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Insulysin (Insulin-Degrading Enzyme)

An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC 3.4.24.56.
Also Known As:
Insulin-Degrading Enzyme; Insulinase; Insulin Protease; Insulin Proteinase; Enzyme, Insulin-Degrading; Insulin Degrading Enzyme; Protease, Insulin; Proteinase, Insulin
Networked: 250 relevant articles (13 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Leissring, Malcolm A: 16 articles (01/2022 - 12/2003)
2. Tang, Wei-Jen: 10 articles (01/2018 - 08/2007)
3. Morelli, Laura: 8 articles (01/2009 - 06/2003)
4. Castaño, Eduardo M: 7 articles (01/2009 - 12/2004)
5. Prince, Jonathan A: 6 articles (09/2007 - 11/2003)
6. Cózar-Castellano, Irene: 5 articles (01/2022 - 11/2018)
7. Merino, Beatriz: 5 articles (01/2022 - 11/2018)
8. Perdomo, Germán: 5 articles (01/2022 - 11/2018)
9. Selkoe, Dennis J: 5 articles (01/2009 - 04/2003)
10. Brookes, Anthony J: 5 articles (07/2005 - 11/2003)

Related Diseases

1. Alzheimer Disease (Alzheimer's Disease)
2. Insulin Resistance
3. Cognitive Dysfunction
4. Amyloid Plaque
5. Hyperinsulinism (Hyperinsulinemia)

Related Drugs and Biologics

1. Insulin (Novolin)
2. Amyloid beta-Peptides
3. Peptides (Polypeptides)
4. Amyloid (Amyloid Fibrils)
5. Proteins (Proteins, Gene)
6. Glucose (Dextrose)
7. Enzymes
8. Metalloproteases (Metalloproteinases)
9. Neprilysin (Neutral Endopeptidase)
10. Amyloid Precursor Protein Secretases (beta-Secretase)

Related Therapies and Procedures

1. Therapeutics
2. Low-Level Light Therapy (LLLT)
3. Electroacupuncture