Hypertension (High Blood Pressure)

Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Also Known As:
High Blood Pressure; Blood Pressures, High; High Blood Pressures; Blood Pressure, High
Networked: 98788 relevant articles (4997 outcomes, 13739 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Heart Failure
2. Stroke (Strokes)
3. Obesity
4. Diabetes Mellitus
5. Cardiovascular Diseases (Cardiovascular Disease)


1. Devereux, Richard B: 133 articles (11/2015 - 02/2002)
2. Dahlöf, Björn: 124 articles (11/2015 - 02/2002)
3. Oparil, Suzanne: 110 articles (01/2016 - 02/2002)
4. Kjeldsen, Sverre E: 110 articles (12/2015 - 01/2002)
5. Schiffrin, Ernesto L: 107 articles (01/2016 - 01/2002)
6. Schmieder, Roland E: 102 articles (12/2015 - 01/2002)
7. Touyz, Rhian M: 100 articles (09/2015 - 01/2002)
8. Böhm, Michael: 93 articles (01/2016 - 01/2002)
9. Johnson, Richard J: 92 articles (01/2016 - 02/2002)
10. Bakris, George L: 92 articles (12/2015 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypertension:
1. Hydrochlorothiazide (Esidrix)FDA LinkGeneric
2. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
3. Antihypertensive Agents (Antihypertensives)IBA
4. CalciumIBA
5. Amlodipine (Norvasc)FDA LinkGeneric
6. Nifedipine (Adalat)FDA LinkGeneric
7. Captopril (Capoten)FDA LinkGeneric
8. ReninIBA
9. Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
10. EnalaprilFDA LinkGeneric

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Denervation
05/01/2013 - "Experimental and clinical studies suggest that renal denervation therapy is an effective and safe treatment for patients with therapy-resistant hypertension leading to a reduction in blood pressure and in systemic and renal sympathetic nervous activation, which plays an important role in the development, progression and prognosis of arterial hypertension. "
03/01/2014 - "The authors found that the percutaneous renal nerve denervation was very effective in blood pressure reduction in these first four cases of Thai patients with resistant hypertension."
12/01/2012 - "These indications may have important implications not only from a clinical point of view, but also from an economic point of view, since a proper identification of patients with true resistant hypertension and an accurate selection of patients suitable for the procedure of renal denervation can contribute to an improved control of blood pressure, and thus a reduced risk of cardiovascular and cerebrovascular complications in these patients."
01/01/2015 - "Recently published results of Symplicity-III trial (HTN-3), the first blinded, randomized, multicenter study on the efficacy of renal denervation for the treatment of resistant hypertension did not show a significant reduction of BP in patients with resistant hypertension 6 months after renal-artery denervation, as compared with controls. "
01/01/2011 - "The entire procedure lasts about 40 min. In early clinical trials, the systolic blood pressure in 87% of patients who underwent the denervation procedure resulted in an average blood pressure drop of greater than 10 mm Hg. The procedure has no systematic side effects, and appears to be beneficial in the management of hypertension in patients refractory to pharmacological therapy."
3. Nephrectomy
4. Angioplasty (Angioplasty, Transluminal)
5. Transplants (Transplant)