Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)

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961 relevant articles (3 outcomes, 72 trials/studies) found for this Bio-Agent

Description: An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.

Also Known As:

Hypoxanthine Guanine Phosphoribosyltransferase; HPRT; HGPRT; HPRTase; Phosphoribosyltransferase, Guanine; Phosphoribosyltransferase, Hypoxanthine; Phosphoribosyltransferase, Hypoxanthine-Guanine; Pyrophosphorylase, IMP; Guanine Phosphoribosyltransferase; Hypoxanthine-Guanine Phosphoribosyltransferase; IMP Pyrophosphorylase; IMP:pyrophosphate phospho-D-ribosyltransferase

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1

Enzymes: 24378

Transferases: 3171

Glycosyltransferases: 159

Pentosyltransferases

Hypoxanthine Phosphoribosyltransferase: 961

Experts

1.	O'Neill, J Patrick: 4 articles (05/2007 - 03/2002)
2.	Vacek, Pamela M: 3 articles (05/2005 - 01/2003)
3.	Finette, Barry A: 3 articles (05/2005 - 01/2003)
4.	Hou, S M: 3 articles (11/2001 - 06/2000)
5.	Jacomelli, Gabriella: 2 articles (11/2006 - 01/2006)
6.	Jinnah, Hyder A: 2 articles (11/2006 - 06/2005)
7.	Micheli, Vanna: 2 articles (11/2006 - 01/2006)
8.	Prior, C: 2 articles (01/2006 - 10/2004)
9.	Torres, R J: 2 articles (01/2006 - 10/2004)
10.	Puig, J G: 2 articles (01/2006 - 10/2004)

Related Diseases

1.	Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome) 11/01/2006 - "Study of the adenosinergic system in the brain of HPRT knockout mouse (Lesch-Nyhan disease)." 01/01/1989 - "Lesch-Nyhan syndrome and HPRT variants: study of heterogeneity at the gene level." 03/05/1986 - "To study the relationships between HPRT, the defective enzyme in Lesch-Nyhan syndrome, and the DA neuronal systems, we have measured the effects of nigro-striatal DA degeneration and intrastriatal neuronal degeneration on HPRT activity" 01/01/1984 - "Studies in fibroblasts of patients with the Lesch-Nyhan syndrome and HPRT variants" 01/01/1973 - "Immunological studies of hypoxanthine-guanine phosphoribosyltransferase in Lesch-Nyhan syndrome." Order ALL the reference details at left...
2.	DNA Damage 12/16/1999 - "The results of this study indicate that even weak mutational responses in the lymphocyte Hprt assay are capable of producing mutation profiles that reflect the DNA damage inducing them." 10/01/2002 - "Adducts were higher in the newborn than the mother, indicating differential susceptibility of the fetus to DNA damage; but HPRT mutation frequency was 4-fold lower, consistent with the long lifetime of the biomarker" 01/01/2002 - "Enhanced frequencies of sister chromatid exchanges and HPRT mutations occurred in the non-irradiated, 'bystander' cells associated with a similar increase in the frequency of micronuclei, indicating the induction of DNA damage in these cells" 01/01/2002 - "Combined with previous data, the results indicate that the two genes are differentially sensitive to many agents, and that the Tk gene is more sensitive than the Hprt gene to some, but not all types of DNA damage." 01/01/2002 - "To evaluate the sensitivity of this model, we have treated Tk(+/-) mice with three agents that induce DNA damage by different mechanisms, and determined spleen lymphocyte mutant frequencies (MFs) in the autosomal Tk gene and in the X-linked Hprt gene" Order ALL the reference details at left...
3.	Nervous System Diseases (Neurological Disorders) 03/01/2001 - "A spectrum of clinical consequences of HPRT deficiency has been recognized in small series of patients, but the complete spectrum of the neurologic disorder has not been described in a single series of patients examined by the same observers" 03/01/1975 - "X-linked hypoxanthine-guanine phosphoribosyltransferase deficiency without neurological disorders" 01/01/1993 - "Further investigations of the HGPRT in the human hippocampus may help to clarify the mechanism underlying the neurological disorders encountered in the Lesch-Nyhan syndrome." 12/01/1996 - "Patients with a partial deficiency of HPRT are spared most of the neurological disorder of Lesch-Nyhan syndrome" 11/13/2001 - "Hypoxanthine-guanine phosphoribosyltransferase-deficiency produces aberrant neurite outgrowth of rodent neuroblastoma used to model the neurological disorder Lesch Nyhan syndrome." Order ALL the reference details at left...
4.	Inborn Errors Metabolism (Inborn Errors of Metabolism) 01/01/1986 - "Further work with these and other vector constructions is underway in the hope that this technique may allow safe and effective treatment of ADA and HPRT deficiencies, paving the way for treatments of other inborn errors of metabolism through somatic gene replacement therapy." Order ALL the reference details at left...
5.	Chromosome Aberrations (Chromosome Abnormalities) 03/20/2007 - "The no observed adverse effect level (NOAEL) for chromosome aberrations and HPRT mutations was 1.794 mg/m(3) (0.812 ppm)--the mean exposure level for the highest exposed worker group in this initial study" 07/25/2002 - "In this study, genetic changes were assessed in randomly selected nine NPC patients receiving radiation therapy by different genotoxical screening methods, the cytokinesis-block micronucleus test (CB-MNT), the buccal mucosa cell micronucleus test (BMC-MNT), the undivided lymphocyte micronucleus test (UL-MNT), chromosomal aberration (CA) test, the comet assay and the hprt gene mutation test (HPRT)" 03/01/2001 - "In vitro genotoxicity studies--bacterial mutagenicity, forward gene mutation (HGPRT and TK loci), sister chromatid exchange, chromosome aberration, UDS and DNA repair tests--have given variable results, ranging from no effect through to weak positive" 05/25/1998 - "To illustrate the problem, a brief review of studies using well validated techniques (chromosome aberrations and hprt gene mutation) to elucidate genotoxic effects of cigarette smoking is presented" 01/01/1990 - "Studies on chromosome aberrations and HPRT mutations in lymphocytes and GPA mutation in erythrocytes of atomic bomb survivors." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Carcinogens
2.	Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)
3.	Hypoxanthine
4.	Transferases
5.	Guanine
6.	purine
7.	DNA (Deoxyribonucleic Acid)
8.	Phosphoglycerate Kinase (Kinase, Phosphoglycerate)
9.	Biological Markers (Surrogate Marker)
10.	Thioguanine (Tioguanine)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)

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