Infertility (Sterility)

12/27/2013 - "Clomiphene citrate (CC) is most commonly used as a first-line treatment of infertility. "
01/01/2000 - "These data suggest statistically and clinically significant improvement in pregnancy rate following clomiphene citrate in women with unexplained infertility. "
04/01/2004 - "Clomiphene citrate combined with IUI is more effective than timed intercourse in the natural cycle at achieving pregnancy in couples with ovulatory infertility. "
04/01/2008 - "The combined treatment of clomiphene citrate, pertubation and insemination can be used as a cost-effective, first-line treatment for couples with unexplained infertility."
08/01/1998 - "Clomiphene citrate + IUI is a cost-effective treatment for unexplained infertility. "

05/01/2017 - "The aim of this study was to evaluate the safety and efficacy of IVF-M HP, a newly developed highly purified human menopausal gonadotrophin preparation, for ovarian stimulation in women with infertility undergoing IVF, intracytoplasmic sperm injection (IVF-ICSI) and embryo transfer using a GnRH antagonist protocol. "
01/01/2023 - "In mammals, including humans, GnRH-producing neurons originate in the embryonic nasal compartment and during early embryogenesis they undergo rapid migration towards the hypothalamus; the increasing knowledge of such mechanisms improved diagnostic and therapeutic approaches to infertility. "
09/15/1975 - "It is expected that this synthetic LH-RH analogue might yield more positive results than with LH-RH when used in infertility problems."
02/01/1978 - " Because of the greater potency of this LH-RH analog, it may be useful in the treatment of infertility."
04/01/1975 - "FSH/LH-RH may prove to be useful in the treatment of some cases of anovulatory sterility of hypothalamic origin."

04/01/2009 - "Is metformin beneficial for the treatment of infertility in women with PCOS?"
11/01/2023 - "The efficacy of M. oleifera was compared with metformin (standard medicine used to treat infertility in women). "
02/01/2010 - "3. Metformin should not be used as a first-line treatment in order to treat infertility. "
12/01/2017 - "The aim of this study was to assess the effect of metformin on AMH level in PCOS patients suffering from infertility. "
08/01/2023 - "The aim of this review was to clarify PCOS, its prevalence, particularly in Saudi Arabia, its pathogenesis, its impact on the patient's health, and to explain the uses of metformin, its mechanism of action, and its role in the treatment of PCOS-related infertility."

11/26/2018 - "Thus, modification of lifestyle through a structured program of educational, environmental, nutritional/physical exercise and psychological support, combined with the use of nutraceutical antioxidants can prevent infertility and therefore, may help couples to obtain better quality of life and improved possibility to conceive spontaneously or optimize their chances of conception."
01/01/2021 - "Natural antioxidant compounds found in fruits, vegetables, and other dietary sources, alone or in combination with other antioxidants, were found to be effective in ameliorating the oxidative stress-mediated infertility problems in both natural and assisted reproductive settings. "
06/29/2012 - "Antioxidant supplementation may be effective in controlling the production of ROS and continues to be explored as a potential strategy to overcome reproductive disorders associated with infertility. "
01/01/2023 - "The Males, Antioxidants, and Infertility (MOXI) trial is of particular interest, being a large multicenter RCT, which demonstrated no improvement in semen parameters or live-birth rates with antioxidant use. "
09/01/2017 - "Our data showed that the omega-3 (especially at 600 mg kg-1 dose level) effectively ameliorates the experimental diabetes-induced infertility in rats by up-regulating the testicular endocrine and antioxidant statuses, preventing mitochondria-dependent apoptosis pathway and potentially improving the sperm quality."

11/05/2019 - "In women with PCOS, letrozole improves live birth and clinical pregnancy rates and reduces time-to-pregnancy compared to CC and therefore can be recommended as the preferred first-line treatment for women with PCOS and infertility. "
01/01/2022 - "We included randomized controlled trials (RCTs) comparing IUI-OS with gonadotrophins, letrozole and CC among couples with unexplained infertility. "
07/01/2021 - "To study the feasibility of a randomized controlled trial (RCT) comparing intrauterine insemination (IUI) with and without letrozole in couples with unexplained or mild male factor infertility STUDY DESIGN: We performed a randomized pilot study including 100 couples with unexplained or mild male factor infertility in the Reproductive Medicine Centre of Peking University Third Hospital in China. "
01/01/2020 - "We included randomized controlled trials that compared a stimulation regimen with CC, Letrozole or gonadotrophins to each other or to natural cycle IUI among couples with unexplained infertility. "
12/01/2018 - "The results of this study demonstrate the stability of letrozole compared to that of CC for infertility treatment in pregnant women."

11/01/1984 - "A study of the excretion of hCG from three men injected with hormone for treatment of infertility indicated that after the first 24 h, hCG was cleared with a single exponential rate and was detectable to a level of 0.01 ng/ml. Application of the IRMA to measurements of hCG in the urine of two artificially inseminated patients indicated that the method was capable of detecting pregnancy as early as 9 days postovulation. "
05/01/2015 - "Improvements demonstrated in the condition(s) causing infertility were measured by improvements in tubal patency and/or improved hormone levels or by pregnancy. "
02/17/2015 - "Outcome Measures • Improvements demonstrated in the condition(s) causing infertility were measured by improvements in tubal patency and/or improved hormone levels or by pregnancy. "
08/01/2000 - "[The efficacy of the complex medication Phyto-Hypophyson L in female, hormone-related sterility. "
01/01/1998 - "To examine the efficacy of IUI on fecundity and baby-take-home rates in cases of infertility attributable to a male factor with and without a woman's hormone factor. "

04/01/1987 - "Whereas constant administration of LHRHA by a slow release system seems very useful for long-term reversible suppression of follicular maturation, further studies should evaluate the clinical usefulness of combined LHRHA/gonadotropin treatment in cases of infertility."
10/01/2021 - "This study examined 197 gonadotropin-stimulated IUI cycles of 148 women diagnosed with unexplained infertility from February 2019 to November 2020. "
04/01/2019 - "The aim of this study is to investigate the clinical value of AMH in predicting pregnancy in younger and older women with unexplained infertility undergoing gonadotropin stimulation and IUI. "
10/01/2017 - "This study aims to introduce a new tool (the Follicular Sensitivity Index; FSI) for objective assessment of follicular responsiveness to exogenous gonadotropins and to evaluate its ability to predict the clinical pregnancy rate in women with unexplained infertility or tubal factor undergoing IVF/ICSI. "
01/01/2014 - "Study population consisted of 387 gonadotropin stimulated IUI cycles performed for unexplained infertility. "

01/01/1995 - "Since there is no gold standard for the diagnosis of immunological infertility, comparison between different methods and of their results with biological tests for the detection of antisperm antibodies must be used in defining the most reliable and clinically relevant method. "
12/01/1985 - "Nearly all of the female sera were free of anti-sperm antibodies and positive results did not appear in greater frequency in women with unexplained infertility as compared with other categories. "
12/01/1995 - "Even though the antifertility efficacy of anti-ZP antibodies in humans is not corroborated by a clear relationship between spontaneous autoimmunization against the ZP and infertility, passive and active immunization studies in laboratory animals have provided convincing results. "
01/01/1994 - "It is concluded that the determination of these antibodies does not contribute to an improved diagnostic of infertility."
09/25/1980 - "The use of a specific radiolabeled antiglobulin test to detect antisperm antibodies has given positive results in 7% of infertile men and 13% of infertile women, and may be a reliable means of identifying and possibly treating patients whose infertility is caused by immune mechanisms. "

02/01/2015 - "There is an increasing body of literature on risk factors, diagnosis, and specific intraoperative interventions, including attention to sterility of instrumentation, application of minimally invasive fusion techniques, intraoperative irrigation, and application of topical antibiotics, that hold the most promise for reduction of SSI. "
07/01/1977 - " While antibiotics have helped to alter the prognosis for infertility significantly, more must be done. "
01/01/1993 - "Therefore, if these organisms play a role in infertility, they are present and eradicated prior to infertility work-up and thus do not supports the use of a routine trial of antibiotics prior to laparoscopy."
08/01/2009 - "Attenuation could be eliminated by exposing larvae to antibiotics only during the first instar without altering larval sterility. "
01/01/2023 - "However, biomonitoring studies on low-dose antibiotic exposure, mainly from food and water, and its relation to the risk of infertility are missing. "

08/01/2012 - "The findings obtained in the present study could be helpful for predicting male factor infertility in patients with a borderline high FSH level (≈4.5 IU/L) and a low testosterone level compared to someone with a borderline high FSH level and a normal testosterone level. "
12/01/2017 - "In conclusion, varicocelectomy significantly improved testosterone in hypogonadal men with subfertility. "
12/01/2012 - "Additional studies are required to establish the frequency of subfertility in male MWS patients, to understand when subfertility occurs in the disease natural history, and, finally, to investigate whether early management with IL-1-targeting drugs, or testosterone treatment or early sperm cryo-conservation may help to allow procreation."
04/18/2022 - "Recent studies reported young men with infertility may have reduced testosterone level. "
01/01/2017 - "The aim of this study was to evaluate the scope of testosterone use in the treatment of male factor infertility by medical practitioners in Lagos, Nigeria. "

01/01/2015 - "Because the generalist will not be tempted to suggest therapies, e.g., IVF-ET because this effective therapy is the best option for the financial success of the REI, but at the expense of financial depletion of the patient, there is plenty of room for generalists taking over as the first line physicians for infertility rather than just a referral service. "
01/01/1983 - "Among these factors, which caused sterility directly or indirectly, there were some, which could be eliminated by psychotherapy, and there were some, which had already caused an irreversible change in the personality,--Beside the success of therapy the effectiveness of the gynecologist-psychologist team-work is remarkable."
11/01/2020 - "An important aspect in the development of extracellular vesicle (EV) therapeutics is identifying and quantifying the key features defining their identity, purity, sterility, potency and stability to ensure batch-to-batch reproducibility of their therapeutic efficacy. "
02/01/2008 - "No medical therapy has proven effective for infertility. "
12/01/1992 - "Using hysteroscopy, which is possible thanks to development of medical technology, seems to be an important improvement in diagnostics and therapy of sterility. "

01/01/2019 - "Although the efficacy of postchemotherapy testicular sperm extraction (TESE)/intracytoplasmic sperm injection (ICSI) was reported recently, it is quite important to inform patients of the potential risk of treatment-induced infertility and the possibility of fertility preservation by sperm cryopreservation before chemotherapy."
01/01/2019 - "Due to low income levels and the high cost of other assisted reproductive techniques, pharmacotherapy remain the major first line treatment option for infertility in Sub-Saharan Africa. "
12/01/2016 - "Therefore, protection against iatrogenic infertility and loss of endocrine ovarian function caused by chemotherapy is currently of high priority. "
01/01/2016 - "Thus, the protection against iatrogenic infertility caused by chemotherapy assumes a high priority. "
08/01/2007 - "Chemotherapy, radiation, or their combination results in a significant reduction of sperm quality and as a consequence an indefinite time of infertility follows. "

01/01/2023 - "There was no significant difference in the basic characteristics, including age, BMI, AMH, AFC, infertility years, infertility types, number of previous transplant cycles, endometrial thickness on transplantation day and number of transplanted embryos (p > 0.05); The positive rate of hCG, clinical pregnancy rate and implantation rate in CE (-) group were significantly increased compared with the weak CE (+) group and non-CE group (p < .01), and the live birth rate also improved (p < .05). "
09/06/2022 - "Uterine transplantation is becoming an increasingly realistic therapeutic for uterine infertility. "
12/01/2020 - "Uterine transplantation (UTx) is the only effective treatment for uterine infertility patients to become genetic mothers. "
12/27/2022 - "Uterus transplantation (UTx) is a promising treatment option for women who wish to give birth but suffer from absolute uterine factor infertility. "
01/01/2021 - "Uterus transplantation is a promising treatment method for women with absolute uterine factor infertility. "

12/01/2021 - "These findings are of interest when considering FertiSTAT as a starting point to discuss contraception and risk factors for infertility at an age at which risk mitigation would prove most effective in preserving future fertility."
08/13/2013 - "Correct resolution of the molecular events governing female and male meiosis is important for treating infertility and devising improved birth control strategies. "
11/01/2013 - "Embryo attachment and implantation is critical to successful reproduction of all eutherian mammals, including humans; a better understanding of these processes could lead to improved infertility treatments and novel contraceptive methods. "
12/01/1990 - "The fecundity of the latter group was significantly greater than that of women with 1 to 4 years' subfertility, being similar to "normal" subjects who had stopped contraception. "
11/01/1979 - " In any event, the cure for secondary sterility after contraception does not present any relevant problems, while the cure for primary sterility is not always successful."

01/01/2003 - "Most recent studies indicate significant improvement of reproduction outcomes after myomectomy, especially in young women with the absence of other factors of infertility. "
10/01/2022 - "Prepregnancy myomectomy is effective for the treatment of infertility or prevention of obstetric complications and is usually performed with laparoscopy. "
08/01/1996 - "Laparoscopic myomectomy was effective for selected patients experiencing infertility."
03/01/2008 - "While hysteroscopic myomectomy has been shown to be safe and effective in the control of menstrual disorders, its effects on infertility remain unclear. "
01/01/2016 - "Myomectomy improved the reproductive outcome in patients who did not conceive with conservative infertility treatments. "