Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)

The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.
Also Known As:
Immunoglobulin Heavy Chain; Heavy Chain, Immunoglobulin; Heavy-Chain Immunoglobulins; Ig Heavy Chains; Immunoglobulin Heavy Chain Subgroup VH-I; Immunoglobulin Heavy Chain Subgroup VH-III; Heavy Chain Immunoglobulins; Heavy Chains, Ig; Heavy Chains, Immunoglobulin; Immunoglobulin Heavy Chain Subgroup VH I; Immunoglobulin Heavy Chain Subgroup VH III; Immunoglobulins, Heavy Chain; Immunoglobulins, Heavy-Chain
Networked: 1295 relevant articles (13 outcomes, 88 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Medeiros, L Jeffrey: 11 articles (04/2013 - 04/2002)
2. Keating, Michael J: 10 articles (08/2014 - 06/2003)
3. Nakamura, Naoya: 10 articles (07/2013 - 06/2002)
4. Gribben, John G: 9 articles (01/2015 - 07/2002)
5. Wierda, William G: 9 articles (08/2014 - 06/2003)
6. Yoshino, Tadashi: 9 articles (07/2013 - 09/2004)
7. Abe, Masafumi: 8 articles (07/2013 - 06/2002)
8. Neri, Antonino: 8 articles (06/2013 - 02/2005)
9. Taniwaki, Masafumi: 8 articles (04/2011 - 04/2003)
10. Gaidano, Gianluca: 7 articles (09/2014 - 05/2002)

Related Diseases

1. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
2. Residual Neoplasm
05/01/2014 - "In the case of long-term remission (≥5 years; n = 8), peripheral blood was tested for minimal residual disease (MRD) by t(11; 14) polymerase chain reaction (PCR) and immunoglobulin heavy-chain (IGH) PCR at the last follow-up. "
06/01/2014 - "In this study, we compared immunoglobulin heavy-chain-gene-based minimal residual disease (MRD) detection by real-time quantitative PCR (RQ-PCR) and next-generation sequencing (NGS) to assess whether NGS could overcome some limitations of RQ-PCR and further increase sensitivity, specificity, accuracy and reproducibility. "
04/01/2013 - "In this study we aimed to assess the value of real-time polymerase chain reaction (RT-PCR) for detecting the immunoglobulin heavy chain (IgH) gene rearrangement using allele-specific molecular beacons as fluorescence probes to quantify minimal residual disease (MRD) and also to correlate post-treatment flow cytometric detection of plasma cells' (PCs) expression of CD19, CD38, CD45, CD56 and CD138 in MM. After diagnosis of 17 MM patients, the CDR1, CDR2 and CDR3 regions of the IgH gene were analysed and sequenced to identify IgH's clonal nature. "
06/01/2011 - "Furthermore, progress in the identification of minimal residual disease (MRD) using consensus primer or patient specific polymerase chain reaction for the immunoglobulin heavy chain variable region gene (IGHV), as well as multiparameter flow cytometry, allows for the detection and eradication of MRD. "
06/01/2006 - "Minimal residual tumor clone identical with the primary lesion was detected using the polymerase chain reaction (PCR) clonality assay for immunoglobulin heavy chain gene (IgH) rearrangement. "
3. Lymphoma (Lymphomas)
4. B-Cell Lymphoma (Lymphoma, B Cell)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Complementarity Determining Regions (Complementarity Determining Region)
2. DNA (Deoxyribonucleic Acid)
3. gamma-delta T-Cell Antigen Receptors (T-Cell Receptor delta-Chain)
4. Oligonucleotides
5. Recombinant DNA (Recombinant DNA Research)
6. T-Cell Antigen Receptors (T-Cell Receptor)
7. Paraffin
8. Carbon Monoxide
9. Immunoglobulins (Immunoglobulin)
10. alpha-beta T-Cell Antigen Receptors (T-Cell Receptor alpha-Chain)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Stem Cell Transplantation
3. Transplants (Transplant)
4. Aftercare (After-Treatment)
5. Vitrectomy