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Inosine Diphosphate (IDP)

An inosine nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
Also Known As:
IDP; Inosine Pyrophosphate; Riboxin; Riboxine; Diphosphate, Inosine; Pyrophosphate, Inosine; Inosine 5'-(trihydrogen diphosphate)
Networked: 380 relevant articles (12 outcomes, 47 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Rizzuti, Bruno: 10 articles (10/2021 - 01/2016)
2. Neira, José L: 9 articles (10/2021 - 01/2016)
3. Iovanna, Juan L: 8 articles (10/2021 - 01/2016)
4. Santofimia-Castaño, Patricia: 6 articles (10/2021 - 08/2017)
5. Abián, Olga: 5 articles (10/2021 - 01/2017)
6. Velázquez-Campoy, Adrián: 5 articles (10/2021 - 01/2017)
7. Zweckstetter, Markus: 4 articles (01/2022 - 06/2010)
8. Cui, Liwang: 4 articles (07/2018 - 07/2015)
9. Yang, Zhaoqing: 4 articles (07/2018 - 07/2015)
10. Uversky, Vladimir N: 4 articles (01/2016 - 01/2009)

Related Diseases

1. Infections
2. Pain (Aches)
3. Weight Loss (Weight Reduction)
4. Acne Vulgaris
10/01/2023 - "This post hoc exploratory analysis of pooled phase 3 data assessed the impact of investigational IDP-126 gel (for moderate to severe acne) on the Acne-Specific Quality of Life Questionnaire (Acne-QoL; exploratory endpoint in the trials).  Methods: A post hoc exploratory analysis using pooled data (N=309; age ≥13 years) was conducted to assess if 1) changes from baseline to week 12 in Acne-QoL domain scores significantly differ by treatment; 2) differences were clinically meaningful, and 3) relative importance of acne severity as measured by the Evaluator's Global Severity Score (EGSS) or lesion counts explains the changes in QoL (Acne-QoL).  Results: Acne-QoL domain scores significantly (P<0.001, each) improved for patients treated with IDP-126 Gel vs vehicle in all four domains (role-emotional [least squares mean difference {LSMean} 4.1], self-perception [LSMean 3.8], acne symptoms [LSMean 2.6], and role-social [LSMean 2.0]). "
10/01/2023 - "Across all Acne QoL domains, the improvement on the EGSS endpoint (53.8-63.3%) was more likely to influence QoL improvements than the inflammatory (20.1-33.4%) and non-inflammatory lesion (9.5-18.7%) counts.  Conclusions: This post hoc exploratory analysis of pooled phase 3 data (moderate to severe acne) suggests that treatment with IDP 126 Gel led to statistically significant and clinically meaningful improvements in QoL and improvement in QoL was primarily influenced by EGSS.J Drugs Dermatol. "
10/01/2023 - "The proportion of responders was significantly higher (P<0.05, each) in the IDP-126 Gel group vs vehicle across Acne-QoL domains, self-perception (odds ratio [OR]: 4.32), acne symptoms (OR: 3.90), role-social (OR: 3.59), and role-emotional (OR: 2.50). "
5. Myocardial Infarction

Related Drugs and Biologics

1. Anti-Bacterial Agents (Antibiotics)
2. Antibodies
3. Antigens
4. Dexamethasone (Maxidex)
5. quinazopyrine
6. Synucleins
7. Acetylcholine (Acetylcholine Chloride)
8. Hemoglobins (Hemoglobin)
9. Gonadotropins
10. Cytidine Triphosphate (CTP)

Related Therapies and Procedures

1. Length of Stay
2. Therapeutics
3. Drug Therapy (Chemotherapy)
4. Catheter Ablation
5. Sutures (Suture)