Infectious Mononucleosis (Glandular Fever)

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1188 relevant articles (21 outcomes, 82 trials/studies) found for this Disease

Description: A common, acute infection usually caused by the Epstein-Barr virus (HERPESVIRUS 4, HUMAN). There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis.

Also Known As:

Glandular Fever; Mononucleosis, Infectious; Fever, Glandular

Relationship Network

Disease Context: Research Results

Virus Diseases: 1376

DNA Virus Infections: 23

Herpesviridae Infections: 355

Epstein-Barr Virus Infections: 1209

Infectious Mononucleosis: 1188

Hemic and Lymphatic Diseases

Lymphatic Diseases: 1961

Lymphoproliferative Disorders: 2359

Infectious Mononucleosis: 1188

Hematologic Diseases: 1480

Leukocyte Disorders: 5

Infectious Mononucleosis: 1188

Immune System Diseases: 1319

Immunoproliferative Disorders: 26

Lymphoproliferative Disorders: 2359

Infectious Mononucleosis: 1188

Related Diseases

1.	Carcinoma (Carcinomatosis)
2.	Burkitt Lymphoma (Burkitt's Lymphoma)
3.	Thrombocytopenia (Thrombopenia)
4.	Non-Hodgkin Lymphoma (Lymphosarcoma)
5.	Jaundice

Experts

1.	Fota-Markowska, Hanna: 2 articles (05/2004 - 01/2004)
2.	Modrzewska, Roma: 2 articles (05/2004 - 01/2004)
3.	Rolla-Szczepańska, Romana: 2 articles (05/2004 - 01/2004)
4.	Brennan, Rebekah M: 1 article (09/2008)
5.	Burrows, Scott R: 1 article (09/2008)
6.	Rison, Richard A: 1 article (06/2008)
7.	Zoraster, Richard M: 1 article (06/2008)
8.	Arévalo, Juan Antonio: 1 article (05/2008)
9.	Mañosa, Míriam: 1 article (05/2008)
10.	Carrión, Silvia: 1 article (05/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Infectious Mononucleosis:

1.	AntigensIBA 03/01/1979 - "Induction of plaque-forming cells in human blood lymphocytes cultured in the presence of antigen and Epstein-Barr virus: a study with normal donors and infectious mononucleosis patients." 10/15/1977 - "These studies indicated that cell-mediate immunity to EBV-associated antigens could be detected by either leukocyte migration inhibition or lymphocyte blast transformation, but neither assay is diagnostic of infectious mononucleosis." 10/31/2009 - "On the basis of seroconversion to Epstein-Barr nuclear antigen (EBNA) Ig G positivity and reduced CMV Ig M titer with persistently negative CMV Ig G, a definite diagnosis of EBV-induced infectious mononucleosis was established 1 year 2 month later." 04/01/2005 - "Serological diagnosis of infectious mononucleosis by chemiluminescent immunoassay using capsid antigen p18 of Epstein-Barr virus." 07/01/2003 - "Down-regulation of pan-T-cell antigens, particularly CD7, in acute infectious mononucleosis." Order ALL the reference details at left...
2.	Membrane Proteins (Integral Membrane Proteins)IBA 07/01/1992 - "Epstein-Barr virus latent membrane protein expression by Hodgkin and Reed-Sternberg-like cells in acute infectious mononucleosis." 08/01/1986 - "Both predicted membrane proteins could be precipitated from cell lines that had been transformed in vitro with EBV or from cell lines derived from infectious mononucleosis patients. " 10/01/2007 - "CD4(+) T-cell responses to Epstein-Barr virus (EBV) latent membrane protein 1 in infectious mononucleosis and EBV-associated non-Hodgkin lymphoma: Th1 in active disease but Tr1 in remission." 10/01/2000 - "AIMS: To study the distribution of Epstein-Barr virus (EBV) variants containing mutations in the latent membrane protein 1 (LMP-1) oncogene and promoter in EBV associated Hodgkin's disease and infectious mononucleosis compared with previous findings in asymptomatic EBV carriers. " 11/01/1997 - "To assess the frequency of malignancy-associated 30-bp deletion variants of the latent membrane protein 1 (LMP-1) in benign conditions, a comparative sequence analysis was done using samples from 20 American children with acute infectious mononucleosis and 16 Swiss children with chronic tonsillar hyperplasia. " Order ALL the reference details at left...
3.	Phenytoin (Dilantin)FDA LinkGeneric 01/01/1980 - "Increased clearance of phenytoin as the presenting feature of infectious mononucleosis." 03/01/1979 - "Increased clearance of phenytoin during infectious mononucleosis." 01/01/1980 - "Ten days later, the blood picture became compatible with infectious mononucleosis, at which time his phenytoin clearance returned to normal." 01/01/1980 - "His blood level of phenytoin, previously in a therapeutic range, was 4.2 microgram/ml. No systemic or laboratory evidence of infectious mononucleosis was found. " 01/01/1960 - "[Diphenylhydantoin exanthema in the form of an infectious mononucleosis.]" Order ALL the reference details at left...
4.	Metronidazole (Metric)FDA LinkGeneric 08/01/1990 - "Although the reasons by which metronidazole produces a rapid clinical improvement are not known, administration of this drug in patients with severe tonsillar involvement appears to be useful in the treatment of infectious mononucleosis." 08/01/1990 - "[Metronidazole and angina caused by infectious mononucleosis]" 01/01/1982 - "Metronidazole in the treatment of anginose infectious mononucleosis." 01/01/1982 - "Treatment of infectious mononucleosis with metronidazole in the pediatric age group." 01/01/1980 - "Treatment of anginose infectious mononucleosis with metronidazole. " Order ALL the reference details at left...
5.	Tinidazole FDA Link 01/01/1986 - "The efficacy of tinidazole was studied in 24 patients with infectious mononucleosis (IM), 13 of whom were randomized for 5 days of tinidazole treatment and 11 for control without placebo. " 01/01/1986 - "Evidence of tinidazole interference in the oropharyngeal inflammatory process during infectious mononucleosis." 01/01/1984 - "Tinidazole and metronidazole have been reported beneficial in the treatment of acute anginose infectious mononucleosis. " Order ALL the reference details at left...
6.	Immunoglobulin M (IgM)IBA 02/01/1980 - "Our studies indicate that the IgM smooth muscle antibody found in infectious mononucleosis by IF techniques is at least in part due to an antitubulin antibody." 11/01/2007 - "IgM-positive specimens increased from spring to autumn only in the youth group, suggesting that infectious mononucleosis in this group occurs more during this time. " 01/01/2007 - "We evaluated a method for determination of human cytomegalovirus (hCMV) immunoglobulin M (IgM) by CLIA, and analyzed its clinical value in patients with infectious mononucleosis. " 04/01/2005 - "CONCLUSION: The CLIA was the excellent method for EBV-VCA IgM measurement at present and can improve the clinical diagnosis of infectious mononucleosis." 04/01/2004 - "Significant liver injury with dual positive IgM antibody to Epstein-Barr virus and cytomegalovirus as a puzzling initial manifestation of infectious mononucleosis." Order ALL the reference details at left...
7.	Immunoglobulin G (IgG)IBA 06/01/1993 - "Application of low-avidity immunoglobulin G studies to diagnosis of Epstein-Barr virus infectious mononucleosis." 01/26/2005 - "Controls with at least 1 infant-year contact had a reduced risk of infectious mononucleosis and a reduced risk of very high composite EBV IgG titers (AOR, 0.33; 95% CI, 0.11-0.98) compared with other controls. " 01/01/2005 - "The mean optical density value for IgG immunoreactivity to Nedd5 C-ter was significantly higher in patients of group A than in those of group B, those with infectious mononucleosis, or healthy subjects (0.17 +/- 0.14 vs, respectively, 0.11 +/- 0.07, P = 0.04; 0.11 +/- 0.06, P = 0.034; and 0.09 +/- 0.045, P = 0.003, on Student's t-test). " 02/01/1998 - "The use of semi-automated EBV IgG avidity determination for the diagnosis of infectious mononucleosis." 05/01/1990 - "A p107-to-polyproline IgG ratio of less than 1 was 98% specific for EBV infectious mononucleosis; sensitivity was 86%. " Order ALL the reference details at left...
8.	Immunoglobulins (Immunoglobulin)IBA 04/01/2009 - "Therefore, when this disorder is suspected, serum analyses are carried out to detect the presence of certain immunoglobulins associated with infectious mononucleosis in the patient's blood. " 01/01/2002 - "There is a selective rise in immunoglobulins encoded by this gene in both infectious mononucleosis and SLE." 02/01/2001 - "Reduced immunoglobulin-coating of the bacteria on the tonsillar surfaces during infectious mononucleosis can explain their tendency to immense local colonization and proneness to penetrate into the epithelial cells." 04/01/1996 - "The findings suggest that the B-lymphotropic Epstein-Barr virus, causative agent of infectious mononucleosis, exerts a transient suppression of immunoglobulin-coating of bacteria harboured on the tonsillar surfaces, with consequent abundant bacterial attachment to the epithelial cells and massive bacterial colonization on the palatine tonsils." 04/01/1996 - "Immunoglobulin-coated bacteria on the tonsillar surface during infectious mononucleosis." Order ALL the reference details at left...
9.	Prednisolone (Predate)FDA LinkGeneric 01/01/1959 - "Severe infectious mononucleosis treated with prednisolone." 02/01/1957 - "[Prednisolone therapy of infectious mononucleosis.]" 08/01/1996 - "Acyclovir and prednisolone treatment of acute infectious mononucleosis: a multicenter, double-blind, placebo-controlled study." 08/01/1996 - "Ninety-four patients with infectious mononucleosis and symptoms < or = 7 days were randomized to treatment with oral acyclovir (800 mg 5 times/day) and prednisolone (0.7 mg/kg for the first 4 days, which was reduced by 0.1 mg/kg on consecutive days for another 6 days; n = 48), or placebo (n = 46) for 10 days. " 04/30/1978 - "[HBsAg positive viral hepatitis, associated with acute infectious mononucleosis simptoms, treated with prednisolone]" Order ALL the reference details at left...
10.	Interferon-gamma (Interferon, gamma)IBA 05/01/2009 - "Previous studies identified EBV latent membrane protein (LMP)-1-induced T(reg) activity [Marshall et al. (2003): J Immunol 170:6183-6189; Marshall et al. (2007): Brit J Haematol 139:81-89], and in this study a significant reduction in interferon-gamma production was found from infectious mononucleosis but not seropositive donor lymphocytes after stimulation with a recall antigen when LMP-1 peptide PRG was added (P = 0.03). " 07/01/1999 - "Here we report that PTLD tissues express significantly lower levels of IL-18, interferon-gamma (IFN-gamma), Mig, and RANTES compared to lymphoid tissues diagnosed with acute EBV-induced infectious mononucleosis, as assessed by semiquantitative RT-PCR analysis. " 07/01/1999 - "Interleukin-18, interferon-gamma, IP-10, and Mig expression in Epstein-Barr virus-induced infectious mononucleosis and posttransplant lymphoproliferative disease." 07/01/1993 - "Serum concentrations of interferon gamma, interleukin-6 and neopterin in patients with infectious mononucleosis and other Epstein-Barr virus-related lymphoproliferative diseases." 07/01/1993 - "Serum levels of interferon gamma, interleukin-6 and neopterin were determined in 15 patients with different forms of Epstein-Barr virus-associated diseases: acute self-limiting infectious mononucleosis, chronic active infectious mononucleosis and X-linked lymphoproliferative syndrome. " Order ALL the reference details at left...

Therapies and Procedures

1.	Transplants (Transplant) 12/01/2005 - "This patient was EBV seronegative pre-transplant; peak EBV load was 14,513 copies/ml. Acute infectious mononucleosis was seen in 1 case. " 05/01/2005 - "This phenotype is consistent with that seen in healthy seropositive controls, post-transplant patients and patients with acute infectious mononucleosis. " 12/01/2004 - "Their results were then compared with those from the healthy controls (HC); monospot test negative (MN-) and infectious mononucleosis positive (IM+) patients; patients who were previously treated for PTLD (pPTLD); those who were currently diagnosed to have PTLD (PTLD+); and patients who had a stable renal, hepatic, or cardiothoracic graft for more than a year. " 01/01/1999 - "The autologous immune response to infectious mononucleosis (IM) 4 weeks post-transplant was normal despite recent and ongoing severe immunosuppression." 01/15/1996 - "Finally, blood donors with a recent history of infectious mononucleosis should probably be identified so that their blood is not given to EBV-negative transplant patients." Order ALL the reference details at left...
2.	Transplantation (Transplant Recipients) 12/15/2002 - "This technique was applied to determine the EBV load in various study groups including healthy controls, transplant recipients, patients on haemodialysis, and patients with infectious mononucleosis. " 02/01/1987 - "To compare the abilities of the nucleic acid dot hybridization assay and the cord blood lymphocyte transformation assay to detect Epstein-Barr virus (EBV), we examined throat washings from healthy control subjects (nine EBV-seronegative and 51 EBV-seropositive), patients with acute infectious mononucleosis, and renal transplant recipients. " 01/01/1999 - "Rapid autologous marrow recovery and eradication of infectious mononucleosis despite severe immunosuppression following second transplantation for aplastic anemia." 07/01/1988 - "Inclusion of uncomplicated infectious mononucleosis in the spectrum of Epstein-Barr virus infections in transplant recipients." 01/01/1998 - "They have been closely associated with Epstein-Barr virus (EBV), and the spectrum of manifestations after transplantation range from an infectious mononucleosis-like syndrome to more serious polyclonal or monoclonal lymphoproliferation, the treatment of which is not well defined and, relying on immuno- and chemotherapy. " Order ALL the reference details at left...
3.	Tonsillectomy 10/21/2002 - "In patients with infectious mononucleosis (IM), acute tonsillectomy is advocated only in the minority who develop severe airway compromise. " 10/21/2002 - "Florid infectious mononucleosis: clinicopathological correlation in acute tonsillectomy." 01/01/2000 - "[Infectious mononucleosis: when is tonsillectomy indicated?]" 07/01/1993 - "Acute tonsillectomy in the management of infectious mononucleosis." 11/01/1992 - "Acute tonsillectomy in the management of infectious mononucleosis." Order ALL the reference details at left...
4.	Splenectomy 03/01/1989 - "No evidence of EBV was found in two splenectomy specimens from patients with infectious mononucleosis. " 04/01/1958 - "Infectious mononucleosis requiring splenectomy and tracheotomy." 09/01/2003 - "On the basis of review of the medical literature and of our own experience, we advocate emergent splenectomy for spontaneous splenic rupture in patients with infectious mononucleosis." 01/01/2003 - "CONCLUSION: We report on a 27-year-old man with infectious mononucleosis who had spontaneous splenic rupture that was successfully managed by splenectomy." 01/01/2003 - "We report on the case of a 27-year-old man with infectious mononucleosis who had spontaneous splenic rupture that was successfully managed by splenectomy. " Order ALL the reference details at left...
5.	Homologous Transplantation (Allograft) 10/01/1996 - "It was noted that many sera of patients with renal allograft produce distinct precipitation lines in gel diffusion tests with about 20% of infectious mononucleosis sera. " 06/01/1990 - "A range of histopathologic changes was noted in the allografts ranging from alterations typically observed in infectious mononucleosis to a distinctive constellation characterized by (a) mixed mononuclear portal and sinusoidal infiltrates containing atypical large noncleaved cells and immunoblasts; (b) associated lobular activity indicative of a hepatitic process, and (c) relatively mild duct damage not in proportion to the severity of the inflammatory infiltrates. " 01/01/1994 - "The frequency of multiple Ebnotypes was relatively low in healthy individuals and in patients with infectious mononucleosis or with haematological diseases who were awaiting a bone marrow transplant [blood, 11 of 74 patients (15%); oropharynx, 12 of 49 patients (24%)], whereas it was relatively high in recipients of bone marrow or cardiac allografts and one patient with AIDS [blood, 12 of 34 patients (35%); oropharynx, 11 of 16 patients (69%)]. " 09/01/1997 - "Clinically, PTLD can present in a number of ways ranging from features resembling infectious mononucleosis, lymphoproliferative masses involving both nodal and extranodal locations, to a fulminant form characterized by a combination of peripheral lymphadenopathy, severe metabolic acidosis, organ failure or allograft dysfunction. " 11/01/1981 - "Tissues from six patients with the X-linked lymphoproliferative syndrome, all five renal allograft recipients with immunoblastic sarcoma, and eight patients with diverse types of immunodeficiency and lymphoproliferative diseases such as fatal infectious mononucleosis or malignant lymphoma associated with antecedent immunodeficiency contained significant numbers of EBV genome equivalents per cell. " Order ALL the reference details at left...

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