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Intercalating Agents

Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.
Also Known As:
Intercalating Ligands; Intercalative Compounds; Agent, Intercalating; Agents, Intercalating; Compound, Intercalative; Compounds, Intercalative; Ligand, Intercalating; Ligands, Intercalating; Intercalating Agent; Intercalating Ligand; Intercalative Compound; Intercalator; Intercalators
Networked: 233 relevant articles (3 outcomes, 16 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Rescifina, Antonio: 4 articles (01/2018 - 01/2011)
2. Peng, Shiqi: 3 articles (01/2019 - 09/2010)
3. Wu, Jianhui: 3 articles (01/2019 - 09/2010)
4. Zhao, Ming: 3 articles (01/2019 - 09/2010)
5. Gill, Martin R: 3 articles (01/2018 - 01/2016)
6. Halder, Swagata: 3 articles (01/2018 - 01/2016)
7. Ramadan, Kristijan: 3 articles (01/2018 - 01/2016)
8. Vallis, Katherine A: 3 articles (01/2018 - 01/2016)
9. Sharma, Vikas: 2 articles (10/2022 - 01/2021)
10. Das, Tapas: 2 articles (01/2020 - 01/2020)

Related Diseases

1. Neoplasms (Cancer)
2. Hypoxia (Hypoxemia)
3. Leukemia
4. Colorectal Neoplasms (Colorectal Cancer)
5. Breast Neoplasms (Breast Cancer)
05/14/2012 - "A significantly higher antiproliferative activity towards MCF-7 breast carcinoma cells was observed for the nucleases 1 and 3, whose IC(50) values of 0.61 and 0.49 were much lower than that of 2.2 μM for bis-intercalator 5. Values of 3.8 μM, only slightly higher than that of 5, were recorded for the 5,6-dimethylphenanthroline complexes 4 and 6, whose bridging ligands are identical to those of 3 and 5, respectively. "
12/01/1992 - "Finally, the anthrapyrazoles are intercalating agents with clinical activity in breast cancer and a toxicity profile that may permit increased dose intensity using colony-stimulating factor support. "
03/01/2000 - "We synthesized three potential novel intercalators, 4,9-diazapyrenium hydrogensulfate derivatives: 5, 10-diphenyl-4,9-dimethyl-4,9-diazapyrenium hydrogensulfate (FDAP), 4, 9-dimethyl-4,9-diazapyrenium hydrogensulfate (GDAP) and 2,4,7, 9-tetramethyl-4,9-diazapyrenium hydrogensulfate (MDAP) and tested their biological effects in vitro on four human tumor cell lines (SKBr3: breast carcinoma, HeLa: cervical carcinoma, CaCo2: colon carcinoma and SW620: poorly differentiated cells from lymph node metastasis of colon carcinoma). "
06/15/1990 - "The pharmacodynamics of a new series of antitumor DNA intercalators, known as arylmethylaminopropanediols (AMAPs), has been evaluated in vitro against adherent (MCF-7 human breast cancer) and nonadherent (P388 murine leukemia) cell lines. "
12/01/1989 - "This assay was used to characterize the antitumor activity of crisnatol (BW A770U), a member of the new arylmethylaminopropanediol class of DNA intercalators, in MCF-7 human breast cancer cells. "

Related Drugs and Biologics

1. DNA (Deoxyribonucleic Acid)
2. Antimetabolites
3. amonafide
4. Proteins (Proteins, Gene)
5. Phosphotransferases (Kinase)
6. Topoisomerase Inhibitors
7. A-Form DNA (A-DNA)
8. Daunorubicin (Cerubidine)
9. Doxorubicin (Adriamycin)
10. Cytotoxins (Cytolysins)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Aftercare (After-Treatment)
4. DON protocol