|1.||Inappropriate ADH Syndrome (SIADH)
|1.||Verbalis, Joseph G: 24 articles (01/2015 - 01/2002)|
|2.||Decaux, Guy: 21 articles (02/2015 - 06/2002)|
|3.||Gheorghiade, Mihai: 20 articles (06/2013 - 06/2003)|
|4.||Ginès, Pere: 17 articles (01/2014 - 04/2003)|
|5.||Schrier, Robert W: 15 articles (10/2013 - 04/2006)|
|6.||Hoffman, Martin D: 14 articles (01/2016 - 05/2010)|
|7.||Rosner, Mitchell H: 14 articles (12/2014 - 02/2004)|
|8.||Orlandi, Cesare: 14 articles (12/2012 - 06/2003)|
|9.||Sterns, Richard H: 13 articles (02/2015 - 05/2002)|
|10.||Moritz, Michael L: 13 articles (01/2015 - 02/2003)|
01/01/2011 - "In short-term (7-day) treatment with the drug, serum sodium concentration (mean ± standard deviation) significantly (P = 0.002) increased from 122.8 ± 6.7 to 133.3 ± 8.3 mEq/l, and symptoms due to hyponatremia were improved. "
05/15/2002 - "As large water loads may result in severe hyponatremia in these patients, moderate fluid restriction appears to be effective in long-term management even after stabilization/normalization of serum sodium. "
11/13/1980 - "Chronic hyponatremia (serum sodium, 120 to 125 mmol per liter) reduced the frequency of painful crises, whereas acutely induced hyponatremia abbreviated the duration of crises. "
08/01/2015 - "Initial hyponatremia occurred in 8.71% (n = 53), and persistent hyponatremia (> 6 months of low serum sodium) in 4.1% (n = 25) of the study population. "
01/01/2015 - "A Medline, Embase and Cochrane search was performed to retrieve all English-language studies of human subjects published up to June 30th 2014, using the following words: "hyponatremia", "hyponatraemia", "mortality", "morbidity" and "sodium". "
06/01/2012 - "The data show that tolvaptan is effective for the treatment of hyponatremia and may produce differing responses in disparate patient groups."
04/01/2010 - "Oral tolvaptan is safe and effective in chronic hyponatremia."
06/01/2007 - "In two multicenter, randomized, double-blind, placebo-controlled trials, the efficacy of tolvaptan was evaluated in patients with euvolemic or hypervolemic hyponatremia. "
11/16/2006 - "In two multicenter, randomized, double-blind, placebo-controlled trials, the efficacy of tolvaptan was evaluated in patients with euvolemic or hypervolemic hyponatremia. "
01/01/2013 - "His hyponatremia was normalized, and his renal function was improved after conversion to tolvaptan. "
|3.||Vasopressin Receptors (Arginine Vasopressin Receptor)IBA
01/01/2010 - "To report successful use of a modified protocol of vasopressin receptor antagonist for effective and safe treatment of hyponatremia in a complexly ill patient in the neurorehabilitation setting. "
09/01/2011 - "Clinical trials have demonstrated that vasopressin receptor antagonists (VRAs) are effective in treating hypervolemic hyponatremia in ADHF without a negative impact on renal function. "
06/01/2003 - "Studies in animal models and humans have demonstrated that antagonists of the AVP V2 receptor in the kidney are effective in correcting hyponatremia. "
01/01/2015 - "Asopressin V2 receptor antagonists is a kind of vaptans, and it has been proved to be effective in hyponatremia patients. "
11/01/2013 - "Vaptans are arginine vasopressin receptor antagonists shown to be effective in correcting water excess in other disease states of euvolemic and hypervolemic hyponatremia. "
09/01/2003 - "Patients were 15 men and women (mean age, 75.7 +/- 5.3 years) who were participants in a treatment study of late-life depression and who were without medical illness or other medications known to cause hyponatremia or alter antidiuretic hormone (ADH) secretion. "
02/01/1997 - "This study also offers further indirect evidence to suggest that the syndrome of hyponatremia with natriuresis is most often caused by "cerebral salt wasting" rather than by the syndrome of inappropriate secretion of antidiuretic hormone."
11/01/1989 - "A study of serum antidiuretic hormone and atrial natriuretic peptide levels in a series of patients with intracranial disease and hyponatremia."
01/01/2016 - "Postsurgical patients are at high risk of developing hyponatremia due to the presence of non-osmotic stimuli for antidiuretic hormone release. "
05/01/2015 - "Cerebral salt wasting and syndrome of inappropriate antidiuretic hormone have been classically described as the 2 most frequent entities responsible of hyponatremia in neurocritical care patients. "
|5.||conivaptan (Vaprisol)FDA Link
01/01/2008 - "The data reveal that conivaptan is useful in the management of significant hyponatremia. "
01/01/2009 - "Oral conivaptan was effective in increasing serum [Na] in patients with euvolemic or hypervolemic hyponatremia and had a favorable safety profile."
01/01/2009 - "Intermittent dosing of conivaptan was effective in increasing free water excretion and correcting hyponatremia in neurologically ill patients. "
07/01/2007 - "Conivaptan: new treatment for hyponatremia."
09/01/2013 - "To review the literature evaluating the clinical safety and efficacy of conivaptan in the management of hyponatremia in a neurologic and neuro-surgical adult patient population. "
08/01/2010 - "Vasopressin antagonists are effective for the treatment of hypervolemic and euvolemic hyponatremia."
12/01/2011 - "Initial studies with vasopressin antagonists showed promise in their ability to increase urine output, provide short-term symptom relief, and correct hyponatremia while maintaining renal function. "
04/01/2012 - "Vasopressin antagonists have recently been shown in short-term studies to correct hyponatremia in diverse patient populations, including individuals with both psychosis and idiopathic hyponatremia. "
07/01/2010 - "Clinical trials in patients with hyponatremia including those with CHF using both selective and nonselective vasopressin antagonists have demonstrated the effectiveness and safety of these agents in correcting this common electrolyte abnormality."
06/01/2009 - "Clinical trials in patients with hyponatremia and CHF using both selective and nonselective vasopressin antagonists have demonstrated the effectiveness of these agents in correcting this common electrolyte abnormality."
|7.||Urea (Carbamide)FDA LinkGeneric
02/01/1989 - "It is concluded that urea and saline administration results in a rapid, safe, and effective correction of hyponatremia, making this method superior to fluid restriction in many neurosurgical patients."
10/01/2012 - "Because of the cost difference between vaptans and urea and while waiting for follow-up studies, urea appears at present as the first-line treatment of hyponatremia in SIAD."
02/01/2015 - "Although there is evidence that urea can diminish hypertonic injury to brain cells caused by rapid correction of hyponatremia, clinical trials are needed that include patients at high risk to develop complications from overcorrection. "
05/01/2015 - "It is preceded by an introduction underscoring the main targets of non-pharmacological treatment in acute severely symptomatic cases, specifically as regards the rate of correction of hyponatremia; subsequently, potential explanations for the discrepancies between the European Guidelines and the consensus statement by US experts concerning the use of vaptans are briefly discussed; the rationale and practical limitations in the clinical use of urea are analyzed in more detail. "
02/01/2015 - "Urea for hyponatremia?"
|8.||Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric
11/01/2014 - "Desmopressin is effective in hyponatremias presenting with dilute urine or developing urinary dilution after saline infusion. "
02/01/2014 - "Desmopressin acetate is effective in curbing the rise of PNa in patients admitted in the intensive care unit for severe hyponatremia, when the initial rate of correction is excessive."
03/01/2008 - "Desmopressin acetate is effective in preventing and reversing inadvertent overcorrection of hyponatremia."
03/01/2008 - "DDAVP is effective in preventing and reversing inadvertent overcorrection of hyponatremia."
08/01/2014 - "Our study aimed to evaluate the extent of hyponatremia caused by DDAVP and to propose a safe and effective treatment regimen for these patients. "
|9.||Arginine Vasopressin (Argipressin)IBA
11/01/2007 - "In clinical trials, a new class of drugs called the arginine vasopressin (AVP) receptor antagonists or aquaretics has been shown to be safe and effective for the treatment of hyponatremia. "
12/01/2012 - "Recently, the vaptans, antagonists of the arginine vasopressin pathway, have shown promise for safe treatment of hyponatremia. "
03/01/2013 - "Hyponatremia occurred in nearly half of the infants and children receiving arginine vasopressin therapy in this study. "
01/01/2011 - "The aim of this study was to investigate the impact of hyponatremia on outcomes in patients with STEMI and secondarily to investigate the contribution of arginine vasopressin (AVP) to hyponatremia in STEMI. "
01/01/1988 - "The present study evaluated these effects in a rat model of SIAD utilizing dilutional hyponatremia induced by continuous infusion of 1-deamino-[8-D-arginine] vasopressin. "
|10.||Hydrocortisone (Cortisol)FDA LinkGeneric
11/01/2015 - "Hydrocortisone replacement greatly improved both the hyponatremia and RTA. "
01/01/2007 - "Hyponatremia was improved immediately after administration of hydrocortisone. "
12/01/2015 - "Hydrocortisone was used to prevent hyponatremia if allowed by the medical condition of the patient. "
03/23/2011 - "Hyponatremia was observed in 7 of 76 (9.2%) in the placebo group vs none in the hydrocortisone group (absolute difference, -9%; 95% CI, -16% to -3%; P = .01). "
12/01/2009 - "Five cases of severe hyponatremia in the elderly successfully treated with low doses of hydrocortisone."
09/01/2015 - "More information is needed to argue the benefits vs risks of short-term use of vaptans for correction of hyponatremia especially just hours-to-days before liver transplant. "
06/01/2015 - "Practical protocol for management of severe hyponatremia in patients undergoing liver transplant surgery."
01/01/2014 - "Patients with hyponatremia and ACLF had a three-month transplant-free survival of only 35.8% compared to 58.7% in those with ACLF without hyponatremia (P <0.001). "
01/01/2013 - " However, rapid correction of hyponatremia is an independent risk factor for the development of post-transplant neurological complications."
09/01/2012 - "DMAIC methods evaluated the common outcome of postoperative hyponatremia, thus resulting in collaboration to prevent hyponatremia in the renal transplant population. "
03/01/1999 - "After ventriculoperitoneal shunt surgery, the symptoms of NPH and hyponatremia improved. "
08/26/2003 - "The authors made a diagnosis of normal pressure hydrocephalus (NPH) and performed a ventriculoperitoneal shunt, which improved the gait disturbance, accompanied by resolution of the fever and hyponatremia."
05/01/2012 - "Hyponatremia was significantly associated with mechanical ventilation, ventriculostomy placement, ventriculoperitoneal shunt placement, and sepsis. "
12/01/2003 - "A 12-year-old boy with tuberculous meningitis and hydrocephalous, after undergoing revision of ventriculo-peritoneal shunt had persistent impairment of sensorium and episodes of hyponatremia (serum sodium 104 to 125 mmol/l), accompanied by polyuria, signs of poor peripheral, perfusion hypotension and low CVP, and high urinary sodium excretion (114-60 mmol/l). "
12/01/2014 - "A 35-year-old female inpatient with an optic chiasm glioma and ventriculoperitoneal shunt for hydrocephalus developed acute hyponatremia (sodium 122 mEq/l) perhaps coinciding with haloperidol treatment. "
|3.||Fluid Therapy (Oral Rehydration Therapy)
10/01/2009 - "Recent studies have focused attention on the incidence of postoperative hyponatremia and associated morbidity and mortality rates, generating debate on the advisability of perioperative fluid therapy and calling into question both the effectiveness of this strategy and the quantities used. "
08/01/1994 - "Our study suggests that the administration of HLS prevents the hyponatremia and hypoosmolarity in patients undergoing TUR-P and that the HLS could be used routinely during this procedure as the essential fluid therapy."
08/18/2015 - "Is isotonic fluid associated with a lower incidence of hyponatremia when compared with hypotonic fluid for maintenance intravenous fluid therapy in children? "
12/01/2014 - "Reduced volume isotonic fluid results in fewer episodes of hyponatremia than hypotonic fluid in sick children during the first 48 hours of intravenous fluid therapy."
12/01/2014 - "A cause of the severe hyponatremia was not identified, and it persisted despite fluid therapy. "
|4.||Length of Stay
06/01/2008 - "Hospital mortality (5.9% vs. 3.0%, p<0.001), mean length of stay (HLOS, 8.6+/-8.0 vs. 7.2+/-8.2 days, p<0.001) and costs ($16,502+/-$28,984 vs. $13,558+/-$24,640, p<0.001) were significantly greater among patients with hyponatremia than those without. "
10/01/2015 - "A statistically significant correlation was also found between the length of stay and the detection of hyponatremia. "
07/01/2014 - "Patients with hyper-CKemia in the setting of diuretic-associated hyponatremia were older and had longer hospital length of stay compared with primary-polydipsia-associated. "
12/01/2013 - "Average length of stay for patients with hyponatremia was 11.67 days (SD 13.01), compared to 9.84 days (SD 11.61) among the general population admitted to IM (p < 0.001). "
06/01/2013 - "Hyponatremia increased overall (24% vs 18.2%, p < 0.001) and late mortality (18.6% vs 13.9%, p < 0.001) and length of stay (LOS; 11 vs 7 days, p < 0.001). "
|5.||Drug Therapy (Chemotherapy)
11/01/1998 - "Chemotherapy plus irradiation improved the hyponatremia. "
11/01/2013 - "This study aimed at evaluating the benefit of changing drug therapy in elderly patients with moderate, potentially drug-induced hyponatremia. "
01/01/2015 - "Known prognostic factors such as age, gender and performance status, the histopathology as well as other new factors such as response to previous chemotherapy and hyponatremia were tested. "
01/01/2014 - "Twenty-four episodes of grade ≥3 hyponatremia were observed in 200 cycles of doublet chemotherapy. "
11/01/2013 - "Hospitalized older adults, with moderate hyponatremia, potentially induced by drugs, were randomized into two arms: an interventional group, whose drug therapy was changed, and a reference group, which received standard care. "