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IMP Dehydrogenase

An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 1.1.1.205.
Also Known As:
Inosine-5-Monophosphate Dehydrogenase; Acid Dehydrogenase, Inosinic; Dehydrogenase, IMP; Dehydrogenase, Inosine-5-Monophosphate; Dehydrogenase, Inosinic Acid; Inosine 5 Monophosphate Dehydrogenase; Inosinic Acid Dehydrogenase; IMP:NAD+ oxidoreductase
Networked: 137 relevant articles (3 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hall, I H: 6 articles (07/2001 - 07/2000)
2. Hedstrom, Lizbeth: 4 articles (01/2014 - 08/2005)
3. Barnes, B J: 4 articles (07/2001 - 04/2001)
4. Izydore, R A: 4 articles (07/2001 - 01/2001)
5. Warren, A E: 3 articles (07/2001 - 01/2001)
6. Wheaton, J R: 3 articles (07/2001 - 01/2001)
7. Li, Min: 2 articles (05/2015 - 09/2008)
8. Mizushina, Yoshiyuki: 2 articles (08/2013 - 11/2009)
9. Sugawara, Fumio: 2 articles (08/2013 - 11/2009)
10. Takeuchi, Toshifumi: 2 articles (08/2013 - 11/2009)

Related Diseases

1. Infections
07/01/2015 - "When mice were immunized with an attenuated mutant strain into which IMP dehydrogenase had been inserted with a transposon, they were protected against V. vulnificus infection. "
12/01/2011 - "IMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice."
08/01/2006 - "Our data do not support the use of ribavirin or other IMP dehydrogenase inhibitors for treating SARS infections in humans."
08/01/2006 - "Because of the conflicting data concerning the SARS-CoV inhibitory efficacy of ribavirin, an inosine monophosphate (IMP) dehydrogenase inhibitor, studies were done to evaluate the efficacy of ribavirin and other IMP dehydrogenase inhibitors (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR), mizoribine, and mycophenolic acid) in preventing viral replication in the lungs of BALB/c mice, a replication model for severe acute respiratory syndrome (SARS) infections (Subbarao, K., McAuliffe, J., Vogel, L., Fahle, G., Fischer, S., Tatti, K., Packard, M., Shieh, W.J., Zaki, S., Murphy, B., 2004. "
07/01/2009 - "The ten stories told here deal with (i) ribavirin as an inhibitor of IMP dehydrogenase and (ii) ribavirin, in combination with pegylated interferon, as the present "standard of care" for hepatitis C; (iii) S-adenosylhomocysteine hydrolase inhibitors as antiviral agents; (iv) new adamantadine derivatives for the treatment of influenza A virus infections; (v) 5-substituted 2'-deoxyuridines (i.e. "
2. Severe Acute Respiratory Syndrome
3. Hepatocellular Carcinoma (Hepatoma)
4. Carcinogenesis
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Inosine Monophosphate (IMP)
2. Mycophenolic Acid (Cellcept)
3. Enzymes
4. tiazofurin
5. Ribavirin (Virazole)
6. Nucleic Acids
7. Guanosine Triphosphate (GTP)
8. purine
9. DNA (Deoxyribonucleic Acid)
10. Transferases

Related Therapies and Procedures

1. Transplantation
2. Drug Therapy (Chemotherapy)
3. Aftercare (After-Treatment)
4. Therapeutics
5. Intraperitoneal Injections