|2.||Heart Arrest (Cardiac Arrest)
|3.||Brain Injuries (Brain Injury)
|1.||Kochanek, Patrick M: 52 articles (05/2015 - 01/2002)|
|2.||Holzer, Michael: 28 articles (10/2015 - 05/2002)|
|3.||Thoresen, Marianne: 28 articles (06/2015 - 01/2003)|
|4.||Tisherman, Samuel A: 23 articles (03/2015 - 01/2002)|
|5.||Butterworth, Roger F: 22 articles (03/2015 - 12/2002)|
|6.||Sterz, Fritz: 21 articles (10/2015 - 02/2002)|
|7.||Steinberg, Gary K: 21 articles (01/2014 - 01/2002)|
|8.||Yenari, Midori A: 21 articles (07/2013 - 01/2002)|
|9.||Ishikawa, Takaki: 20 articles (11/2015 - 05/2005)|
|10.||Maeda, Hitoshi: 20 articles (11/2015 - 05/2005)|
01/01/2005 - "There was significant reduction in KMC vs CMC group of hypothermia (10/44 vs 21/45, p-value < 0.01), higher oxygen saturations (95.7 vs 94.8%, p-value < 0.01) and decrease in respiratory rates (36.2 vs 40.7, p-value < 0.01). "
04/01/1999 - "We advocate the use of whole body hypothermia to reduce tissue oxygen demand and provide a degree of cellular protection against ischaemia allowing time for recovery. "
12/01/1980 - "Improved oxygen delivery to the myocardium during hypothermia by perfusion with 2,3 DPG-enriched red blood cells."
12/01/2003 - "The aim of this study was to investigate the relationship between regional and mixed venous oxygen saturation and distribution of pump flow with respect to hypothermia. "
02/01/2000 - "In this study, we assessed the effects of normothermia and mild hypothermia (32 degrees C) during CPB on jugular oxygen saturation (SjvO2). "
08/01/1982 - "This study in human beings could not demonstrate a specific protective effect of potassium, beyond that afforded by myocardial perfusion hypothermia and wash-out. "
04/01/1960 - "Potassium ion as a cardioplegic agent in total cardiac bypass and during hypothermia with coronary perfusion: an experimental study."
11/01/1959 - "Study of the cardioplegic action of potassium ion during normothermia and hypothermia."
01/01/1956 - "Potassium effects in hypothermia; an experimental study."
01/01/1953 - "[Study of potassium metabolism and its role in the mechanism of death in deep hypothermia]."
|3.||Glucose (Dextrose)FDA LinkGeneric
03/01/1999 - "Despite its proven neuroprotective efficacy, early posttraumatic hypothermia (30 degrees C for 3 hours) nonetheless induces a moderate decline in cerebral perfusion without the (anticipated) improvement in cerebral glucose utilization, so that a state of mild metabolism-greater-than-blood-flow dissociation is perpetuated."
09/01/2015 - "Insufficient glucose supply is linked to hypothermia upon cold exposure in high-fat diet-fed mice lacking PEMT."
04/01/2015 - "Evaluation of glucose management during therapeutic hypothermia at a Tertiary Academic Medical Center."
01/01/2015 - "In this retrospective cohort study, glucose, clinical and demographic data were documented from 23 term newborns treated with whole body therapeutic hypothermia. "
09/01/2014 - "Amino acid administration helps to prevent intraoperative hypothermia but may enhance thermogenesis when combined with glucose infusion. "
|4.||Pentobarbital (Nembutal)FDA Link
01/01/1981 - "PNT, 50 mg/kg reduced K+ accumulation more effectively than either pentobarbital or hypothermia, whose protective effects are likely explained by a different mechanism (i.e., reduced cerebral metabolic rate). "
11/01/1991 - "In pharmacological studies using mice, CBDD and 1S,2R-epoxy-CBD-2',6'-diacetate produced hypothermia, and CBD, CBDM and CBEM prolonged pentobarbital-induced sleep. "
09/01/2013 - "Prior to initiation of hypothermia, four children (80%) received pentobarbital infusions to treat RSE, but relapsed after pentobarbital discontinuation. "
12/01/2010 - "The 100mg/kg dose decreased both treadmill performance and locomotor activity, caused hypothermia, and potentiated pentobarbital-induced sleep. "
01/01/2007 - "Male Wistar rats (n = 88) were anesthetized intraperitoneally with pentobarbital sodium and assigned to one of two protocols: one representing moderate hypothermia (30 degrees -32 degrees C) and the other representing mild hypothermia (33 degrees -35 degrees C). "
|5.||Glutamic Acid (Glutamate)FDA Link
04/01/2000 - "In vivo cerebral microdialysis studies revealed that mild hypothermia resulted in a significant reduction of extracellular glutamate concentrations in the brains of rats with ALF (control: 1. 06 micromol/L; ALF-37 degrees C: 2.74 micromol/L; ALF-35 degrees C: 1.49 micromol/L [P <.01 compared with ALF-37 degrees C]). "
08/01/2014 - "The purpose of present study was to investigate the functioning of glutamate ionotropic receptors in brain slices cooled with different rates during mild, moderate and deep hypothermia. "
09/01/2001 - "The objective of this study was to investigate whether hypothermia would suppress secondary damage in the chronic postischemic stage, in terms of glutamate excitotoxicity. "
01/01/2000 - "In conclusion, the present study demonstrates that hypothermia is a potent neuroprotective method and an inhibition of the glutamate excitotoxic process may contribute the protective mechanisms of hypothermia in this rat acute SDH model."
05/01/1994 - "This study examined the effects of graded hypothermia (32 degrees C, 28 degrees C, and 22 degrees C, vs 38 degrees C) on periischemic extracellular hippocampal glutamate concentrations in the New Zealand White rabbit. "
06/01/2005 - "Our findings demonstrate that post-ischemic treatment with a 24 h duration of modest hypothermia and magnesium is more effective than either treatment used alone."
03/28/2013 - "In this study we compared the efficacy of mild (35°C) and moderate (33°C) hypothermia alone and when combined with magnesium in a transient focal cerebral ischaemia rat model. "
03/28/2013 - "In summary, moderate hypothermia and mild hypothermia with or without magnesium can reduce infarct volume, however magnesium may reduce the efficacy of moderate hypothermia. "
06/01/2006 - "Future preclinical and clinical cerebral ischaemia trials with magnesium should consider combining treatment with mild hypothermia."
06/01/2006 - "Thus the effects of post-ischaemic hypothermia cannot be ruled out as a confounding factor in positive magnesium cerebral ischaemia studies. "
03/01/1984 - "The results show that dry and insulative survival suits can provide excellent protection against fatal levels of hypothermia resulting from ice-water immersion. "
01/01/2013 - "Forty infants were treated with whole-body hypothermia between February 2001 and May 2010, 16 of whom were enrolled in the Infant Cooling Evaluation (ICE) trial, and 18 control infants randomised to normothermia in the ICE trial. "
07/01/2012 - "The aim of this study by the ICE (Italian Cooling Experience) group was to investigate the relationship between the timing of initiation of therapeutic hypothermia (TH) and both patient survival and neurologic outcome. "
01/01/2004 - "The purpose of this study was to document the effects on phrenic nerve injury of whole body hypothermia, use of ice-slush around the heart and mammary artery harvesting. "
06/01/2015 - "The first investigated prehospital induction of hypothermia using ice-cold intravenous saline in 1364 patients. "
|8.||Adenosine Triphosphate (ATP)IBA
10/01/1999 - "To verify this hypothesis, the relation of ATP plasma levels and hypothermia was examined in a clinical study. "
01/01/1999 - "To verify this hypothesis the relation of ATP plasma levels and hypothermia was examined in a clinical study. "
02/01/2015 - "Mitochondrial ATP concentrations were maintained with hypothermia treatment after injury (16.7 ± 9.5 vs. 6.1 ± 5.1 μM, P<0.01). "
12/01/2012 - "Na(+)-K(+) and Ca(2+) adenosine triphosphate enzyme activity in the gastric tissue were significantly high in animals receiving hypothermia treatment compared to controls. "
09/01/2011 - "In contrast, mild hypothermia beginning at 90 minutes had little effect on the levels of SOD, GSH-Px, GSH, and ATP (P > 0.05). "
04/01/1987 - "Although many studies of the protective effects of cardioplegic solutions using hypothermia have been conducted, it is also necessary to examine their protective effects under normothermia as regional increases in myocardial temperature during hypothermic arrest are often reported. "
09/01/1978 - "The evidence from this study indicates that cardioplegic solution exerts a protective effect beyond that which is afforded by hypothermia."
09/01/2010 - "Influence of hypothermia and cardioplegic solutions on expression of alpha-Gal epitope on porcine aortic endothelial cells."
07/15/1996 - "This endogenous mechanism of cardioprotection was effective regardless of whether preservation was accomplished using cardioplegic solution or topical hypothermia alone. "
06/01/1994 - "The Perfusion of cardioplegic solution significantly increased [Ca2+]i, and this effect was further augmented by hypothermia (p < 0.05). "
|10.||Ethanol (Ethyl Alcohol)IBA
09/01/1989 - "Although IV ethanol infusions produced similar or higher blood ethanol levels (BELs) compared to IP administration, the degree of hypothermia was significantly greater with the more rapidly absorbed IP administration. "
06/06/1983 - "These mice had a significantly greater degree of hypothermia on test day than the ethanol-room temperature acquisition group, which showed tolerance, and their degree of hypothermic response was similar to that of mice injected with saline during acquisition. "
01/01/2012 - "The protective effect of ethanol was not improved when paired with hypothermia. "
07/01/1995 - "In adulthood, early handling eliminated the increased hypothermia observed in E and PF compared to C males following an ethanol challenge (2.0 g/kg, IP). "
01/01/2005 - "The aim of the study was to determine whether the cooling process of the organism in the presence of ethanol intoxication may be related to inhibition of the physiological mechanism of ketogenesis induced by hypothermia. "
04/01/2013 - "To compare the efficacy of vinyl bags and thermal warming mattresses in preventing hypothermia during delivery room resuscitation and stabilization of extremely low-gestational-age neonates (ELGANs). "
01/21/2013 - "Since specialized post-resuscitation care, including therapeutic hypothermia, has proved beneficial in randomized studies, CAG should be offered to patients with a high likelihood of thrombotic coronary lesions, i.e. "
06/21/2005 - "When VF was induced in the setting of moderate or severe hypothermia, resuscitative measures were facilitated with significantly improved defibrillation success and resuscitation outcome. "
07/01/2006 - "For improved adoption of therapeutic hypothermia, our data suggest that development of better cooling methodology and recent incorporation into resuscitation guidelines may improve use."
11/01/2015 - "[Mild therapeutic hypothermia : Improved survival after resuscitation]."
02/01/2015 - "Hypothermia showed a significant neuroprotective effect, which can be improved with further studies optimizing the duration of hypothermia and the rewarming period. "
03/01/2007 - "Among these clinical trials, early application of hypothermia, maintenance of cerebral blood flow during hypothermia therapy and prevention of quick rewarming are pointed out to result in good outcome from clinical experiences. "
11/01/2003 - "Studies regarding the use of various active rewarming methods in severe hypothermia casualties revealed low rewarming efficacy for the low heat capacity methods, such as warm air inhalation, and a high rewarming efficacy for the high heat capacity methods, such as forced air methods."
01/01/2014 - "High-quality evidence on other warming methods is also lacking; therefore it is unclear whether other rewarming methods are effective in reversing postoperative hypothermia."
09/01/2012 - "The number of patients requiring rewarming in the mild hypothermia group was significantly greater than in the normothermia group (odds ratio, 33.89; 95% confidence intervals, 3.61-318.36). "
|3.||Induced Heart Arrest (Cardioplegia)
08/01/1992 - "The findings suggest that, even though no consensus exists about its ideal composition, cardioplegia in conjunction with hypothermia is currently the strategy most often used for pediatric myocardial protection."
01/01/1987 - "Cardioplegia is most effective when combined with the additive properties of hypothermia, which plays a significant role in decreasing myocardial metabolism. "
01/01/2014 - "Inclusion criteria thus far have not embraced drug-induced cardiac arrest, but clinical evidence has been mounting that therapeutic hypothermia may be beneficial in such cases. "
09/01/1996 - "In hypertrophied hearts, protection by topical hypothermia alone resulted in significantly improved postischemic recoveries of maximum left ventricular pressure and rate of pressure rise compared with the method of slow cooling or application of cardioplegia (40.6% +/- 5.0% and 38.1% +/- 5.9%, mean +/- standard error of the mean; p < 0.05). "
03/01/1983 - "The small increase in risk compared to the significant improvement from the combined approach has led to the following principles: coronary arteriography on all adult patients requiring valvular operations; bypass of all significant coronary lesions; restoration of valvular function and hemodynamics; and myocardial preservation with cold cardioplegia during a single period of cross clamping, topical cold, and systemic hypothermia."
|4.||Cardiopulmonary Bypass (Heart-Lung Bypass)
04/01/2000 - "Six weeks after this, a right-sided vertebral-to-carotid artery anastomosis was performed during cardiopulmonary bypass (CPB)-induced deep hypothermia for optimal neuronal protection, with good results. "
01/01/1997 - "The application of a cardiopulmonary bypass and hypothermia in high level vena cava thrombi is an important advance that has improved the safety and technical efficacy of a difficult surgical undertaking."
03/01/2008 - "Clinical studies have failed to demonstrate significant benefits of hypothermia for the prevention of postoperative cognitive dysfunction (POCD) after cardiopulmonary bypass (CPB). "
12/01/2001 - "He was treated successfully with cardiopulmonary bypass and hypothermia. "
07/01/1979 - "The recommended technique for Type I and II defects is transaortic closure of the defect by prosthetic patch with the aid of cardiopulmonary bypass, supplemented by profound hypothermia (20 degrees C.), and circulatory arrest for improved exposure in selected cases. "
|5.||Cardiopulmonary Resuscitation (CPR)
01/01/2015 - "Hypothermia treatment after CPR provides better outcome than normothermia treatment in SCA rabbits. "
11/01/2008 - "When hypothermia is induced during cardiopulmonary resuscitation, mortality is also improved. "
10/01/2015 - "Hypothesis/Problem This study examined prehospital therapeutic hypothermia for OHCA, its association with survival, and its complication profile in a large, metropolitan, fire-based Emergency Medical Services (EMS) system, where bystander cardiopulmonary resuscitation (CPR) and post-arrest care are in the process of being optimized. "
03/01/2015 - "Study objective was to determine recent outcome of infants with an Apgar score of 0 at 10 min despite cardiopulmonary resuscitation, treated with therapeutic hypothermia or standard treatment, in randomised cooling studies. "
02/01/2015 - "The aim of this study was to investigate the effects of mild hypothermia therapy on oxidative stress injury of rabbit brain tissue after cardiopulmonary resuscitation (CPR). "