Inositol Phosphates

06/01/1993 - "Thus, we conclude that in an established stage of hypertension there is a specific loss in the number of cardiac alpha 1-adrenoceptors with consequently reduced inositol phosphate turnover. "
12/01/1990 - "Inositol phosphate formation in arterial smooth muscle from rabbits with perinephritis hypertension."
01/01/2022 - "Among those the most significantly associated with hypertension status was the calcium signaling pathway together with other mainly related such as the phosphatidylinositol/inositol phosphate pathways. "
06/01/1993 - "To study potential cardiac alpha 1-adrenoceptor changes in the stage of established hypertension, [3H]prazosin binding characteristics and norepinephrine (NE) stimulated production of inositol phosphates in the ventricular tissue of spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto control rats (WKY) were determined. "
11/21/2019 - "Protein-protein interaction analysis further identified important hypertension related pathways such as inositol phosphate-mediated signaling and calcineurin-NFAT signaling cascade as important biological process associated with PPP3R1 which further strengthen the potential importance of this signal. "

06/07/2000 - "All these conjugates (AdoOC(O)Asp(n), n = 1-4) inhibited the 2MeSADP-stimulated synthesis of inositol phosphates in 1321N1 human astrocytoma cells stably expressing human P2Y(1) receptors. "
07/15/2004 - "PIT blocked 2-methylthio-ADP (2-MeSADP)-induced accumulation of inositol phosphates in 1321N1 astrocytoma cells stably expressing human P2Y(1) receptors in a non-competitive and concentration-dependent manner. "
02/01/2004 - "Using digital calcium imaging and an assay for [3H]-inositol phosphates, we determined whether EGCG increases intracellular [Ca2+] ([Ca2+]i) in non-excitable human astrocytoma U87 cells. "
06/01/2001 - "All three antagonists had no significant effect on the ADP-induced inositol phosphate formation in 1321N1 astrocytoma cells stably expressing the P2Y(1) receptor, when used at concentrations that inhibit platelet aggregation. "
11/01/1999 - "Characterisation of alpha1B-adrenoceptors linked to inositol phosphate formation and calcium mobilisation in human astrocytoma U373 MG cells."

03/01/2001 - "The reduced content of oligosaccharides and inositol phosphates is likely to result in reduced flatulence and improved mineral bioavailability. "

02/16/2015 - "Our results provide a link between inherited variation in the overall inositol phosphate metabolism pathway and several individual genes and cancer. "
02/16/2015 - "We examined the association between inositol phosphate metabolism pathway genes and risk of eight types of cancer using data from genome-wide association studies. "
02/16/2015 - "Whether germline genetic variants in inositol phosphate metabolism pathway are associated with cancer risk remains to be clarified. "
02/16/2015 - "Members of the inositol phosphate metabolism pathway regulate cell proliferation, migration and phosphatidylinositol-3-kinase (PI3K)/Akt signaling, and are frequently dysregulated in cancer. "
02/16/2015 - "Genetic variants in the inositol phosphate metabolism pathway and risk of different types of cancer."

01/03/2011 - "In view of the central role played by hypoxia in numerous types of diseases, the exploration of myo-inositol phosphate derivatives represents an important avenue in the search for substances which act on the oxygenation status of tissues and may have significant potential in the discovery and development of novel drug candidates."
12/01/2010 - "Acute hypoxia augmented inositol phosphate release by 50% and 40% in SMC-PA and SMC-PV, respectively. "
09/01/1992 - "[Role of the inositol phosphate cycle in the cardioprotective effect of adaptation to intermittent hypoxia]."
03/01/1989 - "Under basal conditions, hypoxia did not alter the accumulation of [2-3H]inositol phosphates. "
01/01/1989 - "Effects of in vitro hypoxia on depolarization-stimulated accumulation of inositol phosphates in synaptosomes."