Immunoblastic Lymphadenopathy (Lymphadenopathy, Angioimmunoblastic)

A disorder characterized by proliferation of arborizing small vessels, prominent immunoblastic proliferations and amorphous acidophilic interstitial material. Clinical manifestations include fever, sweats, weight loss, generalized lymphadenopathy and frequently hepatosplenomegaly.

Also Known As:

Networked: 191 relevant articles (11 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	T-Cell Lymphoma (Lymphoma, T Cell)
2.	Aplastic Anemia (Anemia, Hypoplastic)
3.	Lymphoma (Lymphomas)
4.	Lymphadenopathy
5.	Hypergammaglobulinemia (Hyperimmunoglobulinemia)

Experts

1.	Barbera, V: 2 articles (01/2001 - 08/2000)
2.	Florena, A M: 2 articles (01/2001 - 08/2000)
3.	Franco, V: 2 articles (01/2001 - 08/2000)
4.	Mariani, G: 2 articles (01/2001 - 08/2000)
5.	Magro, Cynthia M: 1 article (12/2007)
6.	Morrison, Carl D: 1 article (12/2007)
7.	Porcu, Pierre Luigi: 1 article (12/2007)
8.	Weinerman, David J: 1 article (12/2007)
9.	Courville, P: 1 article (05/2006)
10.	Joly, P: 1 article (05/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Immunoblastic Lymphadenopathy:

1.	Interferon-alpha (Interferon Alfa)IBA 10/01/1991 - "Recombinant human interferon-alpha in the treatment of angioimmunoblastic lymphadenopathy: results in 12 patients." 09/15/1988 - "Alpha-interferon in angioimmunoblastic lymphadenopathy." 07/01/1987 - "Alpha-interferon therapy in refractory angioimmunoblastic lymphadenopathy." 04/01/1994 - "Interferon alpha holds its place in the treatment of skin lymphomas where it leads in a great proportion of lymphomas to remission, and in angioimmunoblastic lymphadenopathy. " 06/01/1991 - "[A remarkable effect of alpha-interferon in a case of angioimmunoblastic lymphadenopathy with dysproteinaemia (AILD) refractory to steroids and combination chemotherapies]."
2.	CytokinesIBA 01/01/1993 - "These results suggest that the T cell functional deficiency of immunoblastic lymphadenopathy is induced by these immunosuppressive cytokines." 08/01/2000 - "Cytoplasmic cytokines in lymphoproliferative disorders: multiple cytokine production in angioimmunoblastic lymphadenopathy with dysproteinemia." 09/01/1996 - "Serum levels of cytokines and in vitro cytokine production by lymph node mononuclear cells (LNMC) were studied in four patients with angio-immunoblastic lymphadenopathy with dysproteinemia (AILD) or AILD-type T cell lymphoma. " 05/15/1995 - "Patterns of cytokine gene expression in peripheral T-cell lymphoma of angioimmunoblastic lymphadenopathy type." 02/01/1993 - "In almost all cases of B cell lymphoma of chronic lymphocytic leukemia, centrocytic, follicular centroblastic/centrocytic, Burkitt's types and T cell lymphoma of lymphoblastic, angioimmunoblastic lymphadenopathy and pleomorphic types, the cytokine-possessing cells were rarely or occasionally present. "
3.	Prednisone (Sone)FDA LinkGeneric 09/01/1992 - "Treatment of angioimmunoblastic lymphadenopathy (AILD)-type T-cell lymphoma using prednisone with or without the COPBLAM/IMVP-16 regimen. " 09/01/1992 - "To describe the clinical course of patients with angioimmunoblastic lymphadenopathy (AILD)-type lymphoma with a sequential treatment with prednisone and COPBLAM/IMVP-16. " 05/01/2006 - "A 62 year-old man with angioimmunoblastic lymphadenopathy was treated with oral prednisone (15 mg/day) and cyclophosphamide. " 03/03/1979 - "Prednisone in treatment of allergen-associated angio-immunoblastic lymphadenopathy." 05/13/1994 - "Treatment with prednisone (2 mg/kg daily for 8 weeks) and vincristine (1 mg/m2 once weekly for 4 weeks) brought about partial remission of the angioimmunoblastic lymphadenopathy with normalization of the clinical and laboratory findings, the splenohepatomegaly regressed, and there was only a small amount of ascites. "
4.	gamma-delta T-Cell Antigen Receptors (T-Cell Receptor delta-Chain)IBA 09/01/1988 - "A case of angioimmunoblastic lymphadenopathy associated with a long spontaneous remission, retrobulbar neuritis, a clonal rearrangement of the T-cell receptor gamma chain gene and an unusual marrow infiltration." 08/01/1994 - "[Detection of T-cell receptor gamma chain V gene rearrangements in angioimmunoblastic lymphadenopathy type T-cell lymphoma by PCR and family specific primers]."
5.	Vincristine (Oncovin)FDA LinkGeneric 05/13/1994 - "Treatment with prednisone (2 mg/kg daily for 8 weeks) and vincristine (1 mg/m2 once weekly for 4 weeks) brought about partial remission of the angioimmunoblastic lymphadenopathy with normalization of the clinical and laboratory findings, the splenohepatomegaly regressed, and there was only a small amount of ascites. " 01/01/1983 - "Therapeutic effect of vincristine, adriamycin and prednisolone (VAP) in angioimmunoblastic lymphadenopathy (AIL)."
6.	Prednisolone (Predate)FDA LinkGeneric 05/15/1981 - "[Disease-specific renal failure in angioimmunoblastic lymphadenopathy - remission by high dose prednisolone. " 01/01/1983 - "Therapeutic effect of vincristine, adriamycin and prednisolone (VAP) in angioimmunoblastic lymphadenopathy (AIL)."
7.	InterferonsIBA 01/01/1991 - "Improved response to chemotherapy after interferon alpha-2b in angioimmunoblastic lymphadenopathy (AILD)" 01/01/1987 - "Plasma samples of patients with angioimmunoblastic lymphadenopathy (AIBL) were tested for anti-HTLV antibodies and for interferon content. "
8.	Antinuclear AntibodiesIBA 06/01/2001 - "The clinical characteristics resembled angioimmunoblastic lymphadenopathy: spontaneous regression of lymphadenopathy and immunological abnormalities such as polyclonal hypergammaglobulinemia, positive results of direct and indirect antiglobulin tests, and a high antinuclear antibody titer. "
9.	antineoplaston A10 (A 10)IBA 07/24/1993 - "We saw a 24-year-old female patient with a fulminant evolution of an angioimmunoblastic lymphadenopathy, possibly a recurrence after a 10 years remission."
10.	AntigensIBA 12/17/1979 - "The presence of rubella virus antigen was demonstrated by means of immunohistological methods in two cases of angioimmunoblastic lymphadenopathy. " 09/01/1979 - "Rubella virus antigen in lymphocytes of patients with angioimmunoblastic lymphadenopathy (AIL)." 08/01/1990 - "Kaposi's sarcoma, angioimmunoblastic lymphadenopathy, and antibody to HIV-1 p24 antigen in a patient nonreactive for HIV-1 with use of ELISA." 05/01/1989 - "Angioimmunoblastic lymphadenopathy is usually characterized as a lymphoproliferative disease caused by an abnormal reaction to various chemical and biological antigens and the possible development into malignant lymphomas of different types. " 12/01/1977 - "Immunoblastic lymphadenopathy may represent a syndrome in which the adenopathy is but a nonspecific part of a systemic hyperimmune response to unknown antigens. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/1983 - "A patient with angioimmunoblastic lymphadenopathy was treated with chemotherapy to complete remission for 13 years. " 01/01/1983 - "She later developed angioimmunoblastic lymphadenopathy (AIL) which became progressively resistant to chemotherapy. " 09/01/1976 - "The cases illustrate the ineffectiveness and possible adverse effect of chemotherapy, as well as the importance of differentiation of immunoblastic lymphadenopathy from frankly malignant lymph node diseases." 12/01/1991 - "High-dose chemotherapy and autologous bone marrow transplantation in relapsing angioimmunoblastic lymphadenopathy with dysproteinemia (AILD)." 01/01/1985 - "The possible role of both chemotherapy and the immunodeficiency associated to angioimmunoblastic lymphadenopathy in the pathogenesis of the leukemia is discussed."
2.	Therapeutics 11/01/1999 - "In recent years important advances have been made in the understanding of angioimmunoblastic lymphadenopathy since substantial controversy has been related to the name, course, prognosis and therapy of the disease. " 09/04/1983 - "[Therapy of angioimmunoblastic lymphadenopathy]." 12/01/1981 - "The clinical features of 13 patients with angioimmunoblastic lymphadenopathy were analyzed to determine prognostic factors and response to therapy. " 01/01/1980 - "Angioimmunoblastic lymphadenopathy was studied prospectively in 5 patients by correlation of light and electron microscopy of biopsy material obtained from lymph nodes, prior to any substantial therapy. " 10/01/1999 - "The present case indicates that administration of CsA may be a very effective and safe selection of therapy for IBL-like T-cell lymphoma, as well as analogous disorders such as IBL and angioimmunoblastic lymphadenopathy with dysproteinemia (AILD), thereby will contribute to improving the prognosis of patients with these diseases."
3.	Combination Drug Therapy (Combination Chemotherapy) 01/01/1986 - "A short-term in vitro chemosensitivity test could predict response to COP combination chemotherapy suggesting that in vitro chemosensitivity testing can be useful for the therapeutic management of angioimmunoblastic lymphadenopathy." 12/31/1982 - "Cutaneous and visceral dissemination of Kaposi's sarcoma (KS) occurred in a patient with angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) who had been treated with combination chemotherapy. " 01/15/1981 - "In a longitudinal study, several immunologic in vitro tests were performed on peripheral lymphocytes in four patients with immunoblastic lymphadenopathy during sequential therapy with Levamisole and polychemotherapy. " 06/01/1991 - "We experienced a remarkable effect of recombinant interferon alpha 2a (alpha-IFN) in a case of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) which was refractory to steroids and combination chemotherapies. " 06/01/1991 - "[A remarkable effect of alpha-interferon in a case of angioimmunoblastic lymphadenopathy with dysproteinaemia (AILD) refractory to steroids and combination chemotherapies]."
4.	Aftercare (After-Treatment) 10/01/1987 - "A case is presented of a 68-year-old woman with the classical form of cutaneous KS in whom disappearance of the lesions after treatment was shortly followed by the development of angioimmunoblastic lymphadenopathy, pursuing a fulminant course to death. " 09/01/1983 - "Hodgkin's disease in a patient after treatment for angioimmunoblastic lymphadenopathy."
5.	Induction Chemotherapy 06/01/1997 - "A 47-year-old man with acute myeloblastic leukemia (AML) developed angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) 4 months after induction chemotherapy for AML. "