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Hypohidrosis

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Abnormally diminished or absent perspiration. Both generalized and segmented (reduced or absent sweating in circumscribed locations) forms of the disease are usually associated with other underlying conditions.

Also Known As:

Anhidrosis

Networked: 110 relevant articles (2 outcomes, 10 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases
- Skin Diseases: 6066
  - Sweat Gland Diseases
    - Hypohidrosis: 110

Related Diseases

1.	Hyperhidrosis
2.	Pain (Aches)
3.	Hereditary Sensory and Autonomic Neuropathies (HSAN)
4.	Mental Retardation (Idiocy)
5.	Fever (Fevers)

Experts

1.	Indo, Y: 6 articles (08/2005 - 01/2000)
2.	Mardy, S: 4 articles (02/2001 - 01/2000)
3.	Miura, Y: 3 articles (02/2001 - 01/2000)
4.	Matsuda, I: 3 articles (02/2001 - 01/2000)
5.	Endo, F: 3 articles (02/2001 - 01/2000)
6.	Seol, In Joon: 1 article (02/2010)
7.	Kim, Sun Jun: 1 article (02/2010)
8.	Kim, Soon Chul: 1 article (02/2010)
9.	Lee, Seung-Tae: 1 article (11/2009)
10.	Lee, Munhyang: 1 article (11/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypohidrosis:

1.	Acetylcholine (Acetylcholine Chloride)FDA Link 01/01/2008 - "The symptom of dry mouth often accompanies the less apparent symptom of hypohidrosis because the muscarinic M(3) acetylcholine receptor type predominates at both sweat and salivary glands. " 01/01/2008 - "As acetylcholine is the principal neuroeccrine mediator, anhidrosis is one of the clinical hallmarks by which acute anticholinergic toxicity may be recognized. " 03/01/1982 - "The alteration of the sudomotor response to intradermal acetylcholine during the course of the illness suggests that the diagnostic utility of pharmacologic sweat tests may be time dependent, limited to a relatively early period following onset of anhidrosis." 03/01/1982 - "Intradermal acetylcholine produced localized sweating in areas of thermoregulatory anhidrosis five months after the onset of symptoms but failed to do so at two years. " 01/01/2000 - "Oral prednisolone improved acetylcholine-induced sweating in Sjögren's syndrome-related anhidrosis." Order ALL the reference details at left...
2.	Prednisolone (Predate)FDA LinkGeneric 04/01/2006 - "We report a 34-year-old man with acquired idiopathic hypohidrosis successfully treated with prednisolone. " 01/01/2000 - "Oral prednisolone improved acetylcholine-induced sweating in Sjögren's syndrome-related anhidrosis." Order ALL the reference details at left...
3.	CreatinineIBA 11/01/2003 - "After 12 months of therapy the mean creatinine clearance increased, there was significant improvement in the acroparaesthesias and in the hypohidrosis. " Order ALL the reference details at left...
4.	topiramate (Topamax)FDA LinkGeneric 02/01/2010 - "The aim of this study was to determine the incidence and define the clinical characteristics of hypohidrosis-related symptoms with topiramate in pediatric patients. " 11/01/2008 - "RESULTS: In our 2 cases with hypohidrosis related to topiramate, electrophysiological study showed normal function of both beta and delta sensory fibers and absent sympathetic skin responses that recovered to normal after topiramate discontinuation. " 11/01/2008 - "METHODS: A neurophysiological study has been performed on 2 children who have developed hypohidrosis under topiramate treatment. " 11/01/2008 - "The aim of our study is to detect a possible skin innervation involvement as the mechanism underlying hypohidrosis in children treated with topiramate. " 11/01/2008 - "Electrophysiological study in 2 children with transient hypohidrosis induced by topiramate." Order ALL the reference details at left...
5.	Botulinum Toxin Type A (Botox)FDA Link 01/01/2003 - "We treated the patient with 2 separate series of subcutaneous botulinum toxin type A injections to the right upper abdomen and achieved anhidrosis in 5 weeks. " 04/01/2002 - "Intracutaneous injections of botulinum toxin type A (BTXA) have recently been shown to induce an effective but temporary anhidrosis, usually for 4 to 6 months. " 05/01/2008 - "The purpose of this study was to investigate the efficacy and persistence of the hypohidrosis induced by iontophoresis of botulinum toxin type A in patients with palmar hyperhidrosis. " 01/01/2007 - "Patients received 3 U/injection of BoNTA(1) (BOTOX, Allergan, Inc.) and were randomly assigned to receive BoNTA(2) (Dysport, Ipsen Ltd.) at a dose ratio of 1:2.5, 1:3, or 1:4. The area of anhidrosis was highlighted using iodine and starch and determined by software from standardized photography. " Order ALL the reference details at left...
6.	Terbutaline (Brethaire)FDA LinkGeneric 07/01/2008 - "This quantitative intradermal terbutaline sweat test should be a useful aid to the study of equine sweating and anhidrosis." Order ALL the reference details at left...
7.	CationsIBA 02/01/1981 - "Studies on the mechanism of topical anhidrosis due to polyvalent cations." Order ALL the reference details at left...
8.	Amyloid (Amyloid Fibrils)IBA 09/01/1998 - "BACKGROUND: Anhidrosis of the distal lower limbs is a prominent feature of FAP type I. METHODS: Qualitative and morphometric study of amyloid deposition, eccrine glands, and their innervation in nine patients with FAP type I (duration of sensory symptoms, 8.4 +/- 3.9 years [mean +/- SD]; range, 3 to 15 years) and seven control subjects. " Order ALL the reference details at left...
9.	AluminumIBA 05/01/1968 - "Studies on the mechanism of aluminum anhidrosis." Order ALL the reference details at left...
10.	3-(2-carboxyindol-3-yl)propionic acidIBA 07/01/2004 - "A novel lymphocyte signaling defect: trk A mutation in the syndrome of congenital insensitivity to pain and anhidrosis (CIPA)." 09/01/2003 - "Patients with congenital insensitivity to pain and anhidrosis (CIPA), caused by mutations in the NTRK1 gene, can be difficult to diagnose because of their variable presentation, the lack of simple diagnostic tests, and the paucity of cases reported in North America. " 05/01/2002 - "The anomalous pain and temperature sensation and anhidrosis in CIPA are due to the absence of afferent neurons activated by tissue-damaging stimuli and a loss of innervation of eccrine sweat glands, respectively. " 02/22/2002 - "Congenital insensitivity to pain with anhidrosis (CIPA) is a rare genetic disease characterized by absence of reaction to noxious stimuli and anhidrosis. " 02/01/2002 - "We investigated the anesthetic management of patients with congenital insensitivity to pain and anhidrosis (CIPA) in Japan. " Order ALL the reference details at left...

Therapies and Procedures

1.	Anesthesia 02/01/2002 - "Anesthesia for patients with congenital insensitivity to pain and anhidrosis: a questionnaire study in Japan." 07/01/1991 - "The present study describes a patient, aged 72 yrs, with pontine crossed syndrome, displaying ipsilateral to the lesion a syndrome of cranial nerves V, VI, VII, VIII, on the right; a right neocerebellar syndrome; anhidrosis in the right hemibody; contralateral to the lesion: thermoalgic anesthesia with hyperhidrosis in the left hemibody. " 09/01/2009 - "[Anesthesia in a patient with congenital insensitivity to pain and anhidrosis]" 02/01/2002 - "We clarified the following three important points: anesthesia is necessary, temperature management must be maintained, and there must be sufficient perioperative sedation in the anesthetic management of patients with congenital insensitivity to pain and anhidrosis." Order ALL the reference details at left...
2.	Electrodes (Electrode) 02/01/1977 - "In our study 90% of the patients treated developed anhidrosis on both the anode and cathode treated palms or soles. " Order ALL the reference details at left...
3.	Injections 01/01/2003 - "We treated the patient with 2 separate series of subcutaneous botulinum toxin type A injections to the right upper abdomen and achieved anhidrosis in 5 weeks. " 04/01/2002 - "Intracutaneous injections of botulinum toxin type A (BTXA) have recently been shown to induce an effective but temporary anhidrosis, usually for 4 to 6 months. " 04/01/2000 - "Recently, low-dose intracutaneous injections of botulinum toxin A have been shown to induce a temporary anhidrosis, with relapses occurring usually after 4 to 6 months. " 12/01/2003 - "Sweat tests were carried out before botulinum toxin type B injections, and at 3 wk, 3 mo, and 6 mo. We studied focal anhidrosis by iodine-starch staining and by capacitance hygrometry after carbachol iontophoresis, according to the quantitative sudomotor axon reflex test (QSART). " Order ALL the reference details at left...
4.	Aftercare (After-Treatment) 01/01/2007 - "RESULTS: During the 6 months after treatment, the area of anhidrosis was larger with BoNTA(2) in 93% (195/210) of medial-medial or lateral-lateral comparisons of the two products and at all dose ratios. " 05/01/2008 - "Twenty-four patients (96%) were partially or fully satisfied with their fair to excellent anhidrosis; only one patient (who developed a transient headache after treatment) was dissatisfied with its therapeutic effect. " Order ALL the reference details at left...
5.	External Fixators 01/01/2001 - "This report describes a patient with congenital sensory neuropathy with anhidrosis (CSNA) with destructive arthropathy of the left ankle joint that was treated with ankle arthrodesis and tibial lengthening, using an Ilizarov external fixator. " Order ALL the reference details at left...

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