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Ischemia

A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Also Known As:
Ischemias
Networked: 55582 relevant articles (3792 outcomes, 7276 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Reperfusion Injury
2. Anoxia (Hypoxia)
3. Myocardial Infarction
4. Stroke (Strokes)
5. Hypothermia

Experts

1. Hwang, In Koo: 98 articles (07/2015 - 11/2002)
2. Yoo, Ki-Yeon: 87 articles (11/2015 - 04/2004)
3. Won, Moo-Ho: 81 articles (12/2015 - 08/2006)
4. Stone, Gregg W: 77 articles (01/2016 - 03/2002)
5. Cuzzocrea, Salvatore: 61 articles (09/2015 - 03/2002)
6. Maslov, L N: 57 articles (10/2015 - 02/2000)
7. Zhang, Li: 55 articles (11/2015 - 04/2002)
8. Zhang, Feng: 54 articles (01/2016 - 01/2002)
9. Busuttil, Ronald W: 53 articles (11/2015 - 01/2002)
10. Zhang, John H: 53 articles (10/2015 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ischemia:
1. Adenosine Triphosphate (ATP)IBA
2. OxygenIBA
3. Retinaldehyde (Retinal)IBA
4. Glucose (Dextrose)FDA LinkGeneric
5. CalciumIBA
6. AdenosineFDA LinkGeneric
04/01/1993 - "In this study we evaluated the protective effects of adenosine (20 microM) on high-energy phosphate metabolism, H+ and Ca2+ accumulation, and glycolytic rate during 30 min of no-flow ischemia. "
01/01/2008 - "Modifications of ARs may play a significant role in determining adenosine effects during ischemia and therefore should be taken into account when evaluating time-dependent protective effects of specific A(2A) active compounds."
08/01/1995 - "Adenosine pretreatment has been shown to be beneficial in several models of ischemia-reperfusion. "
11/01/1993 - "Isolated hearts were Langendorff-perfused at 37 degrees C with oxygenated blood and paced at 3 Hz. They were divided into 5 groups, all subjected to 45 min global ischemia followed by one hour of reperfusion: 1) Control hearts (n = 7) which received no treatment or short ischemia before the long ischemia, 2) preconditioned hearts (n = 7), submitted to 5-min zero-flow global ischemia, followed by 5 min reperfusion before the long ischemia, 3) hearts pretreated with sulfophenyltheophylline (SPT 100 microM) before preconditioning and long ischemia (n = 6), 4) hearts in which preconditioning was substituted by administration of 10 microM phenyl-isopropyl-adenosine (PIA) over 5 min, and 5) hearts in which preconditioning was substituted by the administration of 1.5 mg adenosine over 5 min. Hemodynamic results show significant improvement of the postischemic recovery of left ventricular developed pressure (DP) by preconditioning. "
10/01/1993 - "Ischemia resulted in a significant reduction of high-energy phosphate compounds and an accumulation of nucleotide degradation products, particularly adenosine, in the myocardium. "
7. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
8. Lactic AcidFDA LinkGeneric
9. Glutamic Acid (Glutamate)FDA Link
10. Nitric Oxide (Nitrogen Monoxide)FDA Link

Therapies and Procedures

1. Transplants (Transplant)
2. Angioplasty (Angioplasty, Transluminal)
3. Transplantation (Transplant Recipients)
4. Induced Heart Arrest (Cardioplegia)
5. Amputation