Hypervitaminosis A

02/01/1979 - "Clearance of retinol from plasma increased 2-fold with hypervitaminosis A, exhibited a greater response in the mild group, and increased linearly with vitamin A concentration in plasma. "
12/01/1992 - "This study provides evidence that long-term supplemental vitamin A in doses commonly found in multivitamin supplements does not present a risk for hypervitaminosis A."
12/12/2022 - "Peeling away from hypervitaminosis A: the importance of close monitoring in patients taking high dose vitamin A supplementation."
08/01/2022 - "In this sample, most children had retinol intakes above the Tolerable Upper Intake Level (UL) and liver VA concentrations above the proposed cutoff for "hypervitaminosis A" (>1 µmol/g liver). "
01/01/2022 - "We recommend monitoring vitamin A levels as part of routine nutritional assessments and dietary interventions to prevent hypervitaminosis A to improve bone health in late CKD."

01/01/1977 - "Histochemical studies on respiratory enzymes in hypervitaminosis A."
06/01/1998 - "Alterations in kidney enzyme pattern in acute hypervitaminosis A."
02/01/1976 - "Microsomal enzyme inducers and hypervitaminosis A in rats."
01/01/1971 - "Urinary excretion of lysosomal enzymes in hypovitaminosis and hypervitaminosis A in children."
06/01/1998 - "The relation of excessive doses of vitamin A with various kidney pathologies is well known however, information concerning the relation of kidney enzyme activity with acute hypervitaminosis A is rather scarce. "

03/01/2017 - "Even though ovalbumin and retinoic have been previously applied through intra-tracheal route in cancer prevention and immunological research, the objective of this study was to evaluate their interaction as a remedy for hypervitaminosis A. "

07/01/1970 - "Excessive dietary vitamin E: its alleviation of hypervitaminosis A and lack of toxicity."
07/01/2004 - "In conclusion, vitamin E therapy appears to be an effective treatment for hypervitaminosis A."
10/01/1991 - "These results extend to adult rats previous findings that excess retinyl palmitate alters vitamin E and carotenoid status prior to the manifestation of clinical signs of hypervitaminosis A. "

12/01/1978 - "It is suggested, therefore, that in addition to the increased activities of key gluconeogenic enzymes, reported earlier, a marked decrease in the activities of phosphofructokinase and pyruvate kinase and elevated level of citrate in the liver could account for the enhanced gluconeogenesis in hypervitaminosis A."
05/01/2007 - "In addition to the wide variety of hypercalcemia and/or hyperphosphatemia-causing clinical conditions, GMC has also been associated with atrophic gastritis, hypervitaminosis A, organ transplantation, gastric neoplasia, uremia with eucalcemia/euphosphatemia, and the use of aluminum-containing antacids, citrate-containing blood products, isotretinoin, and sucralfate. "

12/01/1978 - "It is suggested, therefore, that in addition to the increased activities of key gluconeogenic enzymes, reported earlier, a marked decrease in the activities of phosphofructokinase and pyruvate kinase and elevated level of citrate in the liver could account for the enhanced gluconeogenesis in hypervitaminosis A."
12/01/1978 - "Furthermore, hypervitaminosis A decreased the activities of two key hepatic glycolytic enzymes, phosphofructokinase, and pyruvate kinase, without affecting those of hexokinase and glucokinase. "

12/01/1978 - "It is suggested, therefore, that in addition to the increased activities of key gluconeogenic enzymes, reported earlier, a marked decrease in the activities of phosphofructokinase and pyruvate kinase and elevated level of citrate in the liver could account for the enhanced gluconeogenesis in hypervitaminosis A."
12/01/1978 - "Furthermore, hypervitaminosis A decreased the activities of two key hepatic glycolytic enzymes, phosphofructokinase, and pyruvate kinase, without affecting those of hexokinase and glucokinase. "

01/01/1987 - "Ultrastructural study of the lipid storage in rat liver caused by experimental hypervitaminosis A."
01/01/1979 - "Histological studies confirmed the accumulation of abnormal amounts of lipid round the liver Kupffer cells in hypervitaminosis A. "
05/01/2009 - "Hypervitaminosis A altering the lipid profile in a hypercholesterolemic patient."
08/01/1991 - "Perisinusoidal cell lipid overload was not associated with hypervitaminosis A. "
02/01/1987 - "[Changes in the lipid-accumulating cells of the liver during experimental hypervitaminosis A]."

11/01/1983 - "This therapeutic activity in combination with the determination of a therapeutic index (relation between therapeutic action and hypervitaminosis A syndrome) served as criteria in choosing retinoids for clinical trials in dermatologic and oncologic diseases. "
01/12/2015 - "It is hypothesized that liver damage leads to the spillage of toxic retinoid compounds into the circulation, resulting in an endogenous form of hypervitaminosis A and cytotoxicity with widespread apoptosis, mediated by granulysin and recognized as SJS/TEN. "
05/01/2004 - "Two major problems in the clinical use of retinoids are that the doses needed for successful treatment are often toxic, leading to "hypervitaminosis A syndrome" and that patients often develop drug resistance. "
09/01/1999 - "Symptomatologically, the clinical pictures of these patients were comparable to acute hypervitaminosis A or retinoid intoxication. "
03/01/1995 - "Side effects of retinoids are those of the hypervitaminosis A syndrome and have to be considered in every patient treated with this drug. "

08/01/1993 - "Numerous studies of experimental hypo- and hypervitaminosis A have long suggested that retinoic acid (RA) is involved in chondrocyte maturation during endochondral ossification and skeletogenesis. "
03/01/2017 - "The role of retinoic acid (All Trans Retinoic Acid; ATRA) in the development of hypervitaminosis A pathophysiology is not well understood or established in the literature. "
02/01/1996 - "Ultrastructural and biochemical investigations indicated epidermal hypervitaminosis A, probably related to alteration of epidermal retinoic acid metabolism. "
05/01/1992 - "administration in mice and produced no signs of hypervitaminosis A-related toxicity at twenty times the no effect dose of tretinoin. "
09/01/1989 - "Tretinoin cream has an excellent safety record; a local cutaneous hypervitaminosis A reaction is the only common problem."

03/01/2006 - "An 8.5-year-old girl with classical maple syrup urine disease (MSUD) required liver transplantation for hypervitaminosis A and was effectively cured of MSUD over an 8-year clinical follow-up period. "
01/01/2019 - "Liver Cirrhosis From Chronic Hypervitaminosis A Resulting in Liver Transplantation: A Case Report."
03/01/1990 - "The study included liver diseases (such as alcoholic liver diseases, benign and malignant liver tumors, cholestasis of various origins, fulminant hepatitis, acute rejection after orthotopic liver transplantation, Budd-Chiari syndrome), as well as general or extrahepatic diseases (such as diabetes, hemochromatosis, hypervitaminosis A, various hematological disorders), and normal controls. "

01/01/1996 - "A case of hypervitaminosis A (HVA) as a complication of therapy for stage-IV neuroblastoma is presented. "
06/01/1984 - "The putative relationship between uraemic pruritus and hypervitaminosis A and the response of this condition to UV therapy is discussed."
07/01/2004 - "In conclusion, vitamin E therapy appears to be an effective treatment for hypervitaminosis A."
04/01/1992 - "Acitretin therapy has distinctive adverse effects generally typical of hypervitaminosis A. "
01/01/1987 - "Oral retinoid therapy is associated with significant mucocutaneous and systemic toxicity similar to that found in hypervitaminosis A. "

02/01/1995 - "Hypervitaminosis A in two hemodialysis patients."
01/01/1984 - "Hypervitaminosis A toxicity in regular hemodialysis patients."
02/01/1995 - "We will discuss the reason why hemodialysis patients are at special risk for the development of hypervitaminosis A and review the mechanism leading to the associated hypercalcemia."
08/01/1983 - "Hypervitaminosis A, hypercalcemia and hemodialysis."
07/01/1979 - "Hypervitaminosis A in a patient with alopecia receiving renal dialysis."

09/01/1992 - "Most cases of chronic hypervitaminosis A are the result of self-medication or health food faddism. "
01/01/1975 - "Evaluation of the 132 cases of chronic hypervitaminosis-A showed that approximately one quarter cannot be considered as genuine cases, whereas the rest is divided almost equally between vitamin A prescription and self-medication. "
01/01/1975 - "Whereas acute vitamin A intoxication has lost numerical importance during the past 15 years, chronic hypervitaminosis-A, especially that caused by self-medication, has provoked world-wide discussion concerning the safety of retinol intake. "

02/01/1981 - "Development of hypervitaminosis A in a patient on long-term parenteral hyperalimentation."
07/01/1986 - "We present three patients with renal failure receiving total parenteral nutrition (TPN) who developed biochemical and clinical findings of hypervitaminosis A. "
02/01/1981 - "A four and one-half year old boy with intestinal pseudo-obstruction who had been maintained on parenteral hyperalimentation for one year developed classical signs of hypervitaminosis A. "