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Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)

An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
Also Known As:
Hypoxanthine Guanine Phosphoribosyltransferase; HPRT; HGPRT; HPRTase; Phosphoribosyltransferase, Guanine; Phosphoribosyltransferase, Hypoxanthine; Phosphoribosyltransferase, Hypoxanthine-Guanine; Pyrophosphorylase, IMP; Guanine Phosphoribosyltransferase; Hypoxanthine-Guanine Phosphoribosyltransferase; IMP Pyrophosphorylase; IMP:pyrophosphate phospho-D-ribosyltransferase
Networked: 1013 relevant articles (4 outcomes, 75 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Jinnah, H A: 24 articles (01/2015 - 04/2000)
2. Torres, R J: 12 articles (11/2015 - 04/2000)
3. Nyhan, William L: 12 articles (01/2015 - 07/2003)
4. Puig, J G: 11 articles (11/2015 - 04/2000)
5. O'Neill, J P: 10 articles (01/2007 - 01/2000)
6. Vacek, Pamela M: 9 articles (08/2011 - 01/2003)
7. Nguyen, Khue Vu: 8 articles (10/2015 - 06/2011)
8. Friedmann, Theodore: 8 articles (03/2015 - 08/2007)
9. Yamada, Yasukazu: 7 articles (01/2015 - 01/2007)
10. Guibinga, Ghiabe-Henri: 7 articles (01/2015 - 01/2010)

Related Diseases

1. Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome)
2. Neoplasms (Cancer)
3. Nervous System Diseases (Neurological Disorders)
4. Inborn Errors Metabolism (Inborn Errors of Metabolism)
5. Chromosome Aberrations (Chromosome Abnormalities)

Related Drugs and Biologics

1. Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)
2. Fluorouracil (Carac)
3. Hypoxanthine
4. Transferases
5. Guanine
6. DNA (Deoxyribonucleic Acid)
7. tributyl phosphate (TBP)
8. Thioguanine (Tioguanine)
9. Phosphoglycerate Kinase (Kinase, Phosphoglycerate)
10. purine

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Radiotherapy
3. Aftercare (After-Treatment)
4. Heterologous Transplantation (Xenotransplantation)
5. Caloric Restriction