Intrinsic Factor

A glycoprotein secreted by the cells of the GASTRIC GLANDS that is required for the absorption of VITAMIN B 12 (cyanocobalamin). Deficiency of intrinsic factor leads to VITAMIN B 12 DEFICIENCY and ANEMIA, PERNICIOUS.

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Networked: 518 relevant articles (9 outcomes, 29 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Lahner, Edith: 6 articles (01/2021 - 09/2005)
2.	Tanner, Stephan M: 5 articles (10/2012 - 03/2005)
3.	Annibale, Bruno: 4 articles (12/2011 - 09/2005)
4.	Shah, Shailja C: 3 articles (12/2021 - 01/2021)
5.	Toh, Ban-Hock: 3 articles (01/2020 - 04/2014)
6.	Bizzaro, Nicola: 3 articles (04/2019 - 01/2012)
7.	Goldenring, James R: 3 articles (01/2019 - 12/2007)
8.	Haruma, Ken: 2 articles (06/2022 - 10/2019)
9.	Kotera, Tohru: 2 articles (06/2022 - 04/2018)
10.	Kushima, Ryoji: 2 articles (06/2022 - 04/2022)

Related Diseases

1.	Pernicious Anemia 10/01/1985 - "It is reasonable to presume that this assay is clinically useful for detection of intrinsic factor blocking antibody in the diagnosis of pernicious anemia, if false positive results due to B12 medication are excluded." 04/23/2019 - "Aim of this study was to investigate intrinsic factor-specific T cells in the gastric mucosa of pernicious anemia patients and define their functional properties. " 01/01/2012 - "After the successful intervention studies, the next advance was made by Castle who discovered that a gastric component, which he called intrinsic factor, was missing in pernicious anemia. " 01/01/1983 - "Gastric juice in congenital pernicious anemia contains no immunoreactive intrinsic factor molecule: study of three kindreds with variable ages at presentation, including a patient first diagnosed in adulthood." 03/01/1964 - "[STUDY OF A CASE OF PERNICIOUS ANEMIA IN A CHILD WITH NORMAL "INTRINSIC FACTOR" ACTIVITY IN ITS GASTRIC JUICE]."
2.	Atrophic Gastritis 07/14/2020 - "Serum anti-parietal cell antibody and anti-intrinsic factor were measured when autoimmune atrophic gastritis was suspected. " 10/01/2010 - "Intrinsic factor antibody negative atrophic gastritis; is it different from pernicious anaemia?" 01/01/1983 - "The diagnosis was confirmed by demonstration of atrophic gastritis, failure of secretion of Intrinsic Factor and Schilling test. " 10/01/1975 - "No association has been found between any HL-A specificity and an increased incidence of either serum gastric parietal cell or intrinsic factor antibody compared with the overall incidence in pernicious anaemia, atrophic gastritis or in the whole series." 07/01/2023 - "On examination and following labs and other diagnostic investigations, we found megaloblastic anemia due to atrophic gastritis and low intrinsic factor. "
3.	Gastritis 06/21/2023 - "Autoimmune gastritis (AIG) is a progressive, chronic, immune-mediated inflammatory disease characterized by the destruction of gastric parietal cells leading to hypo/anacidity and loss of intrinsic factor. " 11/01/2011 - "Ectopic expression of gastric intrinsic factor (IF) has been described in rodent models of chronic gastritis. " 11/01/2011 - "Production of ectopic gastric intrinsic factor in gastric mucosa of humans with chronic gastritis." 10/01/2010 - "Parietal cell antibody (PCA) and intrinsic factor antibody (IFA) are characteristic of autoimmune gastritis, of which IFA is more specific. " 01/01/1970 - "The secretion of intrinsic factor in patients with chronic gastritis."
4.	Steatorrhea 06/01/1977 - "Schilling tests (with intrinsic factor) improve in two patients and steatorrhea improved in all and there was significant weight gain. " 01/01/1979 - "Three patients with a bodyweight less than 75% of the idealweight died, steatorrhea (8--19 g/die), bloodsugar oscillation in the 24 h-profile (40--820 mg%) and an intrinsic-factor-non-responsive vitamin B12-malabsorption without megaloblastic anemia. "
5.	Intestinal Diseases (Diseases, Intestinal) 06/11/1977 - "This method is also shown to be a sensitive index of improved vitamin B12 absorption after treatment of small-intestinal disease and with the addition of intrinsic factor in pernicious anaemia. " 09/01/1968 - "There is no relation between histamine-stimulated intrinsic factor production and vitamin B(12) absorption in patients with small intestinal disease."

Related Drugs and Biologics

1.	Vitamin B 12 (Cyanocobalamin)
2.	Antibodies
3.	Gastrins
4.	mecobalamin (methylcobalamin)
5.	Proteins (Proteins, Gene)
6.	Autoantibodies
7.	Vitamins
8.	Antigens
9.	Protein Glutamine gamma Glutamyltransferase 2
10.	Pepsin A (Pepsin)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Massage (Zone Therapy)
3.	Therapeutics
4.	Gastrectomy
5.	Oral Administration