Isoamylase

An enzyme that hydrolyzes 1,6-alpha-glucosidic branch linkages in glycogen, amylopectin, and their beta-limit dextrins. It is distinguished from pullulanase (EC 3.2.1.41) by its inability to attack pullulan and by the feeble action of alpha-limit dextrins. It is distinguished from amylopectin 6-glucanohydrolase (EC 3.2.1.69) by its action on glycogen. With EC 3.2.1.69, it produces the activity called "debranching enzyme". EC 3.2.1.68.

Also Known As:

Networked: 195 relevant articles (10 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Amadori, Dino: 1 article (02/2016)
2.	Bravaccini, Sara: 1 article (02/2016)
3.	Burgio, Marco Angelo: 1 article (02/2016)
4.	Casadei Gardini, Andrea: 1 article (02/2016)
5.	Del Monte, Angelo: 1 article (02/2016)
6.	Frassineti, Giovanni Luca: 1 article (02/2016)
7.	Lucchesi, Alessandro: 1 article (02/2016)
8.	Mariotti, Marita: 1 article (02/2016)
9.	Marisi, Giorgia: 1 article (02/2016)
10.	Pini, Sara: 1 article (02/2016)

Related Diseases

1.	Chronic Pancreatitis 10/01/1990 - "In the group with chronic pancreatitis studied during painful relapse, 16 had an increase in P-isoamylase, as determined with the immunoinhibition assay, 13 with the wheat germ inhibition test, and 15 with electrophoresis. " 07/01/1986 - "As for P-isoamylase, a statistical difference was detected only between mean peak concentrations of control versus chronic pancreatitis. " 11/01/1984 - "Only two out of 8 patients with elevated isoamylase P had chronic pancreatitis. " 10/01/1984 - "A low value of pancreatic isoamylase strongly supports a diagnosis of chronic pancreatitis and may obviate the need for further investigation." 10/01/1984 - "The mean pancreatic isoamylase in those with chronic pancreatitis (68 +/- 77 IU/l) was significantly lower (p less than 0.005) than in controls (113 +/- 60 IU/l). "
2.	Hyperamylasemia 05/01/1982 - "The purpose of this study was to determine if routine isoamylase assay would provide valuable diagnostic information in patients with hyperamylasemia. " 10/06/2015 - "A hyperamylasemia was noted, and further characterised by a fractionated isoamylase test, as being predominantly of the salivary type. " 05/01/1998 - "Hyperamylasemia occurred from 6 to 24 hours after the CABG and was mainly caused by pancreatic isoamylase. " 05/01/1995 - "The most useful and accurate method for distinguishing pancreatic from salivary-type hyperamylasemia is isoamylase analysis by electrophoresis. " 08/01/1992 - "2. The isoamylase pattern of postoperative hyperamylasemia was dominant in the salivary type. "
3.	Pancreatitis 06/01/1991 - "An increase in pancreatic isoamylase was found in 27% of the patients; however, none of them had clinical symptoms of pancreatitis. " 06/01/1987 - "Total pancreatic (P-type) isoamylase was elevated in 89% of patients with clinical evidence of pancreatitis, and in only 11% of those without pancreatitis. " 05/01/1987 - "It is suggested that isoamylase P3 determination is the most sensitive assay to screen for the complications of acute pancreatitis." 07/01/1986 - "We sought to determine whether the clinical diagnosis of pancreatitis was supported by elevated serum levels of pancreatic isoamylase, currently the most specific test for pancreatitis. " 03/01/1986 - "Pancreatic isoamylase was elevated in 97% of patients with probable pancreatitis, 92% with possible pancreatitis and 68% in whom pancreatitis had been considered unlikely. "
4.	Pancreatic Diseases (Pancreatic Disease) 03/01/1991 - "Serum pancreatic isoamylase activity in pancreatic disease." 01/01/1991 - "Fecal isoamylase activity in patients with pancreatic diseases." 11/01/1988 - "Serum isoamylase activities in pancreatic diseases." 09/01/1983 - "Assessment of a rapid pancreatic isoamylase assay as a screening test for chronic pancreatic disease." 01/01/1977 - "Serum isoamylase pattern in obstructive pancreatic disease."
5.	Abdominal Pain (Pain, Abdominal) 01/01/2003 - "A 70-year-old man was admitted to our hospital because of abdominal pain with an elevated serum pancreatic isoamylase level. " 05/01/1983 - "Although nine of the 58 patients had abdominal pain and clinical symptoms suggestive of acute pancreatitis, none of these patients had elevated pancreatic isoamylase. " 10/01/1992 - "Total amylase and salivary (S) type isoamylase were measured in serum from 80 women with acute abdominal pain admitted to the Department of Gynecology. " 08/01/1982 - "Since hyperamylasemia with or without abdominal pain is a frequently encountered problem, serum isoamylase analysis in 52 patients was done to see if the organ source of the amylase would be helpful in a clinical setting. " 06/01/1998 - "She subsequently complained of abdominal pain; this was associated with a slight elevation of serum pancreatic isoamylase and lipase levels, and a huge pancreatic pseudocyst was detected. "

Related Drugs and Biologics

1.	Amylases
2.	Enzymes
3.	Albumins
4.	Lipase (Acid Lipase)
5.	Trypsinogen
6.	Pancreatic Elastase (Elastase)
7.	Isoenzymes
8.	alpha-Amylases
9.	acetylcellulose
10.	Indicators and Reagents (Reagents)

Related Therapies and Procedures

1.	Therapeutics
2.	Neck Dissection (Radical Neck Dissection)
3.	Radiotherapy
4.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
5.	Laparotomy