|1.||Huang, Chih-Yang: 15 articles (06/2015 - 01/2002)|
|2.||Belfiore, Antonino: 12 articles (04/2014 - 01/2002)|
|3.||Tsai, Fuu-Jen: 12 articles (01/2012 - 01/2003)|
|4.||Bach, Leon A: 11 articles (06/2015 - 01/2002)|
|5.||Vigneri, Riccardo: 11 articles (12/2013 - 01/2002)|
|6.||Schally, Andrew V: 11 articles (12/2008 - 08/2002)|
|7.||Flyvbjerg, Allan: 10 articles (11/2015 - 03/2003)|
|8.||Yu, Herbert: 10 articles (09/2013 - 08/2002)|
|9.||Gunnell, David: 10 articles (01/2013 - 03/2004)|
|10.||Xu, Haodong: 10 articles (10/2012 - 04/2007)|
02/01/2006 - "This study provides evidence that IGF-II serum levels may serve as an additional parameter for (a) improved determination of tumor staging and (b) better discrimination between BPH and PCa."
07/01/2004 - "Under transient exposure conditions, FP 6/3 was found to be effective when exposure was limited to as few as 10 min and concentrations were as low as 1 nm. These findings with FP 6/3 suggest that it potentially could lead be used as therapy against cancers in which IGF-II is an autocrine growth factor because it brings an inhibition action directly to tumor cells."
12/01/2003 - "After therapy, the IGF-II levels returned to normal in both CIN and cervical cancer patients under remission. "
01/01/2011 - "This study provides novel insight into the mechanism of receptor binding and activation by IGF-II, which may be important for the future development of inhibitors of its action for the treatment of cancer."
10/01/2008 - "Immunohistochemical study revealed positive immunostaining for IGF-II in tumor cells. "
|2.||Ovarian Neoplasms (Ovarian Cancer)
04/01/2011 - "Our previous study showed that methylated let-7a-3 was associated with low IGF-II expression and favorable prognosis of ovarian cancer. "
10/01/2007 - "This study shows that methylation varies among three IGF-II promoters in ovarian cancer and that this variation seems to have biologic implications as it relates to clinical features and prognosis of the disease."
12/01/2006 - "In a previous study, we found IGF-II transcription evaluated at a common translated region was associated with ovarian cancer progression. "
02/01/2005 - "The purpose of the current study is to further elucidate the role of the IGF-2 gene in ovarian cancer development and progression. "
01/01/2011 - "Here, the effects of promoter-specific methylation on IGF-II expression are investigated in ovarian cancer. "
|3.||Neoplasm Metastasis (Metastasis)
02/01/2003 - "Interestingly, we could identify small nests of metastases of malignant cells in the nodes (pauci-cellular metastasis) by using IGF-II as the marker. "
04/01/2002 - "IGF-II protein was not correlated with menopausal status, lymph node metastases, nuclear grade, proliferative activity, ER or p53. "
06/15/2001 - "On multivariate analysis, higher Child-Pugh scores and increased plasma IGF-2 levels (Group 3) were found to be independent risk factors for metastasis. "
06/15/2001 - "The authors also examined the association between changes in plasma IGF-2 levels after TACE and HCC progression, especially in relation to metastasis. "
01/01/1999 - "Invasive margins of liver metastases were stained highly by both IGF-2 (70%) and IGF-1R (83%). "
|4.||Hypoglycemia (Reactive Hypoglycemia)
02/01/2015 - "Western blot analysis of IGF-II in serum at the time of admission showed a high-molecular-weight form of IGF-II, which was considered to have caused hypoglycemia. "
01/01/2014 - "Accumulating literature provides a firm basis for routine IGF-2 laboratory evaluation in patients presenting with spontaneous hypoglycemia with no readily apparent cause."
03/01/2013 - "In this report, we present a case of benign phyllodes tumour with an unusual presentation of recurrent attacks of hypoglycemia, which can be attributed to secretion of insulin-like growth factor II from the tumour. "
04/01/2011 - "Hypoglycemia caused by insulin-like growth factor II is difficult to control. "
03/01/2010 - "In conclusion, immunoreactive IGF-II was detected in SFT that was not associated with hypoglycemia."
|5.||Endometrial Neoplasms (Endometrial Cancer)
05/01/2004 - "The expression of PTEN significantly inhibited the growth of Ishikawa cells, and also significantly inhibited the growth of Ishikawa cells induced by IGF-II. Adenovirus-mediated introduction of exogenous PTEN into human endometrial carcinoma cells can induce growth suppression. "
05/01/2004 - "Women in the highest quartile of IGF-2 were found to have 9.67 (95% confidence interval 3.29-28.43) times the risk of endometrial cancer than women in the lowest quartiles. "
08/01/2003 - "Alterations in Promoter Usage and Expression Levels of Insulin-like Growth Factor-II and H19 Genes in Cervical and Endometrial Cancer."
12/01/2003 - "Serum IGF-II and IGF-BP3 levels were measured, using ELISA kits (Diagnostic Systems Laboratories), in 23 controls; 16 ASC-US with normal biopsies; 14 ASC-US with advanced CIN; 2 pretherapy CIN-I; 8 successfully treated CIN-I; 24 persistent CIN I; 14 pretherapy CIN II/III; 10 posttherapy CIN II/III with normal biopsies; 18 persistent CIN-II/III; 7 with pretherapy cervical cancer; 19 with posttherapy cervical cancer under remission; 15 with posttherapy persistent/recurrent cervical cancer; 10 with persistent ovarian or endometrial cancer; and 3 with endometrial or vulvar with cervical cancer. "
09/01/2005 - "Serum IGF-II levels were normal in ASCUS with normal biopsy, successfully treated CIN-I, II/III, cervical cancer as well as pre-therapy ovarian and endometrial cancers (therapy efficacy: P < 0.0001 by chi-square analysis). "
|1.||Insulin-Like Growth Factor I (IGF-1)
|2.||Messenger RNA (mRNA)
|3.||Insulin-Like Growth Factor Binding Protein 3
|4.||Insulin-Like Growth Factor II (Somatomedin A)
|5.||Biological Markers (Surrogate Marker)
|7.||Carrier Proteins (Binding Protein)
|8.||Insulin-Like Growth Factor Binding Protein 2
|9.||Insulin-Like Growth Factor Binding Proteins
|10.||Transforming Growth Factor alpha (TGF-alpha)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)
|3.||Transplantation (Transplant Recipients)