Hypertrichosis

Excessive hair growth at inappropriate locations, such as on the extremities, the head, and the back. It is caused by genetic or acquired factors, and is an androgen-independent process. This concept does not include HIRSUTISM which is an androgen-dependent excess hair growth in WOMEN and CHILDREN.

Also Known As:

Networked: 520 relevant articles (17 outcomes, 24 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypertension (High Blood Pressure)
2.	Hirsutism
3.	Gingival Hyperplasia
4.	Acanthosis Nigricans
5.	Nevus (Nevi)

Experts

1.	Paus, Ralf: 7 articles (12/2021 - 04/2005)
2.	Paus, R: 5 articles (01/2020 - 06/2010)
3.	Hussain, Khalid: 5 articles (01/2019 - 01/2015)
4.	Cohen, Philip R: 4 articles (01/2020 - 03/2018)
5.	Shapiro, Jerry: 4 articles (05/2019 - 07/2005)
6.	Trüeb, R M: 3 articles (03/2022 - 08/2003)
7.	Greve, B: 3 articles (07/2003 - 01/2000)
8.	Raulin, C: 3 articles (07/2003 - 01/2000)
9.	Bokhari, Laita: 2 articles (01/2022 - 01/2022)
10.	Kazmi, Ahmed: 2 articles (01/2022 - 01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypertrichosis:

1.	Tacrolimus (Prograf)FDA LinkGeneric 01/01/2021 - "Localized hypertrichosis following tacrolimus therapy: A case report and brief review." 07/01/1994 - "Although hypertrichosis is induced by both topical and oral administration of CsA, there has been no report showing that FK506 induces hypertrichosis. " 01/01/2005 - "Focal hypertrichosis during topical tacrolimus therapy for childhood vitiligo." 10/28/2000 - "9 patients were switched from cyclosporine to tacrolimus, 7 for biopsy-proven rejection and 2 for cosmetic reasons (hypertrichosis). " 06/01/1998 - "Elective conversion of patients from cyclosporine to tacrolimus for hypertrichosis."
2.	Glycine (Aminoacetic Acid)FDA LinkGeneric 08/01/2021 - "The study shows that a cosmetic formulation based on capryloyl glycine 4% is highly effective in reducing several parameters related to hair growth and hair thickness vs placebo, thus showing efficacy in the treatment of hypertrichosis." 04/01/2021 - "Capryloyl glycine and soy isoflavonoids in hypertrichosis: An experimental and placebo-controlled clinical study."
3.	Androgen Antagonists (Antiandrogens)IBA 05/01/2002 - "Although frequently used, systemic antiandrogens have not yet proven their efficacy against unwanted hypertrichosis in clinical studies using modern and objective endpoints. " 01/01/1979 - "Use of the antiandrogen cyproterone acetate in the treatment of hirsutism.--25 women with hirsutism or hypertrichosis faciei were subject to a "reverse sequential therapy" with cyproterone acetate (Hammerstein's regimen) for 1 to 3 years. "
4.	Minoxidil (Rogaine)FDA LinkGeneric 07/01/2023 - "A child with generalized hypertrichosis due to secondary topical minoxidil exposure." 03/01/2022 - "Minoxidil-induced hypertrichosis in a breastfed infant." 11/01/2020 - "Given the widespread use of topical minoxidil, it is likely that this etiology of childhood hypertrichosis is underdiagnosed and that it sometimes leads to minimal forms that go unnoticed." 11/01/2020 - "Severe hypertrichosis in infants due to transdermic exposure to 5% and 7% topical minoxidil." 01/01/2020 - "Minoxidil-induced hypertrichosis in an 8-month-old infant."
5.	SolutionsIBA 08/01/1997 - "Topical solution-assisted Q-switched Nd:YAG laser hair removal is a safe and effective method for reducing hair density in cases of extensive hypertrichosis. " 02/01/2000 - "Hirsutism and hypertrichosis are common problems for which a permanent solution has been elusive. " 11/01/1991 - "Since hypertrichosis occurred as an adverse effect in most patients treated, a 2% topical solution was developed for use in men with androgenic alopecia. " 01/01/2023 - "Generalized Hypertrichosis After 5% Minoxidil Solution in Trichorhinophalangeal Syndrome: A Case Report and Review of the Literatures." 05/01/2003 - "Hypertrichosis in females applying minoxidil topical solution and in normal controls."
6.	CholesterolIBA 01/01/2020 - "Altered cholesterol homeostasis is involved in the pathogenesis of primary cicatricial alopecia, mutations in a cholesterol transporter are associated with congenital hypertrichosis, and dyslipidaemia has been linked to androgenic alopecia. " 01/01/2023 - "Reports have associated defects in ABCA5, a membrane transporter, with altered keratinocyte cholesterol distribution in individuals with a form of congenital hypertrichosis, yet the biological basis for this defect in hair growth remains unknown. " 05/01/2005 - "After the switch to tacrolimus, mean total cholesterol was reduced by 15% at month 6. One hundred seventy-seven additional patients were switched primarily for other indications: hypertrichosis, gingival hyperplasia, and arterial hypertension, and these symptoms also improved after the switch. " 06/01/2015 - "Clinically, pharmacological modulation of the activity of selected intrafollicular ABC transporters may permit novel therapeutic interventions, such as protecting HF stem cells from chemotherapy-induced damage, counteracting cholesterol-associated hypertrichosis, and manipulating the intrafollicular prostaglandin balance in androgenetic alopecia." 10/30/2020 - "The secondary outcomes were Total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, fasting glucose, fasting insulin, insulin sensitivity index, body mass index, hypertrichosis score, acne score, adverse reactions, etc. Two reviewers will independently conduct cations retrieval, de-duplication, filtering, quality assessment, and data analysis by Endnote X9.1 and Review Manager software (RevMan V.5.3). "
7.	Thyroxine (Levothyroxine)FDA LinkGeneric 04/01/2006 - "The hypertrichosis resolved after 3 months' of thyroxine replacement treatment. " 09/01/1986 - "Remission of acanthosis nigricans, hypertrichosis, and Hashimoto's thyroiditis with thyroxine replacement." 09/01/2005 - "Acquired ichthyosis and hypertrichosis due to autoimmune thyroiditis: therapeutic response to thyroxine replacement." 08/01/1985 - "A 10 year old girl with hypertrichosis associated with primary hypothyroidism that resolved after 6 months' replacement treatment with thyroxine is reported. "
8.	Prednisolone (Predate)FDA LinkGeneric 11/01/2006 - "Chemotherapy was then switched to cyclophosphamide and prednisolone, resulting in further improvement in muscle power and hypertrichosis. "
9.	Metformin (Glucophage)FDA LinkGeneric 03/01/2016 - "The patient was treated with twice daily injections of rhIGF1 and metformin for more than 5 years with improvement in her acanthosis nigricans, hyperkeratosis and hypertrichosis. "
10.	Growth InhibitorsIBA 01/01/2020 - "Given that unwanted hair growth (hirsutism, hypertrichosis) can cause major psychological distress, new pharmacological treatment strategies with safe and effective hair growth inhibitors that do not destroy the hair follicle (HF) and its stem cells need to be developed. "

Therapies and Procedures

1.	Hair Removal (Depilation) 05/19/2021 - "Hair removal settings of LPNY and LP-Alex were effective in both hypertrichosis and pigment reduction in the initial strategy of treatment of BN in skin of color." 04/02/2014 - "Furthermore, hair removal of congenital and acquired hypertrichosis can relieve psychosocial discomfort and improve quality of life. " 03/01/2012 - "We report a case of 1-year-old girl with congenital hypertrichosis terminalis treated using intense pulsed light for hair removal. " 03/01/2012 - "Intense pulsed light hair removal in a patient with congenital hypertrichosis terminalis." 07/01/2005 - "Postlaser hair removal hypertrichosis is a real but rare occurrence in our experience."
2.	Lasers (Laser) 02/01/2000 - "Laser pulses which selectively damage pigmented hair follicles are a useful treatment for hypertrichosis. " 09/01/1999 - "Laser technologies have improved over recent years, bringing new opportunities for efficacious treatment of hypertrichosis. " 01/01/2011 - "In addition to lasers, intense pulsed light (IPL) sources are widely used in medicine to treat various indications, such as vascular lesions, irregular pigmentation and hypertrichosis. " 07/01/2005 - "All cases of laser-induced hypertrichosis were assessed clinically by history, examination, and laboratory tests, and confirmed by review of serial clinical photographs taken during the course of the laser treatments. " 03/01/2022 - "There are very few treatment experiences on H Syndrome patients and most of them are unsatisfactory apart from hypertrichosis, which is able to treat almost permanently by hair removal lasers. "
3.	Solid-State Lasers 03/01/2000 - "The long-pulsed alexandrite laser at a pulse duration of 20 msec is an effective and safe method of treatment of hypertrichosis in the facial region of women. " 08/01/2008 - "With the alexandrite laser Arion (755 nm), 13 treatments for hypertrichosis were evaluated. " 07/01/2004 - "Naevoid hypertrichosis treated with alexandrite laser." 01/01/2003 - "Lumbosacral hypertrichosis treated with the normal-mode ruby laser." 03/01/2000 - "In the retrospective study on hand, we report on results of 30 female patients with hypertrichosis in the facial area treated with the long pulse alexandrite laser at 20 msec (Cynosure PhotoGenica LPIR/Apogee; 755 nm; 20 msec; up to 30 J/cm2; 10 or 12.5 mm beam diameter) over an 18 month treatment period. "
4.	Therapeutics 03/01/2017 - "We aimed this study to compare the two hair-shortening methods shaving vs. snipping among hirsute women regarding the outcome of the therapy and also the paradoxical hypertrichosis phenomenon (terminal hair regrowth) 6 months after the final therapy session. " 06/01/2010 - "However, as control of eyelash growth and the underlying mechanisms of eyelash hypo- or hypertrichosis are largely obscure, available therapy is limited. " 01/01/2009 - "The cut-off filters frequently used were 695, 755 and 645 nm. Paradoxical hypertrichosis and terminal hair change were detected after a few sessions of IPL therapy among 51 out of 991 patients. " 09/01/2007 - "Therapy of hypertrichosis." 07/01/2001 - "To review the causes, presentation, and therapy of primary generalized and localized symmetrical hypertrichosis in children. "
5.	Semiconductor Lasers 01/01/2015 - "The purpose of this case report is to describe a diode laser resection of gingival hyperplasia in a seven-year-old patient with nonsyndromic HGF and hypertrichosis. " 01/01/2014 - "The study supports the use of low fluence with high-repetition-rate diode laser hair removal as a safe and effective method for the management of hypertrichosis in Becker's nevus."