Immunosuppressive Agents (Immunosuppressants)

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Also Known As:
Immunosuppressants; Agents, Immunosuppressive
Networked: 3323 relevant articles (283 outcomes, 213 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Guillevin, Loïc: 17 articles (08/2015 - 04/2003)
2. Pagnoux, Christian: 14 articles (08/2015 - 04/2003)
3. Cacoub, Patrice: 9 articles (12/2015 - 12/2007)
4. Shoenfeld, Yehuda: 9 articles (09/2013 - 11/2002)
5. Beaugerie, Laurent: 8 articles (09/2015 - 01/2004)
6. Sandborn, William J: 8 articles (09/2014 - 05/2004)
7. Guillevin, L: 7 articles (05/2014 - 12/2000)
8. Mouthon, Luc: 7 articles (01/2012 - 06/2005)
9. Saadoun, David: 6 articles (09/2015 - 11/2009)
10. Peyrin-Biroulet, Laurent: 6 articles (09/2014 - 07/2013)

Related Diseases

1. Infection
2. Uveitis
3. Ulcerative Colitis
4. Pemphigus (Pemphigus Vulgaris)
01/01/2010 - "Thus, we may conclude that: (i) the percentage of patients with oropharyngeal pemphigus vulgaris who achieved complete long-lasting clinical remission was very high; (ii) transient lesions that healed within a week were very frequent and had to be actively controlled; (iii) if treated early, most patients had a good clinical response and could achieve a disease- and drug-free clinical remission; (iv) early treatment may prevent extension or progression of disease; (v) there is a possible role for immunosuppressive agents; and (vi) a more favorable course of the disease, in terms of attainment and duration of clinical remission and a better prognosis, seemed to be related to a rapid response to therapy rather than to the initial severity and extent of the disease."
11/01/2003 - "For the treatment of pemphigus, a course of the lowest possible corticosteroid dosage in combination with immunosuppressive agents appears to be effective and less toxic than a high corticosteroid dosage."
11/01/2002 - "Although pemphigus vulgaris is still a life-threatening disease, today it can be successfully treated with a combination of immunosuppressive agents. "
10/12/2015 - "Eliminating possible drug PV/PF triggers/sustainers may alleviate the clinical symptoms and enable the decrease of dose/range of immunosuppressants regardless of pemphigus form."
10/12/2015 - "Drug triggering should be suspected in every case of newly diagnosed or exacerbated pemphigus, as eliminating possible PV/PF triggers/sustainers may alleviate the clinical symptoms and enable the decrease of dose/range of immunosuppressants regardless of pemphigus form. "
5. Proteinuria

Related Drugs and Biologics

1. Adrenal Cortex Hormones (Corticosteroids)
2. Steroids
3. Cyclosporine (Ciclosporin)
4. Azathioprine (Imuran)
5. Tacrolimus (Prograf)
6. Cyclophosphamide (Cytoxan)
7. Methotrexate (Mexate)
8. Glucocorticoids
9. mycophenolate mofetil (Cellcept)
10. rituximab (Mabthera)

Related Therapies and Procedures

1. Transplants (Transplant)
2. Transplantation (Transplant Recipients)
3. Plasma Exchange
4. Aftercare (After-Treatment)
5. Plasmapheresis