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Hypoprothrombinemias (Prothrombin Deficiency)

Absence or reduced levels of PROTHROMBIN in the blood.
Also Known As:
Prothrombin Deficiency; Hypoprothrombinemia; Factor II Deficiency; Deficiency, Factor II; Deficiencies, Factor II; Deficiencies, Prothrombin; Deficiency, Prothrombin; Factor II Deficiencies; Prothrombin Deficiencies
Networked: 471 relevant articles (16 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hemorrhage
2. Acquired hypoprothrombinemia
3. Aberrant Crypt Foci
4. Thrombocytopenia (Thrombopenia)
5. Systemic Lupus Erythematosus (Libman-Sacks Disease)

Experts

1. Ieko, Masahiro: 5 articles (03/2021 - 04/2013)
2. Naito, Sumiyoshi: 3 articles (08/2019 - 10/2015)
3. Yoshida, Mika: 3 articles (08/2019 - 10/2015)
4. Ishiguro, Akira: 2 articles (03/2021 - 01/2014)
5. Suzuki, Nobuaki: 2 articles (01/2020 - 01/2020)
6. Takahashi, Nobuhiko: 2 articles (08/2019 - 10/2015)
7. Ahluwalia, Jasmina: 2 articles (10/2018 - 07/2017)
8. Kumar, Narender: 2 articles (10/2018 - 07/2017)
9. Girolami, A: 2 articles (01/2018 - 01/2008)
10. Zuily, Stéphane: 2 articles (07/2016 - 02/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypoprothrombinemias:
1. Prothrombin (Factor II)IBA
2. Warfarin (Coumadin)FDA LinkGeneric
3. Vitamin K 1 (Phylloquinone)FDA LinkGeneric
4. Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA
5. Sulfinpyrazone (Anturane)FDA Link
6. Dicumarol (Dicoumarol)FDA Link
7. Vitamin K 2 (Vitamin K2)IBA
8. Antiphospholipid AntibodiesIBA
07/01/2017 - "Investigations revealed prothrombin deficiency along with positivity for antiphospholipid antibodies, which improved with steroid therapy. "
08/01/2016 - "We report for the first time a variation on this theme in a patient with a lupus anticoagulant-type antiphospholipid antibody and hypoprothrombinemia, which corrected with immunosuppression and restoration of normal prothrombin levels."
10/31/2022 - "In very rare cases, these antibodies and associated hypoprothrombinemia are found in patients with lupus anticoagulant (LAC), an antiphospholipid antibody that inhibits phospholipid-dependent coagulation tests. "
07/17/2023 - "Lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS) is a rare acquired bleeding disorder secondary to development of antibodies against prothrombin protein, in the presence of antiphospholipid antibodies. "
10/01/2020 - "The enrolled patients (280) were evaluated for Triiodothyronine, Thyroxine, Thyroid stimulating hormone, prolactin, chromosomal analysis, Haemoglobin A1C, blood sugar, Magnetic resonance imaging, 3D-ultrasound, auto-antibodies profile (antiphospholipid antibodies, anticardiolipin antibodies, lupus anticoagulant, antinuclear antibodies, anti-thyroid antibodies and β2 glycoprotein1), torch profile (Toxoplasmo gondii, rubella, cytomegalo virus and herpes simplex virus), blood vitamin D3 levels, psychological factors, Body mass index and thrombotic factors (protein S and C deficiency, Prothrombin G20210A mutation, anti-thrombin III, Factor V Leiden and Methylenetetrahydrofolate reductase mutation), uterosalpingography (hysteronsalpingography) and hysteroscopy. "
9. SteroidsIBA
10. Rituximab (Mabthera)FDA Link

Therapies and Procedures

1. Therapeutics
2. Intravenous Administration
3. Withholding Treatment
4. Prostheses and Implants (Prosthesis)
5. Liver Transplantation