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Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))

An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
Also Known As:
Isocitrate Dehydrogenase (NAD+); Dehydrogenase, Isocitrate; Isocitrate Dehydrogenase-I; Dehydrogenase, NAD Isocitrate; Isocitrate Dehydrogenase I; Isocitrate Dehydrogenase, NAD; NAD Isocitrate Dehydrogenase; Isocitrate:NAD+ oxidoreductase (decarboxylating)
Networked: 660 relevant articles (10 outcomes, 52 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. von Deimling, Andreas: 26 articles (02/2015 - 12/2008)
2. Kato, Yukinari: 17 articles (10/2015 - 12/2009)
3. Capper, David: 15 articles (02/2015 - 10/2009)
4. Hartmann, Christian: 15 articles (12/2014 - 12/2008)
5. Yan, Hai: 14 articles (01/2016 - 02/2009)
6. Wick, Wolfgang: 14 articles (02/2015 - 10/2009)
7. Weller, Michael: 13 articles (11/2015 - 10/2009)
8. Reifenberger, Guido: 13 articles (12/2014 - 10/2009)
9. Lai, Albert: 11 articles (09/2015 - 05/2011)
10. Park, Jeen-Woo: 11 articles (08/2014 - 03/2002)

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