Infectious Bovine Rhinotracheitis

A herpesvirus infection of CATTLE characterized by INFLAMMATION and NECROSIS of the mucous membranes of the upper RESPIRATORY TRACT.

Also Known As:

Bovine Rhinotracheitides, Infectious; Bovine Rhinotracheitis, Infectious; Infectious Bovine Rhinotracheitides; Rhinotracheitides, Infectious Bovine; Rhinotracheitis, Infectious Bovine

Networked: 243 relevant articles (13 outcomes, 23 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Paramyxoviridae Infections (Parainfluenza)
2.	Diarrhea
3.	Infections
4.	Leptospirosis
5.	Brucellosis (Malta Fever)

Experts

1.	Iscaro, Carmen: 2 articles (01/2020 - 01/2019)
2.	Petrini, Stefano: 2 articles (01/2020 - 01/2019)
3.	Righi, Cecilia: 2 articles (01/2020 - 01/2019)
4.	Waldner, Cheryl L: 2 articles (01/2019 - 07/2008)
5.	Srinivasan, Villuppanoor Alwar: 2 articles (01/2018 - 06/2009)
6.	Gershwin, Laurel J: 2 articles (12/2017 - 01/2015)
7.	Kim, JaeWoo: 2 articles (12/2017 - 01/2015)
8.	Neibergs, Holly L: 2 articles (12/2017 - 01/2015)
9.	Schnabel, Robert D: 2 articles (12/2017 - 01/2015)
10.	Seabury, Christopher M: 2 articles (12/2017 - 01/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Infectious Bovine Rhinotracheitis:

1.	VaccinesIBA 01/01/2023 - "The immunogenicity and efficacy of acommercially available Infectious Bovine Rhinotracheitis (IBR) virus vaccine against a Pakistani field IBR strain." 08/07/1982 - "Safety and efficacy of live and inactivated infectious bovine rhinotracheitis vaccines." 03/01/1978 - "Efficacy of an intranasal infectious bovine rhinotracheitis vaccine for the prevention of abortion in cattle." 01/01/1975 - "Early protection against infectious bovine rhinotracheitis with intramuscularly administered vaccine." 12/01/1971 - "Comparative efficacy of intranasally and parenterally administered infectious bovine rhinotracheitis vaccines."
2.	Combined VaccinesIBA 01/01/2004 - "Rapid onset of protection against infectious bovine rhinotracheitis with a modified-live virus multivalent vaccine." 06/01/2009 - "A combined vaccine against Brucella abortus and infectious bovine rhinotracheitis." 09/01/2004 - "Efficacy of an inactivated quadrivalent vaccine containing infectious bovine rhinotracheitis (IBR) virus, parainfluenza type 3 (PI3) virus, bovine virus diarrhoea virus (BVDV) and bovine respiratory syncytial virus (BRSV) was assessed in naive bovine calves to evaluate short-term (4-18 weeks) and long-term (24-38 weeks) protection following the basic intramuscular vaccination regime of 2 inoculations a month apart. " 06/01/2009 - "The present study was undertaken to study the immune response in calves vaccinated with Brucella abortus strain 19, infectious bovine rhinotracheitis (IBR) vaccines in monovalent form and combined vaccine containing both antigen. "
3.	Inactivated VaccinesIBA 11/01/1996 - "Development of a disease control programme based on the use of an inactivated vaccine against infectious bovine rhinotracheitis." 04/23/1988 - "A commercially available inactivated vaccine against infectious bovine rhinotracheitis (BHV1) was tested to assess its ability to immunise young seronegative calves and protect them against challenge with a virulent strain of BHV1. " 05/01/1979 - "[Immunization effectiveness of the inactivated vaccine against infectious bovine rhinotracheitis (IBR) with an oily adjuvant]." 10/01/1975 - "Following initial vaccination there was no demonstrable serum infectious bovine rhinotracheitis titer in any of the calves receiving the inactivated vaccine with 20.7% of the calves receiving the attenuated vaccines having demonstrable titers. " 11/01/1996 - "Studies to investigate the efficacy of an inactivated vaccine against infectious bovine rhinotracheitis (IBR) suggest that this vaccine can prevent the in utero infection of calves from experimentally infected dams. "
4.	Bacterial VaccinesIBA 03/01/1984 - "somnus bacterin, pasteurella bacterin or the porcine tissue culture infectious bovine rhinotracheitis-parainfluenza type 3 vaccine had a significant effect on treatment rates for respiratory disease. " 02/01/1982 - "Vaccines against infectious bovine rhinotracheitis (IBR), bovine viral diarrhea (BVD), bovine parainfluenza-3 (PI-3), and bacterin against Pasteurella hemolytica and P. " 01/01/2007 - "Replacement heifers (N=799; 10 to 13 months of age) were vaccinated with Vista 5 L5 SQ (Intervet; a reconstituted vaccine-bacterin product containing modified-live cultures of infectious bovine rhinotracheitis [IBR] virus, bovine viral diarrhea virus [BVDV; types 1 and 2], parainfluenza-3 virus, and bovine respiratory syncytial virus and inactivated cultures of Leptospira serovars canicola, grippotyphosa, hardjo, icterohaemorrhagiae, and pomona with a proprietary adjuvant) at either 40 plus/minus 5 days (control; n=399) or 3 days (test; n=400) before peak breeding day. " 04/01/1997 - "The administered vaccine consisted of modified live virus for infectious bovine rhinotracheitis, parainfluenza and bovine viral diarrhea, with 5-way bacterin for leptospirosis and bacterin for vibriosis. " 03/01/1984 - "A field trial to investigate the efficacy of vitamins ADE, a Haemophilus somnus bacterin, a pasteurella bacterin, and two intranasal infectious bovine rhinotracheitis-parainfluenza type 3 vaccines administered to beef calves at least three weeks prior to weaning and shipment was conducted.Over"
5.	Antiviral Agents (Antivirals)IBA 02/01/1976 - "Antiviral activity was demonstrated against infectious bovine rhinotracheitis and equine rhinopneumonitis viruses. " 10/01/2003 - "Bovine herpesvirus 1 (BoHV-1), the cause of infectious bovine rhinotracheitis and infectious pustular vulvovaginitis in cattle, establishes a lifelong infection, despite the presence of antiviral immunity in the host. " 10/01/1974 - "The antiviral activity of several ether derivatives of 5-hydroxymethyldeoxyuridine against the herpesvirus of infectious bovine rhinotracheitis was determined in monolayer cultures of secondary bovine fetal kidney cells. " 12/13/2002 - "This study evaluated the antiviral effect of various dosage forms of proteinase inhibitor-aprotinin as a potential remedy for prophylactics and therapy of infectious bovine rhinotracheitis. "
6.	VitaminsIBA 03/01/1984 - "A field trial to investigate the efficacy of vitamins ADE, a Haemophilus somnus bacterin, a pasteurella bacterin, and two intranasal infectious bovine rhinotracheitis-parainfluenza type 3 vaccines administered to beef calves at least three weeks prior to weaning and shipment was conducted.Over"
7.	Peptide Hydrolases (Proteases)FDA Link 12/13/2002 - "This study evaluated the antiviral effect of various dosage forms of proteinase inhibitor-aprotinin as a potential remedy for prophylactics and therapy of infectious bovine rhinotracheitis. "
8.	Aprotinin (Trasylol)FDA Link 12/13/2002 - "This study evaluated the antiviral effect of various dosage forms of proteinase inhibitor-aprotinin as a potential remedy for prophylactics and therapy of infectious bovine rhinotracheitis. "
9.	Dosage Forms (Dosage Form)IBA 12/13/2002 - "This study evaluated the antiviral effect of various dosage forms of proteinase inhibitor-aprotinin as a potential remedy for prophylactics and therapy of infectious bovine rhinotracheitis. "
10.	Neutralizing AntibodiesIBA 10/01/1983 - "A survey of the age-specific BHV 1 neutralizing antibody pattern may be helpful for tracing animals and herds at risk of an outbreak of infectious bovine rhinotracheitis." 10/01/1987 - "To determine whether consumption of colostrum with high levels of serum neutralizing antibody to bovine herpesvirus 1 would protect neonatal calves from the frequently fatal multisystemic form of infectious bovine rhinotracheitis, Holstein calves were fed for 48 h after birth with either pooled colostrum from seropositive vaccinated cows or colostrum from seronegative unvaccinated cows. " 01/01/1985 - "Vaccinated calves developed neutralizing antibodies but did not show clinical signs of infectious bovine rhinotracheitis (IBR). " 12/01/1983 - "Serum samples (n = 1,146) representing 100 species of exotic ruminants now captive in United States zoos were assayed for neutralizing antibody to infectious bovine rhinotracheitis (IBR) virus (bovine herpesvirus 1). " 02/01/1975 - "Some factors influencing the microtest method for neutralizing antibodies to the virus for neutralizing antibodies to the virus of infectious bovine rhinotracheitis."

Therapies and Procedures

1.	Therapeutics 12/13/2002 - "This study evaluated the antiviral effect of various dosage forms of proteinase inhibitor-aprotinin as a potential remedy for prophylactics and therapy of infectious bovine rhinotracheitis. "
2.	Injections 01/01/1986 - "At wk 12, serum from calves given the high amount of oral supplementation and calves given injections inhibited infectious bovine rhinotracheitis viral replication in tissue cultures as compared with those of unsupplemented calves. " 09/01/2018 - "A total of 468 calves from 3 herds were enrolled and randomized into 3 treatment groups (positive control, PC, n = 211; intranasal vaccine, IN, n = 215; negative control, NC, n = 42) and followed for 8 to 12 wk. The PC consisted of one dose of commercially available multivalent injectable vaccine against bovine respiratory syncytial virus, infectious bovine rhinotracheitis, parainfluenza 3, and bovine viral diarrhea administered subcutaneously at 6 wk of age. " 07/01/1979 - "Infectious bovine rhinotracheitis/infectious pustular vulvovaginitis (IBR/IPV) is probably a venereal disease because virgin wildebeest did not develop vulvovaginitis after betamethasone injections, nor was the virus transmitted to these virgin wildebeest and steers which were in pen contact with the affected animals. " 02/01/2009 - "On May 19, 2006 (d 0), steers were administered one of the following treatment injections: a standard Biobullet containing 100 mg of ceftiofur sodium (Naxel, Pfizer Inc., New York, NY); a traditional needle and syringe dose of ceftiofur sodium; a standard Biobullet containing BallistiVac infectious bovine rhinotracheitis (IBR; Titanium 5, SolidTech Animal Health, Newcastle, OK); a traditional needle and syringe dose of IBR; a traditional needle and syringe dose of Vira Shield 5 (Grand Laboratories Inc., Freeman, SD); a standard placebo Biobullet; or a traditional needle and syringe dose of sterile water. " 12/01/2000 - "Horses received 2 IM injections at 2-week intervals of a vaccine containing inactivated infectious bovine rhinotracheitis, bovine viral diarrhea, and parainfluenza-3 viral antigens and were then randomly assigned to 2 groups. "
3.	Intramuscular Injections 04/01/1994 - "The calves had received an intramuscular injection of modified-live infectious bovine rhinotracheitis parainfluenza-3 vaccine between birth and three days of age. " 05/01/1990 - "Nineteen nulliparous, sexually mature heifers free of antibody to infectious bovine rhinotracheitis (IBR) virus were given two 35 mg intramuscular injections of Lutalyse 10 days apart to synchronize estrus and randomly divided into control and vaccinated groups. "
4.	Nebulizers and Vaporizers (Inhaler) 04/01/1984 - "Four calves (control animals) were inoculated (by aerosol) with Cooper's strain of infectious bovine rhinotracheitis (IBR) virus given with an ultrasonic nebulizer. "
5.	Aftercare (After-Treatment) 01/01/1983 - "A group of 463 calves, kept under one and the same conditions of tending and feeding, were followed up from the fifteenth day after birth up to one year of age, after treatment by subgroups with a hyperimmune antibovine rabbit serum, biomass of chlorella, a tissue preparation of swine embryos, and vaccines against mucosal diseases and infectious bovine rhinotracheitis. "