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Immunoproliferative Small Intestinal Disease

A condition that is caused by HYPERPLASIA of LYMPHOCYTES in the small intestine (INTESTINE, SMALL) and the mesenteric LYMPH NODES. These lymphocytes produce an anomalous alpha heavy chain protein. Generally, these IPSID patients have either concurrent LYMPHOMA or develop lymphoma within a few years. The disease was first described in the Mediterranean region and is characterized by malabsorption; WEIGHT LOSS; DIARRHEA; and STEATORRHEA.
Also Known As:
Disease, alpha-Chain; Diseases, alpha-Chain; Mediterranean Lymphoma; alpha Chain Disease; alpha-Chain Diseases; Heavy Chain Disease, IgA Type; IPSID; Lymphoma, Mediterranean; alpha-Chain Disease
Networked: 69 relevant articles (7 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Lymphoma (Lymphomas)
2. Non-Hodgkin Lymphoma (Lymphosarcoma)
3. Immunoproliferative Small Intestinal Disease
4. Heavy Chain Disease
5. Marginal Zone B-Cell Lymphoma (MALT Lymphoma)

Experts

1. Suarez, Felipe: 2 articles (04/2006 - 01/2004)
2. Lecuit, Marc: 2 articles (04/2006 - 01/2004)
3. Lortholary, Olivier: 2 articles (04/2006 - 01/2004)
4. Criscuolo, A: 1 article (09/2014)
5. Lecuit, M: 1 article (09/2014)
6. Arsène, D: 1 article (09/2014)
7. de La Blanchardière, A: 1 article (09/2014)
8. Coeuret, S: 1 article (09/2014)
9. Brisse, S: 1 article (09/2014)
10. Chèze, S: 1 article (09/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Immunoproliferative Small Intestinal Disease:
1. Anti-Bacterial Agents (Antibiotics)IBA
2. Tetracycline (Achromycin)FDA LinkGeneric
3. Cyclophosphamide (Cytoxan)FDA LinkGeneric
4. Vincristine (Oncovin)FDA LinkGeneric
5. Prednisolone (Predate)FDA LinkGeneric
6. Sulfasalazine (Azulfidine)FDA LinkGeneric
7. Melphalan (Alkeran)FDA LinkGeneric
8. Mebendazole (Vermin)FDA Link
9. OPPA protocolIBA
10. Immunoglobulin A (IgA)IBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Laparotomy
3. Combination Drug Therapy (Combination Chemotherapy)
4. Transplants (Transplant)
5. Pancreaticoduodenectomy