Hypohidrosis

Abnormally diminished or absent perspiration. Both generalized and segmented (reduced or absent sweating in circumscribed locations) forms of the disease are usually associated with other underlying conditions.

Also Known As:

Networked: 309 relevant articles (12 outcomes, 17 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hyperhidrosis
2.	Urticaria (Hives)
3.	Fever (Fevers)
4.	Hypersensitivity (Allergy)
5.	Fabry Disease (Fabry's Disease)

Experts

1.	Tokura, Yoshiki: 7 articles (08/2021 - 01/2011)
2.	Indo, Y: 6 articles (10/2012 - 01/2000)
3.	Nishigori, Chikako: 5 articles (09/2020 - 04/2009)
4.	Tey, Hong Liang: 4 articles (01/2021 - 01/2016)
5.	Fukunaga, Atsushi: 4 articles (09/2020 - 04/2015)
6.	Katayama, Ichiro: 4 articles (01/2018 - 04/2009)
7.	Hide, Michihiro: 3 articles (07/2022 - 10/2019)
8.	Takahagi, Shunsuke: 3 articles (07/2022 - 10/2019)
9.	Nakazato, Yoshihiko: 3 articles (03/2021 - 02/2002)
10.	Ishii, Masaru: 3 articles (01/2018 - 02/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypohidrosis:

1.	Cholinergic Agents (Cholinergics)IBA 04/01/2005 - "Generalised anhidrosis (GA) shows a uniform clinical picture whether the pathogenesis involves intrinsic abnormalities of sweat glands or postganglionic sympathetic cholinergic nerve dysfunction. " 10/26/2004 - "Idiopathic pure sudomotor failure: anhidrosis due to deficits in cholinergic transmission." 08/01/2002 - "Selective loss of cholinergic sudomotor fibers causes anhidrosis in Ross syndrome." 09/01/1998 - "Our laboratory investigations suggest that degeneration of postganglionic sympathetic cholinergic nerve may be the underlying pathogenetic mechanism of anhidrosis in this patient." 10/01/1993 - "Complete anhidrosis with discrete segmental distribution, as well as absence of response to cholinergic agents, was observed in three cases. "
2.	IodineIBA 04/01/2019 - "Iodine test showed hypohidrosis in the described areas, which was confirmed by skin biopsy in both cases. " 08/01/2017 - "The thermoregulatory sweat test using the starch-iodine method (Minor test) with sweating provoked by heat stimulation revealed hypohidrosis of the affected area, whereas no skin lesions were observed on the dorsal hand and wrist where sweating was normal. " 09/01/2014 - "Inclusion criteria included all cases of generalized or partial anhidrosis with no obvious causes, confirmed by provocative starch-iodine sweat test. " 08/01/2016 - "We report a novel method of using an atomizer spray gun to perform the starch-iodine test in a rapid, reproducible, effective, and safe manner suitable for use in the clinical evaluation of hypohidrosis." 12/07/2021 - "Teaching NeuroImage: Starch-Iodine Test: A Colorful Tool for Objectifying Anhidrosis in Horner Syndrome."
3.	Starch (Cornstarch)IBA 08/01/2017 - "The thermoregulatory sweat test using the starch-iodine method (Minor test) with sweating provoked by heat stimulation revealed hypohidrosis of the affected area, whereas no skin lesions were observed on the dorsal hand and wrist where sweating was normal. " 09/01/2014 - "Inclusion criteria included all cases of generalized or partial anhidrosis with no obvious causes, confirmed by provocative starch-iodine sweat test. " 08/01/2016 - "We report a novel method of using an atomizer spray gun to perform the starch-iodine test in a rapid, reproducible, effective, and safe manner suitable for use in the clinical evaluation of hypohidrosis." 12/07/2021 - "Teaching NeuroImage: Starch-Iodine Test: A Colorful Tool for Objectifying Anhidrosis in Horner Syndrome." 09/01/2008 - "We report a patient with Horner syndrome together with anhidrosis affecting the ipsilateral face and extremities confirmed with starch-iodine and sympathetic skin response testing. "
4.	SteroidsIBA 02/01/2015 - "Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis." 04/01/2006 - "Successful steroid treatment of acquired idiopathic partial hypohidrosis." 12/01/1969 - "Percutaneous steroid absorption in anhidrosis." 01/01/2020 - "A rare entity of acquired idiopathic generalised anhidrosis which has been successfully treated with pulse steroid therapy: Does the histopathology predict the treatment response?" 04/01/2006 - "Steroid therapy improved the hypohidrosis. "
5.	Type A Botulinum Toxins (Botox)FDA Link 02/01/2014 - "The area of anhidrosis SC was significantly greater with CBTX-A than onabotulinumtoxinA. " 02/01/2014 - "When BoNTAs were different, the anhidrosis ID area was significantly greater with CBTX-A than onabotulinumtoxinA, the vertical dimension was significantly longer with CBTX-A ID than onabotulinumtoxinA ID and the horizontal dimension was significantly greater with CBTX-A ID than onabotulinumtoxinA ID. " 01/01/2003 - "We treated the patient with 2 separate series of subcutaneous botulinum toxin type A injections to the right upper abdomen and achieved anhidrosis in 5 weeks. " 04/01/2002 - "Intracutaneous injections of botulinum toxin type A (BTXA) have recently been shown to induce an effective but temporary anhidrosis, usually for 4 to 6 months. " 04/01/2000 - "Recently, low-dose intracutaneous injections of botulinum toxin A have been shown to induce a temporary anhidrosis, with relapses occurring usually after 4 to 6 months. "
6.	Pilocarpine (Ocusert)FDA LinkGeneric 08/01/2019 - "Oral pilocarpine alleviates the symptoms of acquired idiopathic generalised anhidrosis." 01/01/1998 - "Application of pilocarpine showed anhidrosis and nerve biopsy revealed a significant decrease in the number of myelinated and unmyelinated nerve fibres." 10/01/1997 - "The result of the application of pilocarpine showed anhidrosis. " 05/01/1993 - "The results of electromyographic examination were normal and the application of pilocarpine showed anhidrosis. " 10/01/2013 - "Of the many aids to document hypohidrosis in HED, we present here the technique of pilocarpine iontophoresis to induce, collect and measure sweat. "
7.	Acetylcholine (Acetylcholine Chloride)FDA Link 03/01/1982 - "The alteration of the sudomotor response to intradermal acetylcholine during the course of the illness suggests that the diagnostic utility of pharmacologic sweat tests may be time dependent, limited to a relatively early period following onset of anhidrosis." 03/01/1982 - "Intradermal acetylcholine produced localized sweating in areas of thermoregulatory anhidrosis five months after the onset of symptoms but failed to do so at two years. " 01/01/2000 - "Oral prednisolone improved acetylcholine-induced sweating in Sjögren's syndrome-related anhidrosis." 01/01/2008 - "As acetylcholine is the principal neuroeccrine mediator, anhidrosis is one of the clinical hallmarks by which acute anticholinergic toxicity may be recognized. " 01/01/2014 - "Decreased expression of acetylcholine esterase in cholinergic urticaria with hypohidrosis or anhidrosis."
8.	incobotulinumtoxinAFDA Link 02/07/2005 - "BoNT/A in general induced a more sustained anhidrosis than BoNT/B." 03/01/2012 - "However, abobotulinumtoxinA, when assuming a 1:2.5 injection volume ratio, produced a statistically significantly greater maximal area of anhidrosis within 6 weeks and AUEC over 6 months compared with incobotulinumtoxinA. " 03/01/2012 - "The results showed that incobotulinumtoxinA and onabotulinumtoxinA displayed comparable spread at 6 weeks (maximal area of anhidrosis within 6 weeks) and area under the effect curve (AUEC) over 6 months. " 02/01/2003 - "Before each session, sweating and local anhidrosis was assessed by iodine starch staining.BoNT/A suppressed sweating as early as from the second day after injection (p < 0.001). "
9.	Prednisolone (Predate)FDA LinkGeneric 04/01/2006 - "We report a 34-year-old man with acquired idiopathic hypohidrosis successfully treated with prednisolone. " 01/01/2000 - "Oral prednisolone improved acetylcholine-induced sweating in Sjögren's syndrome-related anhidrosis."
10.	abobotulinumtoxinAFDA Link 03/01/2012 - "However, abobotulinumtoxinA, when assuming a 1:2.5 injection volume ratio, produced a statistically significantly greater maximal area of anhidrosis within 6 weeks and AUEC over 6 months compared with incobotulinumtoxinA. " 01/01/2007 - "Patients received 3 U/injection of BoNTA(1) (BOTOX, Allergan, Inc.) and were randomly assigned to receive BoNTA(2) (Dysport, Ipsen Ltd.) at a dose ratio of 1:2.5, 1:3, or 1:4. The area of anhidrosis was highlighted using iodine and starch and determined by software from standardized photography. "

Therapies and Procedures

1.	Therapeutics 01/01/2020 - "Conclusion: These findings suggest this acquired generalized hypohidrosis represents a lymphocyte-mediated adverse immune event related to this patient's checkpoint inhibitor therapy." 01/01/2020 - "Hypohidrosis as an immune-related adverse event of checkpoint inhibitor therapy." 02/01/2007 - "The results suggest genomic regulation of cell proliferation and differentiation, as well as of secretory and excretory functions, indicating potential therapies for impaired secretion as in hypohidrosis of aged and diseased skin." 01/01/2019 - "Hypohidrosis, which can cause life-threatening hyperthermia, is amenable to intrauterine therapy with recombinant EDA1. " 01/01/2002 - "In future, therefore, it is likely that neuropathic pain, quantitative sensory testing and hypohidrosis will serve as clinical outcome measures for studies of specific and effective therapies for Fabry disease."
2.	Sympathectomy (Sympathectomies) 04/01/2011 - "In this series, we did not find any significant difference between T2-T4 sympathectomy and T3-T4 sympathicotomy in terms of postsurgical palmar anhidrosis or onset of compensatory hyperhidrosis, while both methods show high efficacy for remission of palmar hyperhidrosis. " 09/01/2007 - "He had previously received bilateral thoracic sympathectomy for axillary hyperhidrosis at another hospital, and was known to have upper body and limb anhidrosis. "
3.	Vertical Dimension (Occlusion Vertical Dimension) 02/01/2014 - "When BoNTAs were different, the anhidrosis ID area was significantly greater with CBTX-A than onabotulinumtoxinA, the vertical dimension was significantly longer with CBTX-A ID than onabotulinumtoxinA ID and the horizontal dimension was significantly greater with CBTX-A ID than onabotulinumtoxinA ID. "
4.	Nebulizers and Vaporizers (Inhaler) 08/01/2016 - "We report a novel method of using an atomizer spray gun to perform the starch-iodine test in a rapid, reproducible, effective, and safe manner suitable for use in the clinical evaluation of hypohidrosis." 08/01/2016 - "Application of iodinated starch powder prepared in-house with the atomizer spray gun achieved a lightweight and homogeneous coat on our patients' skin which allowed for clear visualization of the sweating pattern in areas of anhidrosis. " 08/01/2016 - "Application of iodinated starch powder using an atomizer spray gun - a new and effective tool to evaluate hypohidrosis."
5.	Denervation 02/01/2022 - "Minor's (starch-iodine) test and dilute pilocarpine test were helpful for diagnosis in both cases, indicating areas of anhidrosis and pupillary cholinergic denervation hypersensitivity respectively. "