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Intestinal Atresia

Congenital obliteration of the lumen of the intestine, with the ILEUM involved in 50% of the cases and the JEJUNUM and DUODENUM following in frequency. It is the most frequent cause of INTESTINAL OBSTRUCTION in NEWBORNS. (From Stedman, 25th ed)
Also Known As:
Apple Peel Small Bowel Syndrome; Apple Peel Syndrome; Apple-Peel Intestinal Atresia; Congenital Intestinal Atresia; Familial Apple Peel Jejunal Atresia; Jejunal Atresia; Apple Peel Intestinal Atresia; Apple Peel Syndromes; Apple-Peel Intestinal Atresias; Atresia, Apple-Peel Intestinal; Atresia, Congenital Intestinal; Atresia, Jejunal; Atresias, Apple-Peel Intestinal; Atresias, Congenital Intestinal; Congenital Intestinal Atresias; Intestinal Atresia, Apple-Peel; Intestinal Atresia, Congenital; Intestinal Atresias, Apple-Peel; Intestinal Atresias, Congenital; Atresia, Intestinal
Networked: 156 relevant articles (6 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Necrotizing Enterocolitis
2. Pathologic Constriction (Stenosis)
3. Gastroschisis
4. Esophageal Atresia
5. Umbilical Hernia (Omphalocele)

Experts

1. National Birth Defects Prevention Study: 4 articles (05/2022 - 11/2017)
2. Browne, Marilyn L: 4 articles (11/2018 - 02/2011)
3. Feldkamp, Marcia L: 3 articles (05/2022 - 02/2011)
4. Romitti, Paul A: 3 articles (05/2022 - 02/2011)
5. Fisher, Sarah C: 3 articles (11/2018 - 11/2017)
6. Werler, Martha M: 3 articles (11/2018 - 05/2003)
7. Sarnacki, Sabine: 2 articles (01/2022 - 12/2004)
8. Li, Long: 2 articles (01/2022 - 08/2014)
9. Howley, Meredith M: 2 articles (11/2018 - 11/2017)
10. Van Zutphen, Alissa R: 2 articles (11/2018 - 11/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Intestinal Atresia:
1. teduglutideIBA
2. Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
3. Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA
4. Proteins (Proteins, Gene)FDA Link
09/01/2012 - "Although disruptions in notochord development can be associated with intestinal atresia formation, in the Fgfr2IIIb-/- genetic animal model neither disruptions in notochord development nor the presence of exogenous Shh protein are causative in the formation of these defects."
11/01/2006 - "Does small intestinal atresia affect epithelial protein expression in human newborns?"
10/29/2020 - "TTC7A-deficiency is characterized by apoptotic colitis in milder cases with severe intestinal atresia and immunodeficiency in cases with complete loss of protein. "
12/01/2004 - "Using a series of neuronal (synaptophysin, neuronal nitric oxide synthase, neurofilaments) and nonneuronal markers (glial acidic fibrillary protein and c-Kit) and immunohistochemistry, we have defined developmental steps of the enteric nervous system in normal intestine (12 fetuses, 15 children, and 4 adults) and their alterations above and below the obstacle in 22 human intestinal atresia compared with age-matched controls. "
10/01/2013 - "The purpose of this study was to explore the mechanisms of postoperative intestinal motility disorders in intestinal atresia patients by investigating the expression profiles of proteins, including calretinin (CR), glial-derived neurotrophic factor (GDNF), bone morphogenetic protein 2 (BMP-2), c-kit, α-smooth muscle actin (α-SMA), and S-100 protein; to decipher the correlation between the area of the pathological segment and the alteration of the above 6 proteins; and thereby to provide a clinical specific reference values to determine the removal length for intestinal tract resection. "
5. ElectrolytesIBA
6. Calbindin 2IBA
7. Bone Morphogenetic Protein 2IBA
8. MicroRNAs (MicroRNA)IBA
9. S100 Proteins (S 100 Protein)IBA
10. Caffeine (No Doz)FDA LinkGeneric

Therapies and Procedures

1. Therapeutics
2. Enteral Nutrition (Feeding, Tube)
3. Neonatal Intensive Care
4. Total Parenteral Nutrition
5. Transplantation