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Immunoglobulin Variable Region

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That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.

Also Known As:

Framework Region, Immunoglobulin; Ig Framework Region; Ig Variable Region; Immunoglobulin Framework Region; Immunoglobulin V; Framework Region, Ig; Framework Regions, Ig; Framework Regions, Immunoglobulin; Ig Framework Regions; Ig Variable Regions; Immunoglobulin Framework Regions; Immunoglobulin Variable Regions; Regions, Immunoglobulin Variable; Variable Regions, Ig; Variable Regions, Immunoglobulin; Variable Region, Ig; Variable Region, Immunoglobulin

Networked: 118 relevant articles (1 outcomes, 9 trials/studies) for this Bio-Agent, Comments

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Bio-Agent Context: Research Results

Experts

1.	Stevenson, Freda K: 6 articles (03/2008 - 02/2002)
2.	Rosenquist, Richard: 5 articles (07/2005 - 04/2003)
3.	Ottensmeier, Christian H: 4 articles (03/2008 - 04/2002)
4.	Thunberg, Ulf: 4 articles (07/2005 - 04/2003)
5.	Sundström, Christer: 4 articles (07/2005 - 04/2003)
6.	Steiman-Shimony, Avital: 3 articles (09/2008 - 04/2006)
7.	Mehr, Ramit: 3 articles (09/2008 - 04/2006)
8.	Barak, Michal: 3 articles (09/2008 - 04/2006)
9.	Stott, David I: 3 articles (12/2006 - 01/2005)
10.	Vilpo, Leena: 3 articles (07/2005 - 04/2003)

Related Diseases

1.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 06/15/2005 - "B-cell chronic lymphocytic leukemia (CLL) consists of 2 prognostic entities where cases with mutated immunoglobulin V(H) genes have better outcome than unmutated cases. " 12/01/2009 - "The mutational status of the immunoglobulin variable region heavy chain genes (IGHV) is an important prognostic marker in chronic lymphocytic leukemia (CLL). " 03/01/2007 - "PURPOSE: Genomic features including unmutated immunoglobulin variable region heavy chain (IgVH) genes, del(11q22.3), del(17p13.1), and p53 mutations have been reported to predict the clinical course and overall survival of patients with chronic lymphocytic leukemia (CLL). " 11/01/2006 - "Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia." 01/01/2006 - "Immunoglobulin V(H) genes and CD38 expression analysis in B-cell chronic lymphocytic leukemia." Order ALL the reference details at left...
2.	Lymphoma (Lymphomas) 03/15/2002 - "In the present study, we analyzed individual follicles of 3 FLs by micromanipulation of single cells from individual lymphoma follicles and amplification of immunoglobulin V region genes. " 11/15/1993 - "Moreover, certain sets of somatic mutations distinguish the Ig variable region genes used by RS lymphoma from those expressed by the CLL B cells. " 12/01/2001 - "In this study, we applied a single cell polymerase chain reaction approach to analyze immunoglobulin V(H)/V(L) genes in 532 individual B lymphocytes from histologic sections of four follicle center cell lymphomas localized on the head and trunk, and four large B cell lymphomas on the leg. " 06/01/1997 - "In the present study, a total of 19 cases of DLL (10 cases of centroblastic lymphoma, 5 cases of mediastinal B cell lymphoma, 2 cases of immunoblastic lymphoma, 1 case of T cell-rich B lymphoma and one case of large cell anaplastic lymphoma) were analyzed for somatically mutated immunoglobulin V region genes. " 08/01/1998 - "Somatic mutations in the Ig variable region genes and expression of novel Cmu-germline transcripts in a B-lymphoma cell line ("Farage") not producing Ig polypeptide chains." Order ALL the reference details at left...
3.	Neoplasms (Cancer) 11/01/2007 - "Immunoglobulin variable region gene analysis to the autoantibody-secreting B cells from tumors in association with paraneoplastic autoimmune multiorgan syndrome." 09/01/2005 - "In three cases, genealogical trees were constructed based on the immunoglobulin variable region heavy chain (IgV(H)) gene sequences of tumor clones from LNs and BMs. " 09/01/2003 - "In these tumors, the somatic hypermutation (SHM) process that normally targets immunoglobulin V (IgV) genes in B cells appears to misfire and causes mutations in the 5' sequences of multiple proto-oncogenes, including PIM-1, PAX-5, RhoH/TTF, and c-MYC. " 01/01/2003 - "Our data suggest, that potential tumor binder Ig VH and VL sequences might be selected using a detailed immunoglobulin variable region analysis. " 01/01/2001 - "The Ig variable region genes of B cell tumors present a considerable asset for this area of investigation. " Order ALL the reference details at left...
4.	B-Cell Lymphoma (Lymphoma, B Cell) 03/05/2002 - "Here we show that disruption of AID in the DT40 chicken B cell lymphoma leads to a failure to perform immunoglobulin V gene conversion. " 08/30/2001 - "Here we show that if the RAD51 paralogues XRCC2, XRCC3 or RAD51B are ablated the pattern of diversification of the immunoglobulin V gene in the chicken DT40 B-cell lymphoma line exhibits a marked shift from one of gene conversion to one of somatic hypermutation. " 02/15/2001 - "Hepatitis C virus (HCV)-associated B cell lymphomas were previously shown to express a restricted repertoire of immunoglobulin V(H) and V(L) genes, V(H)1-69 and VkappaA27, respectively. " 10/15/1988 - "Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas." 07/01/1987 - "Retention of an idiotypic determinant in a human B-cell lymphoma undergoing immunoglobulin variable-region mutation." Order ALL the reference details at left...
5.	Rheumatoid Arthritis 04/05/1997 - "Immunoglobulin variable region (IgV) gene expression in rheumatoid factors from monozygotic twins with rheumatoid arthritis." 07/01/1995 - "Monozygotic rheumatoid arthritis twin pairs express similar levels of conserved immunoglobulin V gene in polyclonal rheumatoid factors irrespective of disease status." 11/01/1992 - "Immunoglobulin V genes in rheumatoid arthritis." 02/01/1993 - "Restricted immunoglobulin variable region gene usage by hybridoma rheumatoid factors from patients with systemic lupus erythematosus and rheumatoid arthritis." 08/01/1994 - "A study was performed to compare the use of immunoglobulin V gene segments by rheumatoid factors (RF) produced in physiological responses following a defined antigenic stimulus, with RF produced in rheumatoid arthritis (RA) and RF produced as monoclonal (M)-components in certain lympho-proliferative diseases. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Epitopes
2.	Myeloma Proteins
3.	Antibodies
4.	Immunoglobulins (Immunoglobulin)
5.	Antigens
6.	Immunoglobulin M (IgM)
7.	Autoantibodies
8.	Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)
9.	DNA (Deoxyribonucleic Acid)
10.	Vaccines

Related Therapies and Procedures

1.	Immunotherapy

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