|1.||Jinnah, H A: 24 articles (01/2015 - 04/2000)|
|2.||Torres, R J: 12 articles (11/2015 - 04/2000)|
|3.||Nyhan, William L: 12 articles (01/2015 - 07/2003)|
|4.||Puig, J G: 11 articles (11/2015 - 04/2000)|
|5.||O'Neill, J P: 10 articles (01/2007 - 01/2000)|
|6.||Vacek, Pamela M: 9 articles (08/2011 - 01/2003)|
|7.||Nguyen, Khue Vu: 8 articles (10/2015 - 06/2011)|
|8.||Friedmann, Theodore: 8 articles (03/2015 - 08/2007)|
|9.||Yamada, Yasukazu: 7 articles (01/2015 - 01/2007)|
|10.||Guibinga, Ghiabe-Henri: 7 articles (01/2015 - 01/2010)|
|1.||Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome)
11/01/2006 - "Study of the adenosinergic system in the brain of HPRT knockout mouse (Lesch-Nyhan disease)."
01/01/1989 - "Lesch-Nyhan syndrome and HPRT variants: study of heterogeneity at the gene level."
03/05/1986 - "To study the relationships between HPRT, the defective enzyme in Lesch-Nyhan syndrome, and the DA neuronal systems, we have measured the effects of nigro-striatal DA degeneration and intrastriatal neuronal degeneration on HPRT activity. "
01/01/1984 - "Studies in fibroblasts of patients with the Lesch-Nyhan syndrome and HPRT variants. "
01/01/1973 - "Immunological studies of hypoxanthine-guanine phosphoribosyltransferase in Lesch-Nyhan syndrome."
01/01/2004 - "Significantly elevated fractions of G:C-->C:G and A:T-->T:A transversions in the Hprt gene of BD-exposed mice were consistent with the occurrence of these substitutions as the predominant ras gene mutations in multiple tumor types increased in incidence in carcinogenicity studies of BD in mice. "
06/01/1998 - "The purpose of the present study was to compare the mutagenic potency of BD at the hprt locus of T-lymphocytes of exposed mice and rats and to determine whether mutations induced in this marker gene can be used as a quantitative indicator for species differences in susceptibility to cancer. "
01/01/1991 - "Hprt mutant frequencies in circulating lymphocytes: population studies using normal donors, exposed groups and cancer-prone syndromes."
03/01/2013 - "During growth of human cancers in these mice, hprt-null murine stromal cells replace their human counterparts. "
01/01/2010 - "The results show that genetic heterogeneity is detectable in HPRT and G6PD transcripts in both tumors and nearby healthy tissues of the two studied colon tumors. "
|3.||Nervous System Diseases (Neurological Disorders)
03/01/2001 - "A spectrum of clinical consequences of HPRT deficiency has been recognized in small series of patients, but the complete spectrum of the neurologic disorder has not been described in a single series of patients examined by the same observers. "
03/01/1975 - "X-linked hypoxanthine-guanine phosphoribosyltransferase deficiency without neurological disorders. "
01/01/1993 - "Further investigations of the HGPRT in the human hippocampus may help to clarify the mechanism underlying the neurological disorders encountered in the Lesch-Nyhan syndrome."
12/01/1996 - "Patients with a partial deficiency of HPRT are spared most of the neurological disorder of Lesch-Nyhan syndrome. "
11/13/2001 - "Hypoxanthine-guanine phosphoribosyltransferase-deficiency produces aberrant neurite outgrowth of rodent neuroblastoma used to model the neurological disorder Lesch Nyhan syndrome."
|4.||Inborn Errors Metabolism (Inborn Errors of Metabolism)
|5.||Chromosome Aberrations (Chromosome Abnormalities)
03/20/2007 - "The no observed adverse effect level (NOAEL) for chromosome aberrations and HPRT mutations was 1.794 mg/m(3) (0.812 ppm)--the mean exposure level for the highest exposed worker group in this initial study. "
07/25/2002 - "In this study, genetic changes were assessed in randomly selected nine NPC patients receiving radiation therapy by different genotoxical screening methods, the cytokinesis-block micronucleus test (CB-MNT), the buccal mucosa cell micronucleus test (BMC-MNT), the undivided lymphocyte micronucleus test (UL-MNT), chromosomal aberration (CA) test, the comet assay and the hprt gene mutation test (HPRT). "
03/01/2001 - "In vitro genotoxicity studies--bacterial mutagenicity, forward gene mutation (HGPRT and TK loci), sister chromatid exchange, chromosome aberration, UDS and DNA repair tests--have given variable results, ranging from no effect through to weak positive. "
05/25/1998 - "To illustrate the problem, a brief review of studies using well validated techniques (chromosome aberrations and hprt gene mutation) to elucidate genotoxic effects of cigarette smoking is presented. "
01/01/1990 - "Studies on chromosome aberrations and HPRT mutations in lymphocytes and GPA mutation in erythrocytes of atomic bomb survivors."
|1.||Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)
|6.||DNA (Deoxyribonucleic Acid)
|7.||tributyl phosphate (TBP)
|9.||Phosphoglycerate Kinase (Kinase, Phosphoglycerate)
|1.||Drug Therapy (Chemotherapy)
|4.||Heterologous Transplantation (Xenotransplantation)