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Hypoaldosteronism (Hyporeninemic Hypoaldosteronism)

A congenital or acquired condition of insufficient production of ALDOSTERONE by the ADRENAL CORTEX leading to diminished aldosterone-mediated synthesis of Na(+)-K(+)-EXCHANGING ATPASE in renal tubular cells. Clinical symptoms include HYPERKALEMIA, sodium-wasting, HYPOTENSION, and sometimes metabolic ACIDOSIS.
Also Known As:
Hyporeninemic Hypoaldosteronism; Acidosis, Renal Tubular Type IV; Hypoaldosteronism, Hyporeninemic; Renal Tubular Acidosis, Type IV; Type IV Renal Tubular Acidosis
Networked: 296 relevant articles (6 outcomes, 14 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hyperkalemia
2. Acidosis
3. Chronic Renal Insufficiency
4. Renal Insufficiency (Renal Failure)
5. Acquired Immunodeficiency Syndrome (AIDS)

Experts

1. Okopień, Bogusław: 2 articles (01/2013 - 01/2012)
2. Krysiak, Robert: 2 articles (01/2013 - 01/2012)
3. Balavoine, Anne-Sophie: 2 articles (11/2012 - 12/2011)
4. Vantyghem, Marie-Christine: 2 articles (11/2012 - 12/2011)
5. Douillard, Claire: 2 articles (11/2012 - 12/2011)
6. Bernhardt, Rita: 2 articles (03/2011 - 03/2009)
7. Fumeaux, Z: 2 articles (03/2007 - 02/2005)
8. Nussdorfer, Gastone G: 2 articles (04/2004 - 07/2003)
9. Klein-Vehne, N: 2 articles (04/2004 - 01/2004)
10. Fehsel, K: 2 articles (04/2004 - 01/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypoaldosteronism:
1. FludrocortisoneIBA
2. Furosemide (Lasix)FDA LinkGeneric
3. CreatinineIBA
03/01/1994 - "Serum creatinine levels were normalized in case 1 and they remained at about 2 mg/dl in case 2. Hyporeninemic hypoaldosteronism was transiently seen in case 2. These data suggest that recovery from the acute phase of hemolytic uremic syndrome leads to a good long-term prognosis in MMC nephropathy."
09/01/1999 - "Patients with hyporeninemic hypoaldosteronism show mild to moderate renal insufficiency, with a creatinine clearance of 20-75 ml/min, and asymptomatic hyperkalemia. "
04/01/1994 - "In conclusion, multifactorial causes including insulinopenia, hyperosmolality, elevated serum creatinine level and hypoaldosteronism with possible contribution of altered distal tubular response to aldosterone may have interacted to develop hyperkalemia in these diabetic rats."
04/17/1986 - "We found that prostacyclin, a potent vasodilator and renin secretagogue, was markedly reduced--as reflected by its stable urinary metabolite 6-keto-prostaglandin F1 alpha--in seven patients with hyporeninemic hypoaldosteronism as compared with seven matched controls with renal insufficiency and as compared with 12 normal volunteers (mean +/- SE, 42 +/- 7 vs. 185 +/- 37 and 164 +/- 20 ng per gram of creatinine, respectively; P less than 0.001). "
01/01/1986 - "To further define the pathophysiology of the syndrome of acquired isolated hypoaldosteronism, we determined plasma concentrations of active and inactive renin and urinary kallikrein and prostaglandin E2 excretion rates in 11 patients with the syndrome, 12 patients with similar serum creatinine levels, but without hyperkalemia, and in 12 normotensive patients with normal renal function and low plasma renin activities (PRA). "
4. Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
5. Lisinopril (Prinivil)FDA LinkGeneric
6. Dexamethasone (Maxidex)FDA LinkGeneric
7. AldosteroneIBA
8. ReninIBA
9. PotassiumIBA
10. Adrenocorticotropic Hormone (ACTH)FDA Link

Therapies and Procedures

1. Renal Dialysis (Hemodialysis)
2. Transplants (Transplant)
3. Kidney Transplantation
4. Intravenous Infusions
5. Sodium-Restricted Diet (Diet, Sodium Restricted)