|2.||Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
|1.||Agarwal, Ashok: 35 articles (09/2015 - 08/2002)|
|2.||Hauser, Russ: 19 articles (01/2016 - 03/2004)|
|3.||Brännström, Mats: 18 articles (12/2015 - 10/2003)|
|4.||Diamond, Michael P: 17 articles (09/2015 - 08/2003)|
|5.||Meeker, John D: 15 articles (02/2013 - 05/2007)|
|6.||Legro, Richard S: 14 articles (12/2015 - 02/2007)|
|7.||Casper, Robert F: 14 articles (10/2015 - 06/2002)|
|8.||Skrzypczak, Jana: 13 articles (11/2015 - 06/2003)|
|9.||Fauser, Bart C J M: 13 articles (02/2015 - 01/2002)|
|10.||Bianco, Bianca: 13 articles (01/2015 - 01/2010)|
|1.||Clomiphene (Clomifene)FDA LinkGeneric
01/01/2013 - "Clomiphene citrate (CC) is most commonly used as a first-line treatment of infertility. "
01/01/2000 - "These data suggest statistically and clinically significant improvement in pregnancy rate following clomiphene citrate in women with unexplained infertility. "
04/01/2004 - "Clomiphene citrate combined with IUI is more effective than timed intercourse in the natural cycle at achieving pregnancy in couples with ovulatory infertility. "
04/01/2008 - "The combined treatment of clomiphene citrate, pertubation and insemination can be used as a cost-effective, first-line treatment for couples with unexplained infertility."
08/01/1998 - "Clomiphene citrate + IUI is a cost-effective treatment for unexplained infertility. "
|2.||Gonadotropin-Releasing Hormone (GnRH)FDA Link
06/01/1997 - "Considering the high rate of spontaneous conceptions and the low abortion and complication rates during pregnancy, the combined therapy of GnRH agonists followed by myomectomy represents a major step forwards in the effective treatment of sterility in patients with uterine leiomyomata."
11/01/2000 - "The results of this study demonstrate that GnRH vaccine is effective in inducing a reversible infertility in white-tailed deer, the infertility lasting up to two years without boosting."
02/01/1978 - " Because of the greater potency of this LH-RH analog, it may be useful in the treatment of infertility."
01/01/1988 - "Gonadotropin-releasing hormone therapy has undergone sufficient basic and clinical investigation as a tool for ovulation induction that it should now be considered a safe and effective infertility therapy for office practice. "
05/01/1991 - "In our patients with recalcitrant infertility, the addition of a gonadotropin-releasing hormone agonist to hMG/IUI improved the pregnancy rate, without increasing the rate of multiple births or fetal wastage."
|3.||Metformin (Glucophage)FDA LinkGeneric
07/01/2010 - "Starting from that moment, increasing numbers of studies were performed to demonstrate the efficacy of metformin in controlling and/or modulating several aspects of PCOS, which is the most common cause of menstrual irregularity, inesthetisms and infertility. "
04/01/2009 - "Is metformin beneficial for the treatment of infertility in women with PCOS?"
02/01/2010 - "3. Metformin should not be used as a first-line treatment in order to treat infertility. "
02/01/2014 - "While new clinical applications have been ascribed to metformin, including treatment of anovulatory infertility, its effects on male reproduction have not been investigated. "
01/01/2013 - "Our Objective was to observe the role of Glucophage in treating infertility of polycystic patients within three months in Group A and six months in Group B patients. "
01/01/1995 - "Since there is no gold standard for the diagnosis of immunological infertility, comparison between different methods and of their results with biological tests for the detection of antisperm antibodies must be used in defining the most reliable and clinically relevant method. "
12/01/1985 - "Nearly all of the female sera were free of anti-sperm antibodies and positive results did not appear in greater frequency in women with unexplained infertility as compared with other categories. "
12/01/1995 - "Even though the antifertility efficacy of anti-ZP antibodies in humans is not corroborated by a clear relationship between spontaneous autoimmunization against the ZP and infertility, passive and active immunization studies in laboratory animals have provided convincing results. "
01/01/1994 - "It is concluded that the determination of these antibodies does not contribute to an improved diagnostic of infertility."
09/25/1980 - "The use of a specific radiolabeled antiglobulin test to detect antisperm antibodies has given positive results in 7% of infertile men and 13% of infertile women, and may be a reliable means of identifying and possibly treating patients whose infertility is caused by immune mechanisms. "
04/01/1987 - "Whereas constant administration of LHRHA by a slow release system seems very useful for long-term reversible suppression of follicular maturation, further studies should evaluate the clinical usefulness of combined LHRHA/gonadotropin treatment in cases of infertility."
11/01/1993 - "To study in a randomized and longitudinal manner the efficacy of human menopausal gonadotropin (hMG) superovulation combined with intrauterine insemination (IUI) versus IUI alone in the treatment of various causes of infertility in the presence of normal ovulation. "
01/01/2014 - "Study population consisted of 387 gonadotropin stimulated IUI cycles performed for unexplained infertility. "
10/01/2003 - "Recent studies suggest that the use of gonadotropins to induce follicular development and ovulation can decrease the severity of seasonal postpartum infertility in dairy cows."
06/01/2000 - "Study patients (n = 25) undergoing controlled ovarian hyperstimulation with intrauterine insemination infertility treatment between June 1998 and March 1999 self-administered human menopausal gonadotropin subcutaneously for ovulation induction. "
11/01/1984 - "A study of the excretion of hCG from three men injected with hormone for treatment of infertility indicated that after the first 24 h, hCG was cleared with a single exponential rate and was detectable to a level of 0.01 ng/ml. Application of the IRMA to measurements of hCG in the urine of two artificially inseminated patients indicated that the method was capable of detecting pregnancy as early as 9 days postovulation. "
05/01/2015 - "Improvements demonstrated in the condition(s) causing infertility were measured by improvements in tubal patency and/or improved hormone levels or by pregnancy. "
08/01/2000 - "[The efficacy of the complex medication Phyto-Hypophyson L in female, hormone-related sterility. "
01/01/1998 - "To examine the efficacy of IUI on fecundity and baby-take-home rates in cases of infertility attributable to a male factor with and without a woman's hormone factor. "
03/01/2014 - "Relationship between dyslipidaemia and semen quality and serum sex hormone levels: an infertility study of 167 Japanese patients."
|7.||letrozole (Femara)FDA LinkGeneric
01/01/2015 - "Fewer live births occur with letrozole than standard therapy for unexplained infertility, study shows."
09/01/2013 - "To evaluate the effectiveness of letrozole + FSH combination versus only FSH for contolled ovarian stimulation in unexplained infertility patients undergoing intra-uterine insemination, a prospective randomised trial was undertaken among 55 patients with unexplained infertility completed all together 118 treatment cycles of controlled ovarian stimulation and intra-uterine insemination. "
12/01/2011 - "The safety of letrozole in pregnancy outcome studies has been demonstrated by examination of spontaneous pregnancy loss, multiple pregnancy rates, and congenital anomalies compared with a control group of infertility patients treated with CC. "
10/01/2009 - "This study found no superiority between letrozole and CC for inducing ovulation in women with unexplained infertility before IUI."
04/01/2014 - "Stimulation with letrozole and CC appears to enhance endometrial receptivity in women with unexplained infertility. "
06/01/1984 - "These data suggest that careful diagnosis and the proper choice of treatment are important, and that progesterone supplementation may result in improved pregnancy outcome for patients with infertility and pregnancy wastage who have luteal phase inadequacy."
01/01/1991 - "The continuous use of the ring produced a serum level of progesterone around 4 ng/ml. This was effective in augmenting lactational infertility even through the later phases of breastfeeding when such an effect starts to wane off. "
10/01/1990 - "The luteal phase in a group of women (n = 49) with unexplained infertility was evaluated by improved methods, including the use of the LH surge for precise timing of measurements, quantitative techniques for histological dating of endometrial biopsy and determination of the integrated progesterone concentration in the luteal phase. "
07/01/2012 - "The purpose of this study was to compare the predictive value of progesterone level on IVF success in women with infertility due to tubal factor or PCOS. "
01/01/2011 - "This retrospective analysis of combined data (one Phase II and three Phase III clinical trials) of patients with oligo- or anovulatory infertility aimed to evaluate the association between pregnancy and midluteal serum progesterone (P4) level following ovulation induction and hence the indicative value of P4 for ovulation and pregnancy achievement. "
|9.||Bromocriptine (Parlodel)FDA LinkGeneric
05/01/1984 - "Bromocriptine therapy can thus be justified in mildly hyperprolactinaemic patients to reduce troublesome galactorrhoea, achieve pregnancy, improve the chance of 'spontaneous' resolution of the menstrual problem and infertility, control or reduce tumour growth where a pituitary tumour has been identified, and reduce the risk of tumour development in patients with normal radiographs at the time of presentation."
06/01/1982 - "In order to determine whether infertility of unexplained aetiology would respond to therapy with bromocriptine, 50 regularly ovulating infertile patients were studied in a double-blind placebo controlled trial. "
11/30/1979 - "Idiopathic infertility: a trial of bromocriptine versus placebo."
04/21/1979 - "The results show that bromocriptine in the dose and duration of administration used in the trial is of no value in unexplained primary infertility."
04/21/1979 - "In a double-blind controlled study, 47 women with unexplained primary infertility were allocated at random to treatment with either bromocriptine 2.5 mg twice daily (24 patients) or placebo (23). "
|10.||Insulin (Novolin)FDA Link
04/01/2002 - "While the scientific value of many of these studies is questionable and solid evidence of efficiency and safety is not complete, the honourable intent of lowering high insulin levels in this way prompts the bottom line of this debate to strike a note of cautious optimism that insulin-sensitizing agents will be of some clinical usefulness both in the short-term aiding of infertility treatment and, possibly, in the prevention of the long-term sequelae for this troublesome and very prevalent condition."
05/01/1992 - "The null hypothesis of this study is that infertility and pregnancy outcomes in women with insulin-dependent diabetes are identical to those of nondiabetic control subjects. "
07/01/1970 - "Sterility testing of insulin by membrane filtration: a collaborative study."
07/01/2014 - "There is considerable evidence that insulin-sensitizing agents are not contributory to infertility management in the majority of women with PCOS. "
01/01/2013 - "We found that strains carrying mutations in genes involved in lipid homeostasis enhanced sterility phenotypes, while mutations reducing the activity of the conserved insulin/IGF signaling pathway suppressed sterility phenotypes. "
|1.||Drug Therapy (Chemotherapy)
08/01/2007 - "Chemotherapy, radiation, or their combination results in a significant reduction of sperm quality and as a consequence an indefinite time of infertility follows. "
12/01/2011 - "Treatment of Hodgkin’s disease (HD) has improved over the last two decades, but infertility is a common side effect of chemotherapy. "
11/01/2008 - "Chemotherapy and radiation treatment for malignancies or other conditions such as hematologic and autoimmune disorders, have resulted in improved survival rates but may lead to sterility. "
09/01/1991 - "In Group I (20 adults in clinical remission after chemotherapy), sterility was noted in 93.7% of men and hundred percent of women experienced irregularly mensus during treatment, 50% of them subsequently developing persistent amenorrhoea. "
06/01/2007 - "The objective of this study was to investigate hematological practices and attitude towards chemotherapy-related infertility. "
|2.||Contraception (Birth Control)
08/13/2013 - "Correct resolution of the molecular events governing female and male meiosis is important for treating infertility and devising improved birth control strategies. "
11/01/2013 - "Embryo attachment and implantation is critical to successful reproduction of all eutherian mammals, including humans; a better understanding of these processes could lead to improved infertility treatments and novel contraceptive methods. "
01/01/2004 - "Alleviation of infertility on the one hand and development of improved methods of contraception on the other are global concerns to woman's health. "
08/01/2014 - "Improved knowledge on endometrial receptivity will not only help to improve the diagnosis and treatment of infertility but will also give possibilities to develop new contraceptive methods targeting the endometrium. "
08/01/2004 - "The commonest reason adduced for prolonged birth spacing is failed contraception (56%), followed by secondary infertility (24%) and to a lesser extent re-marriage, improved income and sheer desire. "
11/01/1977 - "For the operation of tubal infertility, a laparotomy is eliminated in about 80% of the cases. "
01/15/2013 - "Findings in uterine biopsies obtained by laparotomy from bitches with unexplained infertility or pregnancy loss: an observational study."
01/01/2009 - "The aim of this study was to compare results of tuboperitoneal infertility treatment by the use of laparoscopy and classical laparotomy. "
01/15/2013 - "Surgical uterine biopsies (SUBs) were obtained by laparotomy from 14 bitches with unexplained infertility whose pregnancy was not confirmed (NCP group) and from 7 bitches that had experienced unexplained pregnancy loss (PL). "
09/01/2009 - "On the other hand, women over the age of 37 with a long history of infertility or those who require a laparotomy are better treated with in-vitro fertilization. "
01/01/2006 - "These results indicate that both compounds 1a and 1b are antispermatogenic in nature and on oral administration in male rats, and finally caused sterility. "
04/01/2003 - "Male rat infertility induction/spermatozoa and epididymal plasma abnormalities after oral administration of Kalanchoe gastonis bonnieri natural juice."
01/01/1983 - "This method can therefore be proposed in the outpatient treatment of sterility in couples in whom the man is paraplegic, until its oral administration has been perfected."
06/01/1979 - "The oral administration of 50 mg DICA/kg at nine weekly or four monthly intervals produced partially reversible infertility in male rats as judged by the results of serial mating and testicular histology. "
12/01/2008 - "The efficacy of oral administration of aqueous leaf extract of Allamanda cathartica (150 mg kg(-1) body weight day(-1) for 14, 28 and 42 days) in inducing infertility and changes in various male reproductive endpoints was evaluated in Parkes strain mice. "
10/01/2005 - "This study aims to estimate testicular dose and the associated risks for infertility and hereditary effects from inverted-Y field irradiation Radiotherapy was simulated on a humanoid phantom using a 6 MV photon beam. "
01/01/2012 - "The risk of sterility in males undergoing radiotherapy in the pelvic region indicates the use of a shielding device, which offers protection to the testes for patients wishing to maintain fertility. "
01/01/2012 - "Quite often, however, polychemiotherapy and/or radiotherapy can induce ovarian damage and significantly reduce the content of follicles and oocytes inside the ovary, thus predisposing the patient to menstrual disorders, infertility, and precocious menopause. "
01/01/2009 - "Toxicity to the ovaries and testicles is a recognized adverse event of chemo- and radiotherapy and can lead to infertility, thus substantially impacting a patient's quality of life. "
07/01/2008 - "bone quality and quantity, implant (length, diameter, location), type of edentulism, PTV, radiotherapy], smoking habits, and breach of sterility during surgery. "