|4.||Wasting Syndrome (Wasting Disease)
|5.||Craniocerebral Trauma (Head Injury)
|1.||Verbalis, Joseph G: 14 articles (01/2014 - 01/2002)|
|2.||Decaux, Guy: 11 articles (01/2014 - 01/2004)|
|3.||Peri, Alessandro: 5 articles (01/2015 - 03/2012)|
|4.||Maesaka, John K: 5 articles (01/2014 - 02/2009)|
|5.||Hensen, J: 4 articles (07/2015 - 12/2010)|
|6.||Soupart, Alain: 4 articles (01/2014 - 11/2006)|
|7.||Musch, Wim: 4 articles (01/2014 - 01/2004)|
|8.||Saito, T: 4 articles (04/2004 - 04/2001)|
|9.||Decaux, G: 4 articles (11/2003 - 10/2000)|
|10.||Burst, Volker: 3 articles (01/2015 - 03/2012)|
12/01/2002 - "Serum antidiuretic hormone (ADH) remained elevated at 0.59 pg/ml in spite of a significant reduction in serum osmolality to 254 mosm/kg. He had no organic disease likely to cause SIADH. "
12/01/2014 - "The goals of this study were to assess the incidence of and risk factors for the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in patients following transsphenoidal surgery (TSS), and to validate the effectiveness of early prophylactic restriction of water intake. "
09/01/1988 - "This study explored whether atrial natriuretic hormone (ANH) might be involved in the escape from salt and water retention that occurs in patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH). "
12/01/2015 - "To determine the distribution of etiologies for the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in hospitalized patients and to characterize patients according to the different etiologies. "
12/01/2015 - "Herein, we report a 6-month-old presenting with syndrome of inappropriate antidiuretic hormone secretion (SIADH) and a suprasellar mass. "
|2.||Urea (Carbamide)FDA LinkGeneric
07/01/2008 - "In SIADH, urea is typically low; this is less specific for elderly patients, for whom lower clearance of urea accounts for higher values. "
01/01/1993 - "Oral urea, even during long periods, is a safe and effective therapeutic approach for patients with chronic SIADH which is not controlled by water restriction alone."
05/01/2012 - "This prospective, long-term study compared the efficacy, tolerability, and safety of two oral vaptans with those of oral urea in patients with SIADH. "
05/01/2012 - "Urea has efficacy similar to that of vaptans for treatment of chronic SIADH. "
05/01/2012 - "Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH."
05/01/2011 - "In patients with SIADH, improvement in serum [Na(+)] was significantly greater (P<0.0001) with tolvaptan than placebo over the first 4 days of therapy as well as the entire 30-day study, with minimal side effects of increased thirst, dry mouth, and urination. "
07/01/2015 - "Although some details from this now concluded register have been published, the final publication of the multinational post-authorization safety study on tolvaptan in the treatment of SIADH has not yet been published. "
02/01/2012 - "Based on the SALT-1 and SALT-2 trials, tolvaptan usage is associated with a shorter hospital LOS than placebo among patients with the SIADH. "
02/01/2012 - "In the SALT-1 and SALT-2 trials, patients with the SIADH receiving tolvaptan had a shorter hospital LOS than patients receiving placebo (4.98 vs 6.19 days, respectively). "
10/01/2010 - "Clinical evaluation of tolvaptan in this setting is based on two comparative double-blind placebo-controlled trials including a total of 448 patients with SIADH or hyponatraemia from various other causes. "
07/01/2008 - "Urine biology can also be helpful in diagnosis of SIADH because patients with SIADH have high urine sodium (Na; >30 mEq/L), and most of them will have a high fractional excretion of Na (>0.5% in 70% of cases), reflecting salt intake. "
04/01/2011 - "In short and long term studies, tolvaptane has been shown to be effective in raising serum sodium levels in a predictable fashion in patients with SIADH with only few side effects, when serum sodium was frequently monitored and dosage of tolvaptans was properly adjusted. "
01/01/2001 - "PNa improved after 2 liters isotonic saline over 24 hours in 90 patients (85%) as opposed to 12 others (9 SIADH and 3 diuretic patients), decreasing their plasma sodium. "
06/01/1999 - "A review of renal/CSWS reveals three studies involving hyponatremic neurosurgical patients who had decreased blood volume, decreased central venous pressure, and inappropriately high urinary sodium concentrations in the majority of them, suggesting that CSWS was more common than SIADH in neurosurgical patients. "
07/01/1986 - "Nine days after admission, she still remained lethargic, and laboratory studies showed a serum sodium value of 93 mEq/l, serum osmolarity 206 mOsm/l and urine osmolarity 270 mOsm/l when she was clinically diagnosed as having SIADH. "
|5.||Vasopressin Receptors (Arginine Vasopressin Receptor)IBA
01/01/2014 - "However, the recently developed vasopressin receptor antagonist class of drugs provides a very useful tool in the management of neurosurgical SIADH. "
08/15/2001 - "In this review, SIADH and other water retaining disorders are briefly discussed, after which the published preclinical and clinical studies in the development of several nonpeptide AVP V2 receptor antagonists are summarized. "
11/01/2013 - "Vaptans, vasopressin V2 receptor antagonists, are new drugs indicated in the treatment of Inappropriate ADH Secretion Syndrome (SIADH). "
10/01/2013 - "Four types of SIADH exist; 10 % of cases represent not SIADH but SIAD (syndrome of inappropriate antidiuresis) due to a constitutive activation of vasopressin receptor that produces water excess. "
04/01/2012 - "Recently vasopressin receptor antagonists, called vaptans, have been introduced as specific and direct therapy of SIADH. "
|6.||Uric Acid (Urate)IBA
01/01/1988 - "In Group C six of the nine had abnormally increased fractional clearance of uric acid (31.6 +/- 3.8) in addition to accepted biochemical criteria of SIADH. "
10/01/2000 - "This study examines the effects of a 2-L infusion of isotonic saline over 24 hours on FE of uric acid in 9 normonatremic volunteers and 17 hyponatremic patients with SIADH. "
09/01/2015 - "Of the 35 patients, 19 (54%) had SIADH; 20 (57%) also had hypouricemia (uric acid level lower than 4 mg/dl). "
11/01/2009 - "We review the persistence of hypouricemia and increased fractional excretion of urate in RSW as compared to correction of both in SIADH, the appropriateness of ADH secretion in RSW, and the importance of differentiating renal RSW from SIADH because of disparate treatment goals: fluid repletion in RSW and fluid restriction in SIADH. "
07/01/2008 - "Low levels of uric acid are more often seen in SIADH (70%) compared with salt-depleted patients (40%). "
05/01/2005 - "The pharmacologic blockade of AVP stimulus in SIADH limits its therapeutic efficacy by discontinuing the vasopressin escape, and the selective inhibition of rBSC1 complements this limitation."
01/01/1998 - "Although resetting of the osmotic threshold for vasopressin release was demonstrated in these studies, this does not seem to have been a primary factor in the development of SIADH in this patient. "
05/01/2013 - "Inappropriate apelin concentrations and apelin to copeptin ratios as a function of natremia in SIADH and CHF patients suggest that the increase in plasma apelin secretion cannot compensate for the higher levels of vasopressin release and may contribute to the corresponding water metabolism defect."
09/01/2010 - "The introduction of small molecule vasopressin receptor-2 (VR2) antagonists, so called vaptans, into clinical medicine for the treatment of SIADH makes a reliable diagnosis of SIADH mandatory. "
01/01/2008 - "The disease results frequently from inappropriate secretion of vasopressin (SIADH). "
|8.||Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric
01/01/2008 - "The SIADH rats, but not the dDAVP-excess rats, showed a marked attenuation of urinary concentrating ability. "
01/01/2008 - "We compared the experimental SIADH rats with 1-deamino-8-D-AVP (dDAVP)-excess rats. "
04/01/2004 - "The SIADH rats, but not the dDAVP excess rats, showed a marked attenuation of urinary concentrating ability. "
04/01/2004 - "We compared experimental SIADH with 1-deamino-8-d-arginine vasopressin (dDAVP)-excess rats, where both groups received continuous subcutaneous administration of dDAVP by osmotic minipump but the SIADH rats also received a liquid diet that induced hyponatraemia. "
01/01/1986 - "A new rat model of the Schwartz--Bartter syndrome was created by the administration of 1-deamino-8-D-arginine vasopressin together with a forced water intake. "
11/01/2000 - "The therapeutic efficacy of VP-343, a selective vasopressin V2 receptor antagonist, in the experimental SIADH rat model."
08/01/2001 - "These results demonstrate the occurrence of histopathologic abnormalities in the kidney and the efficacy of VP-343 in improving abnormalities in the DDAVP-induced SIADH rat model."
08/01/2001 - "Histopathological study of kidney abnormalities in an experimental SIADH rat model and its application to the evaluation of the pharmacologic profile of VP-343, a selective vasopressin V2 receptor antagonist."
11/01/2000 - "These results indicate that VP-343 has efficacy to normalize the abnormalities in DDAVP-induced SIADH."
08/01/2001 - "The aim of this work was to investigate histopathologically the relationship between the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and kidney abnormalities and the therapeutic efficacy of VP-343 ((N-[4-[[(2S,3aR)-2-hydroxy-2,3,3a,4-tetrahydropyrrolo[1,2-alqunoxalin-5(1H)-yl]phenyl]-4'-methyl[1,1'-biphenyl]-2-carboxamide], a selective vasopressin V2 receptor antagonist, in an experimental SIADH rat model. "
|10.||Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA
11/01/2012 - "Effective treatment of SIADH is based on water restriction, hypertonic saline plus loop diuretics, or aquaretics. "
05/15/2004 - "Loop diuretics are useful in managing edematous hyponatremic states and chronic SIADH. "
10/01/2010 - "Effective treatment of SIADH with water restriction, aquaretics, or hypertonic saline + loop diuretics, as opposed to worsening of hyponatremia during parenteral isotonic fluid administration, underscores the importance of an early accurate diagnosis and careful follow-up of these patients."
05/01/2012 - "While hypovolaemic hyponatremia needs to be corrected with the replacement of the lost extracellular fluid by isotonic saline, euvolaemic (SIADH) and hypervolaemic hyponatremia (oedematous states like decompensated heart failure, liver cirrhosis, i.e.) are treated by restriction of fluid intake, loop diuretics and hypertonic saline. "
01/01/2014 - "Prospective studies showing the benefit to treat mild chronic hyponatremia due to SIADH and comparing water restriction, urea, high ceiling diuretics, and antivasopressin antagonist antagonist should be done. "
|1.||Drug Therapy (Chemotherapy)
11/01/2005 - "Uniquely in this case, after chemotherapy the paraneoplastic SIADH improved in parallel with a tumour response and this has not been reported previously."
01/01/2004 - "Several types of tumour and different chemotherapy drugs can produce this SIADH. "
01/01/2004 - "There was no further recurrence of SIADH after the curative surgery and chemotherapy. "
10/01/2001 - "She developed SIADH 48 hours following chemotherapy. "
04/01/1998 - "On the ninth day after chemotherapy of VCR, a consciousness disturbance was found and he was diagnosed as having SIADH. "
01/01/2004 - "After successful chemotherapy and radiotherapy treatment for the neoplasm, her SIADH resolved. "
04/01/2010 - "Carcinomatous meningitis complicated by SIADH was diagnosed and treatment for hyponatremia and whole brain radiotherapy were performed; however, she died two weeks after the radiation therapy. "
03/01/2015 - "We present a case of SIADH, heralding small cell lung cancer and persisting after apparent complete remission of primary tumor following chemotherapy/radiotherapy, in a patient who underwent long-term treatment with tolvaptan without any serious adverse effects. "
|3.||Combination Drug Therapy (Combination Chemotherapy)
08/01/1986 - "SIADH occurred most often with initial presentation (33 of 40), and resolved promptly (less than 3 weeks) with initiation of combination chemotherapy in 80% of evaluable patients. "
01/01/1983 - "However, the initial treatment of choice for SIADH associated with small cell carcinoma of the lung is combination chemotherapy."
01/01/1983 - "Intensive combination chemotherapy produced objective tumor responses in all patients, and syndrome of inappropriate ADH secretion (SIADH) resolved in 16 of 17 evaluable patients within three weeks of initiation of treatment. "
12/01/1998 - "Fluid restriction improved SIADH, and combination chemotherapy for SCLC improved the lactic acidosis although the tumor size did not change."
|4.||Fluid Therapy (Oral Rehydration Therapy)
11/01/1994 - "SIADH is commonly associated with TBM and should be diagnosed early in order to modify the fluid therapy in these cases.(ABSTRACT TRUNCATED AT 250 WORDS)"
10/01/1981 - "Fluid therapy for these patients is described, and the treatment of SIADH is discussed."
01/01/1991 - "Common clinical examples include hastened rehydration therapy, the dialysis disequilibrium syndrome, compulsive polydipsia, the syndrome of inappropriate ADH secretion (SIADH) and post-TURP syndrome. "
01/01/1984 - "This study shows that children with acute asthma are ordinarily not at high risk of SIADH and fluid therapy should be included in the management. "
01/01/2001 - "In a literature review of fluid and electrolyte disturbances and the effect of fluid therapy in bacterial/tuberculous meningitis, the prevalence of hyponatraemia, hypoosmolality and SIADH varied considerably; apparently, non-osmotic stimuli for the secretion of ADH, e.g. "
|5.||Neck Dissection (Radical Neck Dissection)
12/01/2002 - "The purpose of the present study was to test this assumption in an animal model that more closely resembles the clinical condition of bilateral radical neck dissection, in an attempt to discover possible surgical methods for preventing SIADH. "
11/01/2002 - "No clinical symptoms developed in the patients with SIADH, but it seems prudent to suggest limiting fluid intake in the first postoperative 24 hours for patients following neck dissection."
11/01/2002 - "SIADH following neck dissection may be less common than formerly reported. "
11/01/2002 - "The incidence of SIADH in a cohort of patients who underwent neck dissection was prospectively studied. "
11/01/2002 - "The incidence of SIADH following neck dissection was found to be 18% to 30% in two separate reports. "