Immunoglobulin Idiotypes (Idiotype, Immunoglobulin)

Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.

Also Known As:

Networked: 67 relevant articles (6 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Timmerman, John M: 5 articles (03/2009 - 06/2003)
2.	Neelapu, Sattva S: 4 articles (09/2011 - 01/2007)
3.	Levy, Ronald: 4 articles (01/2011 - 12/2004)
4.	Hollander, Nurit: 4 articles (01/2009 - 03/2002)
5.	Levy, R: 4 articles (03/2001 - 01/2000)
6.	Flowers, Christopher R: 3 articles (11/2016 - 06/2007)
7.	Kwak, Larry W: 3 articles (09/2011 - 01/2007)
8.	Haimovich, Joseph: 3 articles (03/2008 - 03/2002)
9.	Levy, Shoshana: 2 articles (01/2011 - 04/2007)
10.	Swartz, James R: 2 articles (01/2011 - 04/2007)

Related Diseases

1.	Lymphoma (Lymphomas) 06/01/2008 - "For lymphoma, vaccination with subject-specific immunoglobulin idiotypes has had the most promising results. " 04/10/2013 - "He has been active in research on the treatment of malignant lymphoma including new treatments targeting CD30, CD40, HLA Class II molecules and immunoglobulin idiotype. " 05/01/2004 - "The ability to generate in vitro T cells to peptides derived from immunoglobulin idiotypes raises the possibility of directly using such cells as a treatment of lymphoma. " 02/15/2000 - "Stimulation of cytotoxic T cells against idiotype immunoglobulin of malignant lymphoma with protein-pulsed or idiotype-transduced dendritic cells." 10/01/1996 - "Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response."
2.	Neoplasms (Cancer) 01/01/2007 - "Immunization with the clonal tumor immunoglobulin, idiotype, expressed on the surface of B-cell malignancies was associated with induction of tumor-specific cellular and humoral immunity, molecular remissions, and prolonged disease-free survival in early clinical trials. " 01/31/2002 - "Unique Sfi I restriction sites were used for the rapid cloning of any tumor specific immunoglobulin idiotype domains and a series of plasmid constructs were made to test changes to the J domain and/or the human C domain to insert the Sfi I restriction sites. " 11/15/2000 - "BsAb were directed against immunoglobulin-idiotype (Id), major histocompatibility class II (MHC II), or CD19 on the tumors and huCD64 on the effectors. " 01/01/1990 - "Immunoglobulin idiotypes in human B cell neoplasia. " 01/01/2009 - "Tumor-specific variable regions of the clonal immunoglobulin (idiotype, Id) expressed by B cell non-Hodgkin lymphoma (NHL) can be targeted by active immunotherapy. "
3.	B-Cell Lymphoma (Lymphoma, B Cell) 08/01/2001 - "A B cell lymphoma model of dormancy in mice was established by prior immunization to the B cell membrane immunoglobulin idiotype. " 01/01/1992 - "Immunoglobulin idiotype expression in reactive lymphoid tissues and B-cell lymphomas." 12/01/2004 - "The unique immunoglobulin idiotype (Id) expressed by each B-cell lymphoma is a target for immunotherapy. " 04/01/1995 - "Isolation of tumor-derived immunoglobulin-idiotype from peripheral blood mononuclear cells in a B-cell lymphoma patient with minimal disease." 09/15/1992 - "The Ig idiotype of B-cell lymphoma can be used as a tumor-specific target. "
4.	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/01/2009 - "Tumor-specific variable regions of the clonal immunoglobulin (idiotype, Id) expressed by B cell non-Hodgkin lymphoma (NHL) can be targeted by active immunotherapy. " 06/01/2008 - "Therapeutic vaccines for B-cell non-Hodgkin lymphoma (NHL) using the clonal tumour immunoglobulin idiotype (Id) have been under development for more than three decades. " 10/01/1999 - "Low-grade lymphoma and multiple myeloma are slowly progressive malignancies, which generally express a unique immunoglobulin idiotype as a potential TAA. " 01/01/1991 - "To investigate the clonal relationship between follicular lymphoma (FL) and transformed diffuse lymphoma (tDL), we examined the expression of tumor idiotype, immunoglobulin (Ig) gene rearrangements and sequence of Ig variable genes in paired tissue specimens. " 05/01/2001 - "The malignant B cells of non-Hodgkin's lymphoma (B-NHL cells) express peptides derived from tumor-specific antigens such as immunoglobulin idiotypes, and also express major histocompatibility complex antigens. "
5.	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 09/09/2010 - "Comparative analysis of predicted HLA binding of immunoglobulin idiotype sequences indicates T cell-mediated immunosurveillance in follicular lymphoma." 01/01/1991 - "To investigate the clonal relationship between follicular lymphoma (FL) and transformed diffuse lymphoma (tDL), we examined the expression of tumor idiotype, immunoglobulin (Ig) gene rearrangements and sequence of Ig variable genes in paired tissue specimens. " 02/01/2006 - "Lymphoma-derived immunoglobulin idiotype (Id) is a tumour-specific antigen used for antitumour vaccination in follicular lymphoma (FL). " 07/01/2001 - "The availability of a truly tumor-specific antigen such as immunoglobulin idiotype, the recent demonstration that MM cells process and present idiotype to T lymphocytes, and formal evidence of an antitumor effect of idiotypic vaccination in follicular lymphoma provide the framework for applying idiotypic vaccination in MM. The ability to generate ex vivo functional dendritic cells has made it possible to fuse them with patients' MM cells, thus producing a different type of customized vaccine. " 07/10/2011 - "Vaccination with hybridoma-derived autologous tumor immunoglobulin (Ig) idiotype (Id) conjugated to keyhole limpet hemocyanin (KLH) and administered with granulocyte-monocyte colony-stimulating factor (GM-CSF) induces follicular lymphoma (FL) -specific immune responses. "

Related Drugs and Biologics

1.	Vaccines
2.	Carrier Proteins (Binding Protein)
3.	Antigens
4.	keyhole-limpet hemocyanin (keyhole limpet hemocyanin)
5.	Glutaral (Glutaraldehyde)
6.	Antibodies
7.	CD20 Antigens
8.	Listeria monocytogenes hlyA protein (listeriolysin O)
9.	Monoclonal Antibodies
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Transplantation
2.	Immunotherapy
3.	Therapeutics
4.	Subcutaneous Injections
5.	Drug Therapy (Chemotherapy)