|1.||Hwang, In Koo: 98 articles (07/2015 - 11/2002)|
|2.||Yoo, Ki-Yeon: 87 articles (11/2015 - 04/2004)|
|3.||Won, Moo-Ho: 81 articles (12/2015 - 08/2006)|
|4.||Stone, Gregg W: 77 articles (01/2016 - 03/2002)|
|5.||Cuzzocrea, Salvatore: 61 articles (09/2015 - 03/2002)|
|6.||Maslov, L N: 57 articles (10/2015 - 02/2000)|
|7.||Zhang, Li: 55 articles (11/2015 - 04/2002)|
|8.||Zhang, Feng: 54 articles (01/2016 - 01/2002)|
|9.||Busuttil, Ronald W: 53 articles (11/2015 - 01/2002)|
|10.||Zhang, John H: 53 articles (10/2015 - 02/2002)|
|1.||Adenosine Triphosphate (ATP)IBA
04/04/2003 - "We recently demonstrated that it induces potent protective effects against ischemia-reperfusion (I-R) injury in rabbit hearts through the opening of mitochondrial ATP-dependent K+ channels. "
10/01/1999 - "Group IV also showed a significant marked inhibition of the decrease in ATP during global ischemia (59+/-5%) and a more significant improvement on recovery of ATP during postischemic reperfusion (86+/-3%) compared with the other 3 groups. "
08/01/1997 - "Group IV also showed a significantly marked improvement of ATP, CrP, and pH and significant suppression in Pi during low-flow ischemia compared with Group III. These were no differences in LV Dev.P and coronary flow among any groups. "
12/01/1990 - "Active force development in acute ischemia is inhibited by the accumulation of ischemic metabolic products (H+, inorganic phosphate (Pi), Mg++) but not by a marked decrease of [ATP]. "
07/01/1990 - "Restoration of CrP levels after complete reperfusion was also significantly greater in group V than in group II. The recovery of ATP after complete reperfusion was also much better in group V being comparable to those in group I, although the total duration of ischemia was longer in group V than in group I. These results indicate the beneficial effects of low-flow perfusion on the preservation during ischemia and recovery after reperfusion of myocardial HEP."
09/01/1993 - "vasogenic oedema, progressive posttraumatic ischemia development, loss of microvascular autoregulation), 3. the striking similarity between posttraumatic CNS pathology and that caused by chemical peroxidative insult, and 4. the protective efficacy of oxygen radical scavenging agents or compounds that inhibit lipid peroxidation."
06/01/1991 - "A number of scavengers of reactive oxygen metabolites reduce myocardial injury when given before ischemia and reperfusion, but few, if any, have proven to be effective when given near the onset of reperfusion. "
08/01/2006 - "The signs of ischemia, measured by transcutaneous partial oxygen pressure and thermography, improved significantly. "
07/01/2004 - "Exp. 2: ARG infusion significantly improved gut blood perfusion ratio during ischemia but had no effect on oxygen tension. "
02/01/1996 - "Lazaroids are inhibitors of oxygen radical-induced lipid peroxidation, and proved beneficial in cases of CNS injury and ischemia. "
09/01/2014 - "A complete functional and histologic protection against retinal ischemic damage can be achieved by previous preconditioning with non-damaging ischemia. "
01/01/2007 - "Histology confirmed that IPC induction by 5 min of retinal ischemia results in a complete protection against the neurodegenerative effects of a 60 min ischemic period applied 24 or 48 h later. "
05/01/2008 - "Histological studies showed that evolving ischemia afflicted the internal retinal layers, primarily involving the layer ofganglionic cells and nerve fibers, which was also attended by a significant reduction in the level of venous outflow and, thus, it was of mixed (arteriovenous) nature."
11/01/2007 - "Studies of retinal ischemia/reperfusion indicate a disparity between the anatomical and functional results; while a large number of rod bipolar cells remain postischemia, there is a significant reduction in the amplitude of the scotopic b-wave of the electroretinogram (ERG). "
04/01/2012 - "EPO deficiency in heterozygous Epo-Tag transgenic mice was associated with more profound retinal dysfunction after OIR, indicated by a significantly greater suppression of ERG amplitudes, but had no measurable effect on the extent of retinal ischemia, preretinal neovascularization, or neuroretinal degeneration in OIR. "
|4.||Glucose (Dextrose)FDA LinkGeneric
08/01/1998 - "The most interesting part of the experiments was the behaviour of the hearts in the reperfusion period after no-flow ischemia of 20 min. The results were: (1) With glucose and high fatty acid concentrations the hearts showed an improved recovery of the left ventricular functions in the reperfusion period compared with low fatty acid concentrations. "
01/01/2013 - "IPC exerted significant cardioprotection and markedly improved myocardial glucose uptake 1 h after reperfusion (P<0.01) as evidenced by PET images and gamma-counter biodistribution assay in ischemia/reperfused rats. "
09/01/2002 - "The data support the adjunctive use of agents that promote glucose uptake during ischemia and suggest that increasing glucose use is more important than decreasing LCAC in the protection against ischemic injury or in the recovery of contractile function."
03/01/2011 - "While rates of fatty acid oxidation or glycolysis from exogenous glucose were similar between groups, improved functional recovery post-ischemia in CR hearts was associated with high rates of glucose oxidation during reperfusion compared to controls. "
03/15/2009 - "The decrease of FAO may switch heart energy substrate preference from fatty acid to glucose, which is beneficial for ischemia heart."
06/01/1988 - "The 3 groups showed a marked decrease in the max calcium binding capacity during ischemia compared with the Control Group but exhibited no further decrease after reperfusion. "
03/01/1988 - "In contrast, calcium reduction had no significant effect after 10 min of ischemia but caused a significant reduction after 20 min of ischemia. "
10/01/2000 - "It is unclear whether preceding repetitive brief ischemia causes any improvement in the energy efficiency of intracellular calcium cycling or crossbridge cycling that may lead to cardioprotection after subsequent sustained ischemia/reperfusion, a phenomenon called ischemic preconditioning. "
11/01/1990 - "The effect on calcium recovery was observed at intraperitoneal doses as low as 0.1 mg/kg. The compound also was effective in partially attenuating 1-week postischemic hippocampal CA1 neuronal loss in a gerbil global ischemia model involving brief (15-minute) bilateral carotid occlusion, but sustained dosing was required. "
01/30/1987 - "Preliminary experience suggests that calcium antagonists and beta blockers are effective in decreasing episodes of silent ischemia in patients with stable exertional angina and that a combination regimen may be more effective than either form of therapy alone."
04/01/1993 - "In this study we evaluated the protective effects of adenosine (20 microM) on high-energy phosphate metabolism, H+ and Ca2+ accumulation, and glycolytic rate during 30 min of no-flow ischemia. "
01/01/2008 - "Modifications of ARs may play a significant role in determining adenosine effects during ischemia and therefore should be taken into account when evaluating time-dependent protective effects of specific A(2A) active compounds."
08/01/1995 - "Adenosine pretreatment has been shown to be beneficial in several models of ischemia-reperfusion. "
11/01/1993 - "Isolated hearts were Langendorff-perfused at 37 degrees C with oxygenated blood and paced at 3 Hz. They were divided into 5 groups, all subjected to 45 min global ischemia followed by one hour of reperfusion: 1) Control hearts (n = 7) which received no treatment or short ischemia before the long ischemia, 2) preconditioned hearts (n = 7), submitted to 5-min zero-flow global ischemia, followed by 5 min reperfusion before the long ischemia, 3) hearts pretreated with sulfophenyltheophylline (SPT 100 microM) before preconditioning and long ischemia (n = 6), 4) hearts in which preconditioning was substituted by administration of 10 microM phenyl-isopropyl-adenosine (PIA) over 5 min, and 5) hearts in which preconditioning was substituted by the administration of 1.5 mg adenosine over 5 min. Hemodynamic results show significant improvement of the postischemic recovery of left ventricular developed pressure (DP) by preconditioning. "
10/01/1993 - "Ischemia resulted in a significant reduction of high-energy phosphate compounds and an accumulation of nucleotide degradation products, particularly adenosine, in the myocardium. "
|7.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/01/2006 - "Marked decrease of plasma VEGF after implantation of autologous bone marrow mononuclear cells in a patient with critical limb ischemia--a case report."
02/16/2001 - "Tissue ischemia and/or VEGF may stimulate capillary sprouting, but this response does not translate to a significant improvement in collateral flow. "
01/01/2015 - "In this work we report on therapeutic efficacy of CS from mouse ADSC transduced to express human vascular endothelial growth factor 165 a/a isoform (VEGF165), which showed potency to restore perfusion and protect tissue in a model of limb ischemia. "
04/01/2009 - "Delivery of exogenous vascular endothelial growth factor (VEGF) to areas of ischemia has shown promise for promoting therapeutic angiogenesis, but its expression must be tightly regulated to avoid adverse effects. "
01/01/2009 - "The use of a non-viral carrier to deliver an ischemia-inducible VEGF construct is effective in the treatment of acutely ischemic myocardium."
|8.||Lactic AcidFDA LinkGeneric
05/01/2003 - "Thus enhanced glycolysis resulted in increased energy efficiency under aerobic conditions but significantly enhanced lactate production with no further improvement in function during demand-induced ischemia. "
07/01/1989 - "Intrarenal lactate content increased significantly from the 5 min ischemia group to the 180 min. These results suggest that no improvement in intrarenal energy metabolism with increasing duration of renal ischemia is showed and ischemic renal injury develops progressively. "
10/01/1984 - "The drug was well tolerated by the patients, virtually did not affect the parameters of myocardial contractility, decreased the work of the heart at the expense of a significant reduction of the after-load and lowered manifestations of the ischemia of the intact myocardium (the coefficient of lactate extraction by the myocardium was found to elevate)."
11/01/1989 - "When compared with hippocampus, lactate was higher in the cerebral cortex after ischemia, and DCA was more effective in reducing those levels. "
07/01/1998 - "AR inhibition improved functional recovery in both control and diabetic hearts, coupled with a lower cytosolic redox state and greater effluent lactate concentrations during ischemia. "
|9.||Glutamic Acid (Glutamate)FDA Link
05/01/2010 - "Acupuncture (ACU) is known to be effective in ischemia treatment, and glutamate (GLU) excitotoxicity is an important factor in neuronal cell death. "
02/01/2010 - "Acupuncture has been known to be effective in ischemia, and glutamate excitotoxicity is an important factor for the neuronal cell death. "
08/27/1999 - "During the second half of 10-min ischemia, a significant increase in glutamate release was induced even in the dentate gyrus where CA4 neurons were eliminated; this increase was significantly suppressed by inhibiting proliferation of astrocytes. "
02/01/1998 - "In contrast, glutamate increased by sixfold during ischemia at 37 degrees C and remained significantly greater during reperfusion in the 34 degrees C and 37 degrees C groups. "
07/01/1997 - "Lesioned animals showed significantly greater numbers of surviving neurons and significantly lower ischemia-induced elevations of extracellular glutamate concentrations than nonlesioned animals. "
|10.||Nitric Oxide (Nitrogen Monoxide)FDA Link
01/01/2006 - "The application of GTN, a nitric oxide donor, has caused significant improvement in renal function when applied prior to an experimentally designed renal ischemia-reperfusion model. "
02/27/2001 - "Although nitric oxide (NO) is thought to be beneficial in hepatic ischemia-reperfusion (I/R), the mechanisms for this effect are not well established. "
11/01/1993 - "Strategies designed to minimize postischemic attenuation of nitric oxide release may be beneficial in the management of acute limb ischemia."
09/01/2001 - "Inhibition of nitric oxide production during global ischemia ameliorates ischemic damage of pyramidal neurons in the hippocampus."
07/01/2001 - "Contribution of nitric oxide to the protective effects of ischemic preconditioning in ischemia-reperfused rat kidneys."
01/01/1998 - "Most notably, we have utilized older donors and grafts with significant microsteatosis and have observed good results with these grafts as long as ischemia time is minimized. "
05/01/1981 - "The best results were obtained in those with the aortofemoral or iliofemoral grafts, but superficial grafts were a satisfactory alternative even in the unfit patients with critical ischemia."
03/01/2002 - "This procedure helped us avoid ischemia of the graft, which showed excellent function pre- and postoperatively. "
10/01/1998 - "Revascularization for persistently symptomatic traumatic ICA dissection eliminated ischemia and was associated with excellent long-term outcomes and graft patency rates."
04/01/1983 - "The arterial reconstructive surgery is very effective for relief of peripheral ischemia in the follow-up studies if good function of the grafts was obtained in the early postoperative period."
|2.||Angioplasty (Angioplasty, Transluminal)
08/01/2007 - "Angioplasty best treatment for silent ischemia. "
04/01/1990 - "We conclude that although the most effective treatment for silent ischemia remains to be determined, our data suggest that coronary angioplasty is a therapeutic option in these patients."
07/01/2014 - "Clinical efficacy of successful angioplasty in critical ischemia--a cohort study."
09/01/1988 - "Elevation of diastolic pressure of the pulmonary artery (8.7 +/- 4.8 vs. 5.7 +/- 2.8 mmHg) and lowering of systolic pressure of the femoral artery (-25.7 +/- 24.3 vs. -11.8 +/- 8.3 mmHg) were significantly greater in Group I. These findings suggest that ST depression in the inferior leads during LAD angioplasty was due to a purely electrical phenomenon and not to the concomitant ischemia of the inferior wall. "
09/01/1987 - "When such ischemia is present, it is eliminated by successful coronary angioplasty."
|3.||Transplantation (Transplant Recipients)
01/01/2005 - "In this study, we investigated the importance of the EP4 receptor, and the efficacy of a selective EP4 agonist to alter hepatic ischemia/reperfusion (I/R) injury, an important cause of damage in liver resection and transplantation. "
04/02/2002 - "With further studies, these cells could provide a source of human endothelial cells that could be beneficial for potential applications such as engineering new blood vessels, endothelial cell transplantation into the heart for myocardial regeneration, and induction of angiogenesis for treatment of regional ischemia."
04/01/2014 - "We found that transplantation of BMSCs at 3 and 24 h, but not 7 days after focal ischemia, significantly reduced the lesion volume and improved motor deficits. "
12/01/2008 - "The early period after transplantation requires maximum immunosuppressive efficacy with minimal ischemia reperfusion and good surgical-related wound healing. "
03/16/2007 - "Bone marrow (BM) transplantation with WT-BM cells in EpoR(-/-)-rescued mice partially but significantly improved blood flow recovery after hindlimb ischemia. "
|4.||Induced Heart Arrest (Cardioplegia)
09/01/1998 - "The experimental results suggest that such interventions could be beneficial in clinical situations such as cardioplegia, heart preservation, or recovery from ischemia."
02/01/1996 - "A significant reduction in endothelium-dependent vascular function was observed after 40 minutes of ischemia (-31.8% +/- 6.6% vs -50.4% +/- 1.6% in control hearts, p < 0.05), and again this was improved by cardioplegia (-45.0% +/- 3.4%, p < 0.05 vs ischemic group). "
12/01/2003 - "Preconditioning with cardioplegia is more effective in reducing apoptosis than is preconditioning with ischemia in the human myocardium."
11/01/1994 - "With the continuing search for superior methods of myocardial protection, we compared the protective efficacy of ischemic preconditioning with that of St Thomas' cardioplegia, alone and in combination, against vascular and myocyte injury during ischemia and reperfusion. "
11/01/1992 - "Retrograde is superior to antegrade continuous warm blood cardioplegia for acute cardiac ischemia."
01/01/2001 - "Duplex scan surveillance is highly effective for patients treated for critical limb ischemia, leading to a reduction of major amputations and consequently to a reduction in costs compared with other surveillance programs. "
05/04/1992 - "The results are best (the highest percentage of good results and without improvement, the least number of amputation and death) in the II period of disease and they become worse when the degree of ischemia increases. "
08/01/2008 - "Primary outcome was efficacy of the procedure measured as healing of defects, frequency of high amputations and change of ischemia grade; among secondary outcomes were safety of the procedure, angiographic changes and changes in quality of life. "
12/01/2012 - "Amputation-free survival (AFS) has been recommended as the gold standard for evaluating No-Option Critical Limb Ischemia (NO-CLI) therapy. "
02/01/2011 - "Until recently, the only approach to treating advanced stage disease was medical therapy and major amputation; however, the advent of revascularization procedures has radically improved the prognosis of patients with critical lower limb ischemia. "