|5.||Brain Ischemia (Cerebral Ischemia)
|1.||Downey, James M: 28 articles (03/2015 - 01/2002)|
|2.||Cohen, Michael V: 27 articles (03/2015 - 01/2002)|
|3.||Boyko, Valentina: 27 articles (12/2010 - 01/2002)|
|4.||Behar, Solomon: 24 articles (03/2009 - 01/2002)|
|5.||Lee, Tsung-Ming: 21 articles (07/2015 - 10/2003)|
|6.||Saeed, Maythem: 19 articles (11/2008 - 01/2002)|
|7.||Tanne, David: 18 articles (01/2012 - 01/2002)|
|8.||Yang, Xi-Ming: 17 articles (03/2015 - 09/2002)|
|9.||Chang, Nen-Chung: 16 articles (07/2015 - 07/2004)|
|10.||Goldbourt, Uri: 16 articles (02/2013 - 01/2002)|
|1.||glucuronyl glucosamine glycan sulfate (Vessel)IBA
02/01/1999 - "Furthermore, no MRI findings were distinct predictors of long-term prognosis, although infarction based on the small vessel disease had rather good outcome in terms of respiratory disease."
09/01/1997 - "The impact of these changes on infarct healing and their association with the improved prognosis of a patent infarct vessel following infarction will require further study."
01/01/2005 - "Baseline characteristics were similar in both groups with a mean lesion length of 34.89+/-11.19 mm, and vessel diameter of 3.03+/-0.54 mm. CBA resulted in reduced incidence of side branch loss (23.2% versus 41.7%, P=0.022) which was associated with less peri-procedural infarction (OR: 11.39 (95% CI: 1.34-96.53), P=0.026). "
12/01/2007 - "The goal of this study was to determine the frequency of subcortical and deep lacunar lesions and its association with large vessel atherosclerotic infarction at the Ali-Ibne-Abi Taleb Hospital, Rafsanjan. "
07/01/2002 - "Neuropathological study of brain and brain vessels was performed in two series of 12 and 20 centenarians, focusing on the prevalence of small vessel lesions, infarction, Alzheimer's changes and mental status. "
|2.||Heparin (Liquaemin)FDA LinkGeneric
02/01/1995 - "Completed clinical trials lead to the following conclusions: 1. The efficacy of heparin in the acute phase of CVA is unknown, given the many biases and methodological imprecisions contained in the studies performed so far, among them a reliance on temporal rather than etiological classification of infarctions and the small number of patients treated. "
01/01/1988 - "These observations suggest that additional controlled studies of the efficacy of heparin in progressing ischemic infarction are warranted."
10/01/2014 - "Four (40%) had infarctions on ASA; 3 of these patients subsequently received heparin. "
10/01/2014 - "Six cases were treated with heparin after either initial or recurrent infarction. "
12/01/2011 - "Others risk factors were analyzed, and the discontinuation of heparin infusion was also considered to have a predominant role in the development of infarction. "
|3.||Nitroglycerin (Dynamite)FDA LinkGeneric
06/27/1983 - "Preliminary studies in patients with acute infarction have confirmed the beneficial effect of intravenous nitroglycerin on S-T segment elevation, and a subsequent study in 31 patients with acute infarction showed a decrease in infarct size with improved hemodynamics. "
04/01/1988 - "Thus, reduced expansion and thinning with nitroglycerin during the first week after infarction improved function, mechanical strength, and resistance to distension at 6 weeks."
05/01/1982 - "Early after infarction, sublingual nitroglycerin improved left, right and regional ejection fraction at the infarct site in some patients. "
04/01/1981 - "Within 24 hours, central chord shortening in the zone of infarction was reduced to 13.1 +/- 9.8%, but improved 27.2 +/- 18.4% (p less than 0.001) after nitroglycerin. "
12/01/1993 - "The aim of this study was to evaluate the ability of echocardiography, associated with nitroglycerin infusion, in the detection of myocardial viability in patients with recent infarction. "
|4.||Verapamil (Calan)FDA LinkGeneric
06/01/1992 - "The findings of the DAVIT II study with verapamil demonstrate a significant reduction in the infarction recurrence rate (18% vs 21.6%) in the treatment group. "
12/01/1990 - "reinfarction or death, has been investigated in two Danish double-blind, placebo-controlled verapamil infarction trials DAVIT I and II. DAVIT I, which was an early intervention trial, demonstrated that after six months there was a statistically non-significant reduction of mortality and reinfarction. "
01/01/1993 - "In the Danish Verapamil Infarction Trial II (DAVIT II), treatment with verapamil 360 mg/day improved reinfarction-free survival compared with administration of placebo. "
05/01/1999 - "Danish Verapamil Infarction Trial."
04/15/1999 - "Danish Verapamil Infarction Trial."
|5.||Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
09/20/2005 - "These results suggest that aspirin should not be routinely used in CHF patients and be avoided in those with refractory CHF, but that it may be beneficial in patients with recent infarction or multiple vascular risk factors."
02/01/2010 - "Simple means of prevention have proved effective in women: regular physical activity thus reduces the risk of infarction by 50% (and also reduces the incidence of diabetes); the effect of aspirin as primary prevention remains controversial."
05/01/1994 - "Aspirin is effective in preventing morning infarction. "
08/01/1995 - "The ISIS studies demonstrated the advantages of combining beta-blockers, thrombolysis and aspirin in acute infarction. "
05/01/1995 - "The prevention of heart infarction with 100 mg aspirin is common practice in Germany, in spite of the fact that it is based on only two small studies, the results of which are not generalized. "
06/01/1986 - "Comparison of radionuclide left ventricular ejection fraction assessed acutely (28 +/- 10 hours after infarction) with left ventricular ejection fraction at hospital discharge (15 +/- 3 days after infarction) showed no significant improvement in either the streptokinase or control group, 0% and +1%, respectively. "
02/01/1992 - "The streptokinase-induced reduction in blood viscosity may lead to an improvement in microcirculation in the infarction area during the early phase, whereas the hyperviscosity observed independently of therapy after 1 week may lead to an impairment of microcirculation."
10/01/2013 - "Specific features of prior trial designs that may have adversely affected outcomes include a prolonged treatment window, inclusion of patients with established infarction on computed tomography scan, failure to treat excessive arterial pressures, a fixed dose of streptokinase, and concomitant use of antithrombotic medications. "
03/01/2000 - "Two hundred fifty-eight AMI patients from the Thrombolytics and Myocardia Infarction phase 7 and Global Utilization of Streptokinase tPA for Occluded coronary arteries phase 1 trials were stratified based on blinded, simultaneous reperfusion assessment on the acute angiogram (divided into TIMI grades 0 & 1, TIMI grade 2 and TIMI grade 3) and ST-segment resolution analysis (divided into: <50% ST-segment elevation resolution or reelevation and > or =50% ST-segment elevation resolution). "
09/01/1996 - "We studied 24 patients in the Australian Streptokinase Trial with acute middle cerebral cortical infarction using 99mTc-hexamethylpropyleneamine oxime single-photon emission CT. "
|7.||Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
09/10/2000 - "We identified eight post-infarction studies for which subgroup analyses of diabetic subjects were available, four with beta blockers and four with ACE inhibitors. "
07/01/1994 - "Studies in animal models and conclusions from clinical trials have shown that angiotensin converting enzyme inhibitors also decrease late mortality and cardiac morbidity after infarction, likely through favorable effects on both hemodynamic and neurohumoral factors specific to this class of medication. "
12/01/1992 - "This provides a possible mechanism for the beneficial effect of ACE inhibitors in postmyocardial infarction trials. "
11/01/1992 - "The Survival and Ventricular Enlargement study (SAVE) has been the first to demonstrate the relationship between limitation of ventricular remodelling and improvement of the secondary prognosis of infarction obtained by angiotensin-converting enzyme inhibitors."
03/01/2005 - "These results warrant caution for the very early use of ACE-inhibitors in smaller infarctions, although this needs to be confirmed in a larger prospective randomised clinical trial."
|8.||Diltiazem (Cardizem)FDA LinkGeneric
01/01/1989 - "These results indicate that high-dose diltiazem is well tolerated, safe, and effective in the prevention of early reinfarction and severe angina after non-Q-wave infarction."
08/14/1986 - "We conclude that diltiazem was effective in preventing early reinfarction and severe angina after non-Q-wave infarction and that it was also safe and generally well tolerated."
12/01/1999 - "In 2 earlier trials, diltiazem lessened cardiac events in patients with nonQ-wave infarctions and those without pulmonary congestion upon presentation. "
06/01/1995 - "Incomplete Infarction Trial of European Research Collaborators Evaluating Prognosis Post-Thrombolysis (diltiazem) (INTERCEPT) Research Group."
03/01/1994 - "Multicenter Diltiazem Post-Infarction Trial Research Group."
05/01/2013 - "In light of the recent publication of clinical trials and meta-analyses, a possible increase in cardiovascular risk, particularly in the form of a myocrdial infarction, is hypothesised in patients taking calcium supplements. "
01/01/1992 - "Analysis of studies in acute infarction showed a neutral effect of calcium-antagonists with unchanged infarct-size, regional and global ventricular function or early mortality. "
08/01/1991 - "Calcium antagonists post-infarction: the significance of experimental studies on potentially lethal early ischemic ventricular arrhythmias."
01/01/2015 - "However, it induced a greater increase in cytosolic calcium, which may explain the lack of effect against infarction that we have seen in isolated rat hearts. "
03/13/2013 - "In vivo calcium imaging showed a significantly large number of astrocytes in the contralateral SSC responding to ipsilateral limb stimulation at the first week after infarction. "
06/20/2000 - "We have previously described a second window of protection against infarction in rabbits 24 to 72 hours after adenosine A(1) receptor (A(1)R) activation. "
05/01/2009 - "Recent trials such as INSPIRE (Adenosine Sestamibi Post-Infarction Evaluation) and the COURAGE (Results from Clinical Outcomes Utilizing Revascularization and Aggressive Guideline-driven Drug Evaluation) Nuclear Imaging Substudy have established clearly that noninvasive risk stratification with vasodilator testing is an important and appropriate step in guiding medical therapy and invasive coronary intervention."
12/19/2006 - "The INSPIRE (Adenosine Sestamibi Post-Infarction Evaluation) trial is a prospective multicenter trial which enrolled 728 clinically stable survivors of AMI who had gated ADSPECT within 10 days of hospital admission and subsequent 1-year follow-up. "
06/07/2005 - "Previous small studies suggest that adenosine may reduce the size of an evolving infarction. "
11/15/1999 - "The AMISTAD trial was a prospective, open-label trial of thrombolysis with randomization to adenosine or placebo in 236 patients within 6 h of infarction onset. "
|1.||Angioplasty (Angioplasty, Transluminal)
11/01/1999 - "Several studies (ACME, MASS, RITA 2) compared the efficacy of angioplasty with medical management in this context with concordant results: significant reduction in the frequency of angina and improved exercise capacity, without reduction in the number of serious events (death, infarction). "
07/01/1988 - "Rapid hemodynamic improvement in right ventricular infarction after coronary angioplasty."
01/01/1997 - "These results were comparable to previously reported figures and confirm that primary angioplasty in acute infarction is possible and effective with an acceptable risk in a small urban community without on-site cardiac surgery."
07/01/2013 - "An adequate door-to-balloon time (<120 minutes) is the necessary condition for the efficacy of primary angioplasty in infarction to translate into effectiveness. "
12/24/1992 - "The degree of improvement in function was not influenced by the length of time between the infarction and the attempted angioplasty. "
|2.||Transplantation (Transplant Recipients)
11/01/2013 - "Furthermore, transplantation of aged SJSCs into the infarcted rat heart significantly reduced the infarction size and improved left ventricular function, whereas transplantation of aged BMSCs was less effective. "
12/01/2009 - "In producing persistently high cell homing at the infarction site, the IM transplantation is superior to the IC transplantation. "
03/01/2008 - "Transplantation of cultured MPCs into the ischemic border area significantly improved cardiac function by reducing infarction size. "
07/20/2007 - "The infarction volume and apoptotic activity of the transplanted hBMSCs were significantly decreased, and functional outcomes were significantly improved in the hBMSC transplantation and bFGF treatment group than in the control group. "
01/01/2013 - "We also found that simultaneous transplantation of cardiac telocytes in the infarcted and border zones of the heart decreased the infarction size and improved myocardial function. "
11/01/1997 - "Conservative intra-arterial thrombolytic therapy is considered to be the most effective treatment for renal infarction."
07/01/2008 - "Compared with fibrinolytic therapy, primary percutaneous coronary intervention (PCI) results in improved short- and long-term survival, a lower incidence of recurrent infarction and a better left ventricular function. "
02/01/1994 - "This study indicates that postoperative intrathecal thrombolytic therapies, especially with less than 4 mg/d of tPA, are effective in lysing subarachnoid clot and preventing vasospasm and infarction safely."
03/18/1997 - "However, in these further identified AMI patients, 78% (7/9) had small enzyme rises with non-Q wave infarction and/or non-ST elevation and therefore may not have benefited from thrombolytic therapy in contrast to the Q wave/raised ST segment infarcts with large enzyme rises identified by clinical means. "
02/01/1988 - "Patients with inferior infarction do not appear to have improved survival with thrombolytic therapy. "
10/01/1994 - "The efficacy of two right ventricular assist systems for severe right ventricular failure caused by multiple ligation of the right coronary artery and right ventricular free wall with ventricular septal infarction was studied in 20 adult dogs in order to determine a better assist system in terms of hemodynamics and ventricular function. "
09/01/2005 - "Ligation resulted in a transmural left ventricular free wall infarction mainly located at the apical region with a consistent endocardial border zone (BZ) as confirmed by histological studies. "
04/01/2004 - "To study effects on ischemic myocytes in the absence of reperfusion, myocardial infarction (MI) was induced in the rat model by irreversible left coronary ligation. "
06/01/2001 - "After coronary ligation or arterial occlusion for 1 or 6 hours, sheep had serial hemodynamic and quantitative echocardiographic studies before and after infarction and 2, 5, 8, and 12 weeks later. "
02/01/1985 - "We used a canine preparation of experimental infarction to study the natural course of echocardiographically defined regional wall motion abnormalities in the 6 weeks after acute coronary ligation. "
08/01/2005 - "At follow-up, younger patients who received surgery had significantly better outcome with mean BI of 75.42 and Rankin score of 3.00; however, none of the elderly survivors had a BI score above 60 or a Rankin score below 4. Decompressive craniectomy in younger patients with malignant MCA territory infarction improves both survival rates and functional outcomes. "
09/01/2001 - "Even though patients in this study were elderly, decompressive craniectomy reduced mortality and improved functional performance, so it seems that this surgery should be aggressively considered for massive infarction of MCA territory."
10/01/2012 - "To evaluate the surgical efficacy of and factors associated with decompressive craniectomy in patients with an internal carotid artery (ICA) territory infarction. "
10/01/2012 - "The clinical efficacy of decompressive craniectomy in patients with an internal carotid artery territory infarction."
09/01/2011 - "To demonstrate the efficacy of a vascular protection technique during decompressive craniectomy (DC) which can reduce the risk of secondary venous infarction due to the blocking pressure for venous outflow through bridging veins. "