|5.||Chromosome Aberrations (Chromosome Abnormalities)
|1.||Agarwal, Ashok: 35 articles (12/2015 - 11/2002)|
|2.||Wang, Xinru: 16 articles (08/2014 - 09/2008)|
|3.||Xia, Yankai: 16 articles (08/2014 - 09/2008)|
|4.||Lu, Chuncheng: 11 articles (08/2014 - 09/2008)|
|5.||Foresta, Carlo: 10 articles (01/2015 - 06/2002)|
|6.||Niederberger, Craig: 10 articles (07/2014 - 01/2005)|
|7.||Garolla, Andrea: 9 articles (01/2015 - 06/2002)|
|8.||Safarinejad, Mohammad Reza: 9 articles (12/2013 - 08/2010)|
|9.||Aitken, R John: 8 articles (04/2015 - 01/2003)|
|10.||Zhou, Zuomin: 8 articles (08/2014 - 12/2008)|
|1.||Clomiphene (Clomifene)FDA LinkGeneric
07/01/2013 - "Based on the reviewed studies there is insufficient evidence to indicate that clomiphene is effective for the treatment of male infertility."
08/01/1992 - "This study provides no evidence for the efficacy of clomiphene citrate for the treatment of idiopathic male infertility."
05/01/1988 - "A controlled comparison of the efficacy of clomiphene citrate in male infertility."
07/01/2013 - "A literature search of MEDLINE (1966-June 2012) and EMBASE (1980-June 2012) was conducted using the medical terms clomiphene and male infertility and 9 clinical studies were identified. "
08/01/1992 - "A double-blind trial of clomiphene citrate for the treatment of idiopathic male infertility. "
|2.||Carnitine (L-Carnitine)FDA LinkGeneric
04/01/2009 - "L-carnitine administration ameliorates these effects by antioxidant and/or anti-inflammatory mechanisms suggesting a protective role against male infertility in severely infected or septic patients."
08/01/2014 - "l-carnitine has been found to improve the quality of spermatozoa in selected cases with male infertility. "
09/01/2015 - "This study aims to explore the effect and mechanism of L-carnitine in male infertility induced by CP. "
06/01/2007 - "The determination of free L-carnitine level in seminal plasma is a useful test in the evaluation of epididymal function, which may serve as a guidance for the clinical treatment of male infertility as well as for the study on the mechanisms of male reproduction."
02/01/2007 - "The level of free L-carnitine in seminal plasma, significantly correlated with sperm concentration, motility and vitality, can be taken as a biochemical index used as a guidance for the clinical treatment of male infertility as well as for the study on the mechanisms of male reproduction."
|3.||Biological Markers (Surrogate Marker)IBA
06/01/2014 - "Multiple testicular biopsies fail to find mature sperm in at least 50 % of cases Therefore; hunting for sensitive and specific biomarkers of spermatogenesis that could better determine the fertility status in NOA can lead to improved management of male infertility. "
05/01/2013 - "As such, proteomic studies will help the development of new techniques to identify novel biomarkers for a better clinical diagnosis and treatment of male infertility."
01/01/2013 - "We detected the testis and epididymis-specific methylated promoters in human cfsDNA, which may be used for noninvasive epigenetic biomarkers for the study and diagnosis of male infertility."
01/01/2011 - "Large-scale proteomic studies using purified protein assays will eventually lead to the development of novel biomarkers that may allow for detection of disease states, genetic abnormalities, and risk factors for male infertility. "
01/15/2016 - "1,5-Anhydro-sorbitol and α-hydroxyisovaleric acid were identified as the potential biomarkers for distinguishing HC from the male infertility patients. "
11/01/2011 - "Gonadotropins administration have been demonstrated effective for the treatment of idiopathic male infertility, even if no clear data regarding their specific mechanism of action on semen quality are at the moment available. "
01/01/2009 - "Data from the literature suggest that gonadotropin treatment of male infertility can lead to a significant increase in pregnancy rates, however larger studies are needed to confirm such findings. "
10/01/2004 - "According to the review of previous prospective randomized studies and meta-analyses, it seems that: (i) when a cervical factor is involved, the advantage of COH in conjunction with i.u.i. is likely but has to be confirmed; (ii) in male infertility, COH with gonadotropins in conjunction with i.u.i. increases the clinical pregnancy rate by two. "
12/01/2011 - "Accordingly, the phenotypes diverge from mild anomalies and enhanced fertility to disrupted gametogenesis, but eventually chronic, enhanced and non-pulsatile action of both FSH and LH leads to female and male infertility and/or hyper- and neoplasias in most of the gonadotropin gain-of-function mice. "
09/01/2010 - "Four hundred and fifty patients with unexplained infertility, male factor, and ovulatory dysfunction underwent controlled ovarian hyperstimulation with gonadotropin. "
07/01/2012 - "This validation study was conducted to calculate the sensitivity, specificity, positive and negative predictive value of serum inhibin B in diagnosis of male infertility, using semen analysis as the gold standard. "
11/01/2008 - "In adult men, inhibin B evaluation is helpful in the investigation of male infertility, especially in the judgment of the prognosis of testicular biopsy in in-vitro fertilization programs. "
11/01/1997 - "We conclude that inhibin B may be a marker of exocrine testicular function and could offer improved diagnosis and treatment modalities for male infertility."
03/01/2013 - "Inhibin B and especially the IFR are more sensitive markers of male infertility than FSH alone."
03/01/2013 - "We performed a retrospective analysis of data from 2448 men who attended our University-based male infertility clinic to evaluate inhibin B in relation to age and semen sample qualities in comparison with FSH. "
|6.||Testosterone (Sustanon)FDA Link
05/01/2014 - "Because previous studies are limited to only few sperm parameters or testosterone concentration, this study investigated the in vivo effects of TA on body and organ weight as well as functional sperm parameters in terms of safety and efficacy in the management of male infertility. "
05/01/2015 - "To determine (1) the frequency of testosterone (T) use in 2 academic male infertility practices, (2) the effect on semen parameters, and (3) the potential for reversibility. "
05/01/2015 - "Medical testosterone: an iatrogenic cause of male infertility and a growing problem."
07/01/2014 - "Re: the polymorphism (-600 C>A) of CpG methylation site at the promoter region of CYP17A1 and its association of male infertility and testosterone levels."
07/01/2014 - "Conditional NR2F2 knockout prior to puberty leads to male infertility due to insufficient testosterone production, suggesting that NR2F2 could positively regulate steroidogenesis and Star expression. "
01/01/1992 - "Zinc supplementation has already proven beneficial in male sterility and in reducing complications during pregnancy. "
01/01/2012 - "This study showed a correlation between smoking and possible male infertility and subfertility, and also that the majority of smoking-induced changes in spermatozoa were prevented by zinc treatment. "
01/01/1988 - "[Experimental studies of male infertility and zinc]."
07/01/1982 - "Zinc concentration in seminal plasma is one of the best biochemical parameters with which to assess prostatic function in the study of male infertility. "
01/01/2012 - "Thus, zinc supplementation may be a promising addition to conventional treatments for male infertility related to smoking."
06/01/2004 - "Numerous studies have evaluated the efficacy of antioxidants in male infertility. "
05/01/2008 - "Until those studies are performed, the use of antioxidants for the treatment of male infertility remains empiric."
02/01/2008 - "Trials of antioxidants for male infertility."
06/01/2004 - "It was found that although many clinical trials have demonstrated the beneficial effects of antioxidants in selected cases of male infertility, some studies failed to demonstrate the same benefit. "
07/01/2014 - "The current literature seems to suggest a beneficial effect of antioxidants on male infertility. "
|9.||Vitamin EFDA LinkGeneric
04/01/2002 - "The controversial efficacy of vitamin E for human male infertility."
04/01/1963 - "Vitamin E in human male sterility."
01/01/1947 - "[Vitamin E in the treatment of male sterility]."
10/01/1995 - "A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility."
03/01/2003 - "The results confirm the protective and beneficial effects of vitamin E and selenium on semen quality and advocate their use in male infertility treatment."
01/01/2008 - "As a first step, hybrids based on genetic male sterility (GMS) were developed in pigeonpea, but the hybrid seed production technique is not farmer-friendly, because in the hybrid seed production plot 50% of the population, which are male-fertile in the female rows, have to be eliminated in time before contamination. "
11/01/2009 - "Although additional studies with larger numbers of samples will be required to validate these results and to identify causal variants, this study represents an important first step in applying genome-wide approaches to identify the genetic causes of male infertility."
06/01/2000 - "Male sterility in hermaphroditic species may represent the first step in the evolution toward dioecy. "
04/01/1992 - "As a first step towards molecular isolation of a 'speciation gene', I mapped and partly characterized a gene causing hybrid male sterility in Drosophila. "
06/01/2015 - "Knowledge of the proteins that make up the sperm cell represents the first step towards understanding its normal function and the molecular anomalies associated with male infertility. "
|1.||Drug Therapy (Chemotherapy)
04/01/2015 - "HN is an important molecule in the regulation of germ cell homeostasis after injury and agonistic analogues may be developed for treating male infertility or protection against chemotherapy side effects. "
10/01/2008 - "The basic understanding of male infertility, the characteristics of its drug therapy, clinically used common drugs, the therapeutic efficacy and effect evaluation are reviewed in this article."
12/01/2008 - "Most of the currently used drug therapies are empirical at best; moreover, many of the studies on drug treatment for male infertility do not fulfill the required standards of evidence-based medicine (randomized, prospective, placebo-controlled), and the statistical endpoints used (sperm quality, pregnancy rate, baby take-home rate) are not uniform. "
11/02/2012 - "Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout a man's life and may have application for treating some cases of male infertility, including those caused by chemotherapy before puberty. "
07/01/2012 - "Chemotherapy is often associated with male infertility. "
|2.||Vasectomy (Vas Occlusion)
08/01/2015 - "Our primary outcome was the correlation of these demographic and socio-economic factors with evaluation for male infertility or vasectomy. "
03/01/2010 - "Genetic vasectomy-overexpression of Prm1-EGFP fusion protein in elongating spermatids causes dominant male sterility in mice."
02/01/1981 - "Reversal of vasectomy and the treatment of male infertility. "
08/22/1978 - " Vas ligation, vasotomy, and vasectomy are three operations to induce male sterility. "
01/01/2013 - "The reliable diagnosis of the absence of spermatozoa in a semen sample is an important criterion not only for diagnosing male infertility but also for ascertaining the success of a vasectomy and for determining the efficacy of hormonal contraception. "
|3.||Contraception (Birth Control)
02/01/2010 - "The present study may shed light on some unexplained male infertility, and on a possible new method for diagnosis of male infertility and strategy for male contraception. "
04/27/2004 - "This study (i) demonstrates that GRTH is essential for completion of spermatogenesis, (ii) provides insights into intrinsic requirements for spermiogenesis, and (iii) establishes a model for studies of male infertility and contraception."
05/01/2014 - "Since Sertoli cells are the key supportive cells for SSCs and they are very receptive to modification, a better understanding of the roles and regulation of Sertoli cells in SSC biology and spermatogenesis would make it feasible to identify novel targets for gene therapy of male infertility as well as seek more efficient and safer strategies for male contraception. "
03/01/2014 - "In view of the involvement in P-induced AR and of the evidence of a role in the pathogenesis of astenozoospermia, CatSper channels may represent a promising target for the development of new drugs for the treatment of male infertility and for non-hormonal contraception. "
09/01/2013 - "Overall, a new insight into the molecular mechanisms driving epididymal sperm maturation was obtained, which could be relevant to development of better approaches in male infertility treatment and contraception. "
|4.||Transplantation (Transplant Recipients)
08/01/2005 - "Germ cell transplantation helped to elucidate the biology of male germ line stem cells and their niche in the testis, develop systems to isolate and culture spermatogonial stem cells, examine defects in spermatogenesis, correct male infertility, and introduce genetic changes into the male germ line. "
09/01/2014 - "224 Chinese Han women with PCOS and 223 in vitro fertilization and embryo transplantation (IVF-ET) infertile women with tubal factor or male infertility served as the controls were recruited in our study. "
01/01/2007 - "Germ cell transplantation provides a system to study the biology of germ line stem cells, to explore stem cell isolation and culture, to examine defects in spermatogenesis and to overcome male infertility. "
03/01/2006 - "Germ cell transplantation provides a bioassay to study the biology of these stem cells, to develop systems for spermatogonial stem cell isolation and culture, to examine defects in spermatogenesis and to correct male infertility. "
10/01/2005 - "Germ cell transplantation provides a bioassay to study the biology of male germ line stem cells, develop systems to isolate and culture spermatogonial stem cells, examine defects in spermatogenesis and treat male infertility. "
01/01/2001 - "Moreover the Authors confirm the importance of spermatic veins ligature following the Ivanissevich method in the treatment of male infertility."
02/01/1990 - "Spermatic vein ligation as treatment for male infertility. "
01/01/1984 - "Ligation of the left spermatic vein in the treatment of male infertility."
11/01/1994 - "Percutaneous embolization and surgical ligation of varicocele are equally effective in improving male infertility and cost about the same. "
12/01/2015 - "To assess duplex ultrasound (DUS) parameters, and predicti the outcome of varicocele ligation in male infertility. This retrospective and follow up study was conducted at Dr. Sulaiman Al Habib Hospital, AlQassim, Saudi Arabia between January 2011 and December 2012. "