Hypoaldosteronism (Hyporeninemic Hypoaldosteronism)

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267 relevant articles (4 outcomes, 12 trials/studies) found for this Disease

Description: A congenital or acquired condition of insufficient production of ALDOSTERONE by the ADRENAL CORTEX leading to diminished aldosterone-mediated synthesis of Na(+)-K(+)-EXCHANGING ATPASE in renal tubular cells. Clinical symptoms include HYPERKALEMIA, sodium-wasting, HYPOTENSION, and sometimes metabolic ACIDOSIS.

Also Known As:

Hyporeninemic Hypoaldosteronism; Acidosis, Renal Tubular Type IV; Hypoaldosteronism, Hyporeninemic; Renal Tubular Acidosis, Type IV; Type IV Renal Tubular Acidosis

Relationship Network

Disease Context: Research Results

Endocrine System Diseases: 391

Adrenal Gland Diseases: 7

Adrenal Insufficiency: 1351

Hypoaldosteronism: 267

Related Diseases

1.	Hyperkalemia
2.	Acidosis
3.	Chronic Renal Insufficiency
4.	Renal Insufficiency
5.	Acquired Immunodeficiency Syndrome (AIDS)

Experts

1.	Tymms, D J: 1 article (05/2008)
2.	Talapatra, I: 1 article (05/2008)
3.	Daubin, Cédric: 1 article (01/2008)
4.	du Cheyron, Damien: 1 article (01/2008)
5.	Ballet, Jean-Jacques: 1 article (01/2008)
6.	Ramakers, Michel: 1 article (01/2008)
7.	Charbonneau, Pierre: 1 article (01/2008)
8.	Bouchet, Bruno: 1 article (01/2008)
9.	Cauquelin, Brigitte: 1 article (01/2008)
10.	Guillotin, Damien: 1 article (01/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypoaldosteronism:

1.	FludrocortisoneIBA 05/01/2008 - "Isolated hypoaldosteronism: Hyponatraemia responds to a small dose of fludrocortisone alone when fluid restriction is ineffective." 08/01/1992 - "Administration of fludrocortisone can rapidly alleviate the signs and symptoms of hyporeninemic hypoaldosteronism" 09/15/1977 - "Amelioration of metabolic acidosis with fludrocortisone therapy in hyporeninemic hypoaldosteronism." 05/01/1987 - "It is concluded that hyporeninemic hypoaldosteronism is responsible for hyperkalemia in some patients with AIDS and that treatment with fludrocortisone is effective in these cases." 01/01/1986 - "Urinary kallikrein excretion rates in the patients with isolated hypoaldosteronism were significantly lower than in the control groups, but increased in response to therapy with fludrocortisone." Order ALL the reference details at left...
2.	Furosemide (Lasix)FDA LinkGeneric 08/01/1984 - "On the basis of this the suggestion is made that Bartter's syndrome and hyporeninaemic hypoaldosteronism represent respectively an excess and a deficiency of a circulating factor similar to frusemide capable of blocking renal tubular chloride transport." 08/01/1984 - "Two contrasting patients are described, one with pseudo-Bartter's syndrome induced by frusemide abuse and the other a case of hyporeninaemic hypoaldosteronism" 11/01/1983 - "Renal hypoprostaglandism, hypertension, and type IV renal tubular acidosis reversed by furosemide." 11/01/1980 - "Urinary prostaglandins following frusemide treatment and salt depletion in normal subjects and subjects with diabetic hyporeninaemic hypoaldosteronism." 01/01/1984 - "Combined therapy ameliorated acidosis in the patient with the most severe degree of hypoaldosteronism, the same patient in whom administration of furosemide without fludrocortisone was ineffective even after 6 months of treatment" Order ALL the reference details at left...
3.	CreatinineIBA 03/01/1994 - "Serum creatinine levels were normalized in case 1 and they remained at about 2 mg/dl in case 2. Hyporeninemic hypoaldosteronism was transiently seen in case 2. These data suggest that recovery from the acute phase of hemolytic uremic syndrome leads to a good long-term prognosis in MMC nephropathy." 09/01/1999 - "Patients with hyporeninemic hypoaldosteronism show mild to moderate renal insufficiency, with a creatinine clearance of 20-75 ml/min, and asymptomatic hyperkalemia" 04/01/1994 - "In conclusion, multifactorial causes including insulinopenia, hyperosmolality, elevated serum creatinine level and hypoaldosteronism with possible contribution of altered distal tubular response to aldosterone may have interacted to develop hyperkalemia in these diabetic rats." 04/17/1986 - "We found that prostacyclin, a potent vasodilator and renin secretagogue, was markedly reduced--as reflected by its stable urinary metabolite 6-keto-prostaglandin F1 alpha--in seven patients with hyporeninemic hypoaldosteronism as compared with seven matched controls with renal insufficiency and as compared with 12 normal volunteers (mean +/- SE, 42 +/- 7 vs. 185 +/- 37 and 164 +/- 20 ng per gram of creatinine, respectively; P less than 0.001)" 01/01/1986 - "To further define the pathophysiology of the syndrome of acquired isolated hypoaldosteronism, we determined plasma concentrations of active and inactive renin and urinary kallikrein and prostaglandin E2 excretion rates in 11 patients with the syndrome, 12 patients with similar serum creatinine levels, but without hyperkalemia, and in 12 normotensive patients with normal renal function and low plasma renin activities (PRA)" Order ALL the reference details at left...
4.	Dexamethasone (Maxidex)FDA LinkGeneric 04/01/1992 - "A case of hyporeninemic hypoaldosteronism improved by dexamethasone treatment]" Order ALL the reference details at left...
5.	AldosteroneIBA 08/01/2008 - "Congenital hypoaldosteronism due to an isolated aldosterone biosynthesis defect is rare" 01/01/2004 - "Clinical symptoms resemble features of hypoaldosteronism, although concentrations of aldosterone are in the normal range" 03/01/1996 - "Cost were the first to suggest a defect of the terminal aldosterone (Aldo) biosynthesis in patients with hypoaldosteronism" 01/01/1987 - "Effect of dopaminergic blockade on plasma aldosterone in acquired hypoaldosteronism." 01/01/1987 - "In patients with CRF with and without hypoaldosteronism (5 undialyzed and all 9 dialyzed patients), plasma aldosterone increased significantly" Order ALL the reference details at left...
6.	ReninIBA 02/01/2002 - "Further endocrine evaluation revealed baseline hypoaldosteronism associated with elevated renin activity" 08/20/1994 - "These results suggest that autonomic dysfunction is a major factor in an impairment of the processing of prorenin to active renin in diabetic patients, and severe autonomic dysfunction may impair the biosynthesis of prorenin in patients with hyporeninemic hypoaldosteronism." 07/01/1982 - "Beta-adrenoceptor blockade increases serum K, which may be related to renin inhibition, hypoaldosteronism, and exercise-induced skeletal muscle release of serum K" 03/01/1978 - "Of the 32 previously reported cases of selective hypoaldosteronism, plasma renin activity was low in the majority of cases in which it was measured" 12/01/1976 - "4. This defect, a probable consequence of chronic renin deficiency on the zona glomerulosa, could be a contributing factor to the hypoaldosteronism." Order ALL the reference details at left...
7.	Angiotensin IIIBA 12/01/1976 - "Selective hypoaldosteronism: a study of steroid biosynthetic pathways under adrenocorticotrophin and angiotensin II infusion." 01/01/1991 - "These results suggest that adrenal insensitivity to angiotensin II was the cause of the selective hypoaldosteronism in our patient, possibly due to a dysfunction of adrenal angiotensin II receptors, a disorder of postreceptors or both." 12/31/1987 - "Selective hypoaldosteronism and impairment of angiotensin II production." 06/25/1987 - "Selective hypoaldosteronism due to an endogenous impairment in angiotensin II production." 03/01/1978 - "Therefore, the lack of circulating angiotensin II seems to be the causative reason of hypoaldosteronism" Order ALL the reference details at left...
8.	Adrenocorticotropic Hormone (ACTH)FDA Link 06/21/1997 - "Corticotropin deficiency and hyporeninism-hypoaldosteronism]" 01/01/1996 - "A case of isolated ACTH deficiency with hyporeninemic hypoaldosteronism." 01/01/1989 - "This paper documents the rare and hitherto unreported association between isolated ACTH deficiency and normoreninemic hypoaldosteronism in a 63-year-old woman" 01/01/1989 - "Normoreninemic hypoaldosteronism in a case of isolated ACTH deficiency." 05/01/1986 - "To our knowledge, this is the first reported case of isolated corticotropin deficiency and hyporeninemic hypoaldosteronism together mimicking primary adrenocortical failure." Order ALL the reference details at left...
9.	SodiumIBA 05/01/1995 - "In the present study, 5 of 16 patients diagnosed with isolated hypoaldosteronism (IHA) had sodium depletion due to renal salt wasting, and four patients had normokalemia" 01/01/1984 - "Hyporeninemic hypoaldosteronism was found in two male siblings with urinary salt wasting and low plasma sodium levels" 01/01/1977 - "Effect of alterations of sodium intake in patients with hyporeninemic hypoaldosteronism." 05/01/1995 - "The most common abnormality in hypoaldosteronism is hyperkalemia, which may be combined with sodium depletion" 07/01/1983 - "Hyporeninemic hypoaldosteronism, sodium wasting and mineralocorticoid-resistant hyperkalemia in two patients with obstructive uropathy." Order ALL the reference details at left...
10.	CorticosteroneIBA 07/01/1984 - "Linkage and segregation analysis of HLA and congenital hypoaldosteronism due to corticosterone methyl-oxydase deficiency type I and type II." 01/01/1991 - "Severe hypoaldosteronism due to corticosterone methyl oxidase type II deficiency in two boys: metabolic and gas chromatography-mass spectrometry studies." 12/01/1986 - "Two adult familial cases of selective hypoaldosteronism due to insufficiency of conversion of corticosterone to aldosterone." 01/01/1986 - "Hypoaldosteronism caused by 18-hydroxydehydrogenase deficiency (or type II corticosterone-methyl-oxidase)]" 01/01/1979 - "Identical male twins suffering from congenital hypoaldosteronism due to a rare adrenal enzyme deficiency between corticosterone and aldosterone were followed-upfrom birth till their present age of 13 years" Order ALL the reference details at left...

Therapies and Procedures

1.	Renal Dialysis (Hemodialysis) 07/01/1998 - "This study was designed to examine whether the discontinuous use of heparin three times a week to prevent thrombosis formation during hemodialysis sessions could also induce hypoaldosteronism and might contribute to increased predialysis kalemia in hemodialysis patients" Order ALL the reference details at left...
2.	Transplants (Transplant) 06/01/1998 - "In 1990 the patient developed amyloidosis of the graft with membranous nephropathy and tubular acidosis due to hyporeninemic hypoaldosteronism" 12/01/2001 - "On the other hand, aldosterone plasma concentrations remain very low, plasma potassium levels are increased, and plasma sodium levels are decreased in animals with intrasplenic adrenal grafts, indicating that aldosterone production is insufficient to avoid hypoaldosteronism." Order ALL the reference details at left...
3.	Kidney Transplantation 03/01/1977 - "Hyporeninemic hypoaldosteronism after renal transplantation." 04/01/2004 - "BACKGROUND: After renal transplantation immunosuppressive drugs-like cyclosporin A (CsA) and FK506 induce either hypoaldosteronism or pseudo-hypoaldosteronism presenting with hyperkalemia and metabolic acidosis" Order ALL the reference details at left...
4.	Sodium-Restricted Diet (Diet, Sodium Restricted) 08/01/1986 - "The indomethacin-induced hyporeninism and hypoaldosteronism were more pronounced when the subjects were receiving a sodium-restricted diet" 12/01/1993 - "Also, the renin-aldosterone stimulation testing on this patient performed by sodium restricted diet and furosemide, upright position and by angiotensin converting enzyme inhibition (captopril, 50 mg) showed the blunted renin and aldosterone responses to each of these stimuli, almost no changes from baseline renin and aldosterone levels, it was concluded that the underlying defect responsible for hyperkalemia in this case was hyporeninemic hypoaldosteronism and this was aggravated by other factors or drugs affecting potassium homeostasis." Order ALL the reference details at left...
5.	Renal Replacement Therapy (Therapies, Renal Replacement) 10/01/2003 - "Duration of ICU stay (p=0.0026) and the need for renal replacement therapy (p=0.0021) were greater in the group with PAC/renin less than 2. CONCLUSIONS: Transient hyperreninemic hypoaldosteronism is common in patients with septic shock" Order ALL the reference details at left...

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