Pulmonary Hypertension (Ayerza Syndrome)

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7453 relevant articles (553 outcomes, 782 trials/studies) found for this Disease

Description: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.

Also Known As:

Ayerza Syndrome; Hypertension, Pulmonary; Ayerza-Arrilaga Syndrome; Ayerza Arrilaga Syndrome; Ayerzas Syndrome; Syndrome, Ayerza; Syndrome, Ayerza-Arrilaga; Ayerza's Syndrome

Relationship Network

Disease Context: Research Results

Respiratory Tract Diseases: 372

Lung Diseases: 8778

Pulmonary Hypertension: 7453

Persistent Fetal Circulation Syndrome: 62

Related Diseases

1.	Anoxia (Hypoxia)
2.	Heart Failure
3.	Chronic Obstructive Pulmonary Disease (COPD)
4.	Adult Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
5.	Hypertension (High Blood Pressure)
524 Diseases and 3505 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Seeger, Werner: 22 articles (07/2008 - 01/2002)
2.	Grimminger, Friedrich: 19 articles (07/2008 - 01/2002)
3.	Weissmann, Norbert: 16 articles (07/2008 - 04/2002)
4.	Adnot, Serge: 15 articles (01/2007 - 01/2002)
5.	Eddahibi, Saadia: 15 articles (01/2007 - 01/2002)
6.	Nagaya, Noritoshi: 14 articles (01/2008 - 02/2003)
7.	Olschewski, Horst: 14 articles (01/2008 - 01/2002)
8.	Eddahibi, S: 13 articles (11/2007 - 03/2000)
9.	Adnot, S: 13 articles (11/2007 - 03/2000)
10.	Humbert, M: 13 articles (08/2007 - 06/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pulmonary Hypertension:

1.	Nitric Oxide (Nitrogen Monoxide)FDA Link 03/01/2003 - "BACKGROUND: Pulsed administration of nitric oxide has proven effective in relieving pulmonary hypertension and in improving oxygenation" 09/01/1997 - "Recently it has been shown that inhaled nitric oxide (NO), which has been proven to contribute to improvement in critical pulmonary hypertension, may provide a favorable effect early after left ventricular assist device (LVAD) support" 11/01/1999 - "CONCLUSIONS: Nitric oxide may be beneficial for patients with ACS because of its ability to ameliorate pulmonary hypertension and ventilation/perfusion mismatch" 06/01/2008 - "In our setting, both drugs were effective in treating moderate persistent pulmonary hypertension of the neonate but nitric oxide (NO) treatment resulted in much faster amelioration of oxygenation index, taken as a marker of the underlying condition" 11/01/2004 - "Inhaled nitric oxide (iNO) therapy is an effective treatment of pulmonary hypertension following left ventricular assist device (LVAD) implantation" Get all the results and reference details, order at left...
2.	Epoprostenol (Prostacyclin)FDA Link 06/01/2004 - "We describe a patient whose severe pulmonary hypertension following mitral valve replacement was treated successfully with continuous intravenous epoprostenol." 12/19/2000 - "BACKGROUND: Prostacyclin has proved to be a beneficial treatment for patients with severe pulmonary hypertension" 06/01/1995 - "This might be explained by the fact that the reduction of pulmonary vascular resistance during PGI2 amounted to only 65% of the effect of NO. In summary, both inhaled NO and PGI2-aerosol showed beneficial effects on RV performance and may prove helpful in the treatment of acute pulmonary hypertension." 09/15/1994 - "CONCLUSIONS: Continuous intravenous prostacyclin resulted in sustained clinical and hemodynamic improvement and probably in improved survival in patients with severe primary pulmonary hypertension" 04/01/1990 - "CONCLUSIONS: Prostacyclin produces substantial and sustained hemodynamic and symptomatic responses in severe primary pulmonary hypertension and may be useful in the management of some patients with this disease." Get all the results and reference details, order at left...
3.	sildenafil (Viagra)FDA Link 01/01/2006 - "CONCLUSIONS: Sildenafil has beneficial effects on cerebral vascular reactivity indicative of an improvement in neurovascular coupling in patients with pulmonary hypertension" 07/01/2002 - "Sildenafil, a pulmonary vasodilator, is likely to be beneficial in primary pulmonary hypertension" 01/01/2008 - "BACKGROUND: Sildenafil has been shown to be effective in the treatment of pulmonary hypertension, and has favourable effects on endothelial function" 02/01/2006 - "The question addressed was whether sildenafil was effective in treating postoperative pulmonary hypertension after pediatric heart surgery" 02/01/2006 - "Is sildenafil effective for treating pulmonary hypertension after pediatric heart surgery?" Get all the results and reference details, order at left...
4.	OxygenIBA 10/01/2000 - "At present long-term oxygen therapy is the best treatment for pulmonary hypertension" 09/01/2002 - "Long-term oxygen therapy (LOT) has become quite popular over the last 20 years due to better knowledge of the beneficial effect (improved life expectancy, improved quality of life, stabilization of the pulmonary hypertension) and to technological progress (concentrators, liquid oxygen)" 03/01/1990 - "This study tested the hypotheses that clearance of Group B Streptococcus (GBS) during transit through the pulmonary circulation of infant piglets is related to oxygen radical-dependent bacterial killing and that killing of the organism is linked to development of pulmonary hypertension" 11/01/2007 - "Long-term oxygen thera- py (LTOT) aims to improve it, withwell known its be- nefits: improvement in quality of life and exercise tole- rance, enhancement of neuropsychological status, pre- vention or delay of pulmonary hypertension, and improvement in survival" 08/01/2001 - "Two adults showed improvement in oxygen saturation but worsening of pulmonary hypertension" Get all the results and reference details, order at left...
5.	Vasodilator Agents (Vasodilators)IBA 01/01/2003 - "Vasodilators may be more effective in reducing pulmonary hypertension in females than in males." 01/01/2006 - "PDE-5 inhibitors are selective pulmonary vasodilators effective in animal models of pulmonary hypertension" 01/01/2004 - "PURPOSE: Vasodilators are considered effective in the treatment of pulmonary hypertension if the vascular reactivity remains reversible" 02/01/1986 - "Diminished relaxation observed after pulmonary hypertension was well established may contribute to the loss in efficacy of vasodilators in the long-term management of pulmonary hypertension." 04/01/2004 - "In cardiothoracic surgery, inhaled vasodilators have been shown to improve pulmonary circulation when severe pulmonary hypertension is present" Get all the results and reference details, order at left...
6.	bosentan (Tracleer)FDA Link 12/01/2006 - "CONCLUSIONS: The results of this study suggest that treatment with bosentan is associated with long-term improvement in clinical variables and exercise capacity in approximately two thirds of the patients with pulmonary hypertension." 07/01/2006 - "The efficacy of bosentan in inoperable chronic thromboembolic pulmonary hypertension: a 1-year follow-up study." 10/01/2005 - "OBJECTIVE: To investigate the safety and efficacy of bosentan therapy in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH)" 02/01/2005 - "First-line bosentan therapy was found to improve survival in patients with advanced primary pulmonary hypertension." 10/20/2007 - "STUDY OBJECTIVES: we performed an open-label national study to evaluate the effects of Bosentan on haemodynamics, exercise capacity, quality of life, safety and tolerability in patients with chronic thromboembolic pulmonary hypertension (CTEPH)" Get all the results and reference details, order at left...
7.	MonocrotalineIBA 11/01/2006 - "CONCLUSIONS: This study showed that increased expression of PCI in the lung is protective against monocrotaline-induced pulmonary hypertension, suggesting a potential beneficial effect of PCI for the therapy of this disease." 12/01/2004 - "We investigated whether CNP ameliorates monocrotaline (MCT)-induced pulmonary hypertension in rats" 11/01/2003 - "We investigated whether inhalation of aerosolized AM ameliorates monocrotaline (MCT)-induced pulmonary hypertension in rats" 06/22/1993 - "reduction of total caloric intake, has been shown to result in protection against monocrotaline (MCT)-induced pulmonary hypertension (PH)" 03/01/2008 - "The present study was designed to investigate chronic effects of oral pumafentrine, a mixed selective PDE-3/4 inhibitor, in monocrotaline (MCT)-induced pulmonary hypertension in rats" Get all the results and reference details, order at left...
8.	Iloprost (Ventavis)FDA Link 01/01/2004 - "While inhaled iloprost has been described to be highly effective in the treatment of primary pulmonary hypertension, the possibility of contrary "paradoxical" reactions in isolated patients is emphasised, with a dramatic increase of PVR and a possible adverse outcome." 03/01/2008 - "In a randomized, double-blind, placebo controlled, multicenter study in 203 patients with pulmonary hypertension inhaled iloprost showed significant improvement of exercise capacity and pulmonary hemodynamics with excellent tolerability and safety" 01/01/2004 - "Inhaled iloprost 2.5 or 5 microg six or nine times daily for 12 weeks (n = 101) significantly (p < 0.01) improved a combined clinical endpoint of a > or =10% increase in distance walked in 6 minutes and an improvement of > or =1 class in New York Heart Association functional class without clinical deterioration or death (16.8 versus 4.9% of placebo recipients, n = 102) in patients with severe PPH or selected forms of nonprimary pulmonary hypertension" 02/01/2004 - "The main objective of the present study was to evaluate the safety and efficacy of inhaled iloprost in HIV-related pulmonary hypertension" 07/15/2008 - "RATIONALE: Iloprost is effective for the treatment of pulmonary hypertension" Get all the results and reference details, order at left...
9.	Nifedipine (Adalat)FDA LinkGeneric 01/01/1994 - "We suggest that high doses of nifedipine may be--in some patients--effective in reducing thromboembolic pulmonary hypertension." 04/01/1983 - "In individual cases, promising results in patients with primary pulmonary hypertension have been reported during long-term therapy with nifedipine provided that a favorable initial response could be documented." 08/01/1993 - "These results suggest that treatment with nifedipine may also be effective in attenuation of pulmonary hypertension when applied to humans." 01/01/1990 - "Nifedipine is potentially useful for the treatment of hypoxic pulmonary hypertension in patients with CF." 06/01/1983 - "Primary pulmonary hypertension improved by long-term oral administration of nifedipine." Get all the results and reference details, order at left...
10.	Alprostadil (Muse)FDA LinkGeneric 01/01/1999 - "These results suggest that administering PGE1 may be effective in the treatment of some forms of pulmonary hypertension in humans." 11/01/1995 - "Administration of prostaglandin E1 (PGE1) was effective in treating residual pulmonary hypertension." 01/01/1992 - "The infusion of prostaglandin E1, a vasodilating substance with predominant effects on the pulmonary vasculature, has been found effective in the management of pulmonary hypertension associated with various diseases" 08/01/1995 - "PGE1 may be useful for the treatment of pulmonary hypertension in humans." 08/01/2005 - "The patients, at the age of 0 days, were divided into 2 groups, PG (+) and PG (-), according to the requirement of prostaglandin E1 (PGE1) to attenuate pulmonary hypertension" Get all the results and reference details, order at left...
1378 Drugs and Important Bio-Agents and 6153 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Endarterectomy (Thromboendarterectomy) 02/01/2008 - "OBJECTIVE: Pulmonary endarterectomy is the best treatment for patients with chronic thromboembolic pulmonary hypertension" 08/05/2006 - "Pulmonary endarterectomy is a complex surgical procedure, which provides permanent relief of thromboembolic pulmonary hypertension and cure for most of the patients" 09/01/2006 - "Although pulmonary endarterectomy (PEA) has been proven a very effective treatment for chronic thromboembolic pulmonary hypertension, it cannot be performed in a substantial proportion of patients" 11/01/2005 - "BACKGROUND: Pulmonary thromboendarterectomy is an effective treatment for patients with chronic thromboembolic pulmonary hypertension" 01/01/2000 - "CONCLUSIONS: Pulmonary thromboendarterectomy provides effective treatment for chronic thromboembolic pulmonary hypertension." Get all the results and reference details, order at left...
2.	Extracorporeal Membrane Oxygenation (ECMO) 05/01/1996 - "However, a second course of ECMO may be beneficial in a select group of infants when recurrent persistent pulmonary hypertension develops" 04/01/1995 - "We describe a case of PPHN in which neither inhaled NO nor ECMO was effective in reversing pulmonary hypertension" 11/01/1994 - "Inhaled NO may be effective in neonates with hypoplastic lungs who have recurrent episodes of pulmonary hypertension after ECMO, even if they were previously unresponsive." 01/01/1994 - "Where persistent pulmonary hypertension is a complicating problem the improved oxygenation resulting from the use of ECMO has a therapeutic role" 05/01/2004 - "Factors that improved the odds of survival were initiation of ECMO in theatre (64% survival (30 of 47)) rather than the cardiac intensive care unit (29% survival (10 of 34)) and initiation of ECMO for reactive pulmonary hypertension" Get all the results and reference details, order at left...
3.	Lung Transplantation 04/01/2006 - "She underwent living-donor lobar lung transplantation (LDLLT), which led to remarkable improvement in both pulmonary hypertension and PLE" 06/01/1996 - "CONCLUSIONS: Results suggest that right lung transplantation is superior to left lung transplantation for pulmonary hypertension in terms of exercise performance in this animal model." 10/01/1993 - "Two-dimensional echocardiography demonstrates sustained improvement in right ventricular function after single-lung transplantation for severe pulmonary hypertension despite severe preoperative dysfunction." 01/01/1989 - "We concluded that single lung transplantation could be an effective treatment for pulmonary hypertension." 03/01/1996 - "CONCLUSION: Inhalation of NO reduced pulmonary vascular resistance in the transplanted lung and may be useful in the treatment of pulmonary hypertension after lung transplantation" Get all the results and reference details, order at left...
4.	Transplantation (Transplant Recipients) 08/19/2003 - "Transplantation of AM gene-transduced EPCs caused significantly greater improvement in pulmonary hypertension in MCT rats than transplantation of EPCs alone" 02/01/1996 - "Selected lung transplant recipients with severe preoperative pulmonary hypertension have previously been shown to have a reduction in right ventricular size and improved function at follow-up evaluation" 02/01/1998 - "During the period of this study, 58 patients with pulmonary hypertension died on our center's waiting list before coming to transplantation" 02/15/2008 - "Blacks were less likely to undergo transplantation after listing compared with whites, despite adjustment for age, lung function, pulmonary hypertension, cardiovascular risk factors, insurance coverage, and poverty level (adjusted hazard ratio, 0.83; 95% confidence interval, 0.70-0.98; P = 0.03)" 12/27/2007 - "Our findings indicate that increased systolic blood pressure, reduced glomerular filtration rate, and idiopathic pulmonary hypertension are risk factors for chronic RD in lung transplant recipients." Get all the results and reference details, order at left...
5.	Heart Transplantation (Grafting, Heart) 02/01/2004 - "Right ventricle-sparing heart transplantation effective against iatrogenic pulmonary hypertension." 05/01/2004 - "We describe a patient whose previously fixed pulmonary hypertension improved to the point that she was once again considered eligible for cardiac transplantation." 01/01/1996 - "This agent also holds promise for evaluating patients with pulmonary hypertension prior to heart transplantation" 05/01/2007 - "CONCLUSIONS: This study supports that LVAD support and continuous nonpulsatile mechanical unloading of the left ventricle can reverse medically unresponsive pulmonary hypertension and render patients eligible for orthotopic heart transplantation." 01/01/2006 - "AIM OF THE STUDY: evaluation of pulmonary hypertension in candidates for heart transplantation" Get all the results and reference details, order at left...
176 Therapies and Procedures and 1969 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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