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Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)

An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
Also Known As:
Hypoxanthine Guanine Phosphoribosyltransferase; HPRT; HGPRT; HPRTase; Phosphoribosyltransferase, Guanine; Phosphoribosyltransferase, Hypoxanthine; Phosphoribosyltransferase, Hypoxanthine-Guanine; Pyrophosphorylase, IMP; Guanine Phosphoribosyltransferase; Hypoxanthine-Guanine Phosphoribosyltransferase; IMP Pyrophosphorylase; IMP:pyrophosphate phospho-D-ribosyltransferase
Networked: 1155 relevant articles (7 outcomes, 95 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Jinnah, H A: 28 articles (01/2021 - 04/2000)
2. Nyhan, William L: 16 articles (01/2020 - 07/2003)
3. Nguyen, Khue Vu: 14 articles (01/2021 - 06/2011)
4. Torres, R J: 13 articles (09/2017 - 04/2000)
5. Torres, Rosa J: 12 articles (01/2022 - 05/2006)
6. Puig, J G: 11 articles (11/2015 - 04/2000)
7. O'Neill, J P: 10 articles (01/2007 - 01/2000)
8. Puig, Juan G: 9 articles (06/2018 - 05/2006)
9. Vacek, Pamela M: 9 articles (08/2011 - 01/2003)
10. Micheli, Vanna: 8 articles (03/2020 - 08/2002)

Related Diseases

1. Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome)
2. Neoplasms (Cancer)
3. Hyperuricemia
4. Nervous System Diseases (Neurological Disorders)
5. Granuloma

Related Drugs and Biologics

1. Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)
2. Enzymes
3. Thioguanine (Tioguanine)
4. Nucleotides
5. Interleukin-4 (Interleukin 4)
6. Fluorouracil (Carac)
7. Hypoxanthine
8. Transferases
9. purine
10. Guanine

Related Therapies and Procedures

1. Therapeutics
2. Enzyme Therapy
3. Immunotherapy
4. Drug Therapy (Chemotherapy)
5. Radiotherapy