Isoxsuprine

A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.

Also Known As:

Networked: 126 relevant articles (5 outcomes, 19 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Kshirsagar, Nitin: 1 article (05/2022)
2.	Ray, Namrata: 1 article (05/2022)
3.	Harada, Hiroyuki: 1 article (01/2021)
4.	Ishigami-Yuasa, Mari: 1 article (01/2021)
5.	Jabur, Murtadha S: 1 article (01/2021)
6.	Jaju, Purushottam B: 1 article (01/2021)
7.	Jalil, Muhannad Sami: 1 article (01/2021)
8.	Kagechika, Hiroyuki: 1 article (01/2021)
9.	Knight-Madden, Jennifer M: 1 article (01/2021)
10.	Manna, Mohammed J: 1 article (01/2021)

Related Diseases

1.	Premature Obstetric Labor (Premature Labor) 09/01/1981 - "Seventy patients treated with isoxsuprine for premature labor were studied. " 09/01/1981 - "Risk:benefit considerations for the use of isoxsuprine in the treatment of premature labor." 02/01/1981 - "An obstetric alternative to premature labor is administration of isoxsuprine, an effective inhibitor of uterine contractions. " 10/01/1980 - "The treatment of premature labor with isoxsuprine." 11/01/1977 - "Arrest of premature labor by isoxsuprine."
2.	Stroke (Strokes) 08/30/2023 - "Formulation and Therapeutic Evaluation of Isoxsuprine-Loaded Nanoparticles against Diabetes-Associated Stroke." 01/01/2014 - "Isoxsuprine, a β2-adrenergic agonist and NR2B subtype-selective N-methyl-D-aspartate (NMDA) receptor antagonist, demonstrated no loss of efficacy when administered up to an hour after reoxygenation in an in vitro stroke model. " 01/01/2014 - "Our demonstration of the significant and novel neuroprotective action of isoxsuprine hydrochloride in an in vivo stroke model and its history of human use suggest that isoxsuprine may be an ideal candidate for further investigation as a potential stroke therapeutic."
3.	Erectile Dysfunction 07/01/2001 - "Isoxsuprine is no better than placebo as a first-line treatment for mixed-type erectile dysfunction." 07/01/2001 - "To determine the effectiveness and safety of high-dose isoxsuprine for the treatment of mixed-type erectile dysfunction. " 07/01/2001 - "Therapeutic effects of high-dose isoxsuprine in the management of mixed-type impotence." 01/01/1996 - "We evaluated the efficacy and safety of yohimbine and isoxsuprine or pentoxifylline in the management of vasculogenic erectile dysfunction. "
4.	Retinal Artery Occlusion 05/05/1968 - "Successful remission of central retinal artery occlusion following the use of isoxsuprine."
5.	Necrosis 10/01/1981 - "In a controlled study of the rat abdominal pedicle flap the area of flap necrosis was not reduced by a course of treatment with isoxsuprine. " 07/01/2015 - "In the macroscopic evaluation of isoxsuprine Group retail presented absolute numbers: final area (p=0.001*) and viable area (p=0.006*) with the highest values; necrosis (p=0.001*) had the lowest value. " 06/01/1979 - "The results imply that necrosis of skeletal muscle in a clinical flap could be prevented by treatment with isoxsuprine." 10/01/1979 - "Prevention of necrosis in island myocutaneous flaps in the pig by treatment with isoxsuprine." 10/01/1980 - "A microangiographic study of hematoma-associated flap necrosis and salvage with isoxsuprine."

Related Drugs and Biologics

1.	Ritodrine (Yutopar)
2.	Nifedipine (Adalat)
3.	N-Methylaspartate (NMDA)
4.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
5.	Vasodilator Agents (Vasodilators)
6.	Isoxsuprine
7.	Sympathomimetics (Sympathomimetic Amines)
8.	Tocolytic Agents (Tocolytics)
9.	Dexamethasone (Maxidex)
10.	Caffeine (No Doz)

Related Therapies and Procedures

1.	Tocolysis
2.	Injections
3.	Intrauterine Blood Transfusion
4.	Therapeutics
5.	Myocutaneous Flap