Interferon Type I

Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).

Also Known As:

Networked: 4788 relevant articles (111 outcomes, 266 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kalinke, Ulrich: 40 articles (01/2022 - 02/2002)
2.	Akira, Shizuo: 32 articles (01/2019 - 07/2005)
3.	Cheng, Genhong: 31 articles (04/2022 - 06/2004)
4.	Niewold, Timothy B: 27 articles (01/2022 - 02/2008)
5.	Diamond, Michael S: 25 articles (01/2022 - 09/2008)
6.	García-Sastre, Adolfo: 25 articles (11/2021 - 05/2002)
7.	Casanova, Jean-Laurent: 24 articles (10/2022 - 06/2007)
8.	Chen, Zhijian J: 22 articles (01/2022 - 09/2005)
9.	Rönnblom, Lars: 22 articles (01/2021 - 12/2002)
10.	Hornung, Veit: 21 articles (11/2022 - 03/2005)

Related Diseases

1.	Infections 01/01/2020 - "Canine, porcine, and rhesus macaque ISG15, such as human ISG15, stabilize USP18, a potent inhibitor of type I interferon (IFN)-I. Type I Interferon-primed ISG15-knockout porcine and rhesus cells demonstrate enhanced ISG expression and protection against vesicular stomatitis Indiana virus infection compared with wild type. " 04/25/1999 - "Thus, type I interferon, as well as IRF-1 and IRF-2, appears to play an important and necessary role in the pathogenesis of, and protection against, VEE infection." 07/01/2004 - "A high expression of a Mx gene, a molecular marker of type I interferon(s) (IFN) occurred in the head kidneys of ABV-challenged flounder from Day 1 to Day 7. These results suggest that the non-specific protection against the secondary VHSV infection in flounder was due to IFN(s) induced by the primary ABV infection." 01/01/2017 - "However, treatment with type I interferons has not been effective in patients with EV71 infection. " 05/14/2014 - "Immune-based therapeutic strategies that specifically induce type I interferon responses are associated with functional cure for both chronic HBV and HCV infections. "
2.	Neoplasms (Cancer) 01/01/2023 - "EGR2 transcriptional regulator knockout not only blocks this type I interferon-mediated inhibitory program but also independently expands early memory CAR T cells with improved efficacy against liquid and solid tumors. " 01/01/2023 - "Here, we describe epigenetic dysregulations in cancer, with a particular focus on those related to innate immune signaling and Type I interferons, and emphasize opportunities and current efforts to translate this knowledge into treatment regimens with improved clinical benefit." 08/09/2014 - "Moreover, up-regulated expressions of CD40LG and IRF7 may make for improved tumor cytolytic function of CIK(IL-2) through type I interferon signaling. " 11/29/2023 - "In this study, we show that local delivery of a bispecific Clec9A-PD-L1 targeted type I interferon (AcTaferon, AFN) overcomes this hurdle by reshaping the tumor immune landscape.Treatment" 08/23/2023 - "These studies indicated that, as in murine and human cells, type I interferons (IFN) play an important role in limiting MYXV replication in canine cancer cells. "
3.	Virus Diseases (Viral Diseases) 01/01/2017 - "Recent studies suggest that myeloid DCs from controllers have improved abilities to recognize HIV-1 through cytoplasmic immune sensors, resulting in more potent, cell-intrinsic type I interferon secretion in response to viral infection. " 01/01/2022 - "In this review, we focus the important role of placenta-derived type I interferon and its downstream ISGs in the regulation of maternal immune homeostasis and protection against viral infection. " 01/01/2021 - "Here, we investigate the safety and efficacy of rLCMV in mice lacking a functional type I interferon system with high susceptibility to viral infections. " 01/01/2011 - "Although both IFNARko and IPS-1ko hepatocytes showed a reduced induction of type I interferons in response to viral infection, only IPS-1-/- cells circumvented cell death from HCV cytopathic effect and significantly improved J6JFH1 replication, suggesting IPS-1 to be a key player regulating HCV replication in mouse hepatocytes. " 09/01/2015 - "Type I interferon is an essential component of the brain's innate immune defence, conferring protection against viral infection. "
4.	Bites and Stings (Sting) 11/09/2021 - "These findings elucidate a molecular mechanism linking TNF to type-I interferon signaling and suggest a potential benefit for therapeutic targeting of cGAS/STING in TNF-driven diseases." 01/01/2023 - "Other noncanonical strategies that activate cGAS-STING signaling, including the use of direct STING agonists and STING trafficking facilitation, also show promise in type I interferon release and antitumor immunity priming. " 01/01/2022 - "In vitro STING binding and cell-based activity assays demonstrated the potency and efficacy of the compounds that function as direct STING agonists by stimulating STING downstream signaling and promoting type I interferon immune responses. " 09/01/2023 - "In this study, we found that pS273R was an important antagonistic viral factor that suppressed cGAS-STING-mediated type I interferon (IFN-I) production. " 01/01/2023 - "Our study showed that overexpression of L83L inhibited the cGAS-STING-mediated type I interferon (IFN-I) signaling pathway. "
5.	COVID-19 01/01/2022 - "Recent studies have identified an association between perturbed type I interferon (IFN) responses and the severity of coronavirus disease 2019 (COVID-19). " 01/01/2021 - "These studies have attributed the severe form of Covid-19 to a dysfunctional innate immune response, such as a delayed and/or deficient type I interferon response, coupled with an exaggerated and/or a dysfunctional adaptive immunity. " 01/01/2021 - "Our study discovered a highly-preserved transcriptional profile of Type I interferon (IFN-I)-dependent genes for COVID-19 complementary diagnosis. " 12/01/2023 - "Impairment of the type I interferon (IFN-I) signaling pathway is associated with increased severity of COVID-19 disease. " 11/17/2023 - "Type I interferon signaling induces a delayed antiproliferative response in respiratory epithelial cells during SARS-CoV-2 infection."

Related Drugs and Biologics

1.	Antiviral Agents (Antivirals)
2.	Cytokines
3.	Interferons
4.	RNA (Ribonucleic Acid)
5.	Janus Kinase Inhibitors
6.	Vaccines
7.	Antibodies
8.	Chemokines
9.	Messenger RNA (mRNA)
10.	Antigens

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Immunotherapy
4.	Radiotherapy
5.	Oral Administration