|3.||Chronic Obstructive Pulmonary Disease (COPD)
|4.||Heart Diseases (Heart Disease)
|5.||Lung Diseases (Lung Disease)
|1.||Seeger, Werner: 69 articles (01/2016 - 01/2002)|
|2.||Humbert, Marc: 64 articles (01/2016 - 03/2002)|
|3.||Grimminger, Friedrich: 63 articles (11/2015 - 01/2002)|
|4.||Weissmann, Norbert: 56 articles (10/2015 - 01/2002)|
|5.||Abman, Steven H: 45 articles (12/2015 - 09/2002)|
|6.||Gladwin, Mark T: 45 articles (10/2015 - 07/2003)|
|7.||Simonneau, Gérald: 43 articles (01/2016 - 06/2002)|
|8.||Naeije, Robert: 39 articles (04/2015 - 03/2002)|
|9.||Voelkel, Norbert F: 36 articles (12/2015 - 04/2002)|
|10.||Fadel, Elie: 32 articles (12/2015 - 10/2003)|
|1.||Nitric Oxide (Nitrogen Monoxide)FDA Link
03/01/2003 - "Pulsed administration of nitric oxide has proven effective in relieving pulmonary hypertension and in improving oxygenation. "
09/01/1997 - "Recently it has been shown that inhaled nitric oxide (NO), which has been proven to contribute to improvement in critical pulmonary hypertension, may provide a favorable effect early after left ventricular assist device (LVAD) support. "
11/01/1999 - "Nitric oxide may be beneficial for patients with ACS because of its ability to ameliorate pulmonary hypertension and ventilation/perfusion mismatch. "
01/01/2012 - "Inhaled nitric oxide is effective in those with pulmonary hypertension, and other adjunctive therapies, including surfactant administration and lung lavage, should be considered in selected cases. "
06/01/2008 - "In our setting, both drugs were effective in treating moderate persistent pulmonary hypertension of the neonate but nitric oxide (NO) treatment resulted in much faster amelioration of oxygenation index, taken as a marker of the underlying condition. "
|2.||sildenafil (Viagra)FDA Link
07/01/2014 - "Intravenous sildenafil treatment has recently shown promising results and good tolerability in the treatment of refractory pulmonary hypertension (PH) in term and near-term neonates, while comparable data in preterm infants are still lacking. "
04/01/2012 - "Alternate therapies such as sildenafil may be beneficial in this specific population as well as in other causes of pulmonary hypertension. "
01/01/2006 - "Sildenafil has beneficial effects on cerebral vascular reactivity indicative of an improvement in neurovascular coupling in patients with pulmonary hypertension. "
08/01/2009 - "Long-term use of sildenafil in patients with secondary forms of pulmonary hypertension is associated with a sustained improvement in cardio-pulmonary haemodynamics. "
05/01/2014 - "It is concluded that sildenafil is effective in reducing pulmonary hypertension when administered preoperatively in patients with severe pulmonary hypertension undergoing mitral valve replacement surgery."
|3.||Epoprostenol (Prostacyclin)FDA LinkGeneric
06/01/2004 - "We describe a patient whose severe pulmonary hypertension following mitral valve replacement was treated successfully with continuous intravenous epoprostenol."
12/19/2000 - "Prostacyclin has proved to be a beneficial treatment for patients with severe pulmonary hypertension. "
06/01/1995 - "This might be explained by the fact that the reduction of pulmonary vascular resistance during PGI2 amounted to only 65% of the effect of NO. In summary, both inhaled NO and PGI2-aerosol showed beneficial effects on RV performance and may prove helpful in the treatment of acute pulmonary hypertension."
09/01/2010 - "Inhaled prostacyclin has been found to be effective in some patients with pulmonary hypertension. "
07/01/2008 - "Exogenous prostacyclin is effective in reducing pulmonary vascular resistance in some forms of human pulmonary hypertension (PH). "
11/01/2006 - "This study showed that increased expression of PCI in the lung is protective against monocrotaline-induced pulmonary hypertension, suggesting a potential beneficial effect of PCI for the therapy of this disease."
01/01/2015 - "Salvia Miltiorrhiza Bge.f.alba Ameliorates the Progression of Monocrotaline-Induced Pulmonary Hypertension by Protecting Endothelial Injury in Rats."
10/15/2014 - "Intratracheal administration of cyclooxygenase-1-transduced adipose tissue-derived stem cells ameliorates monocrotaline-induced pulmonary hypertension in rats."
09/01/2009 - "We tested whether CBDL ameliorates monocrotaline (MCT)-induced pulmonary hypertension (PH) in rats. "
12/01/2004 - "We investigated whether CNP ameliorates monocrotaline (MCT)-induced pulmonary hypertension in rats. "
10/01/2000 - "At present long-term oxygen therapy is the best treatment for pulmonary hypertension. "
09/01/2002 - "Long-term oxygen therapy (LOT) has become quite popular over the last 20 years due to better knowledge of the beneficial effect (improved life expectancy, improved quality of life, stabilization of the pulmonary hypertension) and to technological progress (concentrators, liquid oxygen). "
03/01/1990 - "This study tested the hypotheses that clearance of Group B Streptococcus (GBS) during transit through the pulmonary circulation of infant piglets is related to oxygen radical-dependent bacterial killing and that killing of the organism is linked to development of pulmonary hypertension. "
08/01/2001 - "Two adults showed improvement in oxygen saturation but worsening of pulmonary hypertension. "
08/01/1991 - "Long-term low-flow oxygen therapy can lead to improved exercise capacity and improved hemodynamics in selected patients with pulmonary hypertension. "
|6.||bosentan (Tracleer)FDA Link
08/01/2011 - "Bosentan has proven efficacy in pulmonary hypertension in the short term. "
12/01/2006 - "The results of this study suggest that treatment with bosentan is associated with long-term improvement in clinical variables and exercise capacity in approximately two thirds of the patients with pulmonary hypertension."
03/01/2013 - "Bosentan improved persistent pulmonary hypertension in a case after implantation of a left ventricular assist device."
09/01/2009 - "Long-term efficacy of bosentan in inoperable chronic thromboembolic pulmonary hypertension."
05/01/2009 - "Duration of right ventricular contraction predicts the efficacy of bosentan treatment in patients with pulmonary hypertension."
|7.||Iloprost (Ventavis)FDA Link
03/01/2008 - "In a randomized, double-blind, placebo controlled, multicenter study in 203 patients with pulmonary hypertension inhaled iloprost showed significant improvement of exercise capacity and pulmonary hemodynamics with excellent tolerability and safety. "
06/01/2013 - "Inhaled NO and iloprost significantly reduced pulmonary hypertension and contributed to the improvement in right ventricular function. "
01/01/2004 - "Inhaled iloprost 2.5 or 5 microg six or nine times daily for 12 weeks (n = 101) significantly (p < 0.01) improved a combined clinical endpoint of a > or =10% increase in distance walked in 6 minutes and an improvement of > or =1 class in New York Heart Association functional class without clinical deterioration or death (16.8 versus 4.9% of placebo recipients, n = 102) in patients with severe PPH or selected forms of nonprimary pulmonary hypertension. "
01/01/2008 - "In animals with acute pulmonary hypertension, inhaled iloprost improved global haemodynamics primarily via selective pulmonary vasodilatation and restoration of left ventricular preload. "
02/01/2004 - "The main objective of the present study was to evaluate the safety and efficacy of inhaled iloprost in HIV-related pulmonary hypertension. "
|8.||Idiopathic pulmonary hypertensionIBA
03/01/2006 - "This may be important in the future if new specific therapies for primary pulmonary hypertension are shown to be beneficial in secondary pulmonary hypertension. "
01/01/2009 - "It has been shown recently that similar pharmacotheraeutic approaches as they are used in patients with pulmonary arterial hypertension are effective in some cases of other forms of chronic pulmonary hypertension. "
08/11/2007 - "There have been tremendous progresses in research and improvement in therapeutic options for pulmonary arterial hypertension (PAH) and other types of pulmonary hypertension (PH) over the last 15 years. "
03/01/2006 - "However, although several new selective therapies are effective in idiopathic pulmonary arterial hypertension, their role in secondary pulmonary hypertension remains unclear."
09/01/2006 - "The efficacy of PDE5 inhibition in the treatment of pulmonary arterial hypertension has led to the investigation of its potential utility in the treatment of HF patients with secondary pulmonary hypertension. "
|9.||Vasodilator Agents (Vasodilators)IBA
01/01/2003 - "Vasodilators may be more effective in reducing pulmonary hypertension in females than in males."
01/01/2004 - "Vasodilators are considered effective in the treatment of pulmonary hypertension if the vascular reactivity remains reversible. "
02/01/1986 - "Diminished relaxation observed after pulmonary hypertension was well established may contribute to the loss in efficacy of vasodilators in the long-term management of pulmonary hypertension."
04/01/2004 - "In cardiothoracic surgery, inhaled vasodilators have been shown to improve pulmonary circulation when severe pulmonary hypertension is present. "
08/01/2008 - "Second, there needs to be early detection of pulmonary hypertension, which is an unfavorable prognostic factor and trial of vasodilators in patients with pulmonary hypertension. "
|10.||Alprostadil (Muse)FDA LinkGeneric
05/06/2013 - "This study sought to investigate the efficacy of a noninvasive and long acting polymeric particle based formulation of prostaglandin E1 (PGE1), a potent pulmonary vasodilator, in alleviating the signs of pulmonary hypertension (PH) and reversing the biochemical changes that occur in the diseased lungs. "
01/01/1999 - "These results suggest that administering PGE1 may be effective in the treatment of some forms of pulmonary hypertension in humans."
11/01/1995 - "Administration of prostaglandin E1 (PGE1) was effective in treating residual pulmonary hypertension."
01/01/1992 - "The infusion of prostaglandin E1, a vasodilating substance with predominant effects on the pulmonary vasculature, has been found effective in the management of pulmonary hypertension associated with various diseases. "
08/01/1995 - "PGE1 may be useful for the treatment of pulmonary hypertension in humans."
12/01/2011 - "Pulmonary endarterectomy (PEA) is the most effective treatment for chronic thromboembolic pulmonary hypertension (CTEPH). "
02/01/2008 - "Pulmonary endarterectomy is the best treatment for patients with chronic thromboembolic pulmonary hypertension. "
08/05/2006 - "Pulmonary endarterectomy is a complex surgical procedure, which provides permanent relief of thromboembolic pulmonary hypertension and cure for most of the patients. "
09/01/2006 - "Although pulmonary endarterectomy (PEA) has been proven a very effective treatment for chronic thromboembolic pulmonary hypertension, it cannot be performed in a substantial proportion of patients. "
03/01/2011 - "This study demonstrates that pulmonary thromboendarterectomy surgery in pediatric patients with chronic thromboembolic pulmonary hypertension is well tolerated with improved postoperative hemodynamics, functional status, minimal postoperative complications, and low perioperative mortality, similar to that reported for adults with chronic thromboembolic pulmonary hypertension, with the notable exception being a higher rate of rethrombosis in pediatric patients."
|2.||Extracorporeal Membrane Oxygenation (ECMO)
05/01/1996 - "However, a second course of ECMO may be beneficial in a select group of infants when recurrent persistent pulmonary hypertension develops. "
04/01/2015 - "Improved survival at our institution may be related to recent introduction of ECMO and more aggressive approaches to pulmonary hypertension. "
04/01/1995 - "We describe a case of PPHN in which neither inhaled NO nor ECMO was effective in reversing pulmonary hypertension. "
11/01/1994 - "Inhaled NO may be effective in neonates with hypoplastic lungs who have recurrent episodes of pulmonary hypertension after ECMO, even if they were previously unresponsive."
01/01/1994 - "Where persistent pulmonary hypertension is a complicating problem the improved oxygenation resulting from the use of ECMO has a therapeutic role. "
04/01/2006 - "She underwent living-donor lobar lung transplantation (LDLLT), which led to remarkable improvement in both pulmonary hypertension and PLE. "
12/01/1997 - "Thus, pulmonary thrombendarterectomy is an effective treatment for chronic thromboembolic pulmonary hypertension with results superior to those of lung transplantation."
06/01/1996 - "Results suggest that right lung transplantation is superior to left lung transplantation for pulmonary hypertension in terms of exercise performance in this animal model."
10/01/1993 - "Two-dimensional echocardiography demonstrates sustained improvement in right ventricular function after single-lung transplantation for severe pulmonary hypertension despite severe preoperative dysfunction."
01/01/1989 - "We concluded that single lung transplantation could be an effective treatment for pulmonary hypertension."
|4.||Transplantation (Transplant Recipients)
08/19/2003 - "Transplantation of AM gene-transduced EPCs caused significantly greater improvement in pulmonary hypertension in MCT rats than transplantation of EPCs alone. "
05/01/2014 - "To study the influence of bone marrow mesenchymal stem cells (MSCs) transplantation on hypoxic pulmonary hypertension (HPH) in rats. "
02/01/1998 - "During the period of this study, 58 patients with pulmonary hypertension died on our center's waiting list before coming to transplantation. "
01/01/2016 - "Pulmonary hypertension (PH) among heart transplant recipients is associated with an increased risk of mortality. "
11/01/2015 - "We sought to investigate the effect of continuous-flow left ventricular assist device support on pulmonary hypertension and compare post-transplantation outcomes in patients with preexisting pulmonary hypertension. "
|5.||Heart Transplantation (Grafting, Heart)
02/01/2004 - "Right ventricle-sparing heart transplantation effective against iatrogenic pulmonary hypertension."
05/01/2004 - "We describe a patient whose previously fixed pulmonary hypertension improved to the point that she was once again considered eligible for cardiac transplantation."
01/01/1996 - "This agent also holds promise for evaluating patients with pulmonary hypertension prior to heart transplantation. "
10/01/2013 - "Subjects were children undergoing cardiac catheterization for either routine surveillance after cardiac transplantation (n = 21) or pulmonary hypertension studies (n = 21). "
07/01/2009 - "The goal of this study was to analyze the hemodynamic responses during vasoreactivity tests among candidates for heart transplantation who displayed severe pulmonary hypertension seeking to identify risk markers of nonresponse to the test. "