Indican

A substance occurring in the urine of mammals and also in blood plasma as the normal metabolite of tryptophan. An increased urinary excretion of indican is seen in Hartnup disease from the bacterial degradation of unabsorbed tryptophan.

Also Known As:

Networked: 592 relevant articles (10 outcomes, 58 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Niwa, Toshimitsu: 36 articles (01/2022 - 01/2002)
2.	Nishijima, Fuyuhiko: 17 articles (05/2014 - 01/2008)
3.	Shimizu, Hidehisa: 16 articles (05/2014 - 08/2009)
4.	Brunet, Philippe: 10 articles (04/2020 - 10/2003)
5.	Mafra, Denise: 9 articles (11/2022 - 09/2014)
6.	Maruyama, Toru: 9 articles (12/2021 - 07/2007)
7.	Vanholder, Raymond: 9 articles (09/2021 - 02/2004)
8.	Lin, Cheng-Jui: 9 articles (01/2021 - 01/2011)
9.	Meyer, Timothy W: 8 articles (01/2022 - 07/2008)
10.	Yisireyili, Maimaiti: 8 articles (01/2022 - 01/2012)

Related Diseases

1.	Chronic Kidney Failure (Chronic Renal Failure) 11/01/1997 - "In the present study, we determined whether an oral adsorbent (AST-120) could reduce the serum and urine levels of indoxyl sulfate and suppress the progression of chronic renal failure (CRF) in undialyzed uremic patients. " 01/01/2023 - "The serum concentrations of indoxyl sulfate were higher in the ESRD group (227.29 ± 92.65 μM vs. 41.97 ± 43.96 μM and 6.54 ± 3.45 μM for the CKD and control groups, respectively; p < 0.05). " 01/01/2023 - "Indoxyl sulfate mediates low handgrip strength and is predictive of high hospitalization rates in patients with end-stage renal disease." 01/01/2020 - "Indoxyl Sulfate-Mediated Metabolic Alteration of Transcriptome Signatures in Monocytes of Patients with End-Stage Renal Disease (ESRD)." 03/01/2018 - "The vascular endothelium is permanently exposed to uraemic toxins including indoxyl sulfate, which provokes endothelial damage in subjects with end-stage renal disease. "
2.	Chronic Renal Insufficiency 11/16/2023 - "These studies present a non-bactericidal pan-inhibitor of gut microbial tryptophanases with potential promise for reducing indoxyl sulfate in chronic kidney disease." 01/15/2019 - "Although an emerging body of evidence has suggested that indoxyl sulfate is a key substance for the development of chronic kidney disease, few studies have investigated the direct association of indoxyl sulfate with vascular function. " 11/04/2013 - "The present study explored the effect of indoxyl sulfate, an uremic toxin accumulated in blood of patients with chronic kidney disease. " 11/16/2023 - "Indoxyl sulfate is a microbially derived uremic toxin that accumulates in late-stage chronic kidney disease and contributes to both renal and cardiovascular toxicity. " 10/30/2023 - "The accumulation of the uremic toxin indoxyl sulfate (IS) is a key pathological feature of chronic kidney disease (CKD). "
3.	Cardiovascular Diseases (Cardiovascular Disease) 11/24/2022 - "High indoxyl sulfate (IS) concentration is a serious problem for patients with CKD increasing the risk of cardiovascular diseases and CKD progression. " 01/01/2022 - "The association between serum total indoxyl sulfate (tIS), and cardiovascular disease (CVD) and all-cause mortality is a matter of debate. " 02/01/2021 - "Indoxyl sulfate (IS) is related to the development of cardiovascular disease and total mortality in dialysis patients. " 11/02/2020 - "After adjusting for traditional risk factors for PAD, including age, current smoking, diabetes, and cardiovascular disease, indoxyl sulfate was significantly associated with the risk of PAD (hazard ratio (HR), 1.19 for every 10-μg/mL increase in indoxyl sulfate; 95% confidence interval (CI), 1.05-1.35). " 12/25/2018 - "This article reviews the research progress of uremic toxin indoxyl sulfate in end-stage renal diseases associated cardiovascular diseases."
4.	Renal Insufficiency (Renal Failure) 01/01/2001 - "An oral adsorbent ameliorates renal overload of indoxyl sulfate and progression of renal failure in diabetic rats." 08/27/2020 - "Indoxyl sulfate (IS) is accumulated during severe renal insufficiency and known for its nephrotoxic properties. " 09/01/2018 - "The uremic toxin, indoxyl sulfate (IS), accumulates in the blood in cases of renal failure and leads to bone loss. " 01/01/2018 - "Compared with the non-progression groups, across different stages of renal failure, the baseline plasma indoxyl sulfate concentration was increased in the renal progression group (P<0.05), especially for IRIS stages 2 and 3 animals. " 01/01/2017 - "Elevated concentrations of indoxyl sulfate, the vast majority of parameters affecting hemostasis, and markers of renal insufficiency conditions were observed. "
5.	Blind Loop Syndrome (Bacterial Overgrowth Syndrome) 05/01/1973 - "This diagnostic procedure was applied to the identification of patients with steatorrhoea due to the stagnant loop syndrome, and was compared with other tests for this condition, viz, study of the small intestinal bacterial flora, urinary indican excretion, and the Schilling test with added intrinsic factor. " 01/01/1976 - "Value of urinary simple phenol and indican determinations in the diagnosis of the stagnant loop syndrome." 01/01/1976 - "When applied as diagnostic tests for the stagnant loop syndrome, the phenol excretion showed 2 false negative results, the p-cresol excretion 3 false negative and 2 false positive results, and the indican excretion 6 false positive results. " 01/01/1976 - "The mean excretion of the compounds in the patients with the stagnant loop syndrome and in the control patients, respectively, was 77 and 2.3 mg/24 h of phenol (p less than 0.05), 164 and 39.5 mg/24 h of p-cresol (n.s.), and 369 and 41.5 mg/24 h of indican (p less than 0.01). " 01/01/1976 - "The urinary excretion of phenol, p-cresol, and indican was determined in 7 patients with the stagnant loop syndrome, 26 patients with coeliac disease, chronic pancreatitis, and partial gastrectomy, and 18 control patients. "

Related Drugs and Biologics

1.	Uremic Toxins
2.	Proteins (Proteins, Gene)
3.	Sulfates (Sulfates, Inorganic)
4.	AST 120
5.	4-cresol sulfate
6.	Biomarkers (Surrogate Marker)
7.	4-cresol (p-cresol)
8.	Phenol (Carbolic Acid)
9.	Urea (Carbamide)
10.	Polyamines

Related Therapies and Procedures

1.	Therapeutics
2.	Protein-Restricted Diet (Diet, Protein Restricted)
3.	Renal Dialysis (Hemodialysis)
4.	Nephrectomy
5.	Catheter Ablation