob disease (vCJD) and the consumption of prion contaminated cattle meat as well as recent findings showing that vCJD can be transmitted by blood transfusion have raised public health concerns" Get all the results and reference details, order at left...
4.	Transplants (Transplant) 02/01/2008 - "Although a specific association between the dura mater graft site and neuropathologic observations was not evaluated in the present study, the initial symptoms appear to be closely related to the graft site, indicating a direct transmission of CJD from the graft site to the adjacent brain." 10/24/2008 - "Update: Creutzfeldt-Jakob disease associated with cadaveric dura mater grafts--Japan, 1978-2008." 08/01/2008 - "The time from transplant to onset of CJD symptoms ranged from 2 years, 11 months to 18 years" 08/01/2008 - "Creutzfeldt-Jakob disease in recipients of corneal transplants." 12/01/2007 - "A case of Creutzfeldt-Jakob disease associated with a dura mater graft in the United States." Get all the results and reference details, order at left...
5.	Surgical Instruments (Clip) 06/01/2007 - "There is, in addition, growing scepticism about the actual risk of contracting variant Creutzfeldt-Jakob disease and other blood-borne diseases from reused surgical instruments" 12/22/2006 - "While the number of variant Creutzfeldt-Jakob disease (vCJD) cases continues to decline, concern has been raised that transmission could occur directly from one person to another through routes including the transfer of blood and shared use of surgical instruments" 12/22/2006 - "Factors determining the potential for onward transmission of variant Creutzfeldt-Jakob disease via surgical instruments." 09/15/2006 - "This review discusses our current understanding of the prevalence of variant CJD, the distribution of tissue infectivity, and new methods for the decontamination of surgical instruments" 03/01/2006 - "The detection of PrP(Sc) in muscle tissue from all forms of CJD indicates the possible presence of infectivity in these tissues, suggesting important implications for assessing the potential risk of iatrogenic spread via contaminated surgical instruments." Get all the results and reference details, order at left...
38 Therapies and Procedures and 260 more articles analyzed in the Full Patient-Physician Summary Report, order at left...