Iothalamic Acid (Iotalamic Acid)

A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts.

Also Known As:

Iotalamic Acid; Angio-Conray; Sodium Iothalamate; Iothalamate, Sodium; Conray 420; Iodothalamate; Iothalamate; Iothalamic Acid, Calcium (2:1) Salt; Iothalamic Acid, Monosilver (1+) Salt; Iothalamic Acid, Monosodium Salt; Iothalamic Acid, Monosodium Salt, Dimer; Lopamidol; Acid, Iotalamic; Acid, Iothalamic; Acid, Methalamic; Angio Conray; AngioConray; Methalamic Acid; Benzoic acid, 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)-

Networked: 146 relevant articles (16 outcomes, 18 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Torres, Vicente E: 7 articles (12/2018 - 08/2000)
2.	Chapman, Arlene B: 6 articles (12/2018 - 09/2003)
3.	Lerman, Lilach O: 5 articles (01/2020 - 08/2013)
4.	Rule, Andrew D: 5 articles (01/2020 - 12/2004)
5.	Bennett, William M: 5 articles (12/2018 - 09/2003)
6.	Bae, Kyongtae T: 5 articles (07/2015 - 09/2003)
7.	Grantham, Jared J: 5 articles (07/2015 - 09/2003)
8.	Saad, Ahmed: 4 articles (01/2019 - 08/2013)
9.	Textor, Stephen C: 4 articles (01/2019 - 08/2013)
10.	Christenson, Robert H: 4 articles (01/2018 - 04/2014)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 05/01/1999 - "In 30 outpatients with NIDDM GFR was measured as the urinary clearance of continuously infused [125I]iothalamate. " 02/01/1998 - "In 30 outpatients with NIDDM and normo- (n = 10), micro- (n = 9), or macroalbuminuria (n = 11), GFR was measured as the urinary clearance during continuous infusion of 125I-labeled iothalamate. " 12/01/2022 - "To delineate underlying cellular mechanisms of damage associated with hyperfiltration, transcriptional profiles of kidney biopsies from Pima Indians with type 2 diabetes with or without early-stage diabetic kidney disease were grouped into two hyperfiltration categories based on annual iothalamate GFR measurements. " 01/01/1996 - "CVb and CVr of bolus injection of 51Cr-EDTA, but not CVc of iothalamate and 51Cr-EDTA infusions were twofold to tenfold lower than the percent yearly change reported in IDDM and NIDDM patients. " 05/01/2005 - "Thirty participants with type 2 diabetes in the Diabetic Renal Disease Study met these three eligibility criteria: GFR >20 ml/min per 1.73 m2 at baseline (based on cold iothalamate clearance), 4 yr of follow-up, and yearly measurements of iothalamate clearance and serum cystatin C. "
2.	Chronic Renal Insufficiency 12/01/2018 - "The primary objective of the present study was to compare, in healthy adult kidney donor candidates, GFR measured by the clearance of iothalamate to GFR estimated using the Chronic Kidney Disease Epidemiology Collaboration equation and to determine if eGFR was a suitable stand-alone assessment. " 12/01/2018 - "GFR was measured by the plasma clearance of radioisotopic iothalamate and estimated using the Chronic Kidney Disease Epidemiology Collaboration equation. " 12/01/2018 - "The Chronic Kidney Disease Epidemiology Collaboration eGFR can be used for screening potential kidney donors restricting the use of iothalamate (mGFR) to those donors with an eGFR below the transplant centers' acceptable GFR threshold for donation, thereby effecting cost savings and greater donor convenience. " 01/01/2016 - "We analyzed cross-sectional data among 1342 participants from the Chronic Renal Insufficiency Cohort study with baseline measurement of GFR by iothalamate clearance (iGFR) and CrCl by 24-hour urine collection. " 12/05/2013 - "We did a cross-sectional analysis of 1342 patients with chronic kidney disease from the Chronic Renal Insufficiency Cohort (CRIC) who had baseline measure of iothalamate GFR (iGFR) and 24-hour urine collections. "
3.	Renal Insufficiency (Renal Failure) 02/01/2012 - "We examined associations between the reciprocals of these filtration markers and (125)I iothalamate GFR, expressed per SD, with kidney failure and mortality. " 08/01/1996 - "Plasma iothalamate (IOT) disappearance rates were measured after a single-injection of IOT (113.8 mg/kg, IV) in cats with experimentally induced renal failure. " 08/01/1996 - "The iothalamate clearance in cats with experimentally induced renal failure." 08/01/1991 - "The glomerular filtration rate (iothalamate clearance) was reduced in all patients (0.98 +/- 0.10 (mean +/- SE) mL/s.1.73 m2; P less than 0.001) compared with normal controls (N = 9) (1.93 +/- 0.08 mL/s.1.73 m2), but it was similar to that in controls matched for renal insufficiency (N = 6) (1.15 +/- 0.05 mL/s.1.73 m2). " 11/01/1983 - "These factors were evaluated in 62 patients with various degrees of renal failure in whom we measured plasma BGP, [125I]iothalamate clearance [a measure of glomerular filtration rate (GFR)], and [131I]o-iodohippurate clearance (a measure of effective renal plasma flow). "
4.	Brain Neoplasms (Brain Tumor) 11/01/1984 - "The monoionic dimer ioxaglate is as effective as iothalamate for enhancement of canine brain tumors." 07/01/1984 - "The monoionic dimer ioxaglate is as effective as iothalamate for enhancement of canine brain tumors." 01/01/1986 - "Contrast enhancement of brain tumors and irradiated normal brain: a comparison of iohexol and iothalamate." 01/01/1986 - "The nonionic contrast agent iohexol was compared with the ionic agent iothalamate for contrast enhancement of brain tumors and radiation brain damage in dogs. "
5.	Hypertension (High Blood Pressure) 12/27/2018 - "Linear mixed models, unadjusted and adjusted for age, race, sex, BMI, smoking, hypertension, genetics and time, were used to model height-adjusted total kidney volume (htTKV) and iothalamate clearance (mGFR). " 03/01/1980 - "During AII hypertension, chronic infusion of 5 or 10 mg/day of MP also resulted in a marked renal vasodilation, natriuresis, and reductions in sodium iothalamate space, while causing small reductions in MAP. " 10/01/2006 - "The relationships of 35 baseline factors with eGFR-based outcomes were compared with the relationships of the same factors with iothalamate GFR (iGFR)-based outcomes in the African American Study of Kidney Disease and Hypertension (AASK; n = 1094). " 03/01/2006 - "Hypertension was associated with a decline in iothalamate clearance (odds ratio [OR] 5.8; 95% confidence interval [CI] 2.3 to 14), eGFR (OR [MDRD] 2.0 [95% CI 1.0 to 4.2] or OR [Cockcroft-Gault] 1.9 [95% CI 0.9 to 3.9]), and creatinine clearance (OR 2.0; 95% CI 1.0 to 4.2). " 09/01/1993 - "Associated with the hypertension was an increase in cumulative sodium balance to 507 +/- 107 mmol after 35 days and a rise in sodium iothalamate space, an index of extracellular fluid volume, to 131 +/- 4% of control. "

Related Drugs and Biologics

1.	Creatinine
2.	Ioxaglic Acid (Ioxaglate Meglumine)
3.	Cystatin C
4.	Acids
5.	Iodine
6.	Salts
7.	Albumins
8.	Meglumine
9.	Vancomycin
10.	Mannitol (Osmitrol)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Intravenous Injections
3.	Intravenous Administration
4.	Subcutaneous Infusions
5.	Transplantation