Isodesmosine

2-(4-Amino-4-carboxybutyl)-1-(5-amino-5-carboxypentyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinium. A rare amino acid found in elastin, formed by condensation of four molecules of lysine into a pyridinium ring.

Also Known As:

Pyridinium, 2-(4-amino-4-carboxybutyl)-1-(5-amino-5-carboxypentyl)-3,5-bis(3-amino-3-carboxypropyl)-

Networked: 44 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ma, Shuren: 10 articles (01/2021 - 05/2007)
2.	Turino, Gerard M: 6 articles (01/2021 - 05/2007)
3.	Cantor, Jerome: 5 articles (06/2022 - 06/2015)
4.	Liu, Xingjian: 4 articles (01/2021 - 06/2015)
5.	Turino, Gerard: 4 articles (12/2018 - 06/2015)
6.	Lin, Yong Y: 4 articles (07/2017 - 05/2007)
7.	Cantor, Jerome O: 3 articles (01/2021 - 01/2004)
8.	Luisetti, Maurizio: 3 articles (04/2013 - 09/2011)
9.	Usuki, Toyonobu: 2 articles (01/2020 - 03/2014)
10.	Bischoff, Rainer: 2 articles (03/2016 - 01/2014)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 06/01/2015 - "The Ratio of Free to Bound Desmosine and Isodesmosine May Reflect Emphysematous Changes in COPD." 05/01/2007 - "Measurements of desmosine and isodesmosine by mass spectrometry in COPD." 08/28/1998 - "Micellar electrokinetic chromatography for the determination of urinary desmosine and isodesmosine in patients affected by chronic obstructive pulmonary disease." 09/15/2011 - "Clinical data accumulated over several decades indicate correlations of desmosine and isodesmosine levels with COPD of varying severity and responses to therapy." 06/01/2012 - "The objectives of this study were to determine the validity of urinary and blood total desmosine/isodesmosine in patients with COPD and asthma and to evaluate their relationship to exacerbation status and lung function. "
2.	Cystic Fibrosis (Mucoviscidosis) 06/01/2000 - "The aim of this study was to apply a novel methodology, based on high-performance capillary electrophoresis, to the quantification of desmosine and isodesmosine in 11 patients with stable chronic obstructive pulmonary disease (COPD), 10 with an exacerbation of COPD, nine with alpha1-antitrypsin deficiency, 13 with bronchiectasis, and 11 adults with cystic fibrosis, in comparison to 24 controls. " 04/01/2019 - "Novel methodological approaches now demonstrate that the unique elastin degradation products desmosine and isodesmosine are detectable in plasma of cystic fibrosis patients and correlate to lung function, exacerbation frequency and disease progression http://bit.ly/2VwZOcx." 04/01/2019 - "Cystic fibrosis disease severity correlates with plasma levels of desmosine and isodesmosine, biomarkers of elastin degradation." 01/01/2000 - "The objective of this study was to determine whether differences in the urinary excretion of the elastin crosslinks, desmosine and isodesmosine (which are unique amino acid products of elastase activity), could be discerned between groups of patients with chronic obstructive pulmonary disease (COPD) or cystic fibrosis (CF), and non-diseased, age-matched controls. "
3.	Liver Diseases (Liver Disease) 10/23/2000 - "However, it has been shown that the urinary concentration of elastin specific crosslinks, desmosine and isodesmosine, as well as the urinary concentration of the collagen crosslink, pyridinoline, correlated well with liver fibrosis score in biopsy specimens from patients with liver disease secondary to hepatitis C virus and alcohol. " 12/01/1997 - "The aim of this study was to evaluate the potential of urinary amino acids desmosine (DES) and isodesmosine (IDES) derived from the breakdown of elastin and hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) derived from fibrillar collagen in diagnosing chronic liver disease. "
4.	Atherosclerosis 11/27/1987 - "High-performance liquid chromatographic determination of desmosine and isodesmosine in tissues and its application to studies of alteration of elastin induced by atherosclerosis."
5.	Bronchiectasis 06/01/2000 - "The aim of this study was to apply a novel methodology, based on high-performance capillary electrophoresis, to the quantification of desmosine and isodesmosine in 11 patients with stable chronic obstructive pulmonary disease (COPD), 10 with an exacerbation of COPD, nine with alpha1-antitrypsin deficiency, 13 with bronchiectasis, and 11 adults with cystic fibrosis, in comparison to 24 controls. "

Related Drugs and Biologics

1.	Desmosine
2.	Elastin
3.	Amino Acids
4.	Biomarkers (Surrogate Marker)
5.	pyridinoline
6.	deoxypyridinoline
7.	Fibrillar Collagens
8.	Pancreatic Elastase (Elastase)
9.	Collagen
10.	Hyaluronic Acid (Hyaluronan)

Related Therapies and Procedures

1.	Therapeutics